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Airway obstruction in relation to symptoms in chronic respiratory disease--a nationally representative population study.

https://arctichealth.org/en/permalink/ahliterature198285
Source
Respir Med. 2000 Apr;94(4):356-63
Publication Type
Article
Date
Apr-2000
Author
L. von Hertzen
A. Reunanen
O. Impivaara
E. Mälkiä
A. Aromaa
Author Affiliation
The Finnish Lung Health Association, Helsinki. lvhertzen@filha.fi
Source
Respir Med. 2000 Apr;94(4):356-63
Date
Apr-2000
Language
English
Publication Type
Article
Keywords
Adult
Aged
Bronchitis - complications - epidemiology
Chronic Disease
Cold Temperature - adverse effects
Dyspnea - epidemiology - etiology
Emphysema - complications - epidemiology
Female
Finland - epidemiology
Forced expiratory volume
Humans
Lung Diseases, Obstructive - epidemiology - etiology
Male
Middle Aged
Odds Ratio
Population Surveillance
Prevalence
Questionnaires
Smoking - adverse effects
Abstract
We examined the severity of airway obstruction and the occurrence of respiratory symptoms in a large, nationally representative population sample and in a subgroup of subjects with chronic bronchitis and/or emphysema to obtain information for developing national prevention and treatment strategies for these diseases. The study population comprised of 7217 randomly selected subjects (aged 30 years and older) who participated in a comprehensive health examination survey. The 'cases' were subjects diagnosed as having chronic bronchitis and/or emphysema. The survey methods comprised of questionnaires, interviews, physical measurements, including spirometry, and clinical examinations. In the whole study population, the age-adjusted prevalence of chronic bronchitis and/or emphysema was 22% among men and 7% among women, whilst clinically relevant airways obstruction (FEV1/FVC%
PubMed ID
10845434 View in PubMed
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Association of overweight, trauma and workload with coxarthrosis. A health survey of 7,217 persons.

https://arctichealth.org/en/permalink/ahliterature220211
Source
Acta Orthop Scand. 1993 Oct;64(5):513-8
Publication Type
Article
Date
Oct-1993
Author
M. Heliövaara
M. Mäkelä
O. Impivaara
P. Knekt
A. Aromaa
K. Sievers
Author Affiliation
Social Insurance Institution, Helsinki, Finland.
Source
Acta Orthop Scand. 1993 Oct;64(5):513-8
Date
Oct-1993
Language
English
Publication Type
Article
Keywords
Adult
Aged
Body mass index
Body Weight
Cluster analysis
Cross-Sectional Studies
Female
Finland - epidemiology
Humans
Leg Injuries - complications
Male
Middle Aged
Odds Ratio
Osteoarthritis, Hip - epidemiology - etiology
Prevalence
Retrospective Studies
Risk factors
Stress, mechanical
Abstract
In a population sample health survey, body mass, previous trauma and physical stress were studied for associations with coxarthrosis. A sample of 8,000 persons representative of the Finnish population aged 30 or over was invited for examination, and 90 percent participated. On the basis of a standardized clinical examination, a physician diagnosed coxarthrosis in 6 percent of the women and 4 percent of the men. The prevalence rose with age. In persons with a past traumatic lower-limb injury, the odds ratio of unilateral coxarthrosis was 2.1 and of bilateral coxarthrosis 1.5, as adjusted for sex, age and other determinants using logistic regression. The sum index reflecting self-reported features of physical stress in present or previous occupations was directly proportional to the prevalence of coxarthrosis. Body mass index (kg/m2) was closely associated with bilateral coxarthrosis; the adjusted odds ratio (95 percent confidence intervals) for indices > 35, compared to those
PubMed ID
8237314 View in PubMed
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Cancer incidence among 78,000 asthmatic patients.

