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The 24-hour pulse wave velocity, aortic augmentation index, and central blood pressure in normotensive volunteers.

https://arctichealth.org/en/permalink/ahliterature104335
Source
Vasc Health Risk Manag. 2014;10:247-51
Publication Type
Article
Date
2014
Author
Tatyana Y Kuznetsova
Viktoria A Korneva
Evgeniya N Bryantseva
Vitaliy S Barkan
Artemy V Orlov
Igor N Posokhov
Anatoly N Rogoza
Author Affiliation
Faculty of Medicine, Petrozavodsk State University, Petrozavodsk, Russia.
Source
Vasc Health Risk Manag. 2014;10:247-51
Date
2014
Language
English
Publication Type
Article
Keywords
Adult
Aged
Algorithms
Blood pressure
Blood Pressure Monitoring, Ambulatory - standards
Circadian Rhythm
Diastole
Female
Healthy Volunteers
Heart rate
Humans
Male
Middle Aged
Predictive value of tests
Pulse Wave Analysis - standards
Reference Values
Russia
Signal Processing, Computer-Assisted
Systole
Time Factors
Vascular Stiffness
Abstract
The purpose of this study was to examine the pulse wave velocity, aortic augmentation index corrected for heart rate 75 (AIx@75), and central systolic and diastolic blood pressure during 24-hour monitoring in normotensive volunteers. Overall, 467 subjects (206 men and 261 women) were recruited in this study. Participants were excluded from the study if they were less than 19 years of age, had blood test abnormalities, had a body mass index greater than 2 7.5 kg/m(2), had impaired glucose tolerance, or had hypotension or hypertension. Ambulatory blood pressure monitoring (ABPM) with the BPLab(®) device was performed in each subject. ABPM waveforms were analyzed using the special automatic Vasotens(®) algorithm, which allows the calculation of pulse wave velocity, AIx@75, central systolic and diastolic blood pressure for "24-hour", "awake", and "asleep" periods. Circadian rhythms and sex differences in these indexes were identified. Pending further validation in prospective outcome-based studies, our data may be used as preliminary diagnostic values for the BPLab ABPM additional index in adult subjects.
Notes
Cites: J Invasive Cardiol. 2009 Jun;21(6):270-719494403
Cites: Hypertens Res. 2012 Oct;35(10):980-722622282
Cites: Am J Hypertens. 2010 Feb;23(2):180-519959999
Cites: J Hypertens. 2013 Jul;31(7):1281-35723817082
Cites: Vasc Health Risk Manag. 2011;7:649-5622140314
Cites: Age (Dordr). 2013 Dec;35(6):2345-5523319362
Cites: Hypertension. 2013 Jun;61(6):1148-923630945
Cites: Hypertension. 2013 Jun;61(6):1168-7623630950
Cites: J Hypertens. 2013 Sep;31(9):1731-6824029863
Cites: Eur Heart J. 2010 Oct;31(19):2338-5020530030
PubMed ID
24812515 View in PubMed
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Access and interest: two important issues in considering the feasibility of web-assisted tobacco interventions.

https://arctichealth.org/en/permalink/ahliterature154400
Source
J Med Internet Res. 2008;10(5):e37
Publication Type
Article
Date
2008
Author
John A Cunningham
Author Affiliation
Centre for Addiction and Mental Health, Toronto, ON, Canada. John_Cunningham@camh.net
Source
J Med Internet Res. 2008;10(5):e37
Date
2008
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Attitude to Health
Feasibility Studies
Female
Health Services Accessibility
Health Surveys
Humans
Internet
Male
Middle Aged
Ontario
Predictive value of tests
Regression Analysis
Smoking - adverse effects
Smoking Cessation - methods
Telephone
Therapy, Computer-Assisted - methods
User-Computer Interface
Young Adult
Abstract
Previous research has found that current smokers are less likely to have access to the Internet than nonsmokers. As access to the Internet continues to expand, does this finding remain true? Also, how many smokers are interested in Web-assisted tobacco interventions (WATIs)? These questions are important to determine the potential role that WATIs might play in promoting tobacco cessation.
