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Changes in drug metabolism and lipoproteins in workers occupationally exposed to DDT and lindane.

https://arctichealth.org/en/permalink/ahliterature255171
Source
Arh Hig Rada Toksikol. 1973;24(4):289-96
Publication Type
Article
Date
1973

Organochlorines and bone mineral density in Swedish men from the general population.

https://arctichealth.org/en/permalink/ahliterature195327
Source
Osteoporos Int. 2000;11(12):1036-42
Publication Type
Article
Date
2000
Author
A W Glynn
K. Michaëlsson
P M Lind
A. Wolk
M. Aune
S. Atuma
P O Darnerud
H. Mallmin
Author Affiliation
Toxicology Division, Swedish National Food Administration, Uppsala.
Source
Osteoporos Int. 2000;11(12):1036-42
Date
2000
Language
English
Publication Type
Article
Keywords
Adult
Aged
Androgen Antagonists - metabolism
Bone Density - drug effects
DDT - adverse effects - blood
Environmental Pollutants - adverse effects - blood
Estrogen Receptor Modulators - metabolism
Estrogens - metabolism
Hexachlorobenzene - blood - pharmacology
Humans
Male
Middle Aged
Polychlorinated biphenyls - adverse effects - blood
Regression Analysis
Sweden
Abstract
Persistent organochlorines (POCs), such as polychlorinated biphenyls (PCBs) and DDT, are present at relatively high concentrations in food and show estrogenic, anti-estrogenic or anti-androgenic activity in biological test systems. Because bone mineral density (BMD) in men is influenced by sex hormones, we looked for associations between BMD and serum concentrations of POCs in 115 men (mean age 63 years, range 40-75 years) from the general Swedish population. Ten PCB congeners, five DDT isomers, hexachlorobenzene, three hexachlorocyclohexane isomers, trans-nonachlor and oxychlordane were analyzed by gas chromatography. Quantitative bone measurements were performed by dual-energy X-ray absorptiometry at three sites: whole body, the L2-L4 region of the lumbar spine, and the neck region of the proximal femur, as well as by quantitative ultrasound on the left os calcis (broadband ultrasound attenuation (BUA) and speed of sound (SOS)). After adjustment for confounding factors in linear regression analyses we found no strong association between serum concentrations of single POCs and the five BMD and ultrasound variables. When POCs were grouped according to hormonal activity (estrogenic, anti-estrogenic, anti-androgenic) and the study subjects were divided into organochlorine concentration quartiles, a weak association was indicated between increased serum concentrations of p,p'-DDE (antiandrogenic) and decreased BMD, BUA and SOS. This may suggest that p,p'-DDE could cause negative effects on bone density, but the findings might also be due to chance since multiple comparisons were made in the statistical analysis. Overall our results do not suggest that the studied POCs caused major effects on bone density in our study group.
PubMed ID
11256895 View in PubMed
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Repeated measurements of organochlorine exposure and breast cancer risk (Denmark).

https://arctichealth.org/en/permalink/ahliterature20563
Source
Cancer Causes Control. 2000 Feb;11(2):177-84
Publication Type
Article
Date
Feb-2000
Author
A P Høyer
T. Jørgensen
P. Grandjean
H B Hartvig
Author Affiliation
Copenhagen Center for Prospective Populations Studies, Denmark. APH@post8.tele.dk
Source
Cancer Causes Control. 2000 Feb;11(2):177-84
Date
Feb-2000
Language
English
Publication Type
Article
Keywords
Adult
Age Distribution
Aged
Aged, 80 and over
Breast Neoplasms - chemically induced - epidemiology
Case-Control Studies
Cohort Studies
Confidence Intervals
DDT - adverse effects - blood
Denmark - epidemiology
Environmental Exposure - adverse effects - analysis
Environmental monitoring
Environmental Pollutants - adverse effects
Female
Humans
Incidence
Middle Aged
Pesticides - adverse effects - blood
Probability
Prospective Studies
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Risk assessment
Risk factors
Sampling Studies
Abstract
OBJECTIVE: To prospectively evaluate if repeated measurements of organochlorine exposure provide a more precise measure of breast cancer risk. METHODS: In the Copenhagen City Heart Study (CCHS) participants donated blood twice, in 1976-1978 and 1981 1983. Information on breast cancer risk factors was obtained through standardized questionnaires. A cohort nested case-control study of 155 cases and 274 matched breast cancer-free controls who had participated in both CCHS examinations was conducted. The average serum organochlorine concentration over the course of the two examinations was used, testing a possible association between organochlorine exposure and breast cancer risk. RESULTS: A high serum concentration of p,p'-DDT over the course of the two examinations was associated with a more than three-fold significantly increased risk of breast cancer, and a dose-response relationship was apparent. Furthermore, the risk of breast cancer increased with increasing serum concentrations of PCB congener 118 and 138 and the total amount of DDT isomers (sigmaDDT), but the trends were not significant. CONCLUSION: This study provides new evidence of the adverse effect of some organochlorines on breast cancer risk. Furthermore, repeated assessment of exposure during a relevant time period may provide a more precise risk estimate than a single measurement.
PubMed ID
10710203 View in PubMed
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