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Age at onset of childhood-onset type 1 diabetes and the development of end-stage renal disease: a nationwide population-based study.

https://arctichealth.org/en/permalink/ahliterature76498
Source
Diabetes Care. 2006 Mar;29(3):538-42
Publication Type
Article
Date
Mar-2006
Author
Svensson Maria
Nyström Lennarth
Schön Staffan
Dahlquist Gisela
Author Affiliation
Department of Medicine, Umeå University Hospital, SE-901 85 UMEA, Sweden. maria.svensson@medicin.umu.se
Source
Diabetes Care. 2006 Mar;29(3):538-42
Date
Mar-2006
Language
English
Publication Type
Article
Keywords
Adolescent
Age of Onset
Child
Child, Preschool
Cohort Studies
Diabetes Mellitus, Type 1 - complications - epidemiology
Diabetic Nephropathies - complications - epidemiology
Female
Humans
Infant
Kidney Failure, Chronic - epidemiology
Male
Puberty
Registries
Research Support, Non-U.S. Gov't
Sweden - epidemiology
Abstract
OBJECTIVE: To analyze the impact of age at onset on the development of end-stage renal disease (ESRD) due to diabetic nephropathy in a nationwide population-based cohort with childhood-onset type 1 diabetes. RESEARCH DESIGN AND METHODS: A record linkage between two nationwide registers, the Swedish Childhood Diabetes Registry, including 12,032 cases with childhood-onset diabetes, and the Swedish Registry for Active Treatment of Uraemia was performed. Log-rank test was used to test differences between cumulative risk curves of developing ESRD due to diabetic nephropathy in three different strata of age at onset (0-4, 5-9, and 10-14 years). RESULTS: At a maximum follow-up of 27 years, 33 patients had developed ESRD due to diabetic nephropathy and all had a diabetes duration >15 years. In total, 4,414 patients had diabetes duration >15 years, and thus the risk in this cohort to develop ESRD was 33 of 4,414 (0.7%). A significant difference in risk of developing ESRD was found between the youngest (0-4 years) and the two older (5-9 and 10-14 years) age-at-onset strata (P = 0.03 and P = 0.001, respectively). A significant difference in the risk of developing ESRD was also found between children with prepubertal (0-4 and 5-9 years, n = 2,424) and pubertal (10-14 years, n = 2000) onset of diabetes (P = 0.002). No patient with onset of diabetes before 5 years of age had developed ESRD. CONCLUSIONS: With a median duration of 21 years in this population-based Swedish cohort with childhood-onset diabetes,
PubMed ID
16505502 View in PubMed
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The association between asthma and type 1 diabetes: a paediatric case-cohort study in Finland, years 1981-2009.

https://arctichealth.org/en/permalink/ahliterature298640
Source
Int J Epidemiol. 2018 04 01; 47(2):409-416
Publication Type
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Date
04-01-2018
Author
Johanna Metsälä
Annamari Lundqvist
Lauri J Virta
Minna Kaila
Mika Gissler
Suvi M Virtanen
Jaakko Nevalainen
Author Affiliation
Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.
Source
Int J Epidemiol. 2018 04 01; 47(2):409-416
Date
04-01-2018
Language
English
Publication Type
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Keywords
Adolescent
Asthma - complications - epidemiology
Case-Control Studies
Child
Child, Preschool
Cohort Studies
Diabetes Mellitus, Type 1 - complications - epidemiology
Female
Finland - epidemiology
Humans
Male
Proportional Hazards Models
Registries
Risk factors
Abstract
The association between asthma and type 1 diabetes, two chronic, immune-mediated diseases, has been of longstanding interest, but the evidence is still conflicting. We examined this association in a large, nationwide case-cohort study among Finnish children, using a novel statistical approach.
Among the initial cohort of all children born between 1 January 1981 and 31 December 2008, those who were diagnosed with asthma (n?=?81 473) or type 1 diabetes (n?=?9541) up to age 16 years by the end of 2009 were identified from the Central Drug Register maintained by the Social Insurance Institution of Finland. A 10% random sample from each initial birth year cohort was selected as a reference cohort (n?=?171 138). The association between asthma and type 1 diabetes was studied using a multistate modelling approach to estimate transition rates between healthy and disease states since birth. Hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated to represent the change in the transition rate between the disease states.
After adjusting for sex and birth decade, previous diagnosis of asthma increased the risk of subsequent type 1 diabetes by 41% (95% CI: 1.28, 1.54), whereas previous diagnosis of type 1 diabetes decreased the risk of subsequent asthma by 18% (95% CI: 0.69, 0.98).
The findings of the present study imply that the association between the diseases is more complex than previously thought, and its direction depends on the sequential appearance of the diseases.
PubMed ID
29211844 View in PubMed
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Association between atopic dermatitis and insulin-dependent diabetes mellitus: a case-control study.

