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The 3 mm skin prick test (SPT) threshold criterion is not reliable for Tyrophagus putrescentiae: the re-evaluation of SPT criterion to dust mites.

https://arctichealth.org/en/permalink/ahliterature71486
Source
Allergy. 2002 Dec;57(12):1187-90
Publication Type
Article
Date
Dec-2002
Author
B. Kanceljak-Macan
J. Macan
D. Plavec
T. Klepac
S. Milkovic-Kraus
Author Affiliation
Institute for Medical Research and Occupational Health, Zagreb, Croatia.
Source
Allergy. 2002 Dec;57(12):1187-90
Date
Dec-2002
Language
English
Publication Type
Article
Keywords
Adult
Antibody Specificity - immunology
Comparative Study
Croatia
Cross Reactions - immunology
Dermatophagoides farinae - immunology
Dermatophagoides pteronyssinus - immunology
Female
Humans
Immunoglobulin E - blood - immunology
Male
Middle Aged
Proteins - immunology
Pyroglyphidae - immunology
Regression Analysis
Reproducibility of Results
Sensitivity and specificity
Skin Tests - standards
Urban health
Abstract
BACKGROUND: The mean wheal diameter >/= 3 mm is the usual criterion for positive skin prick test (SPT) reaction to dust mites. The study assessed the accuracy of this SPT criterion with respect to specific IgE values of above 0.35 kUA/l (+ sIgE). METHODS: Specific IgE (ImmunoCAP, Pharmacia AB Diagnostics, Uppsala, Sweden) and standard SPT to Dermatophagoides pteronyssinus (DP) and farinae (DF), Lepidoglyphus destructor (LD) and Tyrophagus putrescentiae (TP) (ALK, Hørsholm, Denmark) were performed in a random sample of 457 subjects, of whom 273 men (mean age 35.3 +/- 11.0 years) and 184 women (mean age 37.9 +/- 9.5 years). Statistical analysis was performed using the chi-square test, regression analysis and discriminant analysis. RESULTS: When the mean wheal diameter of >/= 3 mm was considered positive (+ SPT), the correlation between + SPT and + sIgE was 0.47 for DP (P
PubMed ID
12464048 View in PubMed
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Ancient gene flow from early modern humans into Eastern Neanderthals.

https://arctichealth.org/en/permalink/ahliterature270960
Source
Nature. 2016 Feb 25;530(7591):429-33
Publication Type
Article
Date
Feb-25-2016
Author
Martin Kuhlwilm
Ilan Gronau
Melissa J Hubisz
Cesare de Filippo
Javier Prado-Martinez
Martin Kircher
Qiaomei Fu
Hernán A Burbano
Carles Lalueza-Fox
Marco de la Rasilla
Antonio Rosas
Pavao Rudan
Dejana Brajkovic
Željko Kucan
Ivan Gušic
Tomas Marques-Bonet
Aida M Andrés
Bence Viola
Svante Pääbo
Matthias Meyer
Adam Siepel
Sergi Castellano
Source
Nature. 2016 Feb 25;530(7591):429-33
Date
Feb-25-2016
Language
English
Publication Type
Article
Keywords
Altitude
Animals
Bayes Theorem
Chromosomes, Human, Pair 21 - genetics
Croatia - ethnology
Gene Flow - genetics
Genome, Human - genetics
Genomics
Haplotypes - genetics
Heterozygote
Humans
Hybridization, Genetic - genetics
Neanderthals - genetics
Phylogeny
Population Density
Siberia
Spain - ethnology
Time Factors
Abstract
It has been shown that Neanderthals contributed genetically to modern humans outside Africa 47,000-65,000 years ago. Here we analyse the genomes of a Neanderthal and a Denisovan from the Altai Mountains in Siberia together with the sequences of chromosome 21 of two Neanderthals from Spain and Croatia. We find that a population that diverged early from other modern humans in Africa contributed genetically to the ancestors of Neanderthals from the Altai Mountains roughly 100,000 years ago. By contrast, we do not detect such a genetic contribution in the Denisovan or the two European Neanderthals. We conclude that in addition to later interbreeding events, the ancestors of Neanderthals from the Altai Mountains and early modern humans met and interbred, possibly in the Near East, many thousands of years earlier than previously thought.
PubMed ID
26886800 View in PubMed
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Antibiotic use profile at paediatric clinics in two transitional countries.

