Skip header and navigation

Refine By

9 records – page 1 of 1.

The epidemiology of infectious myocarditis, lymphocytic myocarditis and dilated cardiomyopathy.

https://arctichealth.org/en/permalink/ahliterature7842
Source
Eur Heart J. 1995 Dec;16 Suppl O:36-41
Publication Type
Article
Date
Dec-1995
Author
G. Friman
L. Wesslén
J. Fohlman
J. Karjalainen
C. Rolf
Author Affiliation
Department of Infectious Diseases and Clinical Microbiology, Uppsala University Hospital, Sweden.
Source
Eur Heart J. 1995 Dec;16 Suppl O:36-41
Date
Dec-1995
Language
English
Publication Type
Article
Keywords
Bacterial Infections - epidemiology - pathology
Cardiomyopathy, Dilated - epidemiology - pathology
Cross-Sectional Studies
Death, Sudden, Cardiac - epidemiology - etiology - pathology
Humans
Incidence
Lymphocytosis - epidemiology - pathology
Myocarditis - epidemiology - pathology
Myocardium - pathology
Sweden - epidemiology
Virus Diseases - epidemiology - pathology
Abstract
Infectious myocarditis is a common condition which often passes unrecognized, and the true incidence is thus unknown. Lymphocytic myocarditis has been recorded in 1.06% of 12,747 unselected routine autopsies performed over a 10-year period. Dilated cardiomyopathy (DCM) has an estimated frequency of 7.5-10% per 100,000 inhabitants per year. Overall, the enteroviruses, and particularly the Coxsackie-B viruses, predominate among viruses as the cause of myocarditis. As new molecular biological techniques have become available, the cytomegaloviruses (CMV) seem to have emerged as a more common cause of myocarditis than was previously recognized. Among the bacterial myocarditides, diphtheric myocarditis has become a serious threat in Russia and adjacent states during the 1990s. Among newly identified bacteria, Borrelia burgdorferi infection is accompanied by cardiac involvement in 1-8% of cases, where myocarditis with conduction disturbances is the most prominent feature. Chlamydia pneumoniae may be associated with myocarditis and sudden unexpected death. In AIDS, myocarditis with variable aetiology occurs in up to 50% of patients, although asymptomatic in most cases. In lymphocytic myocarditis and DCM, enteroviral-specific nucleotide sequences have been detected in about 30% of patients, and CMV-specific nucleotide sequences in 14%. Borrelia burgdorferi may occasionally be implicated in DCM. In this contribution we focus also on sudden unexpected death (SUD) in young athletes, since, in Sweden, an increased frequency of SUD has recently been observed in young orienteers and myocarditis was a common feature.
PubMed ID
8682098 View in PubMed
Less detail

Hidden cardiac lesions and psychotropic drugs as a possible cause of sudden death in psychiatric patients: a report of 14 cases and review of the literature.

https://arctichealth.org/en/permalink/ahliterature180745
Source
Can J Psychiatry. 2004 Feb;49(2):100-5
Publication Type
Article
Date
Feb-2004
Author
Dominique Frassati
Alain Tabib
Bernard Lachaux
Natalie Giloux
Jean Daléry
François Vittori
Dorothée Charvet
Cécile Barel
Bernard Bui-Xuan
Rachel Mégard
Louis Pierre Jenoudet
Jacques Descotes
Thierry Vial
Quadiri Timour
Author Affiliation
Centre Hospitalier le Vinatier, Bron, France.
Source
Can J Psychiatry. 2004 Feb;49(2):100-5
Date
Feb-2004
Language
English
Publication Type
Article
Keywords
Adult
Aged
Antipsychotic Agents - adverse effects - therapeutic use
Arrhythmias, Cardiac - chemically induced - mortality - pathology
Brain - pathology
Canada
Death, Sudden, Cardiac - epidemiology - etiology - pathology
Drug Therapy, Combination
Electroencephalography - drug effects
Female
Heart Diseases - complications - mortality - pathology
Humans
Lung - pathology
Male
Mental Disorders - drug therapy - mortality - pathology
Middle Aged
Myocardium - pathology
Psychotropic Drugs - adverse effects - therapeutic use
Retrospective Studies
Abstract
To confirm the hypothesis that psychotropic drugs, especially neuroleptics, lithium, and antidepressants, are implicated as a cause of unexpected sudden death in psychiatric patients because of their cardiotoxicity, especially when hidden cardiac lesions are present.
We performed a full pathological examination of 14 psychiatric patients who unexpectedly and suddenly died between 1980 and 1999.
Neuroleptics were involved in 13 instances, antidepressants in 9, and anxiolytics in 5. Psychotropic drugs were combined in all but a single patient. In all 14 patients, toxicological analyses discarded drug overdose as cause of death. At postmortem examination, the brain and abdominal organs were normal. In 13 patients, the following lesions were found in the heart and lungs: dilated cardiomyopathy (6 patients), left ventricular hypertrophy (2 patients, 1 of which was associated with mitral prolapse and anomalies of His bundle), arrhythmogenic cardiopathy of the right ventricle (1 patient), pericarditis (1 patient), mitral prolapse (1 patient), muscular bridge on the anterior interventricular artery (1 patient), and Mendelsons syndrome (1 patient). In 1 case, no changes were seen. Most of the drugs that were taken immediately prior to death can induce arrhythmias either by prolonging the QT interval, potentially resulting in torsades de pointes, or by widening QRS complexes, possibly leading to reentry and ventricular fibrillation.
Our findings suggest that the arrhythmogenic effects of psychotropic drugs can be exacer bated when preexisting hidden cardiac lesions are present and can result in sudden death. Patients should be systematically evaluated for cardiac lesions prior to starting any treatment with psychotropic drugs; the minimal effective dosage should be used.
PubMed ID
15065743 View in PubMed
Less detail

