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1806 records – page 1 of 181.

A 3-year clinical follow-up of adult patients with 3243A>G in mitochondrial DNA.

https://arctichealth.org/en/permalink/ahliterature82145
Source
Neurology. 2006 May 23;66(10):1470-5
Publication Type
Article
Date
May-23-2006
Author
Majamaa-Voltti K A M
Winqvist S.
Remes A M
Tolonen U.
Pyhtinen J.
Uimonen S.
Kärppä M.
Sorri M.
Peuhkurinen K.
Majamaa K.
Author Affiliation
Department of Internal Medicine, University of Oulu, Oulu, Finland. kirsi.majamaa-voltti@oulu.fi
Source
Neurology. 2006 May 23;66(10):1470-5
Date
May-23-2006
Language
English
Publication Type
Article
Keywords
Adult
Alleles
Blood Glucose - analysis
Cognition Disorders - genetics
DNA, Mitochondrial - genetics
Diabetes Mellitus - blood - genetics
Disease Progression
Electrocardiography, Ambulatory
Electroencephalography
Female
Finland - epidemiology
Follow-Up Studies
Hearing Loss, Sensorineural - genetics
Humans
Hypertrophy, Left Ventricular - genetics - ultrasonography
Lactates - blood
MELAS Syndrome - genetics - mortality
Male
Middle Aged
Mitochondria, Muscle - metabolism
Mosaicism
Neuropsychological Tests
Point Mutation
Pyruvates - blood
Abstract
OBJECTIVE: To follow the clinical course of patients with the mitochondrial DNA mutation 3243A>G for 3 years. METHODS: Thirty-three adult patients with the 3243A>G mutation entered a 3-year follow-up study. They were clinically evaluated annually, audiometry was performed, and samples were drawn for the analysis of blood chemistry and mutation heteroplasmy in leukocytes. Holter recording was performed three times during the follow-up and echocardiography, neuropsychological assessment, and quantitative EEG and brain imaging conducted at entry and after 3 years. RESULTS: The incidence of new neurologic events was low during the 3-year follow-up. Sensorineural hearing impairment (SNHI) progressed, left ventricular wall thickness increased, mean alpha frequency in the occipital and parietal regions decreased, and the severity of disease index (modified Rankin score) progressed significantly. The rate of SNHI progression correlated with mutation heteroplasmy in muscle. The increase in left ventricular wall thickness was seen almost exclusively in diabetic patients. Seven patients died during the follow-up, and they were generally more severely affected than those who survived. CONCLUSIONS: Significant changes in the severity of disease, sensorineural hearing impairment, left ventricular hypertrophy, and quantitative EEG were seen in adult patients with 3243A>G during the 3-year follow-up.
Notes
Comment In: Neurology. 2007 Jan 9;68(2):163-417210904
PubMed ID
16717204 View in PubMed
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The 5alpha-reductase type II A49T and V89L high-activity allelic variants are more common in men with prostate cancer compared with the general population.

https://arctichealth.org/en/permalink/ahliterature173682
Source
Eur Urol. 2005 Oct;48(4):679-85
Publication Type
Article
Date
Oct-2005
Author
Yvonne L Giwercman
Per-Anders Abrahamsson
Aleksander Giwercman
Virgil Gadaleanu
Göran Ahlgren
Author Affiliation
Department of Urology, Malmö University Hospital, Lund University, Wallenberg Laboratory, entrance 46, SE - 205 02 Malmö, Sweden. yvonne.giwercman@kir.mas.lu.se
Source
Eur Urol. 2005 Oct;48(4):679-85
Date
Oct-2005
Language
English
Publication Type
Article
Keywords
3-Oxo-5-alpha-Steroid 4-Dehydrogenase - blood - genetics
Aged
Alanine
Alleles
Arginine
Case-Control Studies
Dihydrotestosterone - blood
Disease Progression
Follow-Up Studies
Genetic Predisposition to Disease
Genotype
Glutamine
Humans
Leucine
Luteinizing Hormone - blood
Male
Middle Aged
Point Mutation
Polymorphism, Genetic
Prostatic Hyperplasia - blood - epidemiology - genetics
Prostatic Neoplasms - blood - epidemiology - genetics
Receptors, Androgen - blood - genetics
Risk factors
Sex Hormone-Binding Globulin - metabolism
Sweden - epidemiology
Terminal Repeat Sequences
Testosterone - blood
Threonine
Tumor Markers, Biological - blood
Valine
Abstract
To compare men with prostate disease with those from the general population regarding polymorphisms in the androgen receptor gene and in the 5alpha-reductase II (SRD5A2) gene.
The SRD5A2 polymorphisms A49T, V89L and R227Q, the androgen receptor CAG and GGN repeats and sex hormone status was investigated in men with prostate cancer (CaP) (n=89), benign prostate hyperplasia (n=45) and healthy military conscripts (n=223).
The SRD5A2 high-activity allele variants A49T AT and V89L LL were more frequent in CaP-patients compared to general population, p=0.026 and p=0.05, respectively. CaP progression was, however, independent of SRD5A2 variants. In contrary, men with GGN
PubMed ID
16039774 View in PubMed
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5th Canadian Melanoma Conference: research frontiers.

