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36 records – page 1 of 4.

Baseline flow in coronary bypass grafts.

https://arctichealth.org/en/permalink/ahliterature53163
Source
J Card Surg. 2005 May-Jun;20(3):205-7
Publication Type
Article
Author
Henrik K Kjaergard
Author Affiliation
The Department of Cardiothoracic Surgery, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark. henrik@dadlnet.dk
Source
J Card Surg. 2005 May-Jun;20(3):205-7
Language
English
Publication Type
Article
Keywords
Age Factors
Aged
Blood Flow Velocity
Cohort Studies
Comparative Study
Coronary Angiography
Coronary Artery Bypass - adverse effects - methods
Coronary Circulation - physiology
Coronary Disease - radiography - surgery
Denmark
Female
Graft Rejection
Graft Survival
Humans
Internal Mammary-Coronary Artery Anastomosis
Male
Mammary Arteries - transplantation
Middle Aged
Prognosis
Retrospective Studies
Risk assessment
Severity of Illness Index
Sex Factors
Vascular Patency
Abstract
BACKGROUND: The purpose of the study is to estimate the total blood flow in coronary artery bypass grafts. METHODS: In a 3-year period 102 patients having a standardized coronary artery bypass grafting (CABG) with the left internal mammary artery (LIMA) anastomosed to the left anterior descending artery and a sequential vein grafted to the remaining diseased coronary arteries were included in the study, 21 females and 81 males. In females a mean of 3.9 anastomosis (range 2-5) were performed and in males a mean of 4.2 (range 2-6) were performed. Flow in the bypass grafts was measured with the transit-time method before termination of cardiopulmonary bypass. RESULTS: Females: LIMA 31 mL/min, vein graft 74 mL/min (26 mL/min per anastomosis), cumulated flow 105 mL/min. Males: LIMA 31 mL/min, vein graft 93 mL/min (29 mL/min per vein anastomosis), cumulated flow 124 mL/min. CONCLUSION: Conventional CABG may restore half of the normal resting coronary artery blood flow (250 mL/min).
PubMed ID
15854078 View in PubMed
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Bradykinin inhibits development of myocardial infarction through B2 receptor signalling by increment of regional blood flow around the ischaemic lesions in rats.

https://arctichealth.org/en/permalink/ahliterature53623
Source
Br J Pharmacol. 2003 Jan;138(1):225-33
Publication Type
Article
Date
Jan-2003
Author
Hiroshi Ito
Izumi Hayashi
Tohru Izumi
Masataka Majima
Author Affiliation
Department of Pharmacology, Kitasato University School of Medicine, Kitasato 1-15-1, Sagamihara, Kanagawa 228-8555, Japan.
Source
Br J Pharmacol. 2003 Jan;138(1):225-33
Date
Jan-2003
Language
English
Publication Type
Article
Keywords
Animals
Bradykinin - metabolism
Comparative Study
Coronary Circulation - physiology
Kininogens - deficiency - genetics
Male
Myocardial Infarction - metabolism - pathology - prevention & control
Myocardial Ischemia - metabolism - pathology
Rats
Rats, Inbred BN
Rats, Sprague-Dawley
Receptor, Bradykinin B2
Receptors, Bradykinin - antagonists & inhibitors - physiology
Research Support, Non-U.S. Gov't
Signal Transduction - physiology
Abstract
1 To identify the roles of endogenous kinins in prevention of myocardial infarction (MI), we performed the permanent ligation of coronary artery in rats. 2 The size of MI 12, 24, and 48 h after coronary ligation in kininogen-deficient Brown Norway Katholiek (BN-Ka) rats was significantly larger (49.7+/-0.2%, 49.6+/-2%, and 51.1+/-1%, respectively) than that of kinin-replete Brown Norway Kitasato (BN-Ki) rats (42+/-2%, 38.5+/-4%, and 41.5+/-1%). 3 Hoe140, a bradykinin (BK) B(2) receptor antagonist injected (1.0 mg kg(-1), i.v.) half an hour before, and every 8 h after, coronary ligation, significantly increased the size of MI in Sprague-Dawley rats. Aprotinin, a kallikrein inhibitor, which was infused intravenously (10,000 Units kg(-1) h(-1)) with an osmotic mini-pump, significantly increased the size of an MI 24 h after ligation. 4 When evaluated using microspheres, the regional myocardial blood flow around the necrotic lesion in BN-Ka rats 6 h after ligation was reduced more than that in BN-Ki rats with MI by 41-46%. The same was true in Hoe140-treated BN-Ki rats. 5 FR190997, a nonpeptide B(2) agonist, which was infused (10 microg kg(-1) h(-1)) into the vena cava of BN-Ka rats for 24 h with an osmotic mini-pump, caused significant reduction in the size of MI (38+/-3%), in comparison with the size in vehicle solution-treated rats (51+/-3%). The size of MI in FR190997-treated BN-Ka rats was the same as in BN-Ki rats. 6 These results suggested that endogenous kinin has the capacity to reduce the size of MI via B(2) receptor signalling because of the increase in regional myocardial blood flow around the ischaemic lesion.
PubMed ID
12522094 View in PubMed
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Calcific degeneration of the aortic valve in old age: is the development of flow obstruction predictable?

