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Decreasing trends in methyldibromo glutaronitrile contact allergy--following regulatory intervention.

https://arctichealth.org/en/permalink/ahliterature156817
Source
Contact Dermatitis. 2008 Jul;59(1):48-51
Publication Type
Article
Date
Jul-2008
Author
Jeanne D Johansen
Niels Veien
Grete Laurberg
Christian Avnstorp
Knud Kaaber
Klaus E Andersen
Evy Paulsen
Mette Sommerlund
Jens Thormann
Niels H Nielsen
Susanne Vissing
Ove Kristensen
Berit Kristensen
Tove Agner
Torkil Menné
Author Affiliation
National Allergy Research Centre, Gentofte Hospital, University of Copenhagen, 2900 Hellerup, Denmark. jedu@geh.regionh.dk
Source
Contact Dermatitis. 2008 Jul;59(1):48-51
Date
Jul-2008
Language
English
Publication Type
Article
Keywords
Adult
Consumer Product Safety - legislation & jurisprudence
Cosmetics - adverse effects - chemistry
Denmark - epidemiology
Dermatitis, Allergic Contact - diagnosis - epidemiology - etiology
Environmental Exposure - legislation & jurisprudence
European Union
Female
Government Regulation
Humans
Male
Middle Aged
Nitriles - adverse effects
Patch Tests
Population Surveillance
Predictive value of tests
Preservatives, Pharmaceutical - adverse effects
Prevalence
Abstract
The preservative methyldibromo glutaronitrile (MDBGN) has been banned, first from stay-on, and later from rinse-off cosmetics, in the EU countries because of increasing rates of contact allergy.
To evaluate the frequency of contact allergy to MDBGN among patients patch tested by the Danish Contact Dermatitis Group just before and following regulatory decisions.
The data set comprised 19 279 consecutive eczema patients patch tested from 2003-2007 with MDBGN 0.3% in petrolatum (pet.) or, in a minority of patients, with Euxyl K 400 1.5% in pet.
A significantly decreasing trend in the frequency of positive patch tests to MDBGN was found from 4.6% in 2003 to 2.6% in 2007 (P
PubMed ID
18537990 View in PubMed
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