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A 10-year (1996-2005) prospective study of the incidence of Type 1 diabetes in Moscow in the age group 0-14 years.

https://arctichealth.org/en/permalink/ahliterature154515
Source
Diabet Med. 2008 Aug;25(8):956-9
Publication Type
Article
Date
Aug-2008
Author
E A Pronina
E E Petraikina
M B Antsiferov
O V Duchareva
A. Petrone
R. Buzzetti
P. Pozzilli
Author Affiliation
Department of Endocrinology, Morozovskaya Children City Clinical Hospital of Moscow, Russia.
Source
Diabet Med. 2008 Aug;25(8):956-9
Date
Aug-2008
Language
English
Publication Type
Article
Keywords
Adolescent
Age Factors
Child
Child, Preschool
Diabetes Mellitus, Type 1 - epidemiology
Female
Humans
Incidence
Infant
Male
Moscow - epidemiology
Prospective Studies
Risk factors
Sex Factors
Statistics as Topic
Time Factors
Abstract
To provide data on the incidence of Type 1 diabetes (T1D) in Moscow, determined prospectively from 1996 to 2005 for a total of > 10 million subjects aged
PubMed ID
18959609 View in PubMed
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Acidic drinking water and risk of childhood-onset type 1 diabetes.

https://arctichealth.org/en/permalink/ahliterature31416
Source
Diabetes Care. 2002 Sep;25(9):1534-8
Publication Type
Article
Date
Sep-2002
Author
Lars C Stene
Dag Hongve
Per Magnus
Kjersti S Rønningen
Geir Joner
Author Affiliation
Diabetes Research Center, Aker and Ullevål University Hospitals, Oslo, Norway. lars.christian.stene@fhi.no
Source
Diabetes Care. 2002 Sep;25(9):1534-8
Date
Sep-2002
Language
English
Publication Type
Article
Keywords
Acids
Adolescent
Case-Control Studies
Child
Diabetes Mellitus, Type 1 - epidemiology
Female
Humans
Male
Minerals
Norway - epidemiology
Research Support, Non-U.S. Gov't
Risk factors
Water supply
Abstract
OBJECTIVE: To estimate the associations of acidity and concentration of selected minerals in household tap water with the risk of type 1 diabetes. RESEARCH DESIGN AND METHODS: We designed a population-based case-control study with 64 cases of type 1 diabetes and 250 randomly selected control subjects. Acidity, color, and mineral content were measured in tap water from each participant's household. RESULTS: Tap water pH 6.2-6.9 was associated with a fourfold higher risk of type 1 diabetes compared with pH > or =7.7 (OR 3.73, 95% CI 1.52-9.15). This result was similar after exclusion of individuals with the highly protective HLA-DQB1*0602 allele, but adjustment for maternal education, urban/rural residence, sex, and age tended to strengthen the estimated association. Higher tap water concentration of zinc was associated with lower risk of type 1 diabetes after adjustment for pH and other possible confounders, but the overall association was strictly not significant. CONCLUSIONS: These results suggest the possibility that quality of drinking water influences the risk of type 1 diabetes. The possible mechanisms by which water acidity or mineral content may be involved in the etiology of type 1 diabetes remain unknown, but the mechanisms are most likely indirect and may involve an influence on survival of microorganisms in the water.
PubMed ID
12196423 View in PubMed
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Adenoidectomy during early life and the risk of asthma.