https://arctichealth.org/en/permalink/ahliterature212459
Source
J Intern Med. 1996 Mar;239(3):269-73
Publication Type
Article
Date
Mar-1996
Author
A M Iivanainen
M. Lindroos
R. Tilvis
J. Heikkilä
M. Kupari
Author Affiliation
Department of Medicine, Helsinki University Central Hospital, Finland.
Source
J Intern Med. 1996 Mar;239(3):269-73
Date
Mar-1996
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Aging - physiology
Aortic Valve - ultrasonography
Aortic Valve Stenosis - epidemiology - physiopathology - ultrasonography
Blood Flow Velocity - physiology
Calcinosis - epidemiology - physiopathology - ultrasonography
Cohort Studies
Coronary Circulation - physiology
Echocardiography, Doppler
Female
Finland - epidemiology
Humans
Male
Prospective Studies
Risk factors
Time Factors
Abstract
Aortic valve calcification and stenosis become increasingly common with advancing age. This work aimed at assessing whether a time-dependent reduction of aortic valve area is detectable in an unselected elderly population and whether the rate of reduction can be predicted from clinical or biochemical characteristics.
A population-based prospective echocardiographic follow-up study.
A university hospital.
In 1990, randomly selected persons born in 1904, 1909 and 1914 (total n = 501) underwent a Doppler echocardiographic study of aortic valve and biochemical tests of glucose, lipid and calcium metabolism. In 1993, echocardiography was repeated in 333 survivors of the original cohorts. These individuals constitute the present study population.
Three-year changes in the aortic valve area and velocity ratio (peak outflow tract velocity/peak aortic jet velocity) determined by Doppler echocardiography.
Aortic valve area decreased from a mean of 1.95 cm2 (95% confidence interval of mean, 1.88-2.03 cm2) to 1.78 cm2 (1.71-1.85 cm2) within 3 years (P
Notes
Comment In: J Intern Med. 1996 Jul;240(1):43-48708592
PubMed ID
8772627 View in PubMed
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Changes in QRS segments during exercise in relation to scintigraphic myocardial perfusion defects: a multivariate analysis.