The aims of the study were to determine whether smokers are less likely than nonsmokers to have access to the Internet and to establish the level of interest in WATIs among a representative sample of smokers.
A random digit dialing telephone survey was conducted of 8467 adult respondents, 18 years and older, in Ontario, Canada from September 2006 to August 2007. All respondents were asked their smoking status and whether they used the Internet (at home or work in the past 12 months; where; how often in the past 12 months). To assess the level of interest in WATIs, current daily smokers were asked whether they would be interested in a confidential program that they could access on the Internet, free of charge, that would allow them to check their smoking and compare it to other Canadians.
Smokers were marginally less likely to have used the Internet than nonsmokers (74% vs 81% in the last year), and, of those who had access to the Internet, smokers used the Internet less often than nonsmokers. Overall, 40% of smokers said they would be interested in a WATI. The number of cigarettes smoked per day was unrelated to level of interest in the WATI, but time to first cigarette after waking was. Smokers who used the Internet were more interested in the WATI than smokers who did not use the Internet (46% vs 20%).
While the difference in level of Internet use between smokers and nonsmokers was greatly reduced compared to 2002 and 2004 data, smokers still remain marginally less likely to use the Internet than nonsmokers. Overall, there was a substantial level of interest in the WATI among smokers, in particular among smokers who currently use the Internet. These results indicate that WATIs have a substantial potential audience among smokers, and, given the growing body of evidence regarding their efficacy, there is growing support that WATIs have a significant role to play in promoting tobacco cessation.
Notes
Cites: Br J Addict. 1989 Jul;84(7):791-92758152
Cites: J Med Internet Res. 2005;7(1):e215829474
Cites: Nicotine Tob Res. 2005 Apr;7(2):207-1616036277
Cites: J Health Commun. 2005;10 Suppl 1:105-1816377603
Cites: J Med Internet Res. 2006;8(3):e1717032633
Cites: Tob Control. 2006 Feb;15(1):7-1216436397
Cites: Addict Behav. 2006 Feb;31(2):264-7715950392
Cites: Drug Alcohol Rev. 2006 Jan;25(1):79-8416492580
Cites: Med Inform Internet Med. 2006 Mar;31(1):53-816754367
Cites: Int J Med Inform. 2006 Jan;75(1):110-616125450
PubMed ID
18984558 View in PubMed
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The accuracy of noninvasive stress myocardial imaging for detecting coronary artery disease in clinical practice.

https://arctichealth.org/en/permalink/ahliterature143550
Source
Hosp Pract (1995). 2010 Apr;38(2):14-8
Publication Type
Article
Date
Apr-2010
Author
Leonard Schwartz
Christopher B Overgaard
Author Affiliation
Toronto General Hospital, Toronto, ON, Canada. Dr.Leonard.Schwartz@uhn.on.ca
Source
Hosp Pract (1995). 2010 Apr;38(2):14-8
Date
Apr-2010
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Chi-Square Distribution
Coronary Angiography - standards
Coronary Artery Disease - diagnosis - epidemiology
Echocardiography - standards
Exercise Test - standards
False Positive Reactions
Female
Humans
Male
Mass Screening - methods - standards
Middle Aged
Ontario - epidemiology
Patient Selection
Predictive value of tests
Prevalence
Sensitivity and specificity
Sex Distribution
Tomography, Emission-Computed, Single-Photon - standards
Abstract
There is a wide variation in reported accuracy ofnoninvasive stress myocardial imaging as a screening tool for coronary artery disease (CAD). This study was undertaken to determine its current accuracy in a wide spectrum of patients with chest pain syndromes using invasive coronary angiography as the gold standard.
The patient population consisted of consecutive patients undergoing coronary angiography in whom noninvasive stress imaging, either nuclear or echocardiographic, was performed within 6 months prior to the angiogram. The specificity, sensitivity, positive and negative predictive values, and diagnostic accuracy for detecting > or =1 lesions with > or =50% diameter coronary stenosis were determined for each modality.