https://arctichealth.org/en/permalink/ahliterature182650
Source
Pediatr Allergy Immunol. 2003 Oct;14(5):358-62
Publication Type
Article
Date
Oct-2003
Author
Petri S Mattila
Sari Hammarén-Malmi
Jussi Tarkkanen
Harri Saxen
Janne Pitkäniemi
Marjatta Karvonen
Jaakko Tuomilehto
Author Affiliation
Department of Otorhinolaryngology, Helsinki University Central Hospital, Helsinki, Finland. petri.mattila@hus.fi
Source
Pediatr Allergy Immunol. 2003 Oct;14(5):358-62
Date
Oct-2003
Language
English
Publication Type
Article
Keywords
Adenoidectomy
Adolescent
Adult
Asthma - epidemiology - etiology
Bronchial Hyperreactivity - epidemiology - etiology
Bronchitis - epidemiology - etiology
Child
Child Welfare
Diabetes Mellitus, Type 1 - epidemiology - surgery
Female
Finland - epidemiology
Follow-Up Studies
Humans
Male
Multivariate Analysis
Otitis Media with Effusion - epidemiology - surgery
Postoperative Complications - epidemiology - etiology
Questionnaires
Recurrence
Respiratory Sounds
Risk factors
Statistics as Topic
Treatment Outcome
Abstract
The objective of the study was to evaluate the risk of asthma in children who had undergone an adenoidectomy, an operation frequently performed on children with glue ear or recurrent otitis media. Two surveys were carried out, a nation-wide questionnaire returned by 483 individuals (survey A) and a survey of hospital discharge records involving 1616 children who had undergone an adenoidectomy and 161 control children who had undergone probing of the nasolacrimal duct due to congenital obstruction (survey B). The questionnaire (survey A) showed that an adenoidectomy before the age of 4 years was associated with asthma (OR 3.19, 95% CI 1.25; 8.13) and with allergy to animal dust (OR 2.50, 95% CI 1.27; 4.95). In survey B, asthma diagnosis was retrieved from the national asthma register. It showed also that adenoidectomy at an early age was associated with an increased risk of asthma (OR 6.74, 95% CI 2.99; 15.2). There was an association between asthma and adenoidectomy, even before adenoidectomy had actually been performed. The risk of asthma was highest among children who had had adenoidectomy because of recurrent otitis media. The observed association between an adenoidectomy and asthma may be explained by an underlying factor predisposing to both recurrent otitis media and asthma.
PubMed ID
14641605 View in PubMed
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Aetiology of insulin-dependent diabetes mellitus--a cornucopia for research?

https://arctichealth.org/en/permalink/ahliterature225597
Source
Ann Med. 1991 Oct;23(4):415-7
Publication Type
Article
Date
Oct-1991
Author
H K Akerblom
M. Knip
Author Affiliation
Children's Hospital II, Department of Pediatrics, University of Helsinki, Finland.
Source
Ann Med. 1991 Oct;23(4):415-7
Date
Oct-1991
Language
English
Publication Type
Article
Keywords
Adult
Autoimmune Diseases
Child
Diabetes Mellitus, Type 1 - epidemiology - etiology
Environmental Exposure
Finland - epidemiology
Humans
Incidence
Registries
Research
PubMed ID
1930938 View in PubMed
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Age at onset of type 1 diabetes in parents and recurrence risk in offspring.

https://arctichealth.org/en/permalink/ahliterature147925
Source
Diabetes. 2010 Jan;59(1):210-4
Publication Type
Article
Date
Jan-2010
Author
Valma Harjutsalo
Niina Lammi
Marjatta Karvonen
Per-Henrik Groop
Author Affiliation
Folkhälsan Institute of Genetics, Folkhälsan Research Centre, Biomedicum Helsinki, Helsinki, Finland. valma.harjutsalo@helsinki.fi
Source
Diabetes. 2010 Jan;59(1):210-4
Date
Jan-2010
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age of Onset
Child
Child, Preschool
Cohort Studies
Diabetes Mellitus, Type 1 - epidemiology - genetics
Fathers
Female
Finland - epidemiology
Humans
Incidence
Infant
Male
Mothers
Recurrence
Sex Characteristics
Abstract
Our aim was to study the recurrence risk of type 1 diabetes in the offspring of parents with adult-onset (15-39 years) type 1 diabetes and to evaluate the transmission of diabetes within a continuum of parental age at onset of diabetes from childhood to adulthood.
Diabetes status of all offspring (n = 9,636) in two Finnish cohorts of parents with type 1 diabetes was defined until the end of year 2007. Cumulative incidences of type 1 diabetes among the offspring were estimated, and several factors contributing to the risk were assessed.
During 137,455 person-years, a total of 413 offspring were diagnosed with type 1 diabetes. The cumulative incidence by 20 years was 4.0% (95% CI 3.1-4.8) for the offspring of parents with adult-onset diabetes. The risk was equal according to the sex of the parents. The cumulative incidence decreased in parallel with the increase in age at onset of diabetes in the fathers. In the offspring of diabetic mothers, the risk was equal regardless of the age at onset of diabetes. However, the reduced risk in the maternal offspring was most pronounced in the daughters of the mothers with a diagnosis age
Notes
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PubMed ID
19833881 View in PubMed
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Age, overweight and physical inactivity increase the risk of latent autoimmune diabetes in adults: results from the Nord-Tr√łndelag health study.