https://arctichealth.org/en/permalink/ahliterature32134
Source
Lancet. 2001 Jun 2;357(9270):1749-52
Publication Type
Article
Date
Jun-2-2001
Author
A B Olesen
S. Juul
N. Birkebaek
K. Thestrup-Pedersen
Author Affiliation
Department of Dermatology, University Hospital of Aarhus, Marselisborg, DK-8000, Aarhus C, Denmark. Annebraae@dadlnet.dk
Source
Lancet. 2001 Jun 2;357(9270):1749-52
Date
Jun-2-2001
Language
English
Publication Type
Article
Keywords
Adolescent
Case-Control Studies
Child
Child, Preschool
Denmark - epidemiology
Dermatitis, Atopic - complications - epidemiology
Diabetes Mellitus, Type 1 - complications - epidemiology
Female
Humans
Incidence
Male
Questionnaires
Registries
Research Support, Non-U.S. Gov't
Retrospective Studies
Abstract
BACKGROUND: Up to two-thirds of children with atopic dermatitis have IgE-mediated allergic reactions and a Th2 immune reactivity pattern with low production of interferon gamma and high production of interleukin 4 after allergen stimulation of T lymphocytes. Insulin-dependent diabetes mellitus (IDDM) seems to be associated with a Th1 immune reactivity pattern. We therefore postulated that these diseases may be inversely associated. METHODS: We designed a case-control study including 920 children with IDDM, registered in the Danish Registry for Childhood Diabetes, and a sample of 9732 non-diabetic children registered in the Danish Medical Birth Registry. The children were aged 3-15 years. Information on atopic dermatitis was obtained by questionnaires. FINDINGS: The cumulative incidence of atopic dermatitis up to age 15 years was 13.1% among children with IDDM and 19.8% in non-diabetic children (p
PubMed ID
11403811 View in PubMed
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The Association of Severe Diabetic Retinopathy With Cardiovascular Outcomes in Long-standing Type 1 Diabetes: A Longitudinal Follow-up.

https://arctichealth.org/en/permalink/ahliterature298354
Source
Diabetes Care. 2018 12; 41(12):2487-2494
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Date
12-2018
Author
Drazenka Pongrac Barlovic
Valma Harjutsalo
Daniel Gordin
Milla Kallio
Carol Forsblom
George King
Per-Henrik Groop
Author Affiliation
University Medical Center Ljubljana, Ljubljana, Slovenia.
Source
Diabetes Care. 2018 12; 41(12):2487-2494
Date
12-2018
Language
English
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Keywords
Adult
Cardiovascular Diseases - diagnosis - epidemiology - etiology
Case-Control Studies
Coronary Disease - complications - diagnosis - epidemiology
Diabetes Mellitus, Type 1 - complications - epidemiology - pathology
Diabetic Angiopathies - diagnosis - epidemiology
Diabetic Nephropathies - complications - epidemiology
Diabetic Retinopathy - complications - epidemiology - pathology
Female
Finland - epidemiology
Follow-Up Studies
Humans
Incidence
Longitudinal Studies
Male
Middle Aged
Prognosis
Severity of Illness Index
Time Factors
Abstract
It is well established that diabetic nephropathy increases the risk of cardiovascular disease (CVD), but how severe diabetic retinopathy (SDR) impacts this risk has yet to be determined.
The cumulative incidence of various CVD events, including coronary heart disease (CHD), peripheral artery disease (PAD), and stroke, retrieved from registries, was evaluated in 1,683 individuals with at least a 30-year duration of type 1 diabetes drawn from the Finnish Diabetic Nephropathy Study (FinnDiane). The individuals were divided into four groups according to the presence of diabetic kidney disease (DKD) and/or SDR (+DKD/+SDR, +DKD/-SDR, -DKD/+SDR, and -DKD/-SDR) at baseline visit. Furthermore, age-specific incidences were compared with 4,016 control subjects without diabetes. SDR was defined as laser photocoagulation and DKD as estimated glomerular filtration rate
PubMed ID
30257963 View in PubMed
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Blood pressure levels but not hypertensive complications have increased in Type 1 diabetes pregnancies during 1989-2010.

