Skip header and navigation

Refine By

11148 records – page 1 of 1115.

ß2-adrenergic receptor polymorphisms, asthma and COPD: two large population-based studies.

https://arctichealth.org/en/permalink/ahliterature129736
Source
Eur Respir J. 2012 Mar;39(3):558-66
Publication Type
Article
Date
Mar-2012
Author
M. Thomsen
B G Nordestgaard
A A Sethi
A. Tybjærg-Hansen
M. Dahl
Author Affiliation
Dept of Clinical Biochemistry, Herlev Hospital, Herlev, Denmark.
Source
Eur Respir J. 2012 Mar;39(3):558-66
Date
Mar-2012
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Asthma - epidemiology - genetics
Denmark - epidemiology
Female
Gene Frequency
Humans
Incidence
Lung - physiopathology
Male
Middle Aged
Polymorphism, Genetic
Prevalence
Pulmonary Disease, Chronic Obstructive - epidemiology - genetics
Receptors, Adrenergic, beta-2 - genetics
Young Adult
Abstract
The ß(2)-adrenergic receptor (ADRB2) is an important regulator of airway smooth muscle tone. We tested the hypothesis that three functional polymorphisms in the ADRB2 gene (Thr164Ile, Gly16Arg and Gln27Glu) are associated with reduced lung function, asthma or chronic obstructive pulmonary disease (COPD). We first genotyped 8,971 individuals from the Copenhagen City Heart Study for all three polymorphisms. To validate our findings, we genotyped an additional 53,777 individuals from the Copenhagen General Population Study for the Thr164Ile polymorphism. We identified 60,910 Thr164Ile noncarriers, 1,822 heterozygotes and 16 homozygotes. In the Copenhagen City Heart Study, the Thr164Ile genotype was associated with reduced forced expiratory volume in 1 s (FEV(1)) % predicted (trend p = 0.01) and FEV(1)/forced vital capacity (FVC) (p = 0.001): Thr164Ile heterozygotes had 3% and 2% reduced FEV(1) % pred and FEV(1)/FVC, respectively, compared with noncarriers. The odds ratio for COPD in Thr164Ile heterozygotes was 1.46 (95% CI 1.05-2.02). In the Copenhagen General Population Study, the Thr164 genotype associated with reduced FEV(1) % pred (p = 0.04) and FEV(1)/FVC (p
PubMed ID
22075484 View in PubMed
Less detail

ß2-adrenergic receptor Thr164Ile polymorphism, obesity, and diabetes: comparison with FTO, MC4R, and TMEM18 polymorphisms in more than 64,000 individuals.