https://arctichealth.org/en/permalink/ahliterature180663
Source
Pharmacoepidemiol Drug Saf. 2004 Mar;13(3):181-5
Publication Type
Article
Date
Mar-2004
Author
Goran Palcevski
Vladimir Ahel
Vera Vlahovic-Palcevski
Svetlana Ratchina
Vesna Rosovic-Bazijanac
L. Averchenkova
Author Affiliation
Department of Paediatrics, University Hospital Centre Rijeka, Rijeka, Croatia. goran.palcevski@ri.tel.hr
Source
Pharmacoepidemiol Drug Saf. 2004 Mar;13(3):181-5
Date
Mar-2004
Language
English
Publication Type
Article
Keywords
Amoxicillin - therapeutic use
Ampicillin - therapeutic use
Anti-Bacterial Agents - classification - therapeutic use
Azithromycin - therapeutic use
Ceftriaxone - therapeutic use
Cefuroxime - therapeutic use
Cephalosporins - therapeutic use
Child
Child, Preschool
Croatia
Data Collection
Developing Countries
Doxycycline - therapeutic use
Drug Utilization Review - economics - statistics & numerical data - trends
Gentamicins - therapeutic use
Hospital records
Hospitals, University
Humans
Infant
Leucomycins - therapeutic use
Outpatient Clinics, Hospital
Pharmacoepidemiology
Retrospective Studies
Russia
Abstract
In this study, we evaluated antibiotic utilisation pattern at two paediatric clinics in different European (transitional) countries: Croatia (Rijeka) and Russia (Smolensk).
Antibiotic utilisation during the year 2000 was observed using the ATC/defined daily doses (DDD) methodology (ATC code-J01). Drug-usage data was expressed in numbers of DDD/100 bed-days and the DU90% profile.
In Rijeka, 35 different systemic antibiotics were used and in Smolensk 22. The overall consumption of antibiotic drugs in Rijeka was more than three times higher than in Smolensk (28.96 vs 8.3 DDD/100 bed-days). The top five antibiotic drugs used in Smolensk were amoxicillin, mydecamicin, ampicilin, doxycylin, gentamicin; and in Rijeka cefuroxime axetil, ceftriaxone, azytromycin, ceftibuten and amoxicillin.
Differences in antibiotic prescribing patterns are greater than expected. The pattern of antibiotic utilisation in both countries implies that regional control measures and guidelines for antibiotic use in children should be urgently established.
PubMed ID
15072118 View in PubMed
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Association of the FAM46A gene VNTRs and BAG6 rs3117582 SNP with non small cell lung cancer (NSCLC) in Croatian and Norwegian populations.

https://arctichealth.org/en/permalink/ahliterature269404
Source
PLoS One. 2015;10(4):e0122651
Publication Type
Article
Date
2015
Author
Godfrey Essien Etokebe
Shanbeh Zienolddiny
Zeljko Kupanovac
Morten Enersen
Sanja Balen
Veljko Flego
Ljiljana Bulat-Kardum
Andelka Radojcic-Badovinac
Vidar Skaug
Per Bakke
Aage Haugen
Zlatko Dembic
Source
PLoS One. 2015;10(4):e0122651
Date
2015
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Alleles
Carcinoma, Non-Small-Cell Lung - genetics - pathology
Croatia
DNA - analysis
Electrophoresis, Capillary
European Continental Ancestry Group - genetics
Female
Gene Frequency
Genome, Human
Genotype
Humans
Lung Neoplasms - genetics - pathology
Male
Middle Aged
Minisatellite Repeats - genetics
Molecular Chaperones - genetics
Norway
Polymorphism, Single Nucleotide
Proteins - genetics
Sequence Analysis, DNA
Smoking
Abstract
We analyzed for associations between a variable number of tandem repeat (VNTR) polymorphism in the Family with sequence similarity 46, member A (FAM46A) gene and a single nucleotide polymorphism (rs3117582) in the BCL2-Associated Athanogene 6 (BAG6) with non small cell lung cancer in Croatian and Norwegian subjects. A total of 503 (262 Croatian and 241Norwegian) non small cell lung cancer patients and 897 controls (568 Croatian and 329 Norwegian) were analyzed. We found that the frequency of allele b (three VNTR repeats) of FAM46A gene was significantly increased in the patients compared to the healthy controls in the Croatian and the combined Croatian and Norwegian subjects. Genotype frequencies of cd (four and five VNTR repeats) and cc (four VNTR repeats homozygote) of the FAM46A gene were significantly decreased in the patients compared to the healthy controls in the Croatian and Norwegian subjects, respectively. Logistic regression analyses revealed FAM46A genotype cc to be an independent predictive factor for non small cell lung cancer risk in the Norwegian subjects after adjustment for age, gender and smoking status. This is the first study to suggest an association between the FAM46A gene VNTR polymorphisms and non small cell lung cancer. We found also that BAG6 rs3117582 SNP was associated with non small cell lung cancer in the Norwegian subjects and the combined Croatian-Norwegian subjects corroborating the earlier finding that BAG6 rs3117582 SNP was associated with lung cancer in Europeans. Logistic regression analyses revealed that genotypes and alleles of BAG6 were independent predictive factor for non small cell lung cancer risk in the Norwegian and combined Croatian-Norwegian subjects, after adjustment for age and gender.
Notes
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PubMed ID
25884493 View in PubMed
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The Balkan beam - Florschütz frame and its use during the Great War.