https://arctichealth.org/en/permalink/ahliterature133428
Source
Expert Rev Anticancer Ther. 2011 Jun;11(6):845-8
Publication Type
Conference/Meeting Material
Date
Jun-2011
Author
Léon C van Kempen
Author Affiliation
Department of Pathology, McGill University and Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Cote Ste-Catherine, Montréal, QC, H3T 1E2, Canada. leon.vankempen@mcgill.ca
Source
Expert Rev Anticancer Ther. 2011 Jun;11(6):845-8
Date
Jun-2011
Language
English
Publication Type
Conference/Meeting Material
Keywords
Antineoplastic Agents - pharmacology - therapeutic use
Canada
Disease Progression
Drug Delivery Systems
Early Detection of Cancer
Humans
Melanoma - pathology - therapy
Neoplasm Metastasis
Skin Neoplasms - pathology - therapy
Survival
Abstract
The prospects for the treatment of metastatic melanoma are improving. Whereas previous scientific meetings dedicated to the treatment of metastatic melanoma patients were overshadowed by our inability to improve overall survival or lengthen the time to progression, the results presented at the most recent meetings are hopeful. The 5th Canadian Melanoma Conference held on 24-27 February in Banff (AB, Canada) was nothing short of optimistic. This year's meeting was divided into three themes: basic science and pathology, dermatology and surgery, and immunology and systemic treatment. In addition, dermoscopy case studies were presented, and Hoffmann la Roche sponsored a symposium on the evaluation of treatment for advanced melanoma. It underscored the importance of early detection and patient stratification, based upon the molecular profile of the tumor, in order to optimize the response to targeted therapy.
PubMed ID
21707280 View in PubMed
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A 5-year prospective population-based study of juvenile chronic arthritis: onset, disease process, and outcome.

https://arctichealth.org/en/permalink/ahliterature124008
Source
Scand J Rheumatol. 2012 Oct;41(5):379-82
Publication Type
Article
Date
Oct-2012
Author
L. Bertilsson
B. Andersson-Gäre
A. Fasth
H. Forsblad-d'Elia
Author Affiliation
Department of Rheumatology and Inflammation Research, University of Gothenburg, Sweden. lennart.bertilsson2@comhem.se
Source
Scand J Rheumatol. 2012 Oct;41(5):379-82
Date
Oct-2012
Language
English
Publication Type
Article
Keywords
Adolescent
Age of Onset
Arthritis, Juvenile - diagnosis - epidemiology - physiopathology
Child
Disease Progression
Female
Humans
Incidence
Longitudinal Studies
Male
Prevalence
Prognosis
Prospective Studies
Questionnaires
Sweden
Uveitis - diagnosis - etiology - physiopathology
Abstract
To investigate, in a population-based cohort of patients with juvenile chronic arthritis (JCA), onset characteristics, progression, outcome, and prognostic factors longitudinally for 5 years.
This cohort consisted of 132 incidence cases identified between 1984 and 1986 in southwestern Sweden followed for 5 years with annual reports of subgroup, joint assessment, disease activity, eye examinations, laboratory measurements, and medication. At the 5-year follow-up, the Childhood Health Assessment Questionnaire (Child-HAQ) was evaluated. European League Against Rheumatism (EULAR) criteria for diagnosis and disease activity were used.
During the 5 years only four patients were lost to follow-up, 34% changed subgroup and 8% developed uveitis. At the 5-year follow-up the disease was active in 12% of the patients, stable in 28%, inactive in 25%, and in remission in 34%. Among those examined, 24% had radiological changes, of whom half had advanced changes. The Child-HAQ median score at the 5-year follow-up was 0.13 (range 0.0-1.9). The number of involved joints at inclusion correlated positively with active disease at the 5-year follow-up. Age at disease onset, the number of involved joints, and the number of joints with arthritis correlated positively with continuous disease and Child-HAQ score. CONCLUSION. Our study shows a diverse disease course during the first 5 years of JCA where one-third changed subgroup and two-thirds did not reach remission. Age of disease onset, the number of involved joints, and the number of joints with arthritis at inclusion were associated with poor outcome at the 5-year follow-up.
PubMed ID
22639832 View in PubMed
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10-year survival and quality of life in patients with high-risk pN0 prostate cancer following definitive radiotherapy.