https://arctichealth.org/en/permalink/ahliterature114036
Source
Diabet Med. 2013 Sep;30(9):1087-93
Publication Type
Article
Date
Sep-2013
Author
M M Klemetti
K. Teramo
M. Nuutila
M. Tikkanen
V. Hiilesmaa
H. Laivuori
Author Affiliation
Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland.
Source
Diabet Med. 2013 Sep;30(9):1087-93
Date
Sep-2013
Language
English
Publication Type
Article
Keywords
Adult
Body mass index
Cohort Studies
Diabetes Mellitus, Type 1 - complications - epidemiology
Female
Finland - epidemiology
Follow-Up Studies
Health Transition
Hospitals, University
Hospitals, Urban
Humans
Hypertension - complications - epidemiology - prevention & control
Hypertension, Pregnancy-Induced - epidemiology - prevention & control
Middle Aged
Obesity - complications - epidemiology
Overweight - complications - epidemiology
Pre-Eclampsia - epidemiology - prevention & control
Pregnancy
Pregnancy Complications, Cardiovascular - epidemiology
Pregnancy in Diabetics - epidemiology
Prehypertension - complications - epidemiology
Young Adult
Abstract
The pre-pregnancy BMI and the third trimester HbA(1c) levels increased in Finnish parturients with Type 1 diabetes during 1989-2008. The aim of the present study was to investigate whether these trends have been accompanied by increases in blood pressure or hypertensive complications. Hypertension trends were analysed using the definitions of hypertension of both the American College of Obstetricians and Gynecologists and the American Diabetes Association. The associations of hypertension, as defined by the latter criteria, with perinatal complications were also studied.
The records of a cohort of 1007 consecutive patients with Type 1 diabetes with a singleton live childbirth during 1989-2010 at the Helsinki University Central Hospital were studied.
The frequencies of hypertensive pregnancy complications did not change, but the mean diastolic blood pressure increased in normotensive parturients in all trimesters. The proportion of patients with systolic blood pressure > 130 mmHg or diastolic blood pressure > 80 mmHg in the first, second and third trimesters of pregnancy increased from 25 to 33%, from 26 to 35% and from 57 to 71%, respectively. Systolic blood pressure of 131-139 mmHg or diastolic blood pressure of 81-89 mmHg in the third trimester was associated with umbilical artery pH
PubMed ID
23659525 View in PubMed
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Cardiovascular autonomic neuropathy is associated with macrovascular risk factors in type 2 diabetes: new technology used for routine large-scale screening adds new insight.

https://arctichealth.org/en/permalink/ahliterature268009
Source
J Diabetes Sci Technol. 2014 Jul;8(4):874-80
Publication Type
Article
Date
Jul-2014
Author
Jesper Fleischer
Knud Yderstraede
Elisabeth Gulichsen
Poul Erik Jakobsen
Hans Henrik Lervang
Ebbe Eldrup
Hans Nygaard
Lise Tarnow
Niels Ejskjaer
Source
J Diabetes Sci Technol. 2014 Jul;8(4):874-80
Date
Jul-2014
Language
English
Publication Type
Article
Keywords
Adult
Aged
Autonomic Nervous System Diseases - epidemiology - etiology - pathology
Capillaries - pathology
Cardiovascular Diseases - etiology - pathology
Cardiovascular System - immunology
Cohort Studies
Cross-Sectional Studies
Denmark - epidemiology
Diabetes Mellitus, Type 1 - complications - epidemiology
Diabetes Mellitus, Type 2 - complications
Diabetic Neuropathies - pathology
Female
Heart Function Tests
Humans
Male
Middle Aged
Outpatients
Prevalence
Risk factors
Abstract
The objective was to identify the presence of cardiovascular autonomic neuropathy (CAN) in a cohort of individuals with diabetes in outpatient clinics from 4 different parts of Denmark and to explore the difference between type 1 and type 2 diabetes in relation to CAN. The DAN-Study is a Danish multicenter study focusing on diabetic autonomic neuropathy. Over a period of 12 months, 382 type 1 and 271 type 2 individuals with diabetes were tested for CAN. Patients were randomly recruited and tested during normal visits to outpatient clinics at 4 Danish hospitals. The presence of CAN was quantified by performing 3 cardiovascular reflex tests (response to standing, deep breathing, and valsalva). To describe possible associations, multivariate analysis with CAN as the dependent variable was performed. The prevalence of CAN was higher among patients with type 2 diabetes (35%) compared to patients with type 1 diabetes (25%). Multivariate analysis revealed significant associations between CAN and different risk markers in the 2 populations. In type 1 diabetes patients CAN was associated with microalbuminuria (P
PubMed ID
24876410 View in PubMed
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Chapter 5.2: major public health problems - diabetes.

