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[Initial experience with the use of abciximab in the salvage treatment of acute coronary thrombosis in the Hemodynamics Laboratory]

https://arctichealth.org/en/permalink/ahliterature54292
Source
Cardiologia. 1998 Nov;43(11):1221-9
Publication Type
Article
Date
Nov-1998
Author
A. Rubboli
S G Fransson
G. Wiklund
P. Sangiorgio
D. Bracchetti
G. Stenport
Author Affiliation
Dipartimento di Radiologia Toracica, Ospedale Universitario, Linköping, Svezia.
Source
Cardiologia. 1998 Nov;43(11):1221-9
Date
Nov-1998
Language
Italian
Publication Type
Article
Keywords
Acute Disease
Aged
Angina, Unstable - drug therapy - radiography
Angioplasty, Transluminal, Percutaneous Coronary
Antibodies, Monoclonal - therapeutic use
Anticoagulants - therapeutic use
Combined Modality Therapy
Coronary Angiography
Coronary Thrombosis - drug therapy - radiography
English Abstract
Female
Hemodynamic Processes
Humans
Immunoglobulin Fab Fragments - therapeutic use
Laboratories, Hospital
Male
Middle Aged
Salvage Therapy - methods
Sweden
Treatment Outcome
Abstract
The optimal treatment of acute thrombotic complications in the Catheterization Laboratory has not been defined yet, due to the limited efficacy shown by various pharmacological regimens, even when associated to coronary angioplasty (PTCA). The aim of our study was therefore to evaluate the effects of abciximab (ReoPro), a new potent inhibitor of the platelet glycoprotein IIb/IIIa, when administered as a "rescue" treatment for acute thrombotic coronary occlusion during diagnostic or interventional procedures. Sixteen patients (12 males, 4 females, mean age 59.3 +/- 9.2 years, range 43-77 years), with unstable angina and consecutively treated with abciximab due to clinical instability attributable to coronary thrombosis angiographically proven during PTCA (9 cases) or diagnostic angiography (7 cases), were identified. The individual angiographic films and medical records were then reviewed in order to evaluate the effects of treatment on coronary flow, thrombus size and occurrence of in-hospital adverse events: death, non-fatal acute myocardial infarction (AMI), need for urgent myocardial revascularization and hemorrhage. The administration of abciximab, in association with PTCA (associated in turn with stent implantation in 8 cases), induced a significant increase of coronary TIMI flow grade (0.3 +/- 0.6 vs 2.4 +/- 0.9; p
PubMed ID
9922589 View in PubMed
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[The appropriateness of diagnostic angiography in cardiology].

https://arctichealth.org/en/permalink/ahliterature189381
Source
Ital Heart J Suppl. 2002 Jun;3(6):598-606
Publication Type
Article
Date
Jun-2002
Author
Guglielmo Bernardi
Giorgio Morocutti
Leonardo Spedicato
Valentino Moretti
Duilio Tuniz
Paolo Maria Fioretti
Author Affiliation
Dipartimento di Scienze Cardiovascolari U.O. di Cardiologia Azienda Ospedaliera S. Maria della Misericordia Piazzale S. Maria della Misericordia, 15, 33100 Udine. guglbern@tin.it
Source
Ital Heart J Suppl. 2002 Jun;3(6):598-606
Date
Jun-2002
Language
Italian
Publication Type
Article
Keywords
Canada
Coronary Angiography - standards - statistics & numerical data
Coronary Disease - radiography
Diagnosis, Differential
Female
Humans
Italy
Male
Minority Groups - statistics & numerical data
Patient Selection
Prognosis
Quality Assurance, Health Care
Sex Distribution
United States
Abstract
Coronary angiography is the most frequently performed invasive diagnostic test in the western world, but regional differences are common and have been outlined in both observational and randomized studies. Appropriateness evaluation is hence fundamental, as the use of invasive cardiac procedures is strongly associated with the population-based availability of catheterization facilities. A procedure is judged appropriate if the expected health benefit exceeds the possible negative consequences by a sufficiently wide margin; it is necessary when not performing it could result in harm for the patient. In the first period (1980-1995) researchers seemed to try to find an explanation for geographic variations regarding overuse: the appropriateness remained at the same level through time (75%), while a trend towards a reduction in the number of inappropriate procedures (
PubMed ID
12116808 View in PubMed
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