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[Clinical and prognostic significance of multifocal atherosclerosis in patients with acute coronary syndromes without ST-segment elevation].

https://arctichealth.org/en/permalink/ahliterature122185
Source
Kardiologiia. 2012;52(7):4-8
Publication Type
Article
Date
2012
Author
S A Berns
D S Zykova
E A Shmidt
E S Iukhno
O V Chuvichkina
M V Zykov
O L Barbarash
Source
Kardiologiia. 2012;52(7):4-8
Date
2012
Language
Russian
Publication Type
Article
Keywords
Acute Coronary Syndrome - epidemiology - etiology - therapy
Atherosclerosis - complications - epidemiology - pathology - physiopathology
Carotid Arteries - pathology
Constriction, Pathologic - diagnosis
Coronary Angiography - methods
Electrocardiography - methods
Female
Hospitalization
Humans
Incidence
Lower Extremity - blood supply
Male
Middle Aged
Prognosis
Risk assessment
Risk factors
Severity of Illness Index
Siberia - epidemiology
Stroke Volume
Survival Analysis
Ultrasonography, Doppler, Color - methods
Abstract
Aim of the study was to determine incidence of multifocal atherosclerosis (MFA), to assess its clinical and prognostic significance in the hospital phase in patients with non-ST elevation acute coronary syndrome (NSTEACS). We studied data from 225 patients with duration of NSTEACS 48 hours or less, who along with usual examination were subjected to coronary angiography and color duplex scanning of extracranial arteries and arteries of lower extremities. As lesions we considered any stenosis irrespective of intima media thickness. MFA was detected in 43.6% of cases. Patients with MFA were older, they more often had history of myocardial infarction, had lower creatinine clearance, and left ventricular ejection fraction. Presence of artery stenoses in 3 vascular regions was associated with multivessel coronary artery disease. Inhospital "endpoints" (myocardial infarction, stroke, death) occurred more frequently in patients with MFA. Patients with lesions in 2 and 3 vascular beds were characterized by maximal Grace score, while those without coronary and peripheral artery involvement- by minimal Grace score. The presence of MFA in patients with NSTEACS was associated with unfavourable course of the disease. Thus ptatients with MFA were characterized by high average rating on Grace scale; involvement of three vascular beds was associated with high mortality.
PubMed ID
22839707 View in PubMed
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[Multifocal atherosclerosis as a factor of unfavorable prognosis in patients with ST elevation myocardial infarction and type 2 diabetes mellitus].

https://arctichealth.org/en/permalink/ahliterature107986
Source
Kardiologiia. 2013;53(4):12-8
Publication Type
Article
Date
2013
Author
V N Karetnikova
Iu A Belen'kova
M V Zykov
I A Kashtalap
I A Shibanova
O L Barbarash
Source
Kardiologiia. 2013;53(4):12-8
Date
2013
Language
Russian
Publication Type
Article
Keywords
Aged
Atherosclerosis - complications - diagnosis - epidemiology
Coronary Angiography
Diabetes Mellitus, Type 2 - complications
Electrocardiography
Female
Follow-Up Studies
Humans
Incidence
Male
Middle Aged
Myocardial Infarction - complications - diagnosis - physiopathology
Prognosis
Risk factors
Russia - epidemiology
Severity of Illness Index
Abstract
Multifocal atherosclerosis (MFA) and diabetes mellitus (DM) determine less favorable course of acute vascular catastrophes. We analyzed dependence of one year prognosis of patients with myocardial infarction (MI) with and without DM on the presence of multifocal atherosclerosis. The analysis showed that number of cardiovascular complications increased with increase of degree of severity of atherosclerosis. Negative impact of DM on prognosis was more pronounced in patients with MFA. This effect rose with rise of atherosclerosis severity. Moreover in patients with MI stenoses of extracranial arteries including those less than 50% appeared to be markers of the disease severity and unfavorable prognosis especially at the background of DM.
PubMed ID
23952946 View in PubMed
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[Optimal timing of the second stage of revascularization in the treatment of patients with ST-elevation myocardial infarction and multivascular involvement].

https://arctichealth.org/en/permalink/ahliterature106919
Source
Kardiologiia. 2013;53(7):9-12
Publication Type
Article
Date
2013
Author
R S Tarasov
V I Ganiukov
P A Shushpannikov
O L Barbarash
L S Barbarash
Author Affiliation
research institute for Complex issues of Cardiovascular Diseases of SB of the rAmS, Sosnovy boul. 6, 650002 kemerovo, russia.
Source
Kardiologiia. 2013;53(7):9-12
Date
2013
Language
Russian
Publication Type
Article
Keywords
Aged
Angioplasty, Balloon, Coronary - methods
Coronary Angiography - methods
Coronary Vessels - pathology
Electrocardiography
Female
Humans
Male
Middle Aged
Myocardial Infarction - diagnosis - mortality - therapy
Retrospective Studies
Russia - epidemiology
Severity of Illness Index
Survival Analysis
Time Factors
Treatment Outcome
Abstract
An assessment of outcomes in 187 patients with ST elevation myocardial infarction (STEMI) with multivessel coronary disease who underwent primary percutaneous coronary intervention (PCI) was done. All patients were divided into two groups: in group 1 (n=39) second phase of revasculrization was performed within 60 days, in group 2 (n=148) it was carried out or planned in more than 60 days after index event. During 12 months of follow up rates of combined end point (death, myocardial infarction, target vessel revascularization [TVR]) and TVR in group 1 were lower than in group 2 (5.1 vs 27.7%, and 0 vs 11.5%, respectivelly, p=0.05). We also observed tendency to lower reinfarction rate in group 1 (0 vs 9.46%, p=0.09). There was no significant difference between groups in number of deaths (5.1% vs 6.7%, respectively).
PubMed ID
24087954 View in PubMed
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[Predictors of coronary adverse events in patients with acute coronary syndrome with ST segment elevation treated with percutaneous coronary interventions with stenting].

