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The 2 Ã? 2 model of perfectionism: a comparison across Asian Canadians and European Canadians.

https://arctichealth.org/en/permalink/ahliterature123132
Source
J Couns Psychol. 2012 Oct;59(4):567-74
Publication Type
Article
Date
Oct-2012
Author
Véronique Franche
Patrick Gaudreau
Dave Miranda
Author Affiliation
School of Psychology, University of Ottawa, Jacques Lussier, ON, Canada. vfran053@uottawa.ca
Source
J Couns Psychol. 2012 Oct;59(4):567-74
Date
Oct-2012
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Asian Continental Ancestry Group - psychology
Canada
Cross-Cultural Comparison
Educational Status
Emigrants and Immigrants - psychology
European Continental Ancestry Group - psychology
Factor Analysis, Statistical
Female
Humans
Male
Middle Aged
Models, Psychological
Personal Satisfaction
Personality
Students - psychology
Abstract
The 2 Ã? 2 model of perfectionism posits that the 4 within-person combinations of self-oriented and socially prescribed perfectionism (i.e., pure SOP, mixed perfectionism, pure SPP, and nonperfectionism) can be distinctively associated with psychological adjustment. This study examined whether the relationship between the 4 subtypes of perfectionism proposed in the 2 Ã? 2 model (Gaudreau & Thompson, 2010) and academic outcomes (i.e., academic satisfaction and grade-point average [GPA]) differed across 2 sociocultural groups: Asian Canadians and European Canadians. A sample of 697 undergraduate students (23% Asian Canadians) completed self-report measures of dispositional perfectionism, academic satisfaction, and GPA. Results replicated most of the 2 Ã? 2 model's hypotheses on ratings of GPA, thus supporting that nonperfectionism was associated with lower GPA than pure SOP (Hypothesis 1a) but with higher GPA than pure SPP (Hypothesis 2). Results also showed that mixed perfectionism was related to higher GPA than pure SPP (Hypothesis 3) but to similar levels as pure SOP, thus disproving Hypothesis 4. Furthermore, results provided evidence for cross-cultural differences in academic satisfaction. While all 4 hypotheses were supported among European Canadians, only Hypotheses 1a and 3 were supported among Asian Canadians. Future lines of research are discussed in light of the importance of acknowledging the role of culture when studying the influence of dispositional perfectionism on academic outcomes.
PubMed ID
22731112 View in PubMed
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2-substituted 1,2-dihydro-3H-dibenz[de,h]isoquinoline-1,3-diones. A new class of antitumor agent.

https://arctichealth.org/en/permalink/ahliterature24099
Source
J Med Chem. 1993 Mar 19;36(6):765-70
Publication Type
Article
Date
Mar-19-1993
Author
S M Sami
R T Dorr
D S Alberts
W A Remers
Author Affiliation
Department of Pharmaceutical Sciences and Cancer Center, University of Arizona, Tucson 85721.
Source
J Med Chem. 1993 Mar 19;36(6):765-70
Date
Mar-19-1993
Language
English
Publication Type
Article
Keywords
Animals
Antineoplastic Agents - chemical synthesis - chemistry - therapeutic use
Female
Humans
Isoquinolines - chemical synthesis - chemistry - therapeutic use
Leukemia L1210 - drug therapy
Leukemia P388 - drug therapy
Male
Melanoma, Experimental - drug therapy
Mice
Mice, Inbred DBA
Ovarian Neoplasms - drug therapy
Research Support, U.S. Gov't, P.H.S.
Structure-Activity Relationship
Tumor Cells, Cultured - drug effects
Abstract
A new class of antitumor agents, having structural analogy to amonafide, but differing by the addition of a fourth ring in the nucleus, was synthesized conveniently from anthracene. Compounds with a variety of substituents, containing a basic nitrogen atom and located on the imide nitrogen, were prepared. Thirteen of 19 new compounds had greater growth inhibitory potency than amonafide in a panel of cultured murine and human tumor cells using the sulforhodamine B and MTT dye assays. The most active agents were similarly more toxic than amonafide to normal neonatal rat myocytes in vitro, but they had better chemotherapeutic indexes. From these compounds, the one with a 2-(dimethylamino)ethyl side chain (named azonafide) was chosen for further study. It showed high potency against a panel of cultured human colon cancer cells and it was active against ip P388 leukemia and subcutaneous B16 melanoma in mice. Preliminary structure-activity correlations suggest that the basicity of the side-chain nitrogen and the length of side chain are important determinants of antitumor potency in vitro. Steric hindrance and rigidity of the side chains might be other determinants.
PubMed ID
8459403 View in PubMed
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3D simulation as a tool for improving the safety culture during remediation work at Andreeva Bay.