https://arctichealth.org/en/permalink/ahliterature262792
Source
Int Orthop. 2014 Oct;38(10):2209-13
Publication Type
Article
Date
Oct-2014
Author
Stella Fatovic-Ferencic
Marko Pecina
Source
Int Orthop. 2014 Oct;38(10):2209-13
Date
Oct-2014
Language
English
Publication Type
Article
Keywords
Croatia
External Fixators - history
Extremities - injuries - surgery
Fracture Fixation - history
Fractures, Bone - history - surgery
History, 20th Century
Humans
Orthopedics - history
Russia
Serbia
World War I
Abstract
We remember the military medical practice of Croatian surgeon, Vatroslav Florschütz (1879-1967), known for his invention of the traction frame for repositioning bone fracture fragments of the upper and lower extremities. The method, known as the Balkan frame / beam or Balkan splint, was introduced and published in 1911 and used in war medicine thereafter. The memory of this invention adds to our orthopaedic heritage and sheds light on its creator working under the most demanding war circumstances. On the occasion of the 100th anniversary of the outbreak of World War I, reminiscence of Florschütz's war experience, his orthopaedic innovation and other innovations contributes to our understanding of human efforts to save lives and restore bodily function of the wounded during wars.
PubMed ID
24859899 View in PubMed
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Beginnings and success in preventing anophelism by means of gambusia fish on the island of Krk in Croatia from 1922 to 1927.

https://arctichealth.org/en/permalink/ahliterature137674
Source
Med Glas (Zenica). 2010 Aug;7(2):106-10
Publication Type
Article
Date
Aug-2010
Author
Ante Skrobonja
Neven Materljan
Ivana Skrobonja
Author Affiliation
Departement for the History of Medicine, Rijeka University School of Medicine, Brace Branchettan 20, Rijeka, Crotia. anteskrobonja@yahoo.com
Source
Med Glas (Zenica). 2010 Aug;7(2):106-10
Date
Aug-2010
Language
English
Publication Type
Article
Keywords
Animals
Croatia
Cyprinodontiformes
History, 20th Century
Humans
Malaria - history - prevention & control
Mosquito Control - history
Pest Control, Biological - history
Abstract
The introductory part has summarized the role of malaria in the course of history and various attempts of its eradication in Croatia before the World War I. Furthemore, there is a list of activities and results accomplished between 1922 and 1927 on the island of Krk by Dr. Otmar Trausmiller. After a systematic sanitation of all anopheles habitats, primarily natural and artificial bodies of still water, and introduction of imported gambusia to those bodies of water, anopheles was virtually eradicated on the island. What followed was an evident decrease of new malaria incidents, and in the campaign against malaria there was still major concern in the form of chronic patients and intensive quinine therapy. Today, about eighty years after it was introduced to Krk, gambusia still abides in ponds across the island and it represents one of the main factors in the protection against potential revival of indigenous malaria.
PubMed ID
21258304 View in PubMed
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The benzodiazepine nation of Croatia: an observational, comparative study of psychotropic drug utilization between Croatia and Sweden 2014-2015.

