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Adipose tissue morphology predicts improved insulin sensitivity following moderate or pronounced weight loss.

https://arctichealth.org/en/permalink/ahliterature272781
Source
Int J Obes (Lond). 2015 Jun;39(6):893-8
Publication Type
Article
Date
Jun-2015
Author
D. Eriksson-Hogling
D P Andersson
J. Bäckdahl
J. Hoffstedt
S. Rössner
A. Thorell
E. Arner
P. Arner
M. Rydén
Source
Int J Obes (Lond). 2015 Jun;39(6):893-8
Date
Jun-2015
Language
English
Publication Type
Article
Keywords
Adipocytes - metabolism - pathology
Adipose Tissue, White - metabolism - pathology
Adult
Bariatric Surgery
Blood Glucose - metabolism
Body mass index
Cell Enlargement
Cohort Studies
Diabetes Mellitus, Type 2 - etiology - metabolism - prevention & control
Diet, Reducing
Female
Humans
Inflammation - etiology - metabolism
Male
Obesity - complications - metabolism - pathology - surgery
Randomized Controlled Trials as Topic
Sweden
Weight Loss
Abstract
Cross-sectional studies show that white adipose tissue hypertrophy (few, large adipocytes), in contrast to hyperplasia (many, small adipocytes), associates with insulin resistance and increased risk of developing type 2 diabetes. We investigated if baseline adipose cellularity could predict improvements in insulin sensitivity following weight loss.
Plasma samples and subcutaneous abdominal adipose biopsies were examined in 100 overweight or obese individuals before and 10 weeks after a hypocaloric diet (7±3% weight loss) and in 61 obese subjects before and 2 years after gastric by-pass surgery (33±9% weight loss). The degree of adipose tissue hypertrophy or hyperplasia (termed the morphology value) in each individual was calculated on the basis of the relationship between fat cell volume and total fat mass. Insulin sensitivity was determined by homeostasis model assessment-estimated insulin resistance (HOMAIR).
In both cohorts at baseline, subjects with hypertrophy displayed significantly higher fasting plasma insulin and HOMAIR values than subjects with hyperplasia (P
PubMed ID
25666530 View in PubMed
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Field test of a group education program for type 2 diabetes: measures and predictors of success on individual and group levels.

https://arctichealth.org/en/permalink/ahliterature47695
Source
Patient Educ Couns. 2001 Aug;44(2):129-39
Publication Type
Article
Date
Aug-2001
Author
A. Sarkadi
U. Rosenqvist
Author Affiliation
Department of Public Health and Caring Sciences, Uppsala University, Uppsala Science Park, SE-751 85, Uppsala, Sweden.
Source
Patient Educ Couns. 2001 Aug;44(2):129-39
Date
Aug-2001
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Attitude to Health
Diabetes Mellitus, Type 2 - etiology - metabolism - prevention & control - psychology
Female
Hemoglobin A, Glycosylated - metabolism
Humans
Interpersonal Relations
Loneliness
Male
Middle Aged
Needs Assessment
Obesity - complications - prevention & control
Patient Education - methods - standards
Predictive value of tests
Program Evaluation
Questionnaires
Research Support, Non-U.S. Gov't
Self Care - methods - standards
Self-Help Groups - standards
Social Support
Sweden
Treatment Outcome
Abstract
We performed field testing of a previously described group education program for type 2 diabetes. HbA(1c) levels at start, 6 and 12 months were collected and demographic factors examined to identify predictors of long-term glycemic control on individual and group levels. "Glycemic success" comprised of (1) achieving target values of HbA(1c)
PubMed ID
11479053 View in PubMed
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