https://arctichealth.org/en/permalink/ahliterature265458
Source
J Radiol Prot. 2014 Dec;34(4):755-73
Publication Type
Article
Date
Dec-2014
Author
K. Chizhov
M K Sneve
I. Szoke
I. Mazur
N K Mark
I. Kudrin
N. Shandala
A. Simakov
G M Smith
A. Krasnoschekov
A. Kosnikov
I. Kemsky
V. Kryuchkov
Source
J Radiol Prot. 2014 Dec;34(4):755-73
Date
Dec-2014
Language
English
Publication Type
Article
Keywords
Decontamination - methods
Hazardous Waste Sites
Imaging, Three-Dimensional - methods
Models, organizational
Norway
Organizational Culture
Radiation Monitoring - methods
Radiation Protection - methods
Radioactive Waste - prevention & control
Russia
Safety Management - organization & administration
Abstract
Andreeva Bay in northwest Russia hosts one of the former coastal technical bases of the Northern Fleet. Currently, this base is designated as the Andreeva Bay branch of Northwest Center for Radioactive Waste Management (SevRAO) and is a site of temporary storage (STS) for spent nuclear fuel (SNF) and other radiological waste generated during the operation and decommissioning of nuclear submarines and ships. According to an integrated expert evaluation, this site is the most dangerous nuclear facility in northwest Russia. Environmental rehabilitation of the site is currently in progress and is supported by strong international collaboration. This paper describes how the optimization principle (ALARA) has been adopted during the planning of remediation work at the Andreeva Bay STS and how Russian-Norwegian collaboration greatly contributed to ensuring the development and maintenance of a high level safety culture during this process. More specifically, this paper describes how integration of a system, specifically designed for improving the radiological safety of workers during the remediation work at Andreeva Bay, was developed in Russia. It also outlines the 3D radiological simulation and virtual reality based systems developed in Norway that have greatly facilitated effective implementation of the ALARA principle, through supporting radiological characterisation, work planning and optimization, decision making, communication between teams and with the authorities and training of field operators.
PubMed ID
25254659 View in PubMed
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A 5-year follow-up study of aggression at work and psychological health.

https://arctichealth.org/en/permalink/ahliterature51790
Source
Int J Behav Med. 2005;12(4):256-65
Publication Type
Article
Date
2005
Author
Annie Hogh
Marie Engström Henriksson
Hermann Burr
Author Affiliation
Institute of Occupational Health, Lersø Parkallé 105, 2100 Copenhagen, Denmark. ah@ami.dk
Source
Int J Behav Med. 2005;12(4):256-65
Date
2005
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aggression
Cohort Studies
Denmark
Female
Humans
Interpersonal Relations
Male
Mental health
Middle Aged
Organizational Culture
Research Support, Non-U.S. Gov't
Workplace
Abstract
In a longitudinal cohort study, organizational climate and long-term effects of exposure to nasty teasing (aggression) at work were investigated. The baseline consisted of a representative sample of Danish employees in 1995 with a response rate of 80% (N = 5,652). Of these, 4,647 participated in the follow-up in 2000 (response rate 84%). In 1995, 6.3% were subjected to nasty teasing with no significant gender difference. At baseline, we found significant associations among nasty teasing, a negative organizational climate, and psychological health effects. In the follow-up analyses, associations were found between exposure to nasty teasing at baseline and psychological health problems at follow-up, even when controlled for organizational climate and psychological health at baseline and nasty teasing at follow-up. Stratified for gender, the follow-up associations were significant for women but not for men. Low coworker support and conflicts at baseline and teasing at follow-up mediated the effects on men.
PubMed ID
16262544 View in PubMed
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6- and 7-substituted 2-[2'-(dimethylamino)ethyl]-1,2-dihydro-3H-dibenz[de,h] isoquinoline-1,3-diones: synthesis, nucleophilic displacements, antitumor activity, and quantitative structure-activity relationships.