https://arctichealth.org/en/permalink/ahliterature219765
Source
Int J Epidemiol. 1993 Dec;22(6):976-82
Publication Type
Article
Date
Dec-1993
Author
E. Vesterinen
E. Pukkala
T. Timonen
A. Aromaa
Author Affiliation
Department of Allergic Diseases, Helsinki University Central Hospital, Finland.
Source
Int J Epidemiol. 1993 Dec;22(6):976-82
Date
Dec-1993
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Asthma - complications
Colonic Neoplasms - epidemiology - etiology
Female
Finland - epidemiology
Humans
Incidence
Leukemia - epidemiology - etiology
Lung Neoplasms - epidemiology - etiology
Male
Middle Aged
Neoplasms - epidemiology - etiology
Registries
Risk factors
Sex Factors
Abstract
The risk of cancer was evaluated among 77,952 asthma patients with bronchial asthma. The series was obtained through linkage of two registers: the Finnish Social Insurance Institution's file of asthma patients and the Finnish Cancer Registry. There was a significant excess risk of lung cancer in both sexes, the standardized incidence ratio (SIR) being 1.32 among men and 1.66 among women. In women, the risk of cancer of the rectum was significantly increased (SIR 1.42), whereas the risks of cancer of the corpus uteri and multiple myeloma were lower than expected (SIR 0.76 and 0.53, respectively). In men, the incidence of cancer of the larynx was significantly reduced (SIR 0.63) and that of the bladder increased (SIR 1.25). When both sexes were combined, cancers of the colon (SIR 1.17) and rectum (SIR 1.28) also showed a significantly elevated risk. A reduction in risk was seen in stomach cancer (SIR 0.88) and lymphatic leukaemia (SIR 0.55). The increased lung cancer risk may be due to local inflammatory changes. It is possible that differences in the immune system, e.g. natural killer cell activity, explain some of the reduced cancer risks.
PubMed ID
8144310 View in PubMed
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Changes in the prevalence and incidence of diabetes mellitus in Finnish adults, 1970-1987.

https://arctichealth.org/en/permalink/ahliterature226396
Source
Am J Epidemiol. 1991 May 1;133(9):850-7
Publication Type
Article
Date
May-1-1991
Author
M. Laakso
A. Reunanen
T. Klaukka
A. Aromaa
J. Maatela
K. Pyörälä
Author Affiliation
Department of Medicine, Kuopio University Central Hospital, Finland.
Source
Am J Epidemiol. 1991 May 1;133(9):850-7
Date
May-1-1991
Language
English
Publication Type
Article
Keywords
Adult
Body mass index
Diabetes Mellitus - epidemiology - etiology - therapy
Female
Finland - epidemiology
Humans
Incidence
Male
Middle Aged
Obesity - complications - diagnosis - epidemiology
Population Surveillance
Prevalence
Registries
Risk factors
Survival Rate
Abstract
Prevalence and incidence of known diabetes mellitus in Finnish subjects aged 30 years or over in 1970-1987 were investigated using a nationwide register of drug recipients and four population surveys. On the basis of the drug-register data, the prevalence of drug-treated diabetes in men increased from 1.5% in 1970 to 2.8% in 1987. In women, the prevalence increased from 2.1% in 1970 to 3.0% in 1979 and declined thereafter slightly to 2.7% in 1987. The increase in the prevalence of drug-treated diabetes was mainly due to the increase of diabetes in the age groups 60 years and older. The prevalence of all known diabetic subjects in the population studies increased from 2.1% in the health examination survey of 1966-1972 (n = 38,676) to 3.5% in the interview survey of 1976 (n = 10,657) and to 4.5% in the health examination survey of 1979-1980 (n = 7,217) but decreased to 3.3% in the interview survey in 1987 (n = 9,522). The increased prevalence of obesity in men and better survival may be important factors contributing to the increasing prevalence rates of diabetes in Finnish subjects aged 30 years and over.
PubMed ID
2028975 View in PubMed
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Circulating anti-Helicobacter pylori immunoglobulin A antibodies and low serum pepsinogen I level are associated with increased risk of gastric cancer.