https://arctichealth.org/en/permalink/ahliterature125626
Source
J Clin Endocrinol Metab. 2012 Jun;97(6):E1074-9
Publication Type
Article
Date
Jun-2012
Author
Mette Thomsen
Morten Dahl
Anne Tybjærg-Hansen
Børge G Nordestgaard
Author Affiliation
Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK-2730 Herlev, Denmark.
Source
J Clin Endocrinol Metab. 2012 Jun;97(6):E1074-9
Date
Jun-2012
Language
English
Publication Type
Article
Keywords
Adult
Body mass index
Cohort Studies
Denmark - epidemiology
Diabetes Mellitus - epidemiology - genetics
Female
Genetic Predisposition to Disease - epidemiology - genetics
Genotype
Humans
Male
Membrane Proteins - genetics
Obesity - epidemiology - genetics
Polymorphism, Single Nucleotide - genetics
Proteins - genetics
Receptor, Melanocortin, Type 4 - genetics
Receptors, Adrenergic, beta-2 - genetics
Risk factors
Abstract
The ß(2)-adrenergic receptor (ADRB2) influences regulation of energy balance by stimulating catecholamine-induced lipolysis in adipose tissue. The rare functional ADRB2rs1800888(Thr164Ile) polymorphism could therefore influence risk of obesity and subsequently diabetes.
We tested the hypothesis that the ADRB2rs1800888(Thr164Ile) polymorphism associates with risk of obesity and diabetes and compared effect sizes with those of FTO(rs9939609), MC4R(rs17782313), and TMEM18(rs6548238).
We conducted a population-based cohort study in Copenhagen, Denmark.
We genotyped more than 64,000 individuals from the Danish general population.
We evaluated body mass index (BMI), obesity (BMI =30 kg/m(2)), and diabetes.
Rare allele frequencies were 0.02 for T for ADRB2rs1800888(Thr164Ile), 0.40 for A for FTOrs9939609, 0.25 for C for MC4Rrs17782313, and 0.20 for T for TMEM18rs6548238. For rare vs. common homozygotes, odds ratio for obesity was 3.32 (95% confidence interval = 1.08-10.19) for ADRB2rs1800888(Thr164Ile), 1.42 (1.35-1.52) for FTOrs9939609, 1.18 (1.06-1.30) for MC4Rrs17782313, and 1.28 (1.10-1.50) for TMEM18rs6548238 (common vs. rare). Corresponding odds ratios for diabetes were 1.85 (0.24-14.29), 1.22 (1.07-1.39), 0.96 (0.80-1.16), and 1.61 (1.17-2.22), respectively. After adjustment for BMI, only TMEM18rs6548238 remained associated with diabetes. BMI was increased in rare vs. common homozygotes in FTOrs9939609, MC4Rrs17782313, and TMEM18rs6548238 (common vs. rare) but not in ADRB2rs1800888(Thr164Ile).
Our results suggest that ADRB2rs1800888(Thr164Ile) rare vs. common homozygotes are not significantly associated with an increase in BMI measured continuously but may be associated with an increased risk of obesity. Also, TMEM18rs6548238 associated with risk of diabetes after adjustment for BMI. These findings need confirmation in other studies.
PubMed ID
22466342 View in PubMed
Less detail

A 3-year follow-up after anterior colporrhaphy compared with collagen-coated transvaginal mesh for anterior vaginal wall prolapse: a randomised controlled trial.

https://arctichealth.org/en/permalink/ahliterature272920
Source
BJOG. 2016 Jan;123(1):136-42
Publication Type
Article
Date
Jan-2016
Author
M. Rudnicki
E. Laurikainen
R. Pogosean
I. Kinne
U. Jakobsson
P. Teleman
Source
BJOG. 2016 Jan;123(1):136-42
Date
Jan-2016
Language
English
Publication Type
Article
Keywords
Collagen
Denmark - epidemiology
Dyspareunia - epidemiology - etiology
Female
Finland - epidemiology
Follow-Up Studies
Gynecologic Surgical Procedures - instrumentation - methods
Humans
Norway - epidemiology
Pelvic Organ Prolapse - epidemiology - surgery
Prospective Studies
Quality of Life
Surgical Mesh
Surveys and Questionnaires
Sweden - epidemiology
Treatment Outcome
Vagina - surgery
Abstract
To compare the 1-year (previously published) and 3-year objective and subjective cure rates, and complications, related to the use of a collagen-coated transvaginal mesh for anterior vaginal wall prolapse against a conventional anterior repair.
Randomised controlled study.
Six departments of obstetrics and gynaecology in Norway, Sweden, Finland, and Denmark.
A total of 138 women, of 55 years of age or older, admitted for stage =2 anterior vaginal wall prolapse.
The women scheduled for primary anterior vaginal wall prolapse surgery were randomised between conventional anterior colporrhaphy and surgery with a collagen-coated prolene mesh. All patients were evaluated using the Pelvic Organ Prolapse Quantification (POP-Q) assessment before and after surgery. Symptoms related to pelvic organ prolapse were evaluated using the Pelvic Floor Impact Questionnaire (PFIQ-7) and the Pelvic Floor Distress Inventory (PFDI-20).
Objective cure, defined as POP-Q stage
PubMed ID
26420345 View in PubMed
Less detail

[4-year experiences with computer-assisted registration of postoperative wound infections and identification of risk factors].