https://arctichealth.org/en/permalink/ahliterature166623
Source
Diabetologia. 2007 Jan;50(1):55-8
Publication Type
Article
Date
Jan-2007
Author
S. Carlsson
K. Midthjell
M Y Tesfamarian
V. Grill
Author Affiliation
Division of Epidemiology, Stockholm Centre of Public Health, Stockholm, Sweden. sofia.carlsson@ki.se
Source
Diabetologia. 2007 Jan;50(1):55-8
Date
Jan-2007
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aging - physiology
Cohort Studies
Diabetes Mellitus, Type 1 - epidemiology - physiopathology
Diabetes Mellitus, Type 2 - epidemiology - physiopathology
Female
Follow-Up Studies
Health Surveys
Humans
Incidence
Insulin Resistance - physiology
Longitudinal Studies
Male
Middle Aged
Motor Activity - physiology
Norway
Obesity - physiopathology
Prospective Studies
Risk factors
Abstract
Latent autoimmune diabetes (LADA) is a common form of diabetes, yet the risk factors are poorly characterised. The aim of this study was to investigate the influence of age, overweight and physical activity on the risk of LADA.
We analysed age, overweight and physical inactivity and the incidence of LADA in 38,800 men and women, observed between 1984 and 1986 and 1995 and 1997 as part of the Nord-Tr?ndelag Health Survey. We also compared such factors with incident cases of type 2 (n = 738) and 'classic' type 1 diabetes (n = 18). Patients classified as LADA (n = 81) had antibodies against GAD and were insulin independent at diagnosis.
The proportion of those who were older, overweight and inactive before diagnosis was almost identical in LADA and type 2 diabetes patients. BMI >or=30 kg/m(2) was strongly associated with LADA incidence (relative risk [RR] = 15.0, 95% CI 7.51-29.97). The association was similar for type 2 diabetes (RR = 15.37, 95% CI 12.07-19.57) but not for type 1 diabetes. Similarly, age (>or=60 years) was an important risk factor for LADA (RR = 5.62, 95% CI 2.36-13.4) as well as for type 2 diabetes (RR = 6.78, 95% CI 5.07-9.06) in contrast to type 1 diabetes. Physical inactivity was associated with an increased risk of both LADA and type 2 diabetes.
This study suggests that increased age, overweight and physical inactivity are as strong risk factors for LADA as for type 2 diabetes. These findings suggest a role for insulin resistance in the pathogenesis of LADA.
PubMed ID
17096113 View in PubMed
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[A high standard of living can contribute to the increase of childhood diabetes. Rapid growth and weight gain are risk factors]

https://arctichealth.org/en/permalink/ahliterature31561
Source
Lakartidningen. 2002 Mar 7;99(10):1046-50
Publication Type
Article
Date
Mar-7-2002
Author
Gisela Dahlquist
Author Affiliation
Norrlands Universitetssjukhus.
Source
Lakartidningen. 2002 Mar 7;99(10):1046-50
Date
Mar-7-2002
Language
Swedish
Publication Type
Article
Keywords
Adolescent
Body Weight
Child
Child, Preschool
Diabetes Mellitus, Type 1 - epidemiology - etiology - genetics
Diabetes Mellitus, Type 2 - epidemiology - etiology - genetics
English Abstract
Genetic markers
Growth
Humans
Incidence
Life Style
Registries
Sweden - epidemiology
Weight Gain
Abstract
According to records kept by The Swedish Child Diabetes Register the incidence of childhood diabetes type I before 15 years of age has increased. The increase is most noticeable in children before the age of 5. The genetic basis of this disease is complex and the different risk genes have a low penetrance, thus indicating non-genetic factors to have a great impact. One risk factor for type I diabetes is rapid growth, measured either as weight or as height gain. As a high standard of living favours rapid growth in children this may contribute to the onset of the disease.
PubMed ID
12024777 View in PubMed
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Alcohol and the risk for latent autoimmune diabetes in adults: results based on Swedish ESTRID study.