https://arctichealth.org/en/permalink/ahliterature141934
Source
Kardiologiia. 2010;50(7):15-20
Publication Type
Article
Date
2010
Author
S A Berns
E A Shmidt
E S Kiprina
A V Klimenkova
O L Barbarash
M V Sin'kov
G V Moiseenkov
L S Barbarash
Source
Kardiologiia. 2010;50(7):15-20
Date
2010
Language
Russian
Publication Type
Article
Keywords
Acute Coronary Syndrome - diagnosis - immunology - mortality - therapy
Aged
Angioplasty, Balloon, Coronary - adverse effects
Biological Markers - blood
Coronary Angiography
Echocardiography
Electrocardiography
Female
Follow-Up Studies
Graft Occlusion, Vascular - immunology
Humans
Interleukin-8 - blood
Male
Middle Aged
P-Selectin - blood
Platelet Aggregation Inhibitors - therapeutic use
Predictive value of tests
Russia
Stents - adverse effects
Time Factors
Tumor Necrosis Factor-alpha - blood
Abstract
The aim of this 12 months observational study was to investigate risk factors of major adverse coronary events, such as death or Q wave myocardial infarction due to stent thrombosis or in stent restenosis.
One hundred fifty four patients with ST segment elevation acute coronary syndrome were treated with percutaneous coronary intervention (PCI) and with implantation of metal stent. TIMI and CADILLAC scores were used for evaluation of initial risk. Blood levels of cytokines and sP selectin were measured on day 1 before PCI and on day 10 of hospitalization.
We proved that CADILLAC score was applicable for evaluation of prognosis in patients with acute coronary syndrome and ST segment elevation treated with coronary stenting. High levels of tumor necrosis factor during first 24 hours of acute coronary syndrome and interleikin 8 on day 10 after PCI were found to be risk factors of major adverse coronary events during subsequent 12 months. High sP selectin level on day 10 predicted stent thrombosis during long term follow up.
PubMed ID
20659039 View in PubMed
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[Prevalence of multifocal atherosclerosis in different age groups].

https://arctichealth.org/en/permalink/ahliterature122187
Source
Kardiologiia. 2012;52(6):28-34
Publication Type
Article
Date
2012
Author
A N Sumin
R A Gaifulin
A V Bezdenezhnykh
M G Mos'kin
E V Korok
A V Karpovich
S V Ivanov
O L Barbarash
L S Barbarash
Source
Kardiologiia. 2012;52(6):28-34
Date
2012
Language
Russian
Publication Type
Article
Keywords
Adult
Age Factors
Aged
Atherosclerosis - blood - diagnosis - epidemiology - physiopathology - surgery
Blood Chemical Analysis
Cardiovascular Surgical Procedures - statistics & numerical data
Coronary Angiography - methods
Echocardiography - methods
Female
Humans
Logistic Models
Male
Middle Aged
Preoperative Care - methods - statistics & numerical data
Prevalence
Risk factors
Severity of Illness Index
Sex Factors
Siberia - epidemiology
Tunica Intima - pathology
Ultrasonography, Doppler, Duplex - methods
Abstract
Aim of the study was to assess prevalence of lesions in several arterial beds in patients with atherosclerosis of various localization in the clinic of cardiovascular surgery. We examined 1018 patients (825 men and 193 women, aged 31-78 years, mean age 59+/-12 years) in the period of preparation to elective surgical interventions on coronary arteries or other arterial beds. All patients were divided into 4 age groups: group 1 - younger than 60 years (n=542), group 2 - 60-64 years (n=215), group 3 - 65-69 years (n=141), group 4-70 years and older (n=120). All patients were subjected to coronary angiography and Doppler ultrasound investigation (USI) of extracranial arteries. USI of arteries of lower extremities and angiography of peripheral arteries were carried out if indicated. Presence of 50% or greater stenosis was considered a criterion of involvement of an arterial vascular bed. Lesions in 2 or more beds were found in 321 patients (31.5%). Stenoses in 2 and 3 arterial beds were revealed in 24 and 3.5%, respectively, of patients in group 1, and in 31.8 and 10%, respectively, of patients in group 4 (p=0.008). Purposeful diagnostics of multifocal atherosclerosis in patients of the given category apparently should not be limited by older age groups.
PubMed ID
22839667 View in PubMed
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[Results of endovascular revascularization in elderly patients with ST-segment elevation myocardial infarction in multivessel disease in relation to the degree of coronary atherosclerosis].