https://arctichealth.org/en/permalink/ahliterature211464
Source
Am J Epidemiol. 1996 Jul 15;144(2):142-9
Publication Type
Article
Date
Jul-15-1996
Author
A. Aromaa
T U Kosunen
P. Knekt
J. Maatela
L. Teppo
O P Heinonen
M. Härkönen
M K Hakama
Author Affiliation
National Public Health Institute, Helsinki, Finland.
Source
Am J Epidemiol. 1996 Jul 15;144(2):142-9
Date
Jul-15-1996
Language
English
Publication Type
Article
Keywords
Aged
Antibodies, Bacterial - blood
Case-Control Studies
Female
Finland - epidemiology
Gastritis, Atrophic - microbiology
Helicobacter Infections - complications - enzymology - immunology
Helicobacter pylori - immunology
Humans
Immunoglobulin A - blood
Incidence
Male
Middle Aged
Odds Ratio
Pepsinogens - blood
Population Surveillance
Prospective Studies
Risk
Risk factors
Stomach Neoplasms - epidemiology - microbiology
Abstract
Helicobacter pylori infection has been suggested to be associated with an increased risk of gastric cancer, and low levels of serum pepsinogen I (PG I) have been linked to atrophic gastritis, which is a risk factor for gastric cancer. In Finland, 39,268 persons from 25 cohorts participated during 1968-1972 in a health examination survey and were followed for up to 13 years. A nested case-control study was performed on 84 stomach cancer patients identified from the Finnish Cancer Registry and 146 controls matched for age, sex, and municipality. Serum samples drawn at the baseline study were analyzed. An elevated level of serum anti-H. pylori immunoglobulin A (IgA) antibodies (a titer > or = 70) and a low serum PG I level ( or = 700), the odds ratio was only 1.50 (95% CI 0.70-3.22). When both high IgA and low PG I were present, the odds ratio was 5.96 (95% CI 2.02-17.57). The association of H. pylori infection with cancer became stronger with longer follow-up times, whereas that of low PG I was strongest at shorter follow-up times. Our findings support the hypothesis that H. pylori infection is a prevalent and potentially preventable cause of gastric cancer. They stress the value of IgA antibody determinations and provide new evidence for a pathogenesis leading from prolonged infection through atrophic gastritis to gastric cancer.
PubMed ID
8678045 View in PubMed
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Decreasing prevalence of helicobacter antibodies in Finland, with reference to the decreasing incidence of gastric cancer.

https://arctichealth.org/en/permalink/ahliterature195086
Source
Epidemiol Infect. 2001 Feb;126(1):37-42
Publication Type
Article
Date
Feb-2001
Author
L. Rehnberg-Laiho
H. Rautelin
P. Koskela
S. Sarna
E. Pukkala
A. Aromaa
P. Knekt
T U Kosunen
Author Affiliation
Department of Bacteriology and Immunology, Haartmnan Institute, University of Helsinki, Finland.
Source
Epidemiol Infect. 2001 Feb;126(1):37-42
Date
Feb-2001
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Antibodies, Bacterial - blood
Female
Finland - epidemiology
Helicobacter Infections - complications - epidemiology
Helicobacter pylori - immunology - isolation & purification
Humans
Immunoenzyme Techniques - methods
Immunoglobulin G - blood
Incidence
Middle Aged
Pregnancy
Risk factors
Seroepidemiologic Studies
Stomach Neoplasms - epidemiology - etiology
Time Factors
Abstract
Time trends and geographical variation of Helicobacter pylori antibodies in Finland were investigated by enzyme immunoassay in 20- to 34-year-old randomly selected females from six localities during 1969-73 (n = 375), and 15- to 45-year-old females representing nine communities and four geographical areas in 1983 (n = 882) and 1995 (n = 842). In the six communities investigated at three different time points, the overall prevalence declined from 38 to 12%, with an emphasis on the latter 12 years. The regionally varying rate of decrease in helicobacter prevalence changed the pre-existing geographical variation, leaving northern Finland with the highest rate. A 10%-units higher local helicobacter prevalence seemed to predict a 23% (95% CI 3-44%) higher gastric cancer incidence 20 years later. The overall decline in helicobacter seropositivity is consistent with earlier reports from Finland and other developed countries, and supports the cohort theory as an explanation for the age-related increase in H. pylori seroprevalence.
PubMed ID
11293681 View in PubMed
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Depression and cardiovascular diseases.