https://arctichealth.org/en/permalink/ahliterature50223
Source
Coron Artery Dis. 1993 Jan;4(1):87-99
Publication Type
Article
Date
Jan-1993
Author
M. Pilhall
L. Jarneborn
M. Riha
S. Jern
Author Affiliation
Department of Clinical Physiology, Ostra Hospital, University of Gothenburg, Sweden.
Source
Coron Artery Dis. 1993 Jan;4(1):87-99
Date
Jan-1993
Language
English
Publication Type
Article
Keywords
Adult
Aged
Angioplasty, Transluminal, Percutaneous Coronary
Coronary Artery Bypass
Coronary Circulation - physiology
Coronary Disease - physiopathology - radionuclide imaging
Electrocardiography - instrumentation
Exercise Test - instrumentation
Female
Graft Occlusion, Vascular - physiopathology - radionuclide imaging
Heart Conduction System - physiopathology
Humans
Male
Middle Aged
Myocardial Infarction - physiopathology - radionuclide imaging
Myocardial Ischemia - physiopathology - radionuclide imaging
Research Support, Non-U.S. Gov't
Signal Processing, Computer-Assisted - instrumentation
Thallium Radioisotopes - diagnostic use
Vectorcardiography - instrumentation
Abstract
BACKGROUND: The relation between QRS changes during exercise and ischemic heart disease is controversial. The present investigation addressed whether exercise QRS changes are related 1) to myocardial ischemia or necrosis, 2) to possibly confounding factors such as baseline QRS size and changes in heart rate and ST magnitude during exercise, and 3) to the location of scintigraphic defects. METHODS: Advanced computerized vectorcardiography (MIDA1000, Ortivus Medical AB, Sweden) was recorded in 71 consecutive patients referred for 201TI exercise myocardial scintigraphy. Maximal exercise tests were performed in the sitting position on a bicycle ergometer. Planar scintigraphic images were obtained immediately after exercise and 4 hours later in three projections, and were evaluated blindly. RESULTS: Exercise QRS changes correlated to baseline QRS size (X, Y, and Z leads; P
PubMed ID
8269188 View in PubMed
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Clinical characteristics, myocardial perfusion deficits, and clinical outcomes of patients with non-specific chest pain hospitalized for suspected acute coronary syndrome: a 4-year prospective cohort study.

https://arctichealth.org/en/permalink/ahliterature269126
Source
Int J Cardiol. 2015 Mar 1;182:126-31
Publication Type
Article
Date
Mar-1-2015
Author
Mette Jensen Stochkendahl
Hans Mickley
Werner Vach
Ahmed Aziz
Henrik Wulff Christensen
Jan Hartvigsen
Poul Flemming Høilund-Carlsen
Source
Int J Cardiol. 2015 Mar 1;182:126-31
Date
Mar-1-2015
Language
English
Publication Type
Article
Keywords
Acute Coronary Syndrome - epidemiology - radionuclide imaging - surgery
Adolescent
Adult
Aged
Chest Pain - complications - radionuclide imaging
Coronary Circulation - physiology
Denmark - epidemiology
Diagnosis, Differential
Exercise Test
Female
Follow-Up Studies
Humans
Inpatients
Male
Middle Aged
Myocardial Revascularization - methods
Prevalence
Prognosis
Prospective Studies
Risk assessment
Risk factors
Survival Rate - trends
Time Factors
Tomography, Emission-Computed, Single-Photon
Young Adult
Abstract
Although the prognostic role of stress SPECT MPI is generally well established, its value in predicting non-fatal cardiac events in patients with acute, non-specific chest pain (NSCP) remains unclear. The aims of this study are 1) to describe the baseline clinical characteristics and prevalence of myocardial perfusion (MP) deficits, by use of an adenosine stress SPECT MPI, in NSCP patients without known CAD discharged after hospitalization for suspected ACS; and 2) to prospectively describe the 4-year clinical outcome in terms of all-cause and cardiac mortality; hospitalization and coronary revascularization procedures; and cardio-vascular events in patients with and without MP deficits.
We evaluated a series of 272 consecutive patients with acute NSCP and aged 18-75years. ICD10-based registries were used to determine the primary outcome (a composite measure of incident CAD death, ACS, or revascularization) and two secondary outcomes (1. all-cause death; 2. a composite measure of cardiovascular death, ACS, revascularization, or stroke). Forty two (15%) participants had a MP deficit. During follow-up (median 1361days), 7 participants had a primary event, 4 died, and 20 had a secondary composite event. Annual event rates were 0.70, 0.39 and 2.07, respectively. MP deficits predicted both subsequent primary and composite secondary events (HR: 7.54; 95% CI=[1.69; 33.69] and 2.93 (95% CI=[1.10; 7.81], respectively). Usual clinical cardiac risk classification could not meaningfully differentiate between patients with and without MP deficits.
SPECT MPI substantially improved prediction of incident CAD beyond usual clinical procedures and risk classification systems among NSCP patients.
PubMed ID
25577748 View in PubMed
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[Coronary vascular reaction in non-ischemic myocardium during experimental acute ischemia reperfusion]