https://arctichealth.org/en/permalink/ahliterature295468
Source
Expert Rev Pharmacoecon Outcomes Res. 2018 Dec; 18(6):641-646
Publication Type
Comparative Study
Journal Article
Date
Dec-2018
Author
Ines Potocnjak
Robert Likic
Vesna Degoricija
Eric Nham
Björn Wettermark
Author Affiliation
a Department of Medicine , University Hospital Centre Sisters of Charity , Zagreb , Croatia.
Source
Expert Rev Pharmacoecon Outcomes Res. 2018 Dec; 18(6):641-646
Date
Dec-2018
Language
English
Publication Type
Comparative Study
Journal Article
Keywords
Adult
Benzodiazepines - therapeutic use
Croatia
Cross-Sectional Studies
Databases, Factual
Drug Utilization - statistics & numerical data - trends
Female
Humans
Inappropriate Prescribing - statistics & numerical data
Male
Practice Patterns, Physicians' - standards - statistics & numerical data - trends
Psychotropic Drugs - therapeutic use
Retrospective Studies
Sweden
Abstract
The consumption of psychotropic drugs (PD) is increasing worldwide with a significant variation between countries. Croatia and Sweden have similar health and pharmaceutical systems; however, Sweden is a high-income country with developed medical care, registries, and prescribing guidelines. We sought to compare the utilization of PD between Croatia and Sweden to identify areas for improvement in rational use of drugs.
This was a cross-sectional study using national databases to assess utilization of PD (ATC N05, N06) in Croatia and Sweden in 2014 and 2015.
Prescribing of PD in Croatia increased from 127 DDD/TID (defined daily dose/1000 inhabitants) in 2014 to 131 DDD/TID in 2015. In Sweden, the total utilization was higher with an increase from 183 DDD/TID in 2014 to 188 DDD/TID in 2015. There were substantial differences. In Croatia, the utilization of benzodiazepine derivatives (N05BA) was 72.5 DDD/TID in 2014 and increased to 74.4 DDD/TID, in 2015. In Sweden, the utilization was only 11.2 DDD/TID for benzodiazepine derivatives in both years.
There were substantial differences in utilization of PD between Croatia and Sweden. Highlighting the problem of inappropriate benzodiazepine utilization in Croatia can help to introduce measures to change prescribing habits and improve prescribing quality.
PubMed ID
30073882 View in PubMed
Less detail

[Change in the occurrence of breast cancer in hospital registries (1980-2000)]

https://arctichealth.org/en/permalink/ahliterature18511
Source
Lijec Vjesn. 2002 Nov-Dec;124(11-12):347-53
Publication Type
Article
Author
Mladen Belicza
Tanja Lenicek
Margareta Glasnovic
Martina Elez
Vedrana Gladic
Ingrid Marton
Suncana Zutekovic
Hrvoje Jurlina
Zvonko Kusic
Drago Cvrtila
Marija Strnad
Davor Tomas
Hrvoje Cupic
Bozo Kruslin
Author Affiliation
Klinicki zavod za patologiju Ljudevit Jural Klinicka bolnica Sestre milosrdnice Vinogradska 29, 10 000 Zagreb.
Source
Lijec Vjesn. 2002 Nov-Dec;124(11-12):347-53
Language
Serbo-Croatian
Publication Type
Article
Keywords
Accidents, Radiation
Adult
Aged
Aged, 80 and over
Breast Neoplasms - epidemiology
Breast Neoplasms, Male - epidemiology
Croatia - epidemiology
English Abstract
Female
Humans
Male
Middle Aged
Prevalence
Registries
Ukraine
War
Abstract
The aim of our retrospective study was to analyze distribution of histological types, age of patients and hormonal dependency of breast cancer cases in the period 1980-2000 using computer database "Thanatos". This period was divided with regard to the war into a pre-war (1980-1990), war (1991-1995) and post-war period (1996-2000). We also paid attention to the Chernobyl accident (pre-Chernobyl from 1980-1986 and post-Chernobyl from 1987-2000). Special attention was focused on the period during the war mainly due to the fact that very little data exist in literature dealing with the war as a stress factor that may have induced and promoted carcinogenesis. During this twenty-one year period 2296 patients were diagnosed with breast cancer. In the female population of 2274, 2228 (98%) of these were ductal and only 46 (2%) were invasive lobular carcinomas. In all of the male cases (22) the cancer was pathohistologically verified as the invasive ductal type. The male:female ratio was 1:103. Comparing the pre-war and war periods we found a more than double increase in the male:female ratio (from 1:131 to 1:66). We observed similar results when we looked at the period after the Chernobyl incident where the ratio increased from 1:139 to 1:79. When we analyzed the distribution of histological types we found a significant increase in lobular carcinomas during the post-war period, from 1.1% to 5.5%; this increase was less significant for the post-Chernobyl period (1.0% to 3.3%). The average age of the patients with invasive ductal carcinomas increased from 56.7 yrs during the pre-war period to 59.7 yrs during the war and finally to 61.1 yrs during the post-war period. The average age of males with breast cancer decreased from 63.6 and 63.5 during the pre-war and war periods to 58.8 yrs during the post-war period. These results suggest that the war could have influenced the shift in the age of occurrence of breast cancer in both sexes appearing in younger males and in females in their postmenopausal period. The most commonly diagnosed stage of invasive ductal carcinoma during the war and post-war periods was T1N0MX, but in the controlled pre-war period the most frequently diagnosed stage was T2N1MX. With this we see that the increase in the age of the patient is not due to a more advanced pTNM stage which suggests that the increased age of our patients seeking medical help is not due to the incapacitating effects that the war may have on people needing medical attention. Our results showed that most of the patients were ER positive (72% throughout the twenty-one year period) and their average rate and number increase with the age of the patient. We found a significant drop in hormone dependent tumors in the period from 1991-95, which could mean that tumors in a war environment manifest a more aggressive phenotype. Our results show that the war within our region most likely had an effect on some clinical parameters involving breast cancer patients. Possible effects caused by "Chernobyl" could not be proved due to the overwhelming effect that war had upon the patients within this region.
Notes
Comment In: Lijec Vjesn. 2003 May-Jun;125(5-6):161; author reply 161-214533470
PubMed ID
12679975 View in PubMed
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Comparison of stress, job satisfaction, perception of control, and health among district nurses in Stockholm and prewar Zagreb.