[Incidence and pathomorphological characteristics of the development of sudden coronary death in coal miners]

https://arctichealth.org/en/permalink/ahliterature55054
Source
Ter Arkh. 1993;65(9):41-3
Publication Type
Article
Date
1993
Author
R A Kopytina
V V Cherkesov
G P Kobets
V M Danilik
B N Zorin
V A Tsygankov
I G Fufaeva
V P Kamkov
Source
Ter Arkh. 1993;65(9):41-3
Date
1993
Language
Russian
Publication Type
Article
Keywords
Adult
Age Distribution
Autopsy
Cause of Death
Coal Mining
Death, Sudden, Cardiac - epidemiology - etiology - pathology
English Abstract
Humans
Incidence
Male
Middle Aged
Myocardium - pathology
Occupational Diseases - mortality - pathology
Ukraine - epidemiology
Abstract
The authors studied autopsy protocols, microscopic and histochemical data on the heart for miners who had died suddenly. No positive trend in the sudden coronary death incidence in miners was reported. A great number of sudden deaths were registered in mines. The deaths are attributed to severe atherosclerosis responsible for irreversible changes in the myocardium, coronary vascular spasms, emergence of pathological agitation triggering lethal ischemia.
PubMed ID
8303594 View in PubMed
Less detail

Platelet glycoprotein Ibalpha HPA-2 Met/VNTR B haplotype as a genetic predictor of myocardial infarction and sudden cardiac death.

https://arctichealth.org/en/permalink/ahliterature193609
Source
Circulation. 2001 Aug 21;104(8):876-80
Publication Type
Article
Date
Aug-21-2001
Author
J. Mikkelsson
M. Perola
A. Penttilä
P J Karhunen
Author Affiliation
Medical School, University of Tampere and Tampere University Hospital, Tampere, Finland. jm56215@uta.fi
Source
Circulation. 2001 Aug 21;104(8):876-80
Date
Aug-21-2001
Language
English
Publication Type
Article
Keywords
Adult
Age Distribution
Aged
Alleles
Antigens, Human Platelet - genetics
Comorbidity
Coronary Disease - epidemiology - genetics - pathology
Death, Sudden, Cardiac - epidemiology - etiology - pathology
Finland - epidemiology
Genetic Linkage
Haplotypes - genetics
Humans
Linkage Disequilibrium - genetics
Male
Middle Aged
Minisatellite Repeats - genetics
Myocardial Infarction - epidemiology - etiology - pathology
Odds Ratio
Platelet Glycoprotein GPIb-IX Complex - genetics
Polymorphism, Genetic
Predictive value of tests
Risk factors
Abstract
Sudden cardiac death (SCD) is one of the leading manifestations of coronary heart disease in early middle age. Platelet glycoprotein (GP) Ib-IX-V receptor complexes play a key role in the initial adhesion of platelets to collagen during the formation of a coronary thrombus. The HPA-2 (Thr145 Met) and VNTR polymorphisms of the gene for GP Ibalpha have been studied previously in hospitalized patients with acute coronary syndromes. The significance of these polymorphisms in victims of sudden cardiac death is not known.
The association of these 2 polymorphisms with coronary atherosclerosis, coronary artery stenosis, coronary thrombosis, myocardial infarction (MI), and SCD was studied in the Helsinki Sudden Death Study, which comprised 2 large autopsy series, collected 10 years apart during 1981 to 1982 and 1991 to 1992, of 700 middle-aged white Finnish men who suffered sudden or violent out-of-hospital death. The 2 polymorphisms showed an almost complete linkage disequilibrium. Men with acute MI (n=80) and coronary thrombosis (n=65) were more likely to be carriers of the HPA-2 Met allele (OR 2.0 and 2.6, respectively, P
PubMed ID
11514372 View in PubMed
Less detail