https://arctichealth.org/en/permalink/ahliterature81919
Source
Scand J Public Health Suppl. 2006 Jun;67:59-68
Publication Type
Article
Date
Jun-2006

Coeliac patients detected during type 1 diabetes surveillance had similar issues to those diagnosed on a clinical basis.

https://arctichealth.org/en/permalink/ahliterature285986
Source
Acta Paediatr. 2017 Apr;106(4):639-646
Publication Type
Article
Date
Apr-2017
Author
Anna U Laitinen
Daniel Agardh
Laura Kivelä
Heini Huhtala
Marja-Leena Lähdeaho
Katri Kaukinen
Kalle Kurppa
Source
Acta Paediatr. 2017 Apr;106(4):639-646
Date
Apr-2017
Language
English
Publication Type
Article
Keywords
Adolescent
Celiac Disease - complications - epidemiology
Child
Child, Preschool
Cohort Studies
Diabetes Mellitus, Type 1 - complications - epidemiology
Female
Finland - epidemiology
Humans
Infant
Male
Mass Screening
Abstract
Screening children with type 1 diabetes for coeliac disease is controversial, because they often appear asymptomatic. Our aim was to establish whether active screening should be recommended.
This study focused on 22 children whose coeliac disease was detected by serological screening during diabetes surveillance and 498 children diagnosed because of a clinical suspicion. We compared the clinical and histological data at diagnosis and the children's adherence and responses to a gluten-free diet.
The serological screening group suffered less from decreased growth (p = 0.016) and clinical symptoms (p
PubMed ID
27935157 View in PubMed
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Continuous glucose monitoring and HbA1c in the evaluation of glucose metabolism in children at high risk for type 1 diabetes mellitus.

https://arctichealth.org/en/permalink/ahliterature278005
Source
Diabetes Res Clin Pract. 2016 Oct;120:89-96
Publication Type
Article
Date
Oct-2016
Author
Olli Helminen
Tytti Pokka
Päivi Tossavainen
Jorma Ilonen
Mikael Knip
Riitta Veijola
Source
Diabetes Res Clin Pract. 2016 Oct;120:89-96
Date
Oct-2016
Language
English
Publication Type
Article
Keywords
Blood Glucose - metabolism
Blood Glucose Self-Monitoring - methods
Case-Control Studies
Child
Child, Preschool
Diabetes Mellitus, Type 1 - complications - epidemiology - metabolism
Female
Finland - epidemiology
Glucose Tolerance Test
Hemoglobin A, Glycosylated - metabolism
Humans
Hyperglycemia - blood - diagnosis - etiology
Hypoglycemia - blood - diagnosis - etiology
Male
Monitoring, Ambulatory - methods
Risk factors
Abstract
Continuous glucose monitoring (CGM) parameters, self-monitored blood glucose (SMBG), HbA1c and oral glucose tolerance test (OGTT) were studied during preclinical type 1 diabetes mellitus.
Ten asymptomatic children with multiple (?2) islet autoantibodies (cases) and 10 age and sex-matched autoantibody-negative controls from the Type 1 Diabetes Prediction and Prevention (DIPP) Study were invited to 7-day CGM with Dexcom G4 Platinum Sensor. HbA1c and two daily SMBG values (morning and evening) were analyzed. Five-point OGTTs were performed and carbohydrate intake was assessed by food records. The matched pairs were compared with the paired sample t-test.
The cases showed higher mean values and higher variation in glucose levels during CGM compared to the controls. The time spent ?7.8mmol/l was 5.8% in the cases compared to 0.4% in the controls (p=0.040). Postprandial CGM values were similar except after the dinner (6.6mmol/l in cases vs. 6.1mmol/l in controls; p=0.023). When analyzing the SMBG values higher mean level, higher evening levels, as well as higher variation were observed in the cases when compared to the controls. HbA1c was significantly higher in the cases [5.7% (39mmol/mol) vs. 5.3% (34mmol/mol); p=0.045]. No differences were observed in glucose or C-peptide levels during OGTT. Daily carbohydrate intake was slightly higher in the cases (254.2g vs. 217.7g; p=0.034).
Glucose levels measured by CGM and SMBG are useful indicators of dysglycemia during preclinical type 1 diabetes mellitus. Increased evening glucose values seem to be common in children with preclinical type 1 diabetes mellitus.
PubMed ID
27525364 View in PubMed
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64 records – page 1 of 7.