https://arctichealth.org/en/permalink/ahliterature271953
Source
Ter Arkh. 2016;88(1):23-8
Publication Type
Article
Date
2016
Author
R S Tarasov
A M Kochergina
V I Ganyukov
O L Barbarash
Source
Ter Arkh. 2016;88(1):23-8
Date
2016
Language
Russian
Publication Type
Article
Keywords
Aged
Coronary Angiography - methods
Coronary Artery Disease - complications - diagnosis
Electrocardiography - methods
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Myocardial Infarction - diagnosis - etiology - mortality - surgery
Patient Outcome Assessment
Percutaneous Coronary Intervention - adverse effects - methods - statistics & numerical data
Prognosis
Risk factors
Russia - epidemiology
Severity of Illness Index
Stroke Volume
Treatment Outcome
Abstract
To investigate the impact of the degree of coronary atherosclerosis evaluated by the SYNTAX scale on the early and late results of endovascular revascularization in elderly and middle-aged patients with ST-segment elevation myocardial infarction (STEMI).
The investigation enrolled 327 consecutively admitted patients with STEMI and multivessel coronary bed disease, who had received revascularization within the first 12 hours after disease onset via primary percutaneous coronary interventions (PCI). The clinical, demographic, and angiographic characteristics of the patients, as well as the specific features of chosen revascularization strategies and treatment outcomes were compared in two groups of 103 elderly patients (=65 years of age) and 224 middle-aged patients (=64 years) in relation to the severity of coronary bed lesion according to the SYNTAX scale.
By and large, severe coronary atherosclerosis (=23 SYNTAX scores) was related to reduced left ventricular ejection fraction and clinical manifestations of acute heart failure in all the analyzed patients regardless of their age and this was most markedly associated with the risk factors of cardiovascular events in the elderly patients. The elderly patients with severe coronary atherosclerosis (=23 SYNTAX scores) were noted to have the lowest frequency of successful PCIs and higher 30-day mortality rates after primary PCI.
The SYNTAX scale is of high prognostic value in the patients with STEMI, by determining the results of endovascular revascularization in elderly and middle-aged patients. The elderly patients with STEMI and severe coronary atherosclerosis are at very high risk for poor outcome within 30 days of follow-up after primary CPI, which necessitates a search for optimal revascularization strategies for this category of patients.
PubMed ID
26978605 View in PubMed
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[The role of multifocal atherosclerosis in realization of new cardiovascular complications during one year after non ST-elevation acute coronary syndrome].

https://arctichealth.org/en/permalink/ahliterature106909
Source
Kardiologiia. 2013;53(8):15-23
Publication Type
Article
Date
2013
Author
S A Berns
D S Zykova
M V Zykov
E A Shmidt
E S Iukhno
O A Nagirniak
O L Barbarash
Author Affiliation
Research Institute for Complex Issues of Cardiovascular Diseases of SB of the RAMS, Sosnovy boul. 6, 650002 Kemerovo, Russia.
Source
Kardiologiia. 2013;53(8):15-23
Date
2013
Language
Russian
Publication Type
Article
Keywords
Acute Coronary Syndrome - diagnosis - etiology - mortality - physiopathology - surgery
Atherosclerosis - complications - diagnosis - epidemiology - physiopathology
Coronary Angiography - methods - statistics & numerical data
Electrocardiography
Female
Follow-Up Studies
Humans
Male
Middle Aged
Outcome Assessment (Health Care)
Percutaneous Coronary Intervention - statistics & numerical data
Prognosis
Risk assessment
Risk factors
Russia - epidemiology
Severity of Illness Index
Ultrasonography, Doppler, Duplex - methods - statistics & numerical data
Abstract
to assess prognostic value of multifocal atherosclerosis (MFA) relative to risk of new cardiovascular catastrophes in patients with non ST elevation acute coronary syndrome (NSTEACS) during one year follow-up.
atients with NSTEACS (n=266) subjected to coronary angiography and color duplex scanning of peripheral arteries (PA) were included in this study. Presence of "end points" (cardiovascular death, stroke, myocardial infarction, unstable angina, decompensation of heart failure) was assessed after one year of follow-up.
aximal GRACE score was revealed in patients with MFA (combined involvement of coronary arteries [CA] and peripheral arteries [PA]). Compared with patients without involvement of CA or PA unfavorable outcomes were 2 times more frequent in the presence of lesions only in CA, 3 times more frequent in the presence of combination of lesions in CA and PA stenoses 50%. Percutaneous coronary intervention at the hospital stage led to 3.3-fold improvement of long term prognosis in patients with single vessel CA involvement and absence of stenoses in PA, and to 1.8 fold improvement - in patients with multivessel CA involvement and PA stenoses >50%.
resence of even nonsignificant PA stenoses in patients with NSTEACS predetermined high rate of unfavorable events during one year follow-up.
PubMed ID
24087995 View in PubMed
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7 records – page 1 of 1.