https://arctichealth.org/en/permalink/ahliterature226352
Source
Ugeskr Laeger. 1991 May 13;153(20):1416-9
Publication Type
Article
Date
May-13-1991
Author
A. Bremmelgaard
A M Sørensen
E. Brems-Dalgaard
D. Raahave
J V Pedersen
Author Affiliation
Frederiksberg Hospital, klinisk mikrobiologisk afdeling.
Source
Ugeskr Laeger. 1991 May 13;153(20):1416-9
Date
May-13-1991
Language
Danish
Publication Type
Article
Keywords
Automatic Data Processing
Denmark - epidemiology
Female
Humans
Male
Registries - statistics & numerical data
Regression Analysis
Risk factors
Surgical Wound Infection - epidemiology - etiology
Abstract
A continuous record of postoperative surgical infections was carried out by electronic data processing of 9,181 orthopaedic and general operations. The overall infection rate was 5.7%, ranging from 2.0% (clean wounds) to 22.1% (dirty wounds). The corresponding deep infection rates were 1.7%, 0.4% and 5.4%, respectively. Employing a multiple logistic regression analysis, ten risk factors were evaluated. Factors found to be significant for both departments were: wound contamination, duration of operation and age. In addition, in the department of orthopaedic surgery: date of operation and surgeon, and in the department of general surgery: planning of operation, length of preoperative stay and anatomic groups. Sex had no influence on postoperative infection. Significant factors altered during the four years. Postoperative stay was, on an average, 13.9 days longer in infected patients.
PubMed ID
2028549 View in PubMed
Less detail

[4 years of experiences with Karbase. A tool for quality development in vascular surgery].

https://arctichealth.org/en/permalink/ahliterature216878
Source
Ugeskr Laeger. 1994 Nov 21;156(47):7032-5
Publication Type
Article
Date
Nov-21-1994
Author
L P Jensen
T V Schroeder
J E Lorentzen
P V Madsen
Author Affiliation
Karkirurgisk afdeling, Rigshospitalet, København.
Source
Ugeskr Laeger. 1994 Nov 21;156(47):7032-5
Date
Nov-21-1994
Language
Danish
Publication Type
Article
Keywords
Denmark - epidemiology
Evaluation Studies as Topic
Follow-Up Studies
Humans
Quality Assurance, Health Care
Registries
Risk factors
Surgical Wound Infection - epidemiology
Vascular Surgical Procedures - adverse effects - standards - statistics & numerical data
Abstract
Karbase, a Danish register for vascular surgery is presented with data from four years experience. The register consists of 65 variables centered on risk factors, the perioperative course as well as follow-up information. During the four-year period 1989-1992 a total of 4902 admissions were registered in 3810 patients. Surgery was performed during 4005 admissions. Output data from Karbase is presented with results on survival and postoperative complications, related to preoperative risk factors. The incidence of surgical wound infections was 3.9%, with a significant reduction during the years (p = 0.004). Karbase is now used by all vascular surgical units in Denmark. We conclude that the establishment of a continuous registration has been beneficial to the department. We have achieved valid data on treatment, outcome and complications in relation to individual risk factors. In the future the use of Karbase will be extended with the aim of further quality development, locally as well as nation wide.
PubMed ID
7817410 View in PubMed
Less detail

A 6-month prospective study of hospital-acquired bacteremia in Copenhagen county.

