Skip header and navigation

Refine By

594 records – page 1 of 60.

Tumor resistance. Proceedings of an international symposium. Holte, Denmark, September 13-14, 1980.

https://arctichealth.org/en/permalink/ahliterature26873
Source
Tokai J Exp Clin Med. 1983 Dec;8(5-6):385-548
Publication Type
Article
Date
Dec-1983
Source
Tokai J Exp Clin Med. 1983 Dec;8(5-6):385-548
Date
Dec-1983
Language
English
Publication Type
Article
Keywords
Animals
Disease Susceptibility
Humans
Neoplasms - immunology
PubMed ID
6681337 View in PubMed
Less detail

Autoimmune hepatitis. Part A: pathogenesis.

https://arctichealth.org/en/permalink/ahliterature161060
Source
Expert Rev Gastroenterol Hepatol. 2007 Oct;1(1):113-28
Publication Type
Article
Date
Oct-2007
Author
Albert J Czaja
Author Affiliation
Mayo Clinic, 200 First Street S.W., Rochester, Minnesota 55905, USA. czaja.albert@mayo.edu
Source
Expert Rev Gastroenterol Hepatol. 2007 Oct;1(1):113-28
Date
Oct-2007
Language
English
Publication Type
Article
Keywords
Disease Susceptibility
Hepatitis, Autoimmune - etiology - genetics - immunology
Humans
Abstract
Autoimmune hepatitis is a consequence of a triggering antigen and genetic factors that favor the presentation of autoantigens, polymorphisms that affect immunocyte activation and durability, cytokine alterations that promote proliferation of liver-infiltrating cytotoxic T cells, and perturbations in the number and function of immune-regulatory cell populations, including T regulatory cells and natural killer T cells. The triggering epitope is probably a short sequence peptide that is common in multiple infectious or toxic agents. Homologies between this epitope and self-antigens (molecular mimicry) may stimulate humoral and cellular responses that are cross-reactive. Sensitized immunocytes extend and perpetuate the inflammation through imprecise targeting of self-antigens that resemble foreign antigens (promiscuous behavior). The occurrence and clinical phenotype of the disease may relate to genetic susceptibility factors that favor protracted exposure to indigenous etiological agents, and these genetic factors can vary in different geographical regions and ethnic groups. The clinical phenotype within a population can be modified further by genetic polymorphisms that are not disease specific and that affect immunocyte activation, differentiation, proliferation and programmed death (apoptosis). Autoimmune hepatitis is a model of autoreactivity that reflects multiple disturbances in the counter-regulatory mechanisms essential for immune homeostasis.
PubMed ID
19072440 View in PubMed
Less detail

Eskimo disease pattern--genes or environment?

https://arctichealth.org/en/permalink/ahliterature243627
Source
Acta Med Scand. 1982;212(3):97-8
Publication Type
Article
Date
1982
Author
B. Harvald
Source
Acta Med Scand. 1982;212(3):97-8
Date
1982
Language
English
Publication Type
Article
Keywords
Disease Susceptibility
Environment
Genetic Predisposition to Disease
Humans
Inuits
PubMed ID
7148512 View in PubMed
Less detail

Investigation of malignant hyperthermia susceptibility in Denmark.

https://arctichealth.org/en/permalink/ahliterature212244
Source
Dan Med Bull. 1996 Apr;43(2):111-25
Publication Type
Article
Date
Apr-1996
Author
H. Ording
Author Affiliation
Danish Malignant Hyperthermia Register, Herlev Hospital; Rigshospitalet, Copenhagen.
Source
Dan Med Bull. 1996 Apr;43(2):111-25
Date
Apr-1996
Language
English
Publication Type
Article
Keywords
Animals
Denmark - epidemiology
Disease Susceptibility
Humans
Malignant Hyperthermia - diagnosis - epidemiology
PubMed ID
8741205 View in PubMed
Less detail

The future of geriatric medicine in Canada.

https://arctichealth.org/en/permalink/ahliterature236370
Source
Gerontion. 1986 Nov-Dec;1(5):19-23
Publication Type
Article
Author
D. Skelton
Source
Gerontion. 1986 Nov-Dec;1(5):19-23
Language
English
Publication Type
Article
Keywords
Aged
Canada
Chronic Disease
Disease Susceptibility
Geriatrics - trends
Humans
Patient care team
PubMed ID
3640719 View in PubMed
Less detail

[On the incidence of exudative diathesis among children under 3 years of age].

