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Level of physical activity associated with risk of cardiovascular diseases and mortality in patients with type-2 diabetes: report from the Swedish National Diabetes Register.

https://arctichealth.org/en/permalink/ahliterature256946
Source
Eur J Prev Cardiol. 2014 Feb;21(2):244-51
Publication Type
Article
Date
Feb-2014
Author
B. Zethelius
S. Gudbjörnsdottir
B. Eliasson
K. Eeg-Olofsson
J. Cederholm
Author Affiliation
Uppsala University, Uppsala, Sweden.
Source
Eur J Prev Cardiol. 2014 Feb;21(2):244-51
Date
Feb-2014
Language
English
Publication Type
Article
Keywords
Aged
Cardiovascular Diseases - diagnosis - etiology - mortality - physiopathology
Diabetes Mellitus, Type 2 - complications - diagnosis - mortality - physiopathology
Female
Humans
Male
Middle Aged
Motor Activity
Proportional Hazards Models
Questionnaires
Registries
Risk assessment
Risk factors
Sweden - epidemiology
Time Factors
Abstract
To estimate risks of coronary heart disease (CHD), cardiovascular disease (CVD), and total mortality with low or higher levels of physical activity (PA) assessed with questionnaire, in an observational study of patients with type-2 diabetes from the Swedish National Diabetes Register.
A total of 15,462 patients (60 years), were followed for 5 years from baseline in 2004 until 2009, with 760 CVD events and 427 total mortality events based on 54,344 person-years.
Comparing 6963 patients with low baseline PA (never or 1-2 times/week for 30?min) and 8499 patients with higher baseline PA (regular 3 times/week or more), hazard ratios for fatal/nonfatal CHD, fatal/nonfatal CVD, fatal CVD, and total mortality were 1.25 (95% CI 1.05-1.48; p?=?0.01), 1.26 (95% CI 1.09-1.45; p?=?0.002), 1.69 (95% CI 1.18-2.41; p?=?0.004), and 1.48 (95% CI 1.22-1.79; p?
PubMed ID
24227183 View in PubMed
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Predicting mortality in people with type 2 diabetes mellitus after major complications: a study using Swedish National Diabetes Register data.

https://arctichealth.org/en/permalink/ahliterature261400
Source
Diabet Med. 2014 Aug;31(8):954-62
Publication Type
Article
Date
Aug-2014
Author
P J Kelly
P M Clarke
A J Hayes
U-G Gerdtham
J. Cederholm
P. Nilsson
B. Eliasson
S. Gudbjornsdottir
Source
Diabet Med. 2014 Aug;31(8):954-62
Date
Aug-2014
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Amputation - adverse effects
Diabetes Mellitus, Type 2 - complications - diagnosis - epidemiology - mortality
Diabetic Angiopathies - mortality - surgery
Diabetic Cardiomyopathies - mortality
Diabetic Nephropathies - mortality
Female
Follow-Up Studies
Heart Failure - complications - mortality
Humans
Life expectancy
Male
Models, Biological
Mortality
Myocardial Infarction - complications - mortality
Prognosis
Prospective Studies
Registries
Renal Insufficiency - complications - mortality
Risk factors
Stroke - complications - mortality
Sweden - epidemiology
Abstract
To predict mortality risk and life expectancy for patients with type 2 diabetes after a major diabetes-related complication.
The study sample, taken from the Swedish National Diabetes Register, consisted of 20 836 people with type 2 diabetes who had their first major complication (myocardial infarction, stroke, heart failure, amputation or renal failure) between January 2001 and December 2007. A Gompertz proportional hazards model was derived which determined significant risk factors associated with mortality and was used to estimate life expectancies.
Risk of death changed over time according to type of complication, with myocardial infarction initally having the highest initial risk of death, but after the first month, the risk was higher for heart failure, renal failure and amputation. Other factors that increased the risk of death were male gender (hazard ratio 1.06, 95% CI 1.02-1.12), longer duration of diabetes (hazard ratio 1.07 per 10 years, 95% CI 1.04-1.10), smoking (hazard ratio 1.51, 95% CI 1.40-1.63) and macroalbuminuria (hazard ratio 1.14, 95% CI 1.06-1.22). Low BMI, low systolic blood pressure and low estimated GFR also increased mortality risk. Life expectancy was highest after a stroke, myocardial infarction or heart failure, lower after amputation and lowest after renal failure. Smoking and poor renal function were the risk factors which had the largest impact on reducing life expectancy.
Risk of death and life expectancy differs substantially among the major complications of diabetes, and factors significantly increasing risk included smoking, low estimated GFR and albuminuria.
PubMed ID
24750341 View in PubMed
Less detail