https://arctichealth.org/en/permalink/ahliterature34967
Source
Scand J Infect Dis. 1996;28(6):601-8
Publication Type
Article
Date
1996
Author
A G Jensen
A. Kirstein
I. Jensen
J. Scheibel
F. Espersen
Author Affiliation
Department of Clinical Microbiology, Herlev University Hospital, Denmark.
Source
Scand J Infect Dis. 1996;28(6):601-8
Date
1996
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Bacteremia - epidemiology - etiology
Child
Child, Preschool
Community-Acquired Infections - epidemiology
Comparative Study
Cross Infection - epidemiology - etiology
Denmark - epidemiology
Drug Resistance, Microbial
Female
Humans
Incidence
Infant
Male
Microbial Sensitivity Tests
Middle Aged
Prospective Studies
Abstract
During a 6-month period, 892 positive blood cultures were detected in the Copenhagen County hospitals. 302 (34%) were regarded as contaminations, and of the remaining cases 419 (71%) were community-acquired and 171 (29%) hospital-acquired, giving incidence rates of 6.8/1,000 admissions and 2.8/1,000 admissions, respectively. Both frequency and rate of hospital-acquired bacteremia were lower compared to most other studies. E. coli was more commonly found in community-acquired infections, while coagulase-negative staphylococci were the organisms most often considered as a contaminant. The main causative organisms in hospital-acquired infections were S. aureus (n = 37) and E. coli (n = 34). The proportion of polymicrobial bacteremias in this study was lower compared to most other studies (8%). E. coli from hospital-acquired infections were resistant to ampicillin in 42% of cases, but other Enterobacteriaceae showed higher percentage of resistance to beta-lactam antibiotics. S. aureus was penicillin-resistant in 92% of cases, but no methicillin-resistant strains were isolated. The frequency of antibiotic resistance was low compared to reports from other countries. A total of 136 hospital-acquired cases were followed prospectively. 61% of the patients were male and 46% were > or = 60 years of age. Most patients had predisposing diseases, 90% had foreign body and/or recent surgery performed, and 74 (54%) had an intraveneous catheter. The portal of entry was known in 132 (97%) of the cases, the most common being the urinary tract (42%), followed by an intravenous catheter (30%). The prevalence of urinary tract catheters gave an increased number of cases with E. coli bacteremia. The mortality was 16%.
PubMed ID
9060064 View in PubMed
Less detail

A 6-year nationwide cohort study of glycaemic control in young people with type 1 diabetes. Risk markers for the development of retinopathy, nephropathy and neuropathy. Danish Study Group of Diabetes in Childhood.

https://arctichealth.org/en/permalink/ahliterature32420
Source
J Diabetes Complications. 2000 Nov-Dec;14(6):295-300
Publication Type
Article
Author
B S Olsen
A. Sjølie
P. Hougaard
J. Johannesen
K. Borch-Johnsen
K. Marinelli
B. Thorsteinsson
S. Pramming
H B Mortensen
Author Affiliation
Department of Paediatrics, Glostrup University Hospital, DK-2600, Glostrup, Denmark.
Source
J Diabetes Complications. 2000 Nov-Dec;14(6):295-300
Language
English
Publication Type
Article
Keywords
Adolescent
Albuminuria - epidemiology
Blood Glucose - metabolism
Child
Cohort Studies
Denmark - epidemiology
Diabetes Mellitus, Type 1 - blood - drug therapy - physiopathology
Diabetic Nephropathies - epidemiology - prevention & control
Diabetic Neuropathies - epidemiology - prevention & control
Diabetic Retinopathy - epidemiology - prevention & control
Female
Humans
Male
Neurologic Examination
Perception
Probability
Risk factors
Vibration
Abstract
The study aimed to identify risk markers (present at the start of the study in 1989) for the occurrence and progression of microvascular complications 6 years later (in 1995) in a Danish nationwide cohort of children and adolescents with Type 1 diabetes (average age at entry 13.7 years). Probabilities for the development of elevated albumin excretion rate (AER), retinopathy, and increased vibration perception threshold (VPT) could then be estimated from a stepwise logistic regression model. A total of 339 patients (47% of the original cohort) were studied. Sex, age, diabetes duration, insulin regimen and dose, height, weight, HbA(1c), blood pressure, and AER were recorded. In addition, information on retinopathy, neuropathy (VPT), and anti-hypertensive treatment was obtained at the end of the study. HbA(1c) (normal range 4.3-5.8, mean 5.3%) and AER (upper normal limit or =20 microg min(-1)) was found in 12.8% of the patients in 1995, and risk markers for this were increased AER and high HbA(1c), in 1989 (both p6.5 V) was found in 62.5% of patients in 1995, for which the risk markers were male sex (p
PubMed ID
11120452 View in PubMed
Less detail

A 7-month outbreak of relapsing postpartum group A streptococcal infections linked to a nurse with atopic dermatitis.