https://arctichealth.org/en/permalink/ahliterature256193
Source
Vopr Okhr Materin Det. 1971 Jul;16(7):88
Publication Type
Article
Date
Jul-1971
Author
M G Mukovnikov
Source
Vopr Okhr Materin Det. 1971 Jul;16(7):88
Date
Jul-1971
Language
Russian
Publication Type
Article
Keywords
Child, Preschool
Disease Susceptibility
Humans
Infant
Infant, Newborn
Moscow
Skin Diseases - epidemiology
PubMed ID
5133775 View in PubMed
Less detail

[Biochemical polymorphic systems in the migrant population of northeastern USSR. VI. Genetic structure of patients in separate nosological groups].

https://arctichealth.org/en/permalink/ahliterature235025
Source
Genetika. 1987 Jul;23(7):1311-8
Publication Type
Article
Date
Jul-1987
Author
L L Solovenchuk
Source
Genetika. 1987 Jul;23(7):1311-8
Date
Jul-1987
Language
Russian
Publication Type
Article
Keywords
Disease Susceptibility
Emigration and Immigration
Genetic markers
Genetics, Medical
Humans
Polymorphism, Genetic
Siberia
Abstract
Genotype frequency distribution for a number of polymorphic loci in patients differs significantly in different nosologic groups, in relation to each other and to a sample of healthy individuals. Genetic structure specificity of each nosologic group and different trends of genetic frequency variations, in relation to the sample of healthy individuals, leads to considerable decrease in genetic differences between the united group of pathology and healthy individuals' sample. Spatial differentiation of genetic structure of separate nosologic groups and healthy individuals' sample also confirms genetic isolation of each of these groups and, at the same time, reveals clearly nonspecific biological resistance of human organism.
PubMed ID
3477515 View in PubMed
Less detail

Canadian collaborative project on genetic susceptibility to MS, phase 2: rationale and method. Canadian Collaborative Study Group.

https://arctichealth.org/en/permalink/ahliterature204811
Source
Can J Neurol Sci. 1998 Aug;25(3):216-21
Publication Type
Article
Date
Aug-1998
Author
A D Sadovnick
N J Risch
G C Ebers
Author Affiliation
Department of Medical Genetics, University of British Columbia, Vancouver.
Source
Can J Neurol Sci. 1998 Aug;25(3):216-21
Date
Aug-1998
Language
English
Publication Type
Article
Keywords
Canada - epidemiology
Disease Susceptibility
Genetic Testing
Geography
Humans
Multiple Sclerosis - epidemiology - genetics
Questionnaires
Abstract
Results from the Canadian Collaborative Project on Genetic Susceptibility to Multiple Sclerosis (MS)-Phase 1 (CCPGSMS-Phase 1) together with other family data published since 1982 have led to the following conclusions about the etiology of MS: (i) genetic and non-genetic (environmental) factors are involved in the etiology of MS on a population basis; (ii) the familial aggregation of MS is genetic; (iii) maternal factors do not influence the risk for siblings to develop MS; and (iv) MS appears to be oligogenic. The present paper describes the rationale and methodology for the CCPGSMS-Phase 2.
The CCPGSMS-Phase 2 is a nation-wide collaborative effort involving all the 15 Canadian MS clinics. A series of structured questionnaires is administered to MS index cases, spouse controls and mothers of index cases and spouse controls (if available) by trained interviewers. Blood samples are taken for molecular genetic studies. This national effort is coordinated by the MS Clinics in Vancouver and London.
The CCPGSMS-Phase 2 is in progress so specific results are not available. The study is designed to (i) increase the database for genetic epidemiological/molecular genetic research and (ii) gather population-based data to further our understanding of the non-genetic factors in the etiology of MS.
It is anticipated that the results from this study will impact on the eventual prevention, cure and treatment of MS.
PubMed ID
9706723 View in PubMed
Less detail
Source
Am Heart J. 1973 Sep;86(3):425-6
Publication Type
Article
Date
Sep-1973
Author
G A Sheehan
Source
Am Heart J. 1973 Sep;86(3):425-6
Date
Sep-1973
Language
English
Publication Type
Article
Keywords
Age Factors
Denmark
Disease Susceptibility
England
Humans
Longevity
Somatotypes
Sports Medicine
United States
PubMed ID
4727274 View in PubMed
Less detail

A follow-up on workers with predicted individual susceptibility to silicosis.

https://arctichealth.org/en/permalink/ahliterature221125
Source
Med Lav. 1993 May-Jun;84(3):249
Publication Type
Article

594 records – page 1 of 60.