Of the 227 eligible patients, 141 were men and 86 were women; 70% had significant CAD. The diagnostic accuracy overall was 71% and was no different for nuclear or echocardiographic testing. The positive predictive value (86% vs. 52%; P = 0.002) and diagnostic accuracy (83% vs. 51%; P = 0.002) were better in men than in women.
In this study, noninvasive stress imaging lacked the accuracy of a good screening test for significant CAD. This finding was particularly true for women, for whom it was not much better than a coin toss.
PubMed ID
20469609 View in PubMed
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The accuracy of quantitative parameters in (99m) Tc-MAG3 dynamic renography: a national audit based on virtual image data.

https://arctichealth.org/en/permalink/ahliterature277742
Source
Clin Physiol Funct Imaging. 2016 Mar;36(2):146-54
Publication Type
Article
Date
Mar-2016
Author
Gustav Brolin
Lars Edenbrandt
Göran Granerus
Anna Olsson
David Afzelius
Agneta Gustafsson
Cathrine Jonsson
Jessica Hagerman
Lena Johansson
Katrine Riklund
Michael Ljungberg
Source
Clin Physiol Funct Imaging. 2016 Mar;36(2):146-54
Date
Mar-2016
Language
English
Publication Type
Article
Keywords
Computer simulation
Feasibility Studies
Female
Gamma Cameras
Humans
Image Interpretation, Computer-Assisted
Kidney - physiopathology - radionuclide imaging
Kidney Diseases - physiopathology - radionuclide imaging
Male
Monte Carlo Method
Observer Variation
Phantoms, Imaging
Predictive value of tests
Radioisotope Renography - instrumentation - methods - standards
Radiopharmaceuticals - administration & dosage
Reproducibility of Results
Software
Sweden
Technetium Tc 99m Mertiatide - administration & dosage
Abstract
Assessment of image analysis methods and computer software used in (99m) Tc-MAG3 dynamic renography is important to ensure reliable study results and ultimately the best possible care for patients. In this work, we present a national multicentre study of the quantification accuracy in (99m) Tc-MAG3 renography, utilizing virtual dynamic scintigraphic data obtained by Monte Carlo-simulated scintillation camera imaging of digital phantoms with time-varying activity distributions. Three digital phantom studies were distributed to the participating departments, and quantitative evaluation was performed with standard clinical software according to local routines. The differential renal function (DRF) and time to maximum renal activity (Tmax ) were reported by 21 of the 28 Swedish departments performing (99m) Tc-MAG3 studies as of 2012. The reported DRF estimates showed a significantly lower precision for the phantom with impaired renal uptake than for the phantom with normal uptake. The Tmax estimates showed a similar trend, but the difference was only significant for the right kidney. There was a significant bias in the measured DRF for all phantoms caused by different positions of the left and right kidney in the anterior-posterior direction. In conclusion, this study shows that virtual scintigraphic studies are applicable for quality assurance and that there is a considerable uncertainty associated with standard quantitative parameters in dynamic (99m) Tc-MAG3 renography, especially for patients with impaired renal function.
PubMed ID
25348641 View in PubMed
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Acetabular fracture assessment in four different pelvic trauma centers: have the Judet views become superfluous?

https://arctichealth.org/en/permalink/ahliterature269564
Source
Arch Orthop Trauma Surg. 2015 Jul;135(7):913-8
Publication Type
Article
Date
Jul-2015
Author
John Clarke-Jenssen
Stein Arne Øvre
Olav Røise
Jan Erik Madsen
Source
Arch Orthop Trauma Surg. 2015 Jul;135(7):913-8
Date
Jul-2015
Language
English
Publication Type
Article
Keywords
Acetabulum - injuries - radiography
Adult
Female
Hip Fractures - radiography
Humans
Male
Norway
Observer Variation
Predictive value of tests
Reproducibility of Results
Tomography, X-Ray Computed - methods - standards
Trauma Centers - statistics & numerical data
Abstract
The present study was designed to examine whether oblique radiographs (Judet views) in addition to 2D and 3D CT scans improved the intra- and interobserver reliability when assessing acetabular fractures.