https://arctichealth.org/en/permalink/ahliterature53490
Source
Fiziol Zh. 2003;49(4):14-23
Publication Type
Article
Date
2003
Author
O O Moibenko
M Ia Iuz'kiv
V I Azarov
Author Affiliation
A.A. Bogomoletz Institute of Physioligy, Kiev.
Source
Fiziol Zh. 2003;49(4):14-23
Date
2003
Language
Ukrainian
Publication Type
Article
Keywords
Acute Disease
Animals
Coronary Circulation - physiology
Coronary Vessels - physiology
Disease Models, Animal
Dogs
Electrocardiography
English Abstract
Myocardial Reperfusion Injury - metabolism - physiopathology
Myocardium - metabolism
Nitric Oxide - antagonists & inhibitors - biosynthesis
Nitroarginine - pharmacology
Vasodilation - physiology
Abstract
The aim of this study was to investigate coronary vascular responses, particularly NO-dependent, in the non-ischemic miocardium during local acute myocardial ischemia/reperfusion. The experiments were performed on the dogs with closed chest. Occlusion of a branch of the coronary artery resulted in a dilatation of the coronary vessels within the intact part of the myocardium. Neither inhibition of prostanoid production and KATP-channels, nor administration of atropine sulfate and dissection of the vagus nerve altered coronary dilatation within the non-ischemic myocardium. Whereas inhibition of NOS by L-NNA (50 mg/kg) completely changed it after coronary occlusion, furthermore coronary resistance temporally increased. Thus, the most reliable mechanism of that response was NO-dependent.
PubMed ID
14509923 View in PubMed
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Delayed recovery of myocardial perfusion in acute myocardial infarction: a scintigraphic study after early thrombolytic treatment.

https://arctichealth.org/en/permalink/ahliterature54318
Source
Coron Artery Dis. 1998;9(7):443-9
Publication Type
Article
Date
1998
Author
F. Bouvier
J. Höjer
B A Samad
K. Jensen-Urstad
H. Ruiz
J. Hulting
M. Jensen-Urstad
Author Affiliation
Department of Clinical Physiology, Söder Hospital, Stockholm, Sweden. bouvier.info@swipnet.se
Source
Coron Artery Dis. 1998;9(7):443-9
Date
1998
Language
English
Publication Type
Article
Keywords
Adenosine - diagnostic use
Comparative Study
Coronary Circulation - physiology
Female
Fibrinolytic Agents - therapeutic use
Heart - radionuclide imaging
Humans
Male
Middle Aged
Myocardial Infarction - drug therapy - physiopathology - radionuclide imaging
Myocardial Stunning - radionuclide imaging
Prospective Studies
Radiopharmaceuticals - diagnostic use
Streptokinase - therapeutic use
Technetium Tc 99m Sestamibi - diagnostic use
Thrombolytic Therapy
Time Factors
Tissue Plasminogen Activator - therapeutic use
Tomography, Emission-Computed, Single-Photon
Vasodilator Agents - diagnostic use
Abstract
BACKGROUND: Assessments of compromised myocardium and infarct size early after thrombolytic treatment in acute myocardial infarction (AMI) are important for risk stratification and for treatment management. We have therefore evaluated the clinical usefulness of myocardial perfusion scintigraphy (MIBI-SPECT) for the assessment of myocardial viability early after AMI. METHODS: Seventy-one patients [53 men and 18 women, aged 64 +/- 9 years (range 45-75 years)] with AMI treated by thrombolysis took part in this prospective study at University Hospital, Stockholm, Sweden. Sixty of them underwent adenosine-stress and resting MIBI-SPECT 2-4 days after AMI, and 11 were examined only at rest. Six months after the AMI, a repeat MIBI-SPECT at rest was obtained for comparison. RESULTS: All patients had significant perfusion defects compared with an age- and sex-matched healthy reference population. Seventy-six percent of the patients able to undergo a complete adenosine-stress and rest SPECT showed signs of reversible perfusion defects. Defect size (extent) and severity at rest decreased between the tests at 2-5 days and 6 months after AMI (P
PubMed ID
9822863 View in PubMed
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Determinants of myocardial hypoperfusion analyzed for the interventricular septum using power Doppler harmonic imaging with contrast echocardiography in humans: a methodologic approach for clinical practice.