https://arctichealth.org/en/permalink/ahliterature259455
Source
Eur J Endocrinol. 2014 Nov;171(5):535-43
Publication Type
Article
Date
Nov-2014
Author
Bahareh Rasouli
Tomas Andersson
Per-Ola Carlsson
Mozhgan Dorkhan
Valdemar Grill
Leif Groop
Mats Martinell
Tiinamaja Tuomi
Sofia Carlsson
Source
Eur J Endocrinol. 2014 Nov;171(5):535-43
Date
Nov-2014
Language
English
Publication Type
Article
Keywords
Adult
Aged
Alcohol drinking - epidemiology
Case-Control Studies
Diabetes Mellitus, Type 1 - epidemiology
Diabetes Mellitus, Type 2 - epidemiology
Female
Humans
Male
Middle Aged
Questionnaires
Risk factors
Sweden - epidemiology
Abstract
Moderate alcohol consumption is associated with a reduced risk of type 2 diabetes. Our aim was to investigate whether alcohol consumption is associated with the risk of latent autoimmune diabetes in adults (LADA), an autoimmune form of diabetes with features of type 2 diabetes.
A population-based case-control study was carried out to investigate the association of alcohol consumption and the risk of LADA.
We used data from the ESTRID case-control study carried out between 2010 and 2013, including 250 incident cases of LADA (glutamic acid decarboxylase antibodies (GADAs) positive) and 764 cases of type 2 diabetes (GADA negative), and 1012 randomly selected controls aged =35. Logistic regression was used to estimate the odds ratios (ORs) of diabetes in relation to alcohol intake, adjusted for age, sex, BMI, family history of diabetes, smoking, and education.
Alcohol consumption was inversely associated with the risk of type 2 diabetes (OR 0.95, 95% CI 0.92-0.99 for every 5-g increment in daily intake). Similar results were observed for LADA, but stratification by median GADA levels revealed that the results only pertained to LADA with low GADA levels (OR 0.85, 95% CI 0.76-0.94/5?g alcohol per day), whereas no association was observed with LADA having high GADA levels (OR 1.00, 95% CI 0.94-1.06/5?g per day). Every 5-g increment of daily alcohol intake was associated with a 10% increase in GADA levels (P=0.0312), and a 10% reduction in homeostasis model assessment of insulin resistance (P=0.0418).
Our findings indicate that alcohol intake may reduce the risk of type 2 diabetes and type 2-like LADA, but has no beneficial effects on diabetes-related autoimmunity.
Notes
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PubMed ID
25117461 View in PubMed
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Alcohol consumption is associated with reduced risk of Type 2 diabetes and autoimmune diabetes in adults: results from the Nord-Tr√łndelag health study.