https://arctichealth.org/en/permalink/ahliterature192371
Source
Scand J Infect Dis. 2001;33(10):734-7
Publication Type
Article
Date
2001
Author
T. Ejlertsen
J. Prag
E. Pettersson
A. Holmskov
Author Affiliation
Department of Clinical Microbiology, Viborg Hospital, Denmark. tej@aas.nja.dk
Source
Scand J Infect Dis. 2001;33(10):734-7
Date
2001
Language
English
Publication Type
Article
Keywords
Adult
Carrier State - microbiology - transmission
Denmark - epidemiology
Dermatitis, Atopic - microbiology
Disease Outbreaks
Female
Follow-Up Studies
Humans
Infectious Disease Transmission, Professional-to-Patient
Puerperal Infection - epidemiology - microbiology
Streptococcal Infections - epidemiology - microbiology - transmission
Streptococcus pyogenes - isolation & purification
Abstract
A 7-month outbreak of 15 cases of postpartum sepsis with group A haemolytic Streptococci (GAS) was stopped when a carrier was identified. Comparing delivery dates with duty rotas revealed that the carrier had been present during delivery in 13 of the 15 cases. The epidemic GAS type, T3-13-B3264, was found in a carbuncle in her groin and in atopic dermatitis lesions behind her ears and on her eyelids. Thus, it was not the microbiological screening of staff that helped detect the carrier. The outbreak went unnoticed for 6 months, as no 2 cases were diagnosed by the same physician and 5 cases were diagnosed by different general practitioners. The main risk factors for infection were presence of the carrier relative risk (relative risk RR 47.8, 95% confidence interval (CI) 10.9-209.5) and suturing of episiotomy (RR 11.0; 95% CI 2.6-47.9). We recommend that a thorough epidemiological investigation should be carried out in every single case of GAS postpartum infection. Despite initial intravenous treatment with penicillin, 8 patients experienced > 15 recurring postpartum GAS infections, such as endometritis, wound infection, tonsillitis, erysipelas and Brodie's abscess. Eradication of GAS should be confirmed after completion of treatment.
PubMed ID
11728037 View in PubMed
Less detail

A 10-year follow-up study of an adolescent psychiatric clientele and early predictors of readmission.

https://arctichealth.org/en/permalink/ahliterature31747
Source
Nord J Psychiatry. 2001;55(1):11-6
Publication Type
Article
Date
2001
Author
J. Pedersen
T. Aarkrog
Author Affiliation
Department of Child Psychiatry, Centralsygehuset i Holbaek, Gl. Ringstedvej 1, DK-4300 Holbaek, Denmark.
Source
Nord J Psychiatry. 2001;55(1):11-6
Date
2001
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Affective Disorders, Psychotic - diagnosis - epidemiology - psychology
Borderline Personality Disorder - diagnosis - epidemiology - psychology
Child
Denmark - epidemiology
Female
Follow-Up Studies
Humans
Male
Mental Disorders - diagnosis - epidemiology - therapy
Patient Readmission - statistics & numerical data
Psychiatric Status Rating Scales
Recurrence
Research Support, Non-U.S. Gov't
Risk factors
Schizophrenia, Childhood - diagnosis - epidemiology - psychology
Utilization Review
Abstract
Over a period of 20 years (from 1968 to 1988) all inpatients (n = 839) who were admitted for the first time to the adolescent psychiatric unit in Copenhagen were registered, and 40 social and psychiatric variables were recorded, to investigate early predictors of later readmission. Overall, 44.8% of the patients were readmitted within a certain observation period (range, 1.5-21.5 years). Among a subsample of 488 patients (58%) who could be followed up for more than 10 years after their first admission 26% became heavy users of psychiatric services, defined as long-term inpatients or revolving-door patients. Severe early diagnoses (schizophrenia and affective psychoses) were strongly associated with rapid relapses and frequent readmissions. A statistical estimate of the risk of later heavy use based on 12 independent variables is presented.
PubMed ID
11827601 View in PubMed
Less detail

[10-year follow-up study of mortality among users of hostels for homeless people in Copenhagen].

https://arctichealth.org/en/permalink/ahliterature179879
Source
Ugeskr Laeger. 2004 Apr 26;166(18):1679-81
Publication Type
Article
Date
Apr-26-2004

11148 records – page 1 of 1115.