Low dose naltrexone (LDN) has become a popular off-label therapy for multiple sclerosis (MS). A few small, randomized studies indicate that LDN may have beneficial effects in MS and other autoimmune diseases. If proven efficacious, it would be a cheap and safe alternative to the expensive treatments currently recommended for MS. We investigated whether a sudden increase in LDN use in Norway in 2013 was followed by changes in dispensing of other medications used to treat MS. We performed a quasi-experimental before-and-after study based on population data from the Norwegian Prescription Database (NorPD). We included all patients that collected at least one LDN prescription in 2013, and had collected at least two medications with a reimbursement code for MS, or collected a medication with MS as the only indication in 2009 or 2010. Outcomes were differences in cumulative dispensed doses and incidence of users of disease modifying MS therapies, and medications used to treat MS symptoms two years before and two years after dispensing the initial LDN prescription. The eligible 341 patients collected 20 921 prescriptions in the observation period. Apart from changes in line with general trends in MS therapy in Norway, there was no difference in neither dispensed cumulative doses or number of prevalent users of MS specific medication. Initiation of LDN was not followed by reductions of other medications used to treat symptoms associated with MS.
Cites: Pharmacoepidemiol Drug Saf. 2017 Jun;26(6):685-69328370746
Cites: Mult Scler J Exp Transl Clin. 2016 Sep 29;2:205521731667224228607740
Cites: Neurol Neuroimmunol Neuroinflamm. 2014 Aug 21;1(3):e2525340078
Cites: Tidsskr Nor Laegeforen. 2011 May 6;131(8):844-621556092
Cites: Cochrane Database Syst Rev. 2010 Dec 08;(12):CD00186721154349
The literature data and own investigations of the use of the nanotechnologies in medicine have been analyzed in the article. First investigations in the field of nanotechnology made the basis of new decisions in medicine, pharmacology, gene engineering and robot technology. Miniaturisation defines new chemical, physical and biological characteristics of biological objects, which differ from macroobject's characteristics. Study of this unique properties allows developing new technologies and methods in medicine. Nanomedications are used for diagnostic of different conditions, in the first place, cancer diseases. Nanoparticles can be mediators of effective substations or be active drug components. The use of nanotechnology allows reducing the dose of medicine and makes the treatment more safe. Fulerens, nano dispersible silica oxide, nanocaps, liposoms, created by nanotechnology are used in medical practice. It was established that suspension of nano dispersible silica oxide decreases toxicity of antituberculosis drugs, chemical substances of different structure.