https://arctichealth.org/en/permalink/ahliterature22674
Source
J Med Chem. 1996 Apr 12;39(8):1609-18
Publication Type
Article
Date
Apr-12-1996
Author
S M Sami
R T Dorr
A M Sòlyom
D S Alberts
B S Iyengar
W A Remers
Author Affiliation
Department of Pharmacology and Toxicology, University of Arizona, Tucson, 85721, USA.
Source
J Med Chem. 1996 Apr 12;39(8):1609-18
Date
Apr-12-1996
Language
English
Publication Type
Article
Keywords
Animals
Antineoplastic Agents - chemical synthesis - pharmacology
Humans
Isoquinolines - chemical synthesis
Male
Mice
Mice, Inbred DBA
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Structure-Activity Relationship
Tumor Cells, Cultured
Abstract
New 2-[2'-(dimethylamino)ethyl]-3H-dibenz[de,h]isoquinoline-1,3-diones with substituents at the 6- and 7-positions were prepared. Nucleophilic aromatic displacement was a key reaction in the syntheses. Ten of the new compounds were more potent than the unsubstituted compound, azonafide, in a panel of tumor cells including human melanoma and ovarian cancer and murine sensitive and MDR L1210 leukemia. They also were less cardiotoxic in cell culture. Four of these compounds were not cross-resistant with the MDR leukemia, and one of them, 6-ethoxyazonafide, was nearly as potent against solid tumor cells as leukemia cells. These compounds also had good potency against human breast, colon, and lung cancer cells, including doxorubicin and mitoxantrone resistant cell lines. Advantages of the new analogues over azonafide were less in vivo, but 6-ethoxyazonafide was more effective against L1210 leukemia and subcutaneous B16 melanoma in mice. Although correlations of antitumor potency in cells and physicochemical properties of substituents were not found, there were statistically significant correlations of DNA melt transition temperature (delta Tm) with potency in solid tumor cells and sensitive and MDR resistant L1210 leukemia cells for 6-substituted azonafides and with solid tumors for 7-substituted azonafides.
PubMed ID
8648600 View in PubMed
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6-Bromoindole Derivatives from the Icelandic Marine Sponge Geodia barretti: Isolation and Anti-Inflammatory Activity.

https://arctichealth.org/en/permalink/ahliterature298348
Source
Mar Drugs. 2018 Nov 08; 16(11):
Publication Type
Journal Article
Date
Nov-08-2018
Author
Xiaxia Di
Caroline Rouger
Ingibjorg Hardardottir
Jona Freysdottir
Tadeusz F Molinski
Deniz Tasdemir
Sesselja Omarsdottir
Author Affiliation
Faculty of Pharmaceutical Sciences, University of Iceland, Hagi, Hofsvallagata 53, IS-107 Reykjavik, Iceland. xid1@hi.is.
Source
Mar Drugs. 2018 Nov 08; 16(11):
Date
Nov-08-2018
Language
English
Publication Type
Journal Article
Keywords
Alkaloids - chemistry - isolation & purification - pharmacology
Animals
Anti-Inflammatory Agents - chemistry - isolation & purification - pharmacology
Aquatic Organisms
CD4-Positive T-Lymphocytes - drug effects - metabolism
Cell Differentiation - drug effects
Cells, Cultured
Coculture Techniques
Dendritic Cells
Geodia
Humans
Iceland
Indoles - chemistry
Inhibitory Concentration 50
Interleukin-10 - metabolism
Interleukin-12 Subunit p40 - metabolism
Peptides, Cyclic - chemistry - isolation & purification - pharmacology
Stereoisomerism
Abstract
An UPLC-qTOF-MS-based dereplication study led to the targeted isolation of seven bromoindole alkaloids from the sub-Arctic sponge Geodia barretti. This includes three new metabolites, namely geobarrettin A?C (1?3) and four known compounds, barettin (4), 8,9-dihydrobarettin (5), 6-bromoconicamin (6), and l-6-bromohypaphorine (7). The chemical structures of compounds 1?7 were elucidated by extensive analysis of the NMR and HRESIMS data. The absolute stereochemistry of geobarrettin A (1) was assigned by ECD analysis and Marfey's method employing the new reagent l-Na-(1-fluoro-2,4-dinitrophenyl)tryptophanamide (l-FDTA). The isolated compounds were screened for anti-inflammatory activity using human dendritic cells (DCs). Both 2 and 3 reduced DC secretion of IL-12p40, but 3 concomitantly increased IL-10 production. Maturing DCs treated with 2 or 3 before co-culturing with allogeneic CD4? T cells decreased T cell secretion of IFN-?, indicating a reduction in Th1 differentiation. Although barettin (4) reduced DC secretion of IL-12p40 and IL-10 (IC50 values 11.8 and 21.0 µM for IL-10 and IL-12p40, respectively), maturing DCs in the presence of 4 did not affect the ability of T cells to secrete IFN-? or IL-17, but reduced their secretion of IL-10. These results indicate that 2 and 3 may be useful for the treatment of inflammation, mainly of the Th1 type.
PubMed ID
30413031 View in PubMed
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[9th Danish nursing symposium in Falkoner Center, Copenhagen].

