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The 2010 WHO classification of digestive neuroendocrine neoplasms: a critical appraisal four years after its introduction.

https://arctichealth.org/en/permalink/ahliterature260854
Source
Endocr Pathol. 2014 Jun;25(2):186-92
Publication Type
Article
Date
Jun-2014
Author
G. Rindi
G. Petrone
F. Inzani
Source
Endocr Pathol. 2014 Jun;25(2):186-92
Date
Jun-2014
Language
English
Publication Type
Article
Keywords
Digestive System Neoplasms - classification
Humans
Neoplasm Grading - standards
Neoplasm Staging - standards
Neuroendocrine Tumors - classification
World Health Organization
Abstract
This paper briefly illustrates the basis, rules of application, and present outcome of the current World Health Organization (WHO) classification for neuroendocrine neoplasms. Established in 2010 upon the proposal from the European Neuroendocrine Tumor Society (ENETS), the WHO 2010 fostered some definitional changes (most notably the use of neuroendocrine tumor (NET) instead of carcinoid) and indicated the tools of grading and staging. Specific rules for its application were also defined. The data generated from the use of WHO 2010 classification substantially endorsed its rules and prognostic efficacy. In addition, the application demonstrated some issues, among which are the possible re-definition of the cutoff for grading G1 vs G2, as well as the possible identification of cases with somewhat different clinical behavior within the G3 neuroendocrine cancer class. Overall, since the recent introduction of WHO 2010 grading and staging, it appears wise to keep the current descriptors to avoid unnecessary confusion and to generate comparable data. Homogenous data on large series are ultimately needed to solve such issues.
PubMed ID
24699927 View in PubMed
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[Classification of gastro-entero-pancreatic neuroendocrine tumors].

https://arctichealth.org/en/permalink/ahliterature152578
Source
Radiologe. 2009 Mar;49(3):198-205
Publication Type
Article
Date
Mar-2009
Author
A. Perren
A. Schmitt
P. Komminoth
M. Pavel
Author Affiliation
Institut für Pathologie und pathologische Anatomie, Klinikum rechts der Isar, Technische Universität München, München, Deutschland. aurel.perren@lrz.tum.de
Source
Radiologe. 2009 Mar;49(3):198-205
Date
Mar-2009
Language
German
Publication Type
Article
Keywords
Cell Transformation, Neoplastic - pathology
Diagnostic Imaging
Digestive System Neoplasms - classification - diagnosis - pathology
Disease Progression
Humans
Neoplasm Invasiveness
Neoplasm Staging
Neuroendocrine Tumors - classification - diagnosis - pathology
Prognosis
Terminology as Topic
Abstract
Tumors of the disseminated/diffuse neuroendocrine system (NET) are characterized by a common phenotype. However, the biology varies according to histomorphology, endocrine symptoms and organ of origin. The WHO classification takes these differences into account and uses a common framework, where the parameters size and extent of invasion vary according to the organ of origin. In order to achieve a further standardization of reporting the European Neuroendocrine Tumor Society (ENETS) recently proposed a tumor-node-metastasis (TNM) staging and grading system for gastro-entero-pancreatic NET.
PubMed ID
19224191 View in PubMed
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[Pathology of neuroendocrine neoplasms].

https://arctichealth.org/en/permalink/ahliterature135332
Source
Chirurg. 2011 Jul;82(7):567-73
Publication Type
Article
Date
Jul-2011
Author
M. Anlauf
P. Gerlach
M. Schott
A. Raffel
M. Krausch
W T Knoefel
M. Pavel
G. Klöppel
Author Affiliation
Institut für Pathologie, Endokrines Tumorzentrum am Universitätsklinikum Düsseldorf, Moorenstrasse 5, Düsseldorf, Germany. martin.anlauf@med.uni-duesseldorf.de
Source
Chirurg. 2011 Jul;82(7):567-73
Date
Jul-2011
Language
German
Publication Type
Article
Keywords
Cell Proliferation
Digestive System Neoplasms - classification - pathology - surgery
Humans
Neoplasm Grading
Neoplasm Staging
Neuroendocrine Tumors - classification - pathology - surgery
Prognosis
Terminology as Topic
Tumor Markers, Biological - analysis
Abstract
During the last 5 years the European Neuroendocrine Tumor Society (ENETS) has developed basic recommendations for a standardized pathological diagnosis and classification of neuroendocrine neoplasms (NEN) of the gastroenteropancreatic system. These were included in the novel classification of tumors of the digestive system by the World Health Organization (WHO 2010) and the TNM classification of the union for international cancer control (2009). This review presents the pathology diagnosis regarding (1) basic diagnosis, (2) clinically relevant optional diagnosis, (3) proliferation-based grading, (4) nomenclature and (5) TNM classification. It is emphasized that a standardized diagnosis of NEN, together with clinical and radiological findings, is crucial for prognostic stratification and optimal therapy of patients with NEN. Therefore a close interdisciplinary collaboration is essential.
PubMed ID
21487814 View in PubMed
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