https://arctichealth.org/en/permalink/ahliterature219289
Source
Acta Psychiatr Scand Suppl. 1994;377:77-82
Publication Type
Article
Date
1994
Author
A. Aromaa
R. Raitasalo
A. Reunanen
O. Impivaara
M. Heliövaara
P. Knekt
V. Lehtinen
M. Joukamaa
J. Maatela
Author Affiliation
Social Insurance Institution, Helsinki, Finland.
Source
Acta Psychiatr Scand Suppl. 1994;377:77-82
Date
1994
Language
English
Publication Type
Article
Keywords
Adult
Aged
Cardiovascular Diseases - complications - mortality - psychology
Causality
Cause of Death
Comorbidity
Coronary Disease - mortality - psychology
Cross-Sectional Studies
Depressive Disorder - complications - mortality - psychology
Female
Finland - epidemiology
Follow-Up Studies
Humans
Longitudinal Studies
Male
Middle Aged
Risk factors
Survival Rate
Abstract
We first review the associations between depression and cardiovascular diseases (CVDs). Then we examine them in the nationally representative Mini-Finland Health Survey, which covers 8,000 persons. Chronic somatic diseases and mental disorders were diagnosed using standardized methods. Cross-sectionally, CVDs and neurotic depression were associated both before and after adjustment for covariates. The strongest associations were observed in the case of severe CVDs. During a 6.6 year follow-up, the risk of CVD death and coronary death was elevated in depressed persons both with and without CVDs at entry. Much of the cross-sectional association is probably due to depression caused by CVDs. The outcome of CVD may be poorer in depressed persons. The hypothesis that depression is a cause of CVDs requires further study.
PubMed ID
8053372 View in PubMed
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Determinants of osteoporotic thoracic vertebral fracture. Screening of 57,000 Finnish women and men.

https://arctichealth.org/en/permalink/ahliterature224024
Source
Acta Orthop Scand. 1992 Apr;63(2):198-202
Publication Type
Article
Date
Apr-1992
Author
S. Santavirta
Y T Konttinen
M. Heliövaara
P. Knekt
P. Lüthje
A. Aromaa
Author Affiliation
Orthopedic Hospital of the Invalid Foundation, Helsinki, Finland.
Source
Acta Orthop Scand. 1992 Apr;63(2):198-202
Date
Apr-1992
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aging
Cross-Sectional Studies
Epidemiologic Factors
Female
Finland - epidemiology
Humans
Male
Middle Aged
Odds Ratio
Osteoporosis - complications
Population Surveillance
Prevalence
Risk factors
Sex Factors
Spinal Fractures - epidemiology - etiology
Thoracic Vertebrae - injuries
Abstract
A population sample of 27,000 Finnish women and 30,000 men was studied for the presence of a thoracic vertebral fracture. In both sexes, the prevalence of such fractures increased with age: after 40 years of age in the men and after 55 years of age in the women. The interaction of sex and age was significant, and even when the other determinants were adjusted for. In the women aged 35-44, 55-64, and 75 years or more, the prevalence per 1,000 was respectively 2.4, 5.1, and 29, and in the men in the corresponding age groups 5.2, 15, and 28. A previous history of trauma was a fracture determinant in both sexes. In the men, but not in the women, there was an increased risk of fracture when there was a history of tuberculosis and/or peptic ulcer, and in current smokers. Thus, contrary to observations on extremity fractures, the men had an increased risk of sustaining a thoracic vertebral fracture compared with the women. This may reflect differences in the development of osteoporosis in the axial skeleton versus the appendicular skeleton.
PubMed ID
1590058 View in PubMed
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Diffuse idiopathic skeletal hyperostosis (DISH) and spondylosis deformans as predictors of cardiovascular diseases and cancer.