Sports-related sudden cardiac death in a competitive and a noncompetitive athlete population aged 12 to 49 years: data from an unselected nationwide study in Denmark.

https://arctichealth.org/en/permalink/ahliterature263450
Source
Heart Rhythm. 2014 Oct;11(10):1673-81
Publication Type
Article
Date
Oct-2014
Author
Bjarke Risgaard
Bo Gregers Winkel
Reza Jabbari
Charlotte Glinge
Ole Ingemann-Hansen
Jørgen Lange Thomsen
Gyda Lolk Ottesen
Stig Haunsø
Anders Gaarsdal Holst
Jacob Tfelt-Hansen
Source
Heart Rhythm. 2014 Oct;11(10):1673-81
Date
Oct-2014
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age Distribution
Athletes - statistics & numerical data
Autopsy
Cardiomyopathies - complications - diagnosis - mortality
Cause of Death - trends
Child
Death Certificates
Death, Sudden, Cardiac - epidemiology - etiology - pathology
Denmark - epidemiology
Female
Follow-Up Studies
Humans
Incidence
Male
Mass Screening - methods
Middle Aged
Retrospective Studies
Risk assessment
Risk factors
Sports - statistics & numerical data
Survival Rate - trends
Young Adult
Abstract
Preparticipation screening programs have been suggested to reduce the numbers of sports-related sudden cardiac deaths (SrSCD).
The purpose of this study was to identify and characterize all SrSCD aged 12-49 years and to address the difference in incidence rates between competitive and noncompetitive athletes.
All deaths among persons aged 12-49 years from 2007-2009 were included. Death certificates were reviewed. History of previous admissions to hospital was assessed, and discharge summaries and autopsy reports were read. Sudden cardiac deaths (SCDs) and SrSCD cases were identified.
In the 3-year period, there were 881 SCDs, of which we identified 44 SrSCD. In noncompetitive athletes aged 12-35 years, the incidence rate of SrSCD was 0.43 (95% confidence interval [CI] 0.16-0.94) per 100,000 athlete person-years vs 2.95 (95% CI 1.95-4.30) in noncompetitive athletes aged 36-49 years. In competitive athletes, the incidence rate of SrSCD was 0.47 (95% CI 0.10-1.14) and 6.64 (95% CI 2.86-13.1) per 100,000 athlete person-years in those aged 12-35 years and 36-49 years, respectively. The incidence rate of SCD in the general population was 10.7 (95% CI 10.0-11.5) per 100.000 person-years.
The incidence rates of SrSCD in noncompetitive and competitive athletes are not different. The study showed an increase in the incidence rate of SrSCD in persons aged 36-49 years in both noncompetitive and competitive athletes compared to those aged 12-35 years. Importantly, SCD in the general population is much more prevalent than is SrSCD in all age groups.
Notes
Comment In: Heart Rhythm. 2014 Oct;11(10):1682-324893123
PubMed ID
24861446 View in PubMed
Less detail

Sudden cardiac death during physical exercise: Characteristics of victims and autopsy findings.

https://arctichealth.org/en/permalink/ahliterature270240
Source
Ann Med. 2015 May;47(3):263-8
Publication Type
Article
Date
May-2015
Author
Tomi Toukola
Eeva Hookana
Juhani Junttila
Kari Kaikkonen
Jani Tikkanen
Juha Perkiömäki
Marja-Leena Kortelainen
Heikki V Huikuri
Source
Ann Med. 2015 May;47(3):263-8
Date
May-2015
Language
English
Publication Type
Article
Keywords
Aged
Autopsy
Cause of Death
Coronary Artery Disease - mortality - pathology
Death, Sudden, Cardiac - epidemiology - etiology - pathology
Exercise - physiology
Female
Finland - epidemiology
Heart Diseases - mortality - pathology
Humans
Male
Middle Aged
Myocardial Ischemia - mortality - pathology
Prospective Studies
Risk factors
Abstract
To provide data on the risk factors and characteristics of subjects who experience sudden cardiac death (SCD) during physical exercise.
We assessed the characteristics and the medico-legal autopsy findings of SCD victims who had experienced a witnessed fatal cardiac arrest at rest (n = 876) or in relation to physical exercise (n = 328) in the Finnish Study of Genotype and Phenotype Characteristics of SCD (FinGesture). A total of 876 (73%) witnessed SCDs occurred at rest (R group) and 328 (27%) during or immediately after physical exercise (PE group). Male gender was more common in the PE group compared to the R group (309/328, 94% versus 678/876, 77%, P
PubMed ID
25861828 View in PubMed
Less detail