https://arctichealth.org/en/permalink/ahliterature208747
Source
Klin Sygepleje. 1997 Apr;11(2):93-6
Publication Type
Conference/Meeting Material
Date
Apr-1997

A 10-year survey of blood culture negative endocarditis in Sweden: aminoglycoside therapy is important for survival.

https://arctichealth.org/en/permalink/ahliterature93395
Source
Scand J Infect Dis. 2008;40(4):279-85
Publication Type
Article
Date
2008
Author
Werner Maria
Andersson Rune
Olaison Lars
Hogevik Harriet
Author Affiliation
Department of Infectious Diseases, South Alvsborg Hospital, Borås, Sweden. maria.werner@vgregion.se
Source
Scand J Infect Dis. 2008;40(4):279-85
Date
2008
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Aminoglycosides - therapeutic use
Anti-Bacterial Agents - therapeutic use
Blood - microbiology
Culture Media
Echocardiography
Endocarditis, Bacterial - drug therapy - epidemiology - mortality
Female
Humans
Male
Middle Aged
Sweden - epidemiology
Abstract
We estimated the prevalence of blood culture negative endocarditis (CNE) and described and analysed data with special attention to antibiotic treatment from patients with infective endocarditis (IE) reported to the Swedish endocarditis registry during the 10-y period 1995-2004. All 29 departments of infectious diseases in Sweden reported data to the registry. During the 10-y period, 2509 IE episodes (78% Duke definite) were identified in 2410 patients. 304 CNE episodes (25% Duke definite) were found. The proportion of CNE was measured to be 12% of all IE episodes. Fatal outcome occurred in 10.7% of all IE patients and in 5% of the CNE patients. The risk of dying was significantly increased in female (9%) compared to male (2%) CNE patients (OR 5.1). Mortality was significantly decreased in patients treated with an aminoglycoside (3%) versus patients without aminoglycoside therapy (13%), OR 0.2. In conclusion, the prevalence of CNE was 12% in Swedish IE patients in a 10-y survey. The mortality in IE was low (10.7%) and 4.6% for CNE. Women have higher mortality rates than men in CNE. CNE patients who received aminoglycoside therapy survived more frequently than CNE patients without this therapy.
PubMed ID
18365919 View in PubMed
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12-month prevalence of panic disorder with or without agoraphobia in the Swedish general population.