Four international orthopedic pelvic trauma centers reviewed the radiological images for 20 acetabular fracture patients. Three different image sets were made; one set containing plain radiographs including oblique (Judet) views and 2D axial CT scans. The second set contained an AP radiograph of the pelvis, without oblique views, 2D and 3D CT scans. The third set contained all the images. The image sets were evaluated in three separate sessions, for each session the raters were asked to classify the fracture according to Letournel, as well as record a number of other important radiological features concerning the fracture.
The interobserver agreement for the Letournel classification was found to be moderate for all image sets. The image set without oblique views showed the best agreement with a kappa value of 0.60. The intra- and interobserver agreement for important modifiers were found to be substantial. The addition of oblique radiographs did not seem to increase the intra- or interobserver agreement for any of the factors evaluated except for the roof arc score.
The moderate agreement found for the Letournel classification is to be expected given the complexity of the classification. The addition of oblique radiographs to the image sets does not seem to improve the reliability and thus its routine use for classification and decision making may be debated.
PubMed ID
25931251 View in PubMed
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The added value of hybrid ventilation/perfusion SPECT/CT in patients with stable COPD or apparently healthy smokers. Cancer-suspected CT findings in the lungs are common when hybrid imaging is used.

https://arctichealth.org/en/permalink/ahliterature266278
Source
Int J Chron Obstruct Pulmon Dis. 2015;10:25-30
Publication Type
Article
Date
2015
Author
Jonas Jögi
Hanna Markstad
Ellen Tufvesson
Leif Bjermer
Marika Bajc
Source
Int J Chron Obstruct Pulmon Dis. 2015;10:25-30
Date
2015
Language
English
Publication Type
Article
Keywords
Aged
Case-Control Studies
Comorbidity
Female
Heart Failure - epidemiology - radiography - radionuclide imaging
Humans
Lung - radiography - radionuclide imaging
Lung Neoplasms - diagnosis - epidemiology - radiography - radionuclide imaging
Male
Middle Aged
Multimodal Imaging
Perfusion Imaging - methods
Predictive value of tests
Prospective Studies
Pulmonary Disease, Chronic Obstructive - diagnosis - epidemiology - radiography - radionuclide imaging
Pulmonary Embolism - epidemiology - radiography - radionuclide imaging
Pulmonary Emphysema - diagnosis - epidemiology - radiography - radionuclide imaging
Severity of Illness Index
Smoking - adverse effects - epidemiology
Sweden - epidemiology
Tomography, Emission-Computed, Single-Photon
Tomography, X-Ray Computed
Abstract
Ventilation/perfusion (V/P) single-photon emission computed tomography (SPECT) is recognized as a diagnostic method with potential beyond the diagnosis of pulmonary embolism. V/P SPECT identifies functional impairment in diseases such as heart failure (HF), pneumonia, and chronic obstructive pulmonary disease (COPD). The development of hybrid SPECT/computed tomography (CT) systems, combining functional with morphological imaging through the addition of low-dose CT (LDCT), may be useful in COPD, as these patients are prone to lung cancer and other comorbidities. The aim of this study was to investigate the added value of LDCT among healthy smokers and patients with stable COPD, when examined with V/P SPECT/CT hybrid imaging. Sixty-nine subjects, 55 with COPD (GOLD I-IV) and 14 apparently healthy smokers, were examined with V/P SPECT and LDCT hybrid imaging. Spirometry was used to verify COPD grade. Only one apparently healthy smoker and three COPD patients had a normal or nearly normal V/P SPECT. All other patients showed various degrees of airway obstruction, even when spirometry was normal. The same interpretation was reached on both modalities in 39% of the patients. LDCT made V/P SPECT interpretation more certain in 9% of the patients and, in 52%, LDCT provided additional diagnoses. LDCT better characterized the type of emphysema in 12 patients. In 19 cases, tumor-suspected changes were reported. Three of these 19 patients (ie, 4.3% of all subjects) were in the end confirmed to have lung cancer. The majority of LDCT findings were not regarded as clinically significant. V/P SPECT identified perfusion patterns consistent with decompensated left ventricular HF in 14 COPD patients. In 16 patients (23%), perfusion defects were observed. HF and perfusion defects were not recognized with LDCT. In COPD patients and long-time smokers, hybrid imaging had added value compared to V/P SPECT alone, by identifying patients with lung malignancy and more clearly identifying emphysema. V/P SPECT visualizes comorbidities to COPD not seen with LDCT, such as pulmonary embolism and left ventricular HF.