https://arctichealth.org/en/permalink/ahliterature94068
Source
Int J Radiat Oncol Biol Phys. 2007 Nov 15;69(4):1074-83
Publication Type
Article
Date
Nov-15-2007
Author
Berg Arne
Lilleby Wolfgang
Bruland Oyvind Sverre
Fosså Sophie Dorothea
Author Affiliation
Faculty of Medicine, University of Oslo, Oslo, Norway. arne.berg@radiumhospitalet.no
Source
Int J Radiat Oncol Biol Phys. 2007 Nov 15;69(4):1074-83
Date
Nov-15-2007
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Analysis of Variance
Case-Control Studies
Disease Progression
Erectile Dysfunction - physiopathology
Follow-Up Studies
Health status
Health Surveys
Humans
Male
Middle Aged
Neoplasm Staging
Norway
Prostatic Neoplasms - mortality - pathology - radiotherapy
Quality of Life
Radiotherapy, Conformal
Survival Analysis
Urination Disorders - physiopathology
Abstract
PURPOSE: To evaluate long-term overall survival (OS), cancer-specific survival (CSS), clinical progression-free survival (cPFS), and health-related quality of life (HRQoL) following definitive radiotherapy (RT) given to T(1-4p)N(0)M(0) prostate cancer patients provided by a single institution between 1989 and 1996. METHODS AND MATERIALS: We assessed outcome among 203 patients who had completed three-dimensional conformal RT (66 Gy) without hormone treatment and in whom staging by lymphadenectomy had been performed. OS was compared with an age-matched control group from the general population. A cross-sectional, self-report survey of HRQoL was performed among surviving patients. RESULTS: Median observation time was 10 years (range, 1-16 years). Eighty-one percent had high-risk tumors defined as T(3-4) or Gleason score (GS) > or =7B (4+3). Among these, 10-year OS, CSS, and cPFS rates were 52%, 66%, and 39%, respectively. The corresponding fractions in low-risk patients (T(1-2) and GS or =7B.
PubMed ID
17703896 View in PubMed
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14-year incidence, progression, and visual morbidity of age-related maculopathy: the Copenhagen City Eye Study.