https://arctichealth.org/en/permalink/ahliterature71618
Source
Soc Psychiatry Psychiatr Epidemiol. 2002 May;37(5):207-11
Publication Type
Article
Date
May-2002
Author
Per Carlbring
Henrik Gustafsson
Lisa Ekselius
Gerhard Andersson
Author Affiliation
Department of Psychology, Uppsala University, Box 1225, Sweden.
Source
Soc Psychiatry Psychiatr Epidemiol. 2002 May;37(5):207-11
Date
May-2002
Language
English
Publication Type
Article
Keywords
Adult
Agoraphobia - diagnosis - epidemiology
Comorbidity
Comparative Study
Cross-Cultural Comparison
Cross-Sectional Studies
Female
Health Surveys
Humans
Male
Middle Aged
Panic Disorder - diagnosis - epidemiology
Research Support, Non-U.S. Gov't
Sweden - epidemiology
Abstract
OBJECTIVE: The present study examined the prevalence of panic disorder with or without agoraphobia according to DSM-IV criteria in the Swedish general population. METHOD: Data were obtained by means of a postal survey administrated to 1000 randomly selected adults. The panic disorder module of the World Health Organization's Composite International Diagnostic Interview (CIDI) was included in the survey. RESULTS: 12-month prevalence was estimated at 2.2 % (CI 95 % 1.02 % - 3.38 %). There was a significant sex difference, with a greater prevalence for women (5.6 %) compared to men (1 %). CONCLUSION: The Swedish panic disorder prevalence is relatively consistent with findings in most other parts of the western world.
PubMed ID
12107711 View in PubMed
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17beta-estradiol induces the proliferation of the in vitro cultured human urothelium.

https://arctichealth.org/en/permalink/ahliterature89268
Source
Scand J Urol Nephrol. 2009;43(3):179-85
Publication Type
Article
Date
2009
Author
Koskela Sanna
Lehtonen Siri
Santala Markku
Venhola Mika
Parpala-Spårman Teija
Lehenkari Petri
Author Affiliation
Department of Anatomy and Cell Biology, University of Oulu, Oulu, Finland. sannako@paju.oulu.fi
Source
Scand J Urol Nephrol. 2009;43(3):179-85
Date
2009
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Blotting, Western
Cell Nucleus - metabolism
Cell Proliferation - drug effects
Cells, Cultured
Child
Child, Preschool
Cytoplasm - metabolism
Estradiol - pharmacology
Female
Humans
Immunohistochemistry
Keratin-7 - metabolism
Male
Middle Aged
Urothelium - cytology
Young Adult
Abstract
OBJECTIVE: The genitourinary tract is considered to be a target for the actions of sex steroid hormones. Decreased ovarian function and lack of estrogen after menopause are associated with lower genitourinary tract symptoms as well as bladder dysfunctions such as incontinence. Estrogen may also affect urothelial cells. The estrogen receptors (ERs) are found in the mucosa of the urinary tract. The purpose of this study was to culture human urothelial cells (HUCs) originating from urothelial tissue biopsies and to use them as a reproducible test platform to evaluate the effect of 17beta-estradiol (E2). MATERIAL AND METHODS: Urothelial tissue biopsies were obtained from 95 patients undergoing gynaecological open surgery for urinary incontinence, paediatric vesicoureteral reflux or transurethral resection of the prostate (TURP) for benign prostatic hyperplasia. HUCs originating from biopsies were cultured in vitro in the absence or in the presence of 0.1 nmol, 0.01 micromol and 1 micromol of E2. ER expression of the cultured HUCs was examined by Western analysis and immunofluorescence microscopy, which was also used for HUC characterization. The effect of E2 in the proliferation of the HUCs was determined by tetrazolium salt 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT)-assay. RESULTS: HUCs were cultured successfully in four to six passages but there was variation between samples. The cultured cells showed expression of beta(4)-integrin, E-cadherin and cytokeratins 7, 8, 9 and 19, indicating the epithelial origin of the cells. Both types of ERs, ERalpha and ERbeta, were found in the in vitro cultured HUCs. E2 treatment of HUCs did not affect remarkably the expression of ERalpha but cell proliferation was induced. However, no concentration-dependent effect was seen. CONCLUSIONS: This study indicates that HUCs originating from small tissue biopsies can be cultured in several passages in vitro and could have potential in repairing or restoring urinary tract tissue by tissue engineering therapy. HUCs serve as a good in vitro test platform, as shown by analysing E2-treated HUCs. E2 induced the proliferation of cultured HUCs even though concentration dependency was not observed. The findings of this study may have relevance in determining the mechanisms of estrogen therapy in postmenopausal urinary tract symptoms and in the future development of tissue engineering technology.
PubMed ID
19384677 View in PubMed
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6277 records – page 1 of 628.