https://arctichealth.org/en/permalink/ahliterature53735
Source
J Am Soc Echocardiogr. 2002 May;15(5):404-15
Publication Type
Article
Date
May-2002
Author
Andreas Hagendorff
Alexander Göckritz
Andre Wunderlich
Sigmund Frigstad
Dietrich Pfeiffer
Harald Becher
Author Affiliation
Department of Cardiology-Angiology, University of Leipzig, Germany. hagendorff@gmx.net
Source
J Am Soc Echocardiogr. 2002 May;15(5):404-15
Date
May-2002
Language
English
Publication Type
Article
Keywords
Albumins - diagnostic use
Contrast Media
Coronary Angiography
Coronary Circulation - physiology
Coronary Disease - physiopathology
Echocardiography, Doppler - methods
Fluorocarbons - diagnostic use
Heart Septum - physiology
Humans
Retrospective Studies
Abstract
BACKGROUND: To evaluate determinants of myocardial hypoperfusion using power Doppler harmonic imaging (PDHI) with myocardial contrast echocardiography (MCE) in clinical practice, a retrospective clinical study was performed comparing echocardiographic and angiographic data. Angiographic data of patients with a normal coronary angiogram (non-CAD) and symptomatic patients with low flow conditions caused by a stenosis of the left anterior descending coronary artery (LAD) or occlusion, or TIMI-II-flow in the LAD were compared with the PDHI data. METHODS AND RESULTS: In 32 patients, MCE was performed with a System Five Performance ultrasound system (GE Vingmed Ultrasound, Horten, Norway). Myocardial perfusion was semiquantitatively analyzed with the EchoPac 6.2b.134 software, bolus injection with Optison (0.35 mL with 5 mL saline flush), and continuous infusion with Levovist (400 mg/mL(-1); 3.5-5 mL/min(-1)) were performed (8 non-CAD patients, 8 CAD patients, respectively). After bolus injection, Doppler intensity (DI) kinetics showed a significant decrease of maximum DI wash-in rate (eg, apical septum [AS]: 4.9 +/- 3.3 vs 2.4 +/- 1.9 dB/s(-1)), of peak maximum DI (eg, AS: 25.3 +/- 6.3 vs 16.4 +/- 5.7 dB), and of DI determined 10 and 20 seconds after peak maximum DI (eg, AS: 22.1 +/- 4.9 vs 10.8 +/- 4.6 dB; AS: 20.4 +/- 5.3 vs 8.0 +/- 3.8 dB, respectively) using a trigger interval once every 3 cardiac cycles when normal perfused areas were compared with hypoperfused areas. During infusion coronary transit time (3.3 +/- 0.9 vs 7.0 +/- 3.6 seconds), maximum DI wash-in rate (eg, AS: 3.2 +/- 1.3 vs 1.3 +/- 0.8 dB/s(-1)) and DI-maximum plateau (eg, AS: 28.6 +/- 4.7 vs 18.3 +/- 6.4 dB) significantly decreased, respectively. CONCLUSION: Regional myocardial hypoperfusion at rest can be detected by using PDHI with MCE in clinical practice, according to a standardized methodologic protocol.
PubMed ID
12019423 View in PubMed
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[Determination of the stable mitochondrial factor in vivo]