Notes
Cites: Am J Respir Crit Care Med. 1995 Sep;152(3):1107-367663792
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Cites: Nucl Med Commun. 2007 Aug;28(8):667-7217625390
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Cites: J Intern Med. 2008 Oct;264(4):379-8718823506
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Cites: J Nucl Med. 2009 Dec;50(12):1987-9219910421
Cites: Chest. 2010 Jun;137(6 Suppl):39S-51S20522579
Cites: Radiology. 2010 Aug;256(2):625-3220551182
Cites: Eur J Nucl Med Mol Imaging. 2011 Jul;38(7):1344-5221365251
Cites: J Environ Public Health. 2011;2011:85010522187575
Cites: J Am Board Fam Med. 2012 Jan-Feb;25(1):33-4122218622
Cites: Int J Radiat Oncol Biol Phys. 2012 Mar 15;82(4):e631-822197235
Cites: Rev Esp Med Nucl Imagen Mol. 2014 May-Jun;33(3):153-824485808
Cites: Clin Imaging. 2014 Nov-Dec;38(6):831-524852679
Cites: J Thromb Thrombolysis. 2015 Feb;39(2):166-7224942995
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Cites: Cancer Control. 2014 Jan;21(1):9-1424357736
Cites: Radiol Technol. 2014 Jan-Feb;85(3):297CT-314CT; quiz 315CT-318CT24395909
Cites: Nuklearmedizin. 2001 Dec;40(6):179-8611797505
PubMed ID
25565797 View in PubMed
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Additional value of thallium-201 SPECT to a conventional exercise test for the identification of severe coronary lesions after an episode of unstable coronary artery disease.

https://arctichealth.org/en/permalink/ahliterature46494
Source
Int J Card Imaging. 1995 Jun;11(2):127-37
Publication Type
Article
Date
Jun-1995
Author
J E Karlsson
A. Björkholm
E. Nylander
J. Ohlsson
L. Wallentin
Author Affiliation
Department of Cardiology, University Hospital, Linköping, Sweden.
Source
Int J Card Imaging. 1995 Jun;11(2):127-37
Date
Jun-1995
Language
English
Publication Type
Article
Keywords
Adult
Aged
Coronary Angiography
Coronary Disease - diagnosis - drug therapy - radionuclide imaging
Double-Blind Method
Electrocardiography
Exercise Test
Heart - radionuclide imaging
Humans
Logistic Models
Male
Middle Aged
Predictive value of tests
Prospective Studies
Research Support, Non-U.S. Gov't
Sensitivity and specificity
Sweden
Thallium Radioisotopes - diagnostic use
Tissue Plasminogen Activator - therapeutic use
Tomography, Emission-Computed, Single-Photon
Abstract
The additional value of thallium-201 SPECT to a conventional exercise test for the identification of patients with severe coronary lesions was evaluated in 170 men, one month after an episode of unstable coronary artery disease. Severe coronary lesions at coronary angiography--defined as three vessel disease, left main stenosis or proximal left anterior descending artery stenosis as part of two vessel disease--were observed in 45.9%. In the SPECT image, the left ventricular myocardium was divided into nine segments and each segment was classified as either normal (= 0), reduced uptake (= 1) or uptake defect (= 2). The sum of gradings in all segments post-exercise was denoted "SPECT score". The patients were divided into nine different groups regarding ST-depression during exercise (no ST-depression, ST-depression in 1-2 leads or > or = 3 leads) and "SPECT score" (no SPECT score, 1-3 scores or > or = 4 scores). Severe coronary lesions were, in 68% identified by SPECT score > or = 4 and in 65% by ST-depression in > or = 1 lead at exercise test. The specificity for identification of severe coronary lesions was, for both tests, 65%. SPECT score > or = 4 and/or ST-depression in > or = 3 leads identified 82% of the patients with severe coronary lesions with a specificity of 63%. Furthermore, SPECT score > or = 3 identified more patients with isolated proximal left anterior descending artery stenosis than ST-depression alone at exercise test.
