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Accelerated recovery of ischemic canine myocardium induced by AMP. Preliminary report.

https://arctichealth.org/en/permalink/ahliterature55698
Source
Adv Myocardiol. 1985;6:483-90
Publication Type
Article
Date
1985
Author
H M Sami
J R Koke
N. Bittar
Source
Adv Myocardiol. 1985;6:483-90
Date
1985
Language
English
Publication Type
Article
Keywords
Adenosine Diphosphate - metabolism
Adenosine Monophosphate - metabolism - pharmacology
Adenosine Triphosphate - metabolism
Animals
Coronary Disease - drug therapy
Creatine - metabolism
Dogs
Energy Metabolism - drug effects
Female
Male
Myocardial Contraction - drug effects
Nitroprusside - pharmacology
Phosphocreatine - metabolism
Abstract
Experiments were conducted on 18 dogs using an in situ blood-perfused canine heart model. Intracoronary infusion of AMP resulted in increased ATP and total adenine nucleotide levels. On reperfusion following a 15-min period of ischemia, ATP and total adenine nucleotide levels were significantly higher than control. Most important, contractile function recovered more rapidly in the AMP-treated dogs. It is therefore concluded that the delayed functional recovery noted after periods of ischemia is likely to be a direct result of delayed ATP resynthesis.
PubMed ID
3992046 View in PubMed
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Neuroimaging and neurophysiology studies in carriers of cree leukoencephalopathy.

https://arctichealth.org/en/permalink/ahliterature137060
Source
Can J Neurol Sci. 2011 Mar;38(2):347-8
Publication Type
Article
Date
Mar-2011

Quantification of metabolites from single-voxel in vivo 1H NMR data of normal human brain by means of time-domain data analysis.

https://arctichealth.org/en/permalink/ahliterature11357
Source
MAGMA. 1995 Sep-Dec;3(3-4):129-36
Publication Type
Article
Author
M. Ala-Korpela
J P Usenius
J. Keisala
A. van den Boogaart
P. Vainio
J. Jokisaari
S. Soimakallio
R. Kauppinen
Author Affiliation
Department of Physical Sciences, University of Oulu, Finland.
Source
MAGMA. 1995 Sep-Dec;3(3-4):129-36
Language
English
Publication Type
Article
Keywords
Aspartic Acid - analogs & derivatives - metabolism
Brain - anatomy & histology - metabolism
Choline - metabolism
Comparative Study
Creatine - metabolism
Humans
Magnetic Resonance Spectroscopy - methods
Protons
Research Support, Non-U.S. Gov't
Signal Processing, Computer-Assisted
Abstract
We present here a combination of time-domain signal analysis procedures for quantification of human brain in vivo 1H NMR spectroscopy (MRS) data. The method is based on a separate removal of a residual water resonance followed by a frequency-selective time-domain line-shape fitting analysis of metabolite signals. Calculation of absolute metabolite concentrations was based on the internal water concentration as a reference. The estimated average metabolite concentrations acquired from six regions of normal human brain with a single-voxel spin-echo technique for the N-acetylaspartate, creatine, and choline-containing compounds were 11.4 +/- 1.0, 6.5 +/- 0.5, and 1.7 +/- 0.2 mumol kg-1 wet weight, respectively. The time-domain analyses of in vivo 1H MRS data from different brain regions with their specific characteristics demonstrate a case in which the use of frequency-domain methods pose serious difficulties.
PubMed ID
8749730 View in PubMed
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