https://arctichealth.org/en/permalink/ahliterature244926
Source
Scand J Rheumatol. 1981;10(3):241-8
Publication Type
Article
Date
1981
Author
H. Julkunen
A. Aromaa
P. Knekt
Source
Scand J Rheumatol. 1981;10(3):241-8
Date
1981
Language
English
Publication Type
Article
Keywords
Adult
Aged
Cardiovascular Diseases - etiology
Exostoses - complications
Female
Finland
Follow-Up Studies
Humans
Male
Middle Aged
Neoplasms - etiology
Risk
Spinal Osteophytosis - complications
Abstract
The associations between DISH (diffuse skeletal Hyperostosis) and spondylosis deformans on the one hand and cardiovascular disease and cancer on the other were studied in a follow-up investigation of 6 167 persons in Finland. Mean duration of follow-up investigation of 6 167 persons in Finland. Mean duration of follow-up was 6.3 years. Similar methods were employed in the baseline and follow-up examination. A finding of DISH or of spondylosis was based on a reading of lateral X-ray films. Age-adjusted incidence of hypertension, ECG findings suggesting coronary heart disease (CHD), CHD history, enlargement of the heart determined by interpretation of photofluorograms, digitalis medication, cerebrovascular incidents and a history of cancer were compared in persons with and without DISH/spondylosis and free of these conditions at baseline. A further analysis, in which the data were analysed separately for DISH and spondylosis present at baseline and cases which developed during follow-up, was also carried out. A slight association between DISH and spondylosis, and hypertension probably due to obesity was observed. According to several criteria degenerative heart disease (CHD, heart enlargement, digitalis use) was associated with DISH and spondylosis, particularly in men. An association with heart enlargement was observed with DISH but not with spondylosis. No associations with cerebrovascular accidents or cancer were observed, but the paucity of cases prevents definite conclusions. Thus, there were some difference between spondylosis and DISH with regard to risk of future cardiovascular disease.
PubMed ID
7291956 View in PubMed
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Does antibacterial treatment for urinary tract infection contribute to the risk of breast cancer?

https://arctichealth.org/en/permalink/ahliterature199075
Source
Br J Cancer. 2000 Mar;82(5):1107-10
Publication Type
Article
Date
Mar-2000
Author
P. Knekt
H. Adlercreutz
H. Rissanen
A. Aromaa
L. Teppo
M. Heliövaara
Author Affiliation
National Public Health Institute, Helsinki, Finland.
Source
Br J Cancer. 2000 Mar;82(5):1107-10
Date
Mar-2000
Language
English
Publication Type
Article
Keywords
Adult
Age Distribution
Aged
Aged, 80 and over
Anti-Bacterial Agents - adverse effects - therapeutic use
Breast Neoplasms - chemically induced - epidemiology
Female
Finland - epidemiology
Follow-Up Studies
Humans
Longitudinal Studies
Middle Aged
Risk factors
Urinary Tract Infections - complications - drug therapy
Abstract
Low lignan status has been reported to be related to an elevated risk of breast cancer. Since lignan status is reduced by antibacterial medications, it is plausible to hypothesize that repeated use of antibiotics may also be a risk factor for breast cancer. History of treatment for urinary tract infection was studied for its prediction of breast cancer among 9,461 Finnish women 19-89 years of age and initially cancer-free. During a follow-up in 1973-1991, a total of 157 breast cancer cases were diagnosed. Women reporting previous or present medication for urinary tract infection at baseline showed an elevated breast cancer risk in comparison with other women. The age-adjusted relative risk was 1.34 (95% confidence interval (CI) = 0.98-1.83). The association was concentrated to women under 50 years of age. The relative risk for these women was 1.74 (95% CI 1.13-2.68), whereas it was 0.97 (95% CI 0.59-1.58) for older women. The relative risk in the younger age-group was 1.47 (95% CI 0.73-2.97) during the first 10 years of follow-up, and 1.93 (95% CI 1.11-3.37) for follow-up times longer than 10 years. These data suggest that premenopausal women using long-term medication for urinary tract infections show a possible elevated risk of future breast cancer. The results are, however, still inconclusive and the hypothesis needs to be tested by other studies.
Notes
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Cites: Lancet. 1982 Dec 11;2(8311):1295-96128595
Cites: J Appl Bacteriol. 1985 Jan;58(1):37-432984153
Cites: J Steroid Biochem. 1986 Nov;25(5B):791-73027456
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Cites: Am J Med Sci. 1997 Oct;314(4):245-99332263
Cites: N Engl J Med. 1992 Jul 30;327(5):319-281620171
PubMed ID
10737394 View in PubMed
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31 records – page 1 of 4.