PubMed ID
7673760 View in PubMed
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Adrenal incidentaloma--experience of a standardized diagnostic programme in the Swedish prospective study.

https://arctichealth.org/en/permalink/ahliterature18871
Source
J Intern Med. 2002 Sep;252(3):239-46
Publication Type
Article
Date
Sep-2002
Author
B. Bülow
B. Ahrén
Author Affiliation
Department of Medicine, Lund University, Lund, Sweden. b.bulow@telia.com
Source
J Intern Med. 2002 Sep;252(3):239-46
Date
Sep-2002
Language
English
Publication Type
Article
Keywords
Adenoma - blood - diagnosis - surgery
Adolescent
Adrenal Gland Neoplasms - blood - diagnosis - surgery
Adult
Age Factors
Aged
Aged, 80 and over
Biopsy
Carcinoma - blood - diagnosis - surgery
Child
Diagnostic Techniques and Procedures - standards
Diagnostic Techniques, Endocrine - standards
Disease Progression
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Pheochromocytoma - blood - diagnosis - surgery
Predictive value of tests
Prospective Studies
Research Support, Non-U.S. Gov't
Sex Factors
Sweden
Tomography, X-Ray Computed
Abstract
OBJECTIVE: To report the 5-year experience of a diagnostic programme for adrenal incidentaloma with special emphasis to diagnose hormonally active and malignant lesions. DESIGN: A prospective study in which new cases of adrenal incidentalomas in Sweden have been evaluated by a standardized diagnostic protocol between January 1996 and July 2001. SETTING: Thirty-three different Swedish hospitals have contributed with cases. SUBJECTS: A total of 381 patients (217 females, 164 males) with adrenal incidentalomas were studied. INTERVENTIONS: Diagnostic procedures were undertaken according to a standardized programme. Operation was recommended if the incidentaloma had a size of more than 3-4 cm or if there was a suspicion of a hypersecreting tumour. MAIN OUTCOME MEASURES: The size of the incidentaloma, clinical characteristics of the patients and results of biochemical diagnostic tests were registered. RESULTS: The median age of the patients was 64 years (18-84 years), and the median size of the incidentalomas was 3 cm (1-20 cm). A total of 85(22%) patients were operated. Twenty of these patients were diagnosed with a benign hypersecreting tumour and 14 with a malignant tumour. Fourteen of 15 operated patients with diagnosed pheochromocytoma had elevated 24-h urinary noradrenaline and all of the patients operated because of a biochemical suspicion of aldosterone or cortisol hypersecretion (n = 6) were found to have adrenal adenomas. Of the 14 operated patients with malignant diseases, 10 were adrenal carcinomas (median size 10 cm; range 4-16 cm). In a multiple logistic regression model, incidentaloma size was significantly associated with the risk of a malignant tumour (P = 0.009), and there was a tendency of an association between age/male sex and the risk of a malignancy (both, P = 0.07). CONCLUSION: In this Swedish multicentre study of 381 cases with adrenal incidentalomas, 5% had benign hypersecreting tumours and nearly 4% had malignant tumours. The results of the biochemical diagnostic tests used had a high compatibility with the histological diagnosis found at operation in the patients with hypersecreting tumours. Tumour size, male gender and high age were predictive for the risk of a malignant tumour. A follow-up of the patients is warranted in order to establish whether there are undiscovered cases of malignant or hypersecreting tumours amongst the nonoperated patients.
Notes
Comment In: J Urol. 2003 Jun;169(6):2423-414558539
PubMed ID
12270004 View in PubMed
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The Alberta Stroke Program Early CT Score in clinical practice: what have we learned?

https://arctichealth.org/en/permalink/ahliterature148474
Source
Int J Stroke. 2009 Oct;4(5):354-64
Publication Type
Article
Date
Oct-2009
Author
V. Puetz
I. Dzialowski
M D Hill
A M Demchuk
Author Affiliation
Department of Neurology, Dresden University Stroke Centre, University of Technology Dresden, Dresden, Germany.