https://arctichealth.org/en/permalink/ahliterature50573
Source
Ophthalmology. 2005 May;112(5):787-98
Publication Type
Article
Date
May-2005
Author
Helena Buch
Niels V Nielsen
Troels Vinding
Gorm B Jensen
Jan U Prause
Morten la Cour
Author Affiliation
Department of Ophthalmology, National University Hospital (Rigshospitalet), Copenhagen, Denmark. hbh@dadlnet.dk
Source
Ophthalmology. 2005 May;112(5):787-98
Date
May-2005
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Denmark - epidemiology
Disease Progression
Female
Follow-Up Studies
Humans
Incidence
Macular Degeneration - epidemiology - physiopathology
Male
Middle Aged
Research Support, Non-U.S. Gov't
Retinal Drusen - epidemiology - physiopathology
Retinitis Pigmentosa - epidemiology - physiopathology
Risk factors
Vision Disorders - epidemiology - physiopathology
Visual acuity
Visually Impaired Persons - statistics & numerical data
Abstract
PURPOSE: To describe the 14-year incidence of age-related maculopathy (ARM) lesions and the related visual loss. DESIGN: Population-based cohort study. PARTICIPANTS: Nine hundred forty-six residents (age range, 60-80 years) of Copenhagen participated in the study from 1986 through 1988. Excluding participants who had died since baseline, 359 persons (97.3% of survivors) were reexamined from 2000 through 2002. METHODS: Participants underwent extensive ophthalmologic examinations. Age-related maculopathy lesions were determined by grading color fundus photographs from the examinations using a modified Wisconsin Age-Related Maculopathy Grading System. MAIN OUTCOME MEASURES: Incidence of drusen type and size, pigmentary abnormalities, pure geographic atrophy, exudative ARM, visual impairment, and blindness. RESULTS: The 14-year incidences of early and late ARM were 31.5% and 14.8%, respectively. Individuals 75 to 80 years of age at baseline had significantly (P or =125 microm; 34.2% vs. 12.8%, respectively), soft drusen (45.2% vs. 21.4%), pigmentary abnormalities (31.4% vs. 17.0%), pure geographic atrophy (17.4% vs. 1.0%), and exudative ARM (23.3% vs. 5.7%). Severe drusen type, large drusen, and retinal pigmentary abnormalities at baseline were important predictors of incident late ARM. The 14-year incidences of visual impairment (20/200) or legal blindness from late ARM were 6.0% and 3.4%, respectively. Late ARM caused 35.7% of all visual impairment and 66.7% of all blindness. CONCLUSIONS: There is a high incidence of ARM lesions in this elderly white population. Severe drusen type and size or a combination of drusen and pigmentary abnormalities significantly increases the risk of developing late ARM, the most frequent cause of legal blindness in this population.
PubMed ID
15878058 View in PubMed
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The 16-year incidence, progression and regression of diabetic retinopathy in a young population-based Danish cohort with type 1 diabetes mellitus: The Danish cohort of pediatric diabetes 1987 (DCPD1987).

https://arctichealth.org/en/permalink/ahliterature259744
Source
Acta Diabetol. 2014;51(3):413-20
Publication Type
Article
Date
2014
Author
Rebecca Broe
Malin Lundberg Rasmussen
Ulrik Frydkjaer-Olsen
Birthe Susanne Olsen
Henrik Bindesboel Mortensen
Tunde Peto
Jakob Grauslund
Source
Acta Diabetol. 2014;51(3):413-20
Date
2014
Language
English
Publication Type
Article
Keywords
Adolescent
Blood pressure
Child
Child, Preschool
Cohort Studies
Denmark - epidemiology
Diabetes Mellitus, Type 1 - complications - metabolism
Diabetic Retinopathy - epidemiology - etiology - metabolism - pathology
Disease Progression
Female
Hemoglobin A, Glycosylated - metabolism
Humans
Male
Young Adult
Abstract
The aim was to investigate the long-term incidence of proliferative diabetic retinopathy (PDR), and progression and regression of diabetic retinopathy (DR) and associated risk factors in young Danish patients with Type 1 diabetes mellitus. In 1987-89, a pediatric cohort involving approximately 75 % of all children with Type 1 diabetes in Denmark
PubMed ID
24193810 View in PubMed
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17 beta-hydroxysteroid dehydrogenases and cancers.

