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Irritable bowel syndrome: a co-twin control analysis.

https://arctichealth.org/en/permalink/ahliterature84570
Source
Am J Gastroenterol. 2007 Oct;102(10):2220-9
Publication Type
Article
Date
Oct-2007
Author
Wojczynski Mary K
North Kari E
Pedersen Nancy L
Sullivan Patrick F
Author Affiliation
Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Source
Am J Gastroenterol. 2007 Oct;102(10):2220-9
Date
Oct-2007
Language
English
Publication Type
Article
Keywords
Adult
Case-Control Studies
Depressive Disorder, Major - complications - epidemiology - genetics
Female
Humans
Irritable Bowel Syndrome - epidemiology - genetics - psychology
Logistic Models
Male
Middle Aged
Odds Ratio
Registries
Sweden - epidemiology
Twins, Dizygotic
Twins, Monozygotic
Abstract
OBJECTIVES: Among individuals who satisfy diagnostic criteria for both major depressive disorder (MDD) and irritable bowel syndrome (IBS), little is known about the role of familial tendency and environmental influences in disease susceptibility. Therefore, we aimed to examine if there is a genetic component to the co-occurrence of MDD and IBS in participants from the population-based Swedish Twin Registry. METHODS: We implemented a nested case-control analysis and a co-twin control analysis. IBS cases were ascertained using an adapted version of the Rome II criteria and MDD cases were assessed using a shortened version of the Computerized International Diagnostic Interview. The case-control analysis included individuals with complete covariate information (N = 29,616), and adjusted for twin pair, 3-yr age band, and sex. The co-twin control analysis considered 288 twin pairs discordant for IBS. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using generalized estimating equations for the case-control analysis and conditional logistic regression for the co-twin control analysis. RESULTS: In all analyses, comorbid disorders of chronic widespread pain, chronic fatigue-like illness, and MDD were more common in IBS cases than controls. In the case-control analysis, individuals with IBS had an increased odds of MDD (OR 2.7, 95% CI 2.3-3.2). In the co-twin analysis, the association was similar (OR 2.2, 95% CI 1.5-3.3) when both MZ and DZ twins were used, and larger among only MZ twins (OR 3.2, 95% CI 1.7-6.1). CONCLUSIONS: From this analysis, we found no evidence that genetic and family environmental factors explain the association between MDD and IBS. Rather, one of these disorders appears to be part of the disease-causing sequence of events, or biologic disease pathway, for the other disorder. However, it was not possible to evaluate the timing of onset between MDD and IBS in this study.
Notes
Comment In: Am J Gastroenterol. 2007 Oct;102(10):2230-117897338
PubMed ID
17897337 View in PubMed
Less detail

Twin studies used to prove that the comorbidity of major depressive disorder with IBS is NOT influenced by heredity.

https://arctichealth.org/en/permalink/ahliterature84569
Source
Am J Gastroenterol. 2007 Oct;102(10):2230-1
Publication Type
Article
Date
Oct-2007
Author
Whitehead William E
Source
Am J Gastroenterol. 2007 Oct;102(10):2230-1
Date
Oct-2007
Language
English
Publication Type
Article
Keywords
Depressive Disorder, Major - complications - epidemiology - genetics
Humans
Irritable Bowel Syndrome - epidemiology - genetics - psychology
Reproducibility of Results
Research Design
Sweden - epidemiology
Twin Studies as Topic
Twins, Dizygotic
Twins, Monozygotic
Abstract
Twin studies have traditionally been used to assess the heritability of diseases such as irritable bowel syndrome (IBS) by comparing concordance rates in monozygotic twins (identical genetic endowment) to dizygotic twins (half of genes shared). Wojczynski et al. used twins in a novel way-they studied monozygotic twins who were discordant for IBS (but who shared identical genes) to show that the comorbidity of IBS with major depressive disorder could NOT be due to genetic influences. This paradigm provides the most rigorous method for separating genetic from environmental influences and should be adopted by other researchers. However, the authors' conclusion that major depressive disorder and IBS are part of the same pathophysiological process is questioned on the basis of (a) incomplete co-occurrence of IBS and major depressive disorder (13-45% co-occurrence) and (b) lack of specificity-the authors show that chronic widespread pain (related to fibromyalgia) and chronic fatigue are also strongly associated with IBS. This study provides precise, generalizable estimates from a large population-based study for the comorbidity of IBS with major depressive disorder, chronic widespread pain, and chronic fatigue.
Notes
Comment On: Am J Gastroenterol. 2007 Oct;102(10):2220-917897337
PubMed ID
17897338 View in PubMed
Less detail