Source
Int J Stroke. 2009 Oct;4(5):354-64
Date
Oct-2009
Language
English
Publication Type
Article
Keywords
Alberta
Brain Ischemia - drug therapy - radiography
Cerebral Angiography - methods
Humans
Predictive value of tests
Prognosis
Reproducibility of Results
Stroke - drug therapy - physiopathology - radiography
Thrombolytic Therapy - adverse effects
Time Factors
Tomography, X-Ray Computed - methods
Abstract
The introduction of brain imaging with computed tomography revolutionised the treatment of patients with acute ischaemic stroke. With the visual differentiation of haemorrhagic stroke from ischaemic stroke, thrombolytic therapy became feasible. The Alberta Stroke Program Early CT Score was devised to quantify the extent of early ischaemic changes in the middle cerebral artery territory on noncontrast computed tomography. With its systematic approach, the score is simple and reliable. However, the assessment of early ischaemic changes and Alberta Stroke Program Early CT scoring require training. The Alberta Stroke Program Early CT Score is a strong predictor of functional outcome. Furthermore, the effectiveness of intraarterial thrombolysis in patients with middle cerebral artery occlusion shows effect modification by the Alberta Stroke Program Early CT Score. This review summarises the Alberta Stroke Program Early CT Score methodology. We illustrate current knowledge regarding Alberta Stroke Program Early CT Score applied to clinical trials and comment on how Alberta Stroke Program Early CT Score may facilitate clinical treatment decision making and future trial design. Moreover, we introduce a modification of the Alberta Stroke Program Early CT Score methodology that disregards isolated cortical swelling, i.e. focal brain swelling without associated parenchymal hypoattenuation, as early ischaemic changes in the Alberta Stroke Program Early CT Score system.
PubMed ID
19765124 View in PubMed
Less detail

Altered frequency distribution in the electroencephalogram is correlated to the analgesic effect of remifentanil.

https://arctichealth.org/en/permalink/ahliterature269341
Source
Basic Clin Pharmacol Toxicol. 2015 May;116(5):414-22
Publication Type
Article
Date
May-2015
Author
Carina Graversen
Lasse P Malver
Geana P Kurita
Camilla Staahl
Lona L Christrup
Per Sjøgren
Asbjørn M Drewes
Source
Basic Clin Pharmacol Toxicol. 2015 May;116(5):414-22
Date
May-2015
Language
English
Publication Type
Article
Keywords
Adult
Analgesics, Opioid - administration & dosage
Brain - drug effects - physiopathology
Brain Waves - drug effects
Cross-Over Studies
Denmark
Double-Blind Method
Electroencephalography
Healthy Volunteers
Hot Temperature - adverse effects
Humans
Infusions, Parenteral
Male
Multivariate Analysis
Pain - etiology - physiopathology - prevention & control
Pain Measurement
Pain Perception - drug effects
Pain Threshold - drug effects
Piperidines - administration & dosage
Predictive value of tests
Pressure - adverse effects
Signal Processing, Computer-Assisted
Time Factors
Young Adult
Abstract
Opioids alter resting state brain oscillations by multiple and complex factors, which are still to be elucidated. To increase our knowledge, multi-channel electroencephalography (EEG) was subjected to multivariate pattern analysis (MVPA), to identify the most descriptive frequency bands and scalp locations altered by remifentanil in healthy volunteers. Sixty-two channels of resting EEG followed by independent measures of pain scores to heat and bone pain were recorded in 21 healthy males before and during remifentanil infusion in a placebo-controlled, double-blind crossover study. EEG frequency distributions were extracted by a continuous wavelet transform and normalized into delta, theta, alpha, beta and gamma bands. Alterations relative to pre-treatment responses were calculated for all channels and used as input to the MVPA. Compared to placebo, remifentanil increased the delta band and decreased the theta and alpha band oscillations as a mean over all channels (all p = 0.007). The most discriminative channels in these frequency bands were F1 in delta (83.33%, p = 0.0023) and theta bands (95.24%, p
PubMed ID
25250670 View in PubMed
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223 records – page 1 of 23.