https://arctichealth.org/en/permalink/ahliterature53441
Source
Fiziol Zh. 2003;49(5):25-30
Publication Type
Article
Date
2003
Author
S M Nadtochii
A Iu Bohuslavs'kyi
V F Sahach
Author Affiliation
A.A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev.
Source
Fiziol Zh. 2003;49(5):25-30
Date
2003
Language
Ukrainian
Publication Type
Article
Keywords
Animals
Arsenicals - pharmacology
Biological Markers - blood
Coronary Circulation - physiology
Dogs
English Abstract
Hindlimb - blood supply
Ion Channels - metabolism
Mitochondrial Proteins - blood
Myocardial Contraction - physiology
Myocardial Reperfusion Injury - blood - metabolism - physiopathology
Oxidative Stress - drug effects - physiology
Regional Blood Flow - physiology
Abstract
We have determined a release of a stable mitochondrial factor (SMF) into the outflowing blood in vivo. That effect was induced by ischemia/reperfusion or phenylarsin oxide (PAO)--the activators of the mitochondrial permeability transition pore (MPTP) and the oxidative stress. The SMF was measured by a spectrophotometer in the range of wave-lengths 230-260 nm with the absorption maximum of 240-250 nm. The SMF release was accompanied with a decrease in the myocardial contractility, disturbances in cardiodynamics and regional blood circulation. The data obtained have demonstrated that the SMF can be used as a marker of MPTP opening in vivo.
PubMed ID
14663887 View in PubMed
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[Early marker of myocardial injury of the ischemia-reperfused heart in dogs and during operations with artificial circulation in humans]

https://arctichealth.org/en/permalink/ahliterature80761
Source
Fiziol Zh. 2006;52(4):3-8
Publication Type
Article
Date
2006
Author
Sahach V F
Maksymenko V B
Dmytriieva A V
Bubnova Iu O
Bohuslavs'kyi A Iu
Knyshev H V
Source
Fiziol Zh. 2006;52(4):3-8
Date
2006
Language
Ukrainian
Publication Type
Article
Keywords
Adult
Animals
Aspartate Aminotransferases - blood
Biological Markers - blood
Coronary Circulation - physiology
Creatine Kinase - blood
Dogs
Electrocardiography
Extracorporeal Circulation
Heart Arrest, Induced - adverse effects
Heart Atria - metabolism - physiopathology
Heart Rate - physiology
Humans
L-Lactate Dehydrogenase - blood
Middle Aged
Mitochondria, Heart - metabolism
Myocardial Reperfusion Injury - blood - etiology - physiopathology
Oxygen Consumption - physiology
Abstract
The model of ischemia/reperfusion was reproduced on 9 unconscious dogs. Simultaneously with registration of indexes heart work, hemodynamic and mitochondrial factor (MF) in venous blood from right atrium was defined. Measures were done by spectrophotometria. We have also performed spectrophotometric determination of MF in 11 patients in course of operation with blood cardioplegia. Samples of mixed venous blood from the right atrium were taken on different stages of artificial blood circulation: ischemia and reperfusion. Besides that, patients' level of enzymes was defined: creatine kinase (CK), mv-creatine kinase (mv-CK), lactatedehydrogenase (LDG), aspartataminotransferase (AST), within first day of postoperative period, and also ECG-recording within pre- and after operative period were done. Maximal MF level correlates with frequency and severity of cardiac rhythm disturbance, severity of myocardial hypoxia (r = 0.81). Maximum MF level also demonstrated correlation with KK (r = 0.97), mvKK (r = 0.92), LDG(r = 0.81), AST (r = 0.85). Thus, in experimental and clinic conditions myocardial ischemia was accompanied by mPTP activation, which led to reperfusion myocardial injuries and to release of MF. Method of MF determination gives opportunity to propose its usage as early marker of ischemic injuries and also as marker of mPTP opening in vivo.
PubMed ID
16958209 View in PubMed
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36 records – page 1 of 4.