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Diseases associated with the low copy number of the C4B gene encoding C4, the fourth component of complement.

https://arctichealth.org/en/permalink/ahliterature93811
Source
Cytogenet Genome Res. 2008;123(1-4):118-30
Publication Type
Article
Date
2008
Author
Szilágyi A.
Fust G.
Author Affiliation
3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary.
Source
Cytogenet Genome Res. 2008;123(1-4):118-30
Date
2008
Language
English
Publication Type
Article
Keywords
Complement C4 - genetics - metabolism
Disease - genetics
Gene Dosage - genetics
Humans
Phenotype
Polymorphism, Genetic - genetics
Risk factors
Abstract
In this review article, earlier and recent work of the research group on the copy number polymorphism of the C4B gene are summarized. In a study performed in 1991 a sharp decrease was found among healthy elderly (>60 years old) people as compared to healthy young (
PubMed ID
19287146 View in PubMed
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Serum complement C3/C4 ratio, a novel marker for recurrent cardiovascular events.

https://arctichealth.org/en/permalink/ahliterature164347
Source
Am J Cardiol. 2007 Apr 1;99(7):890-5
Publication Type
Article
Date
Apr-1-2007
Author
Anil Palikhe
Juha Sinisalo
Mikko Seppänen
Heikki Haario
Seppo Meri
Ville Valtonen
Markku S Nieminen
Marja-Liisa Lokki
Author Affiliation
Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland.
Source
Am J Cardiol. 2007 Apr 1;99(7):890-5
Date
Apr-1-2007
Language
English
Publication Type
Article
Keywords
Aged
Alleles
Analysis of Variance
Angina, Unstable - blood - mortality
Biological Markers - blood
Cerebral Infarction - blood - mortality
Complement C3 - genetics - metabolism
Complement C4 - genetics - metabolism
Coronary Disease - blood - epidemiology
Female
Finland - epidemiology
Follow-Up Studies
Humans
Inflammation Mediators - blood
Kaplan-Meier Estimate
Logistic Models
Male
Middle Aged
Myocardial Infarction - blood - mortality
Natriuretic Peptide, Brain - blood
Proportional Hazards Models
Randomized Controlled Trials as Topic
Recurrence
Risk factors
Sensitivity and specificity
Survival Analysis
Syndrome
Abstract
Acute coronary syndrome is an inflammatory disease, during which the complement cascade is activated. We assessed the complement C3 and C4 concentration ratio (C3/C4 ratio) in serum as a potential measurement to predict cardiovascular attacks. Patients with acute coronary syndrome (n=148) were followed after an initial attack for subsequent ischemic cardiovascular events (composite end point of death, myocardial infarction, recurrent unstable angina, or stroke). During the follow-up period (average 555 days), 44 patients met an end point. Blood samples were taken at hospitalization, 1 week, 3 months, and 1 year after hospital admission. Serum complement C3 and C4 concentrations and the C3/C4 ratio were analyzed. Patients with an end point had, throughout the follow-up period, a higher C3/C4 ratio than patients without these end points (repeated measures analysis of variance, p=0.007). When all traditional cardiovascular risk factors and other potential confounding factors were included in a Cox multivariate logistic regression survival analysis, the C3/C4 ratio emerged as the novel risk factor for any new cardiovascular event (odds ratio 1.33, 95% confidence interval 1.08 to 1.63, p=0.007). When the C3/C4 ratio was divided into 4 quartiles, 24% in quartiles 1 and 2 (lowest) and 48% in quartile 4 (highest) had end points during follow-up (odds ratio 3.04, 95% confidence interval 1.27 to 7.29, p=0.01). In conclusion, increased serum C3/C4 ratio is a readily available and novel marker for recurrent cardiovascular events in acute coronary syndrome. The relative increase in serum C3 protein and decrease in C4 protein could explain changes in the C3/C4 ratio.
PubMed ID
17398178 View in PubMed
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