[The influence of alcohol consumption on the chronological patterns of sudden cardiac death].

https://arctichealth.org/en/permalink/ahliterature265692
Source
Sud Med Ekspert. 2015 May-Jun;58(3):21-5
Publication Type
Article
Author
S P Sapozhnikov
V A Kozlov
A V Golenkov
V A Kichigin
P B Karyshev
O Yu Samarkina
Source
Sud Med Ekspert. 2015 May-Jun;58(3):21-5
Language
Russian
Publication Type
Article
Keywords
Age Factors
Alcohol Drinking - adverse effects - blood - epidemiology
Death, Sudden, Cardiac - epidemiology - etiology - pathology
Ethanol - blood
Female
Humans
Male
Middle Aged
Risk factors
Russia - epidemiology
Seasons
Sex Factors
Time Factors
Abstract
The objective of the present study was the retrospective analysis of the materials collected by the Republican Bureau of Forensic Medical Expertise, Ministry of Health and Social Development of Chuvash Republic, during the period from 1997 till 2002 for the elucidation of the chronological patterns of sudden cardiac death (SCD) associated with alcohol consumption depending on the sex and age of the victims, days of the week and months of the year as well as weather conditions. It was shown that the peak of mortality among men and women taking no alcohol fell on Monday. It was highest in May and decreased by February. The alcohol consumption significantly changes the chronological patterns of mortality from cardiovascular pathology. It was highest among the women abusing alcohol in August and October. The study has demonstrated a weak negative correlation between the frequency of sudden cardiac death among non-consumers of alcohol and dew-point temperature among the persons having alcohol in blood.
PubMed ID
26245099 View in PubMed
Less detail

Toll-like receptor 4 polymorphism is associated with coronary stenosis but not with the occurrence of acute or old myocardial infarctions.

https://arctichealth.org/en/permalink/ahliterature166565
Source
Scand J Clin Lab Invest. 2006;66(8):667-75
Publication Type
Article
Date
2006
Author
J. Hernesniemi
T. Lehtimäki
R. Rontu
M S Islam
C. Eklund
J. Mikkelsson
E. Ilveskoski
O. Kajander
S. Goebeler
L E Viiri
M. Hurme
P J Karhunen
Author Affiliation
Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere University Hospital and the Medical School at the University of Tampere, Finland. jussi.hernesniemi@uta.fi
Source
Scand J Clin Lab Invest. 2006;66(8):667-75
Date
2006
Language
English
Publication Type
Article
Keywords
Acute Disease
Comorbidity
Coronary Stenosis - epidemiology - genetics - pathology
Death, Sudden, Cardiac - epidemiology - etiology - pathology
European Continental Ancestry Group - genetics
Finland - epidemiology
Humans
Male
Middle Aged
Myocardial Infarction - epidemiology - genetics - pathology
Polymorphism, Genetic
Toll-Like Receptor 4 - genetics
Abstract
Atherosclerosis is considered to be a chronic inflammatory disease. Toll-like receptor 4 (TLR-4), a key mediator in activating inflammatory cascade, has an A-to-G functional polymorphism that changes aspartic acid to glycine at position 299. TLR-4 is activated by, for example, lipopolysaccharides. The purpose of this study was to investigate the role of a common Asp299Gly polymorphism of the TLR-4 gene in atherosclerosis.
The study comprised autopsy material from 657 men (the Helsinki Sudden Death Study; mean age 53, range 33-70 years).
Fewer G-allele carriers had 3-vessel coronary artery disease compared with AA homozygotes (OR 0.32; 95 % CI, 0.12-0.88, p = 0.027), and they also had a lower mean value for maximal coronary stenosis (p = 0.019). TLR-4 polymorphism was not significantly associated with the occurrence of acute or old myocardial infarction (MI).
The G allele of the TLR-4 gene, which is associated with a lower inflammation response, was associated with a lower risk of coronary stenosis but not with the occurrence of MI and hence is not a major factor in the development of coronary atherosclerosis.
PubMed ID
17101559 View in PubMed
Less detail

9 records – page 1 of 1.