https://arctichealth.org/en/permalink/ahliterature72539
Source
Scand J Soc Med. 1998 Jun;26(2):106-14
Publication Type
Article
Date
Jun-1998
Author
S. Tholdy Doncevic
A. Romelsjö
T. Theorell
Author Affiliation
Department of Public Health Sciences, Karolinska Institute, Sundbyberg, Sweden.
Source
Scand J Soc Med. 1998 Jun;26(2):106-14
Date
Jun-1998
Language
English
Publication Type
Article
Keywords
Adult
Aged
Burnout, Professional - psychology
Community Health Nursing
Comparative Study
Croatia
Cross-Cultural Comparison
Female
Health Resources
Humans
Internal-External Control
Job Satisfaction
Middle Aged
National Health Programs
Nurses - psychology
Personality Inventory
Risk factors
Sweden
Abstract
The increasing number of studies of stress among nurses in the last two decades have mainly dealt with nurses in hospitals. A few studies have included community-based nurses. However, no comparative studies of district nurses in different countries have been published. We have conducted a study to identify sources of stress, job satisfaction, perceived demands, control and health among district nurses (DNs) in Zagreb (Croatia) and Stockholm (Sweden), working in a polyvalent health care organization. Data were obtained regarding altogether 305 district nurses by means of self-administered questionnaires using identical methods and items, with response rates between 88% and 95%. In general, district nurses reported high levels of job-related stress, satisfaction and control. Organizational sources of stress, such as ongoing changes in the primary care organization, and reorganization of tasks, were of importance for the district nurses in Stockholm. They reported also more job satisfaction and commitment than the district nurses in Zagreb. The district nurses in Zagreb had significantly higher level of "lack of resources". They displayed significantly higher scores of psychological demands but also a greater feeling of control than the district nurses in Stockholm. Significant differences were also found between the groups in ranking of self-reported stressors. Thus results show that differences in work organization and in essential resources have a substantial impact of perceived stress, job satisfaction, and on the generality both of single association and on the applications of models.
PubMed ID
9658509 View in PubMed
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Congenital anomalies of the central nervous system at autopsy in Croatia in the period before and after the Chernobyl accident.

https://arctichealth.org/en/permalink/ahliterature58967
Source
Acta Med Croatica. 1998;52(2):103-7
Publication Type
Article
Date
1998
Author
B. Kruslin
S. Jukic
M. Kos
G. Simic
A. Cviko
Author Affiliation
Department of Pathology, School of Medicine, University of Zagreb, Croatia.
Source
Acta Med Croatica. 1998;52(2):103-7
Date
1998
Language
English
Publication Type
Article
Keywords
Abnormalities, Radiation-Induced - epidemiology
Accidents, Radiation
Autopsy
Central Nervous System - abnormalities
Croatia - epidemiology
Female
Humans
Incidence
Infant, Newborn
Male
Power Plants
Ukraine
Abstract
In this study, we analyzed the frequency, type and sex distribution of congenital anomalies of the central nervous system (CNS) at autopsy in the period prior to and after the Chernobyl accident in northwest Croatia, one of the areas with the highest exposure to nuclear contamination from Chernobyl. All autopsies in both periods were performed by the same technique, i.e. dissection of the trunk and head, and inspection of the extremities. There were 53 infants with congenital anomalies of the CNS in the period prior to, and 99 in the period after the Chernobyl accident. Our results showed a statistically significant increase in the incidence of CNS anomalies in general (chi 2 = 4,719, p
PubMed ID
9682497 View in PubMed
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42 records – page 1 of 5.