https://arctichealth.org/en/permalink/ahliterature18539
Source
J Steroid Biochem Mol Biol. 2002 Dec;83(1-5):119-22
Publication Type
Article
Date
Dec-2002
Author
P. Vihko
P. Härkönen
O. Oduwole
S. Törn
R. Kurkela
K. Porvari
A. Pulkka
V. Isomaa
Author Affiliation
Biocenter Oulu and Research Center for Molecular Endocrinology, University of Oulu, P.O. Box 5000, FIN-90014 Oulu, Finland. pvihko@whoccr.oulu.fi
Source
J Steroid Biochem Mol Biol. 2002 Dec;83(1-5):119-22
Date
Dec-2002
Language
English
Publication Type
Article
Keywords
17-Hydroxysteroid Dehydrogenases - metabolism
Breast Neoplasms - enzymology
Cell Line
Colonic Neoplasms - enzymology - pathology
Disease Progression
Female
Humans
Male
Neoplasms - enzymology
Oxygen - metabolism
Prostatic Neoplasms - enzymology
Protein Isoforms
Research Support, Non-U.S. Gov't
Tumor Cells, Cultured
Abstract
17 beta-Hydroxysteroid dehydrogenases (17HSDs) catalyze the interconversions between active 17 beta-hydroxysteroids and less-active 17-ketosteroids thereby affecting the availability of biologically active estrogens and androgens in a variety of tissues. The enzymes have different enzymatic properties and characteristic cell-specific expression patterns, suggesting differential physiological functions for the enzymes. Epidemiological and endocrine evidence indicate that estrogens play a key role in the etiology of breast cancer while androgens are involved in mechanisms controlling the growth of prostatic cells, both normal and malignant. Recently, we have developed, using LNCaP prostate cancer cell lines, a cell model to study the progression of prostate cancer. In the model LNCaP cells are transformed in culture condition to more aggressive cells, able to grow in suspension cultures. Our results suggest that substantial changes in androgen and estrogen metabolism occur in the cells during the process. These changes lead to increased production of active estrogens during transformation of the cells. Data from studies of breast cell lines and tissues suggest that the oxidative 17HSD type 2 may predominate in human non-malignant breast epithelial cells, while the reductive 17HSD type 1 activity prevails in malignant cells. Deprivation of an estrogen response by using specific 17HSD type 1 inhibitors is a tempting approach to treat estrogen-dependent breast cancer. Our recent studies demonstrate that in addition to sex hormone target tissues, estrogens may be important in the development of cancer in some other tissues previously not considered as estrogen target tissues such as colon. Our data show that the abundant expression of 17HSD type 2 present in normal colonic mucosa is significantly decreased during colon cancer development.
PubMed ID
12650708 View in PubMed
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20-year follow-up of patients receiving high-cost dental care within the Swedish Dental Insurance System: 1977-1978 to 1998-2000.

https://arctichealth.org/en/permalink/ahliterature81267
Source
Swed Dent J. 2006;30(2):77-86
Publication Type
Article
Date
2006
Author
Petersson Kerstin
Pamenius Madeleine
Eliasson Alf
Narby Birger
Holender Frieda
Palmqvist Sigvard
Håkansson Jan
Author Affiliation
Dept of Endodontics, Faculty of Odontology, Malmö University, Sweden. kerstin.petersson@od.mah.se
Source
Swed Dent J. 2006;30(2):77-86
Date
2006
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Denture, Partial, Fixed - economics
Disease Progression
Female
Follow-Up Studies
Humans
Insurance, Dental - economics
Interviews
Male
Middle Aged
Oral Health
Periodontitis - diagnosis
Prognosis
Root Canal Therapy - economics
Sweden
Tooth Loss - diagnosis
Treatment Outcome
Abstract
The objective was to perform a long-term follow-up study of patients that had received high cost dental care within the Swedish National Dental Insurance System in 1977-1978 with special focus on remaining teeth, periodontal disease progression, change in the prevalence of root-filled teeth and teeth with apical periodontitis as well as the survival of fixed prosthetic reconstructions. All 262 patients who had had their treatment plans sent for approval for high-cost dental care in 4 local health insurance districts and who were sampled for base-line studies in 1977-1978, were offered a free clinical examination including radiographs in 1998. 177 patients (68 % of the original sample) could be reached for telephone interview and 104 of them (40 % of the original sample) were examined clinically and radiographically. Comparisons were made with records and radiographs from 1977-1978. The analyses were performed with the individual patient as the studied unit. The low progression of severe periodontal disease during the 20-23 year follow-up period and the decrease in number of teeth with apical periodontitis among a majority of the patients examined, indicated that the dental care received resulted in a limitation of dental disease on the individual level. Furthermore 63 % of the patients had the fixed prosthetic reconstructions, received after approval 1977-1978, in full extention after 20-23 years. However, more tooth losses were observed among the patients in this study than in similar studies in Swedish general populations over the same decades. Furthermore multiple tooth extractions were significantly more frequent in patients with severe periodontitis at baseline and in patients with less apical periodontitis at follow-up in this study. Thus it seems that tooth extraction not seldom was a treatment choice for teeth with severe periodontitis and apical periodontitis among the patients examined clinically in this study.
PubMed ID
16878683 View in PubMed
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1806 records – page 1 of 181.