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Effect of cigarette smoking on recurrence of Crohn's disease.

https://arctichealth.org/en/permalink/ahliterature229176
Source
Gastroenterology. 1990 May;98(5 Pt 1):1123-8
Publication Type
Article
Date
May-1990
Author
L R Sutherland
S. Ramcharan
H. Bryant
G. Fick
Author Affiliation
Division of Gastroenterology, University of Calgary, Alberta, Canada.
Source
Gastroenterology. 1990 May;98(5 Pt 1):1123-8
Date
May-1990
Language
English
Publication Type
Article
Keywords
Alberta - epidemiology
Crohn Disease - epidemiology - etiology - mortality - surgery
Follow-Up Studies
Humans
Questionnaires
Recurrence
Reoperation
Risk factors
Sex Factors
Smoking - adverse effects - epidemiology
Abstract
The effect of cigarette smoking on recurrence (defined in this study as the need for repeat surgery) in patients who had previously required surgery for Crohn's disease was assessed in a historical cohort of 174 patients. Mean follow-up was 10.8 yr. The 5- and 10-yr recurrence rates were 28% and 56%, respectively. Five- and 10-yr rates were significantly different for smokers (36%, 70%) and nonsmokers (20%, 41%). When patients were stratified by gender, the increased risk was more apparent in women (odds ratio 4.2, 95% confidence interval 2.0-4.2) than in men (odds ratio 1.5, 95% confidence interval 0.8-6.0). Evidence for a dose-response relationship could be identified in women but not men. Cigarette smoking may not only be a risk factor for development of Crohn's disease but also may influence disease activity following surgery.
PubMed ID
2323505 View in PubMed
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