https://arctichealth.org/en/permalink/ahliterature124182
Source
Diabet Med. 2013 Jan;30(1):56-64
Publication Type
Article
Date
Jan-2013
Author
B. Rasouli
A. Ahlbom
T. Andersson
V. Grill
K. Midthjell
L. Olsson
S. Carlsson
Author Affiliation
Department of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. bahareh.rasouli@ki.se
Source
Diabet Med. 2013 Jan;30(1):56-64
Date
Jan-2013
Language
English
Publication Type
Article
Keywords
Adult
Aged
Alcohol drinking - epidemiology
Diabetes Mellitus, Type 1 - epidemiology
Diabetes Mellitus, Type 2 - epidemiology
Female
Follow-Up Studies
Humans
Incidence
Male
Middle Aged
Norway - epidemiology
Risk factors
Abstract
We investigated the influence of different aspects of alcohol consumption on the risk of Type 2 diabetes and autoimmune diabetes in adults.
We used data from the Nord-Trøndelag Health Survey (HUNT) study, in which all adults aged = 20 years from Nord-Trondelag County were invited to participate in three surveys in 1984-1986, 1995-1997 and 2006-2008. Patients with diabetes were identified using self-reports, and participants with onset age = 35 years were classified as having Type 2 diabetes if they were negative for anti-glutamic acid decarboxylase (n = 1841) and as having autoimmune diabetes if they were positive for anti-glutamic acid decarboxylase (n = 140). Hazard ratios of amount and frequency of alcohol use, alcoholic beverage choice, and binge drinking and alcohol use disorders were estimated.
Moderate alcohol consumption (adjusted for confounders) was associated with a reduced risk of Type 2 diabetes in men, but not in women (hazard ratio for men 10-15 g/day 0.48, 95% CI 0.28-0.77; hazard ratio for women = 10 g/day 0.81, 95% CI 0.33-1.96). The reduced risk was primarily linked to consumption of wine [hazard ratio 0.93, 95% CI 0.87-0.99 (per g/day)]. No increased risk was seen in participants reporting binge drinking or in problem drinkers. The results were also compatible with a reduced risk of autoimmune diabetes associated with alcohol consumption [hazard ratio 0.70, 95% CI 0.45-1.08 (frequent consumption) and hazard ratio 0.36, 95% CI 0.13-0.97 (2-7 g/day)].
Moderate alcohol consumption associates with reduced risk of both Type 2 diabetes and autoimmune diabetes. A protective effect of alcohol intake may be limited to men. High alcohol consumption does not seem to carry an increased risk of diabetes.
PubMed ID
22612671 View in PubMed
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Altered immune profile from pre-diabetes to manifestation of type 1 diabetes.

https://arctichealth.org/en/permalink/ahliterature115633
Source
Diabetes Res Clin Pract. 2013 Apr;100(1):74-84
Publication Type
Article
Date
Apr-2013
Author
Anna Rydén
Maria Faresjö
Author Affiliation
Division of Paediatrics & Diabetes Research Centre, Department of Clinical & Experimental Medicine, Faculty of Health Sciences, Linköping University, S-581 85 Linköping, Sweden.
Source
Diabetes Res Clin Pract. 2013 Apr;100(1):74-84
Date
Apr-2013
Language
English
Publication Type
Article
Keywords
Adolescent
Age of Onset
Chaperonin 60 - metabolism
Chemokines
Child
Child, Preschool
Cytokines
Diabetes Mellitus, Type 1 - epidemiology - genetics - immunology - physiopathology
Female
Forkhead Transcription Factors - metabolism
Glutamate Decarboxylase - metabolism
Humans
Male
Membrane Transport Proteins - metabolism
Mitochondrial Proteins - metabolism
Prediabetic State - epidemiology - genetics - immunology - physiopathology
Real-Time Polymerase Chain Reaction
Sweden - epidemiology
T-Lymphocytes, Regulatory
Tumor Necrosis Factor-alpha - metabolism
Up-Regulation
Abstract
While the mechanisms leading to ß-cell destruction and clinical onset of T1D are still unclear, the composition of the immune profile is probably important for the outcome of immune activity. The aim of this study was to investigate the composition and possible changes of the immunological profile, spontaneously and following stimulation with the autoantigens GAD65, and HSP60, at high-risk and T1D onset and further to 8 months post diagnosis.
Fifteen first-degree relatives of T1D patients with a high risk of developing the disease within five years, 25 children approximately four days and 8 months after diagnosis of T1D and 16 healthy children were included in the study. Cytokines (IL-1ß, -6, -7, -10, -13, -17, IFN-? and TNF-a) and chemokines (CCL2, -3, -4, -5 and CXCL10) associated with Th1, Th2, Tr1 and inflammatory cells were detected in cell culture supernatants by Luminex-technique, and markers associated with regulatory T-cells (FOXP3, CTLA-4 and TGF-ß) by real-time RT-PCR.
High-risk individuals differed in immunity from that seen in healthy and T1D children. High-risk individuals had a low TNF-a response and fewer responders from mitogen exposure as well as low spontaneous secretions of IL-13 compared to healthy children. High-risk individuals that later developed T1D, had a lower FOXP3 and CTLA-4 mRNA expression, following stimulation with GAD65, in combination with higher secretion of the pro-inflammatory chemokine CCL4.
Changes in immunity seen in individuals with high risk of developing T1D points to alterations/actions in the immune system already early in the pre-diabetic phase.
PubMed ID
23485080 View in PubMed
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482 records – page 1 of 49.