ACC/AHA/ESC guidelines recommend sublingual nitroglycerin (SNG) in patients with stable angina pectoris and coronary artery disease (CAD). However, the shelf life of SNG following first use is six months for SNG tablets and two years for SNG sprays. We investigated the frequency of prescription of SNG tablets/sprays in patients having anginal symptoms and documented CAD and the awareness levels of patients about appropriate use of SNG.
Three hundred patients (201 men, 99 women; mean age 61.7±10.8 years) with documented CAD and angina were enrolled into this study. Angina pectoris was categorized according to the functional classification system of the Canadian Cardiovascular Society. Data on cardiovascular past histories, risk factors, medications, and the use of SNG were recorded.
At least one risk factor was present in 96% of the patients. Only 46% of the patients had a prescription for SNG. Of those with a prescription of SNG tablet and spray, 91.8% and 84.4% did not know the shelf life of the product, respectively. Of those who were routinely carrying SNG, 35.6% had an expired product. Of those with a prescription of SNG, only 65.9% were informed by the physician on the proper use of SNG.
Our results show that, despite recommendations of the guidelines, SNG is not prescribed to a substantial percentage of patients with CAD and angina, a considerable fraction of patients carry an expired product, and that patients are not adequately informed by the physicians on the use of SNG. These problems will certainly affect the optimal medical management of CAD and its efficacy.
Idiopathic chronic eosinophilic pneumonia (ICEP) is a rare cause of chronic lung disease in children and adolescents. We described four-years old boy presenting with recurrent pneumonia and symptoms of bronchial asthma. Because of peripheral eosinophilia and bilateral pulmonary infiltrates patient investigated comprehensive and chronic eosinophilic pneumonia determined histopathologically. Other conditions causing eosinophilic pneumonia were ruled out. He showed a dramatic response to oral corticosteroid therapy. This report emphasizes that ICEP should be considered in pediatric age group on a cause for chronic hypoxemi or intractable symptoms of respiratory system.
The aim of this study was to investigate the presence of Herpes simplex virus (HSV) type 1 and type 2 DNA from the clinical samples sent to our routine laboratory, by real-time polymerase chain reaction (PCR). A total of 328 samples collected from 306 female and 7 male patients who were admitted to different outpatient clinics were included in the study. The samples included 235 cervical swab samples (of which 150 were from pregnant women), 77 amniotic fluid, 8 blood, 6 cerebrospinal fluid (CSF), one pericardial fluid and one cervical biopsy. DNA extraction were performed with High Pure Viral Nucleic Acid Kit (Roche, Germany) and amplified in Light Cycler (Roche, Germany) with a commercial amplification mix (Metis Biotechnology, Ankara). HSV-DNA positivity were found in 2.1% of the cervical samples (three of 150 pregnant and two of 85 non-pregnant women), two of the blood samples and one of the CSF sample, while there were no positive result for the other clinical specimens. It can be concluded that, real-time PCR would be preferred in conditions requiring rapid diagnosis such as HSV infections of central nervous system and HSV suspected infections of immunosupressed patients, as a rapid and practical method.
Human Parvovirus (HPV) is a DNA virus which causes the aplastic rises in the chronic hemolytic anemias. HPV IgG was found positive in the newborns with CMV and Rubella negative congenital intrauterine infection. Recently, it was reported that nonimmunologic hydrops fetalis caused by HPV Now, HPV (especially B 19) is a well known virus which takes significant place in the public health and pediatrics.