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10148 records – page 1 of 1015.

A 1-year comparison of turbuhaler vs pressurized metered-dose inhaler in asthmatic patients.

https://arctichealth.org/en/permalink/ahliterature11215
Source
Chest. 1996 Jul;110(1):53-7
Publication Type
Article
Date
Jul-1996
Author
R A Pauwels
F E Hargreave
P. Camus
M. Bukoski
E. Ståhl
Author Affiliation
Department of Respiratory Diseases, University Hospital, Ghent, Belgium.
Source
Chest. 1996 Jul;110(1):53-7
Date
Jul-1996
Language
English
Publication Type
Article
Keywords
Administration, Inhalation
Adrenergic beta-Agonists - administration & dosage
Adult
Asthma - drug therapy - physiopathology
Bronchodilator Agents - administration & dosage
Budesonide
Comparative Study
Female
Glucocorticoids - administration & dosage
Humans
Male
Nebulizers and Vaporizers
Peak Expiratory Flow Rate
Pregnenediones - administration & dosage
Research Support, Non-U.S. Gov't
Terbutaline - administration & dosage
Abstract
An open, randomized, parallel-group study was conducted to investigate whether asthmatic patients, considered adequately treated with a corticosteroid and/or short-acting beta 2-agonist via pressurized metered-dose inhaler (pMDI), could be transferred to a corresponding nominal dose of budesonide and/or terbutaline via Turbuhaler, an inspiratory flow-driven multidose dry powder inhaler (Astra Draco; Lund, Sweden), without a decrease in the effect of treatment. One thousand four patients (555 women; mean age, 44 years; mean peak expiratory flow [PEF], 102% predicted normal value) were randomized and treated with either pMDI (current therapy) or Turbuhaler for 52 weeks. The variables studied were asthma-related events, morning PEF, and inhaler-induced clinical symptoms. Asthma-related events were defined in two ways: (1) sum of health-care contacts plus doublings or additions of steroids, and (2) number of 2 consecutive days with PEF less than 80% of baseline. Baseline was obtained from a 2-week run-in period while receiving previous therapy. No statistically significant difference was found in asthma-related events according to definition 1. According to definition 2, there was a statistically significant difference between the groups in favor of Turbuhaler (p = 0.008). The mean number of events was 1.7 with Turbuhaler and 2.2 with pMDI. The mean number of weeks per patient with a PEF less than 90% of baseline was 4.5 with Turbuhaler compared with 6.0 with pMDI (p = 0.002). The sum of inhaler-induced symptoms after 1 year of use was statistically significantly lower with Turbuhaler (0.40) than with pMDI (0.75) (p = 0.0001). In conclusion, budesonide and terbutaline in Turbuhaler offered a superior alternative to corticosteroids and bronchodilators delivered by pMDIs in the maintenance treatment of asthma.
PubMed ID
8681664 View in PubMed
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A 1-year follow-up of low birth weight infants with and without bronchopulmonary dysplasia: health, growth, clinical lung disease, cardiovascular and neurological sequelae.

https://arctichealth.org/en/permalink/ahliterature59584
Source
Early Hum Dev. 1992 Sep;30(2):109-20
Publication Type
Article
Date
Sep-1992

[2 cities or: Contrasts within mental deficiency care]

https://arctichealth.org/en/permalink/ahliterature43050
Source
Ugeskr Laeger. 1974 Mar 11;136(11):611-4
Publication Type
Article
Date
Mar-11-1974

A 2-dose regimen of a recombinant hepatitis B vaccine with the immune stimulant AS04 compared with the standard 3-dose regimen of Engerix-B in healthy young adults.

https://arctichealth.org/en/permalink/ahliterature56626
Source
Scand J Infect Dis. 2002;34(8):610-4
Publication Type
Article
Date
2002
Author
K. Levie
I. Gjorup
P. Skinhøj
M. Stoffel
Source
Scand J Infect Dis. 2002;34(8):610-4
Date
2002
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Belgium
Comparative Study
Denmark
Dose-Response Relationship, Drug
Female
Hepatitis B - prevention & control
Hepatitis B Antibodies - analysis
Hepatitis B Surface Antigens - analysis
Hepatitis B vaccines - administration & dosage
Humans
Immunity - physiology
Immunization - methods
Immunization Schedule
Male
Reference Values
Research Support, Non-U.S. Gov't
Sensitivity and specificity
Single-Blind Method
Vaccines, Synthetic - administration & dosage
Abstract
An open-label randomized study was undertaken to compare a 2-dose regimen (Months 0 and 6) of hepatitis B surface antigen (HBsAg) vaccine formulated with a novel adjuvant (HBsAg/AS04) with a standard 3-dose regimen (Months 0, 1 and 6) of licensed recombinant HBsAg vaccine in terms of immunogenicity and reactogenicity when administered to healthy subjects aged between 15 and 40 y. At 1 and 6 months after the full vaccination course there was a 100% seroprotection rate (anti-HBs > or = 10 mIU/ml) with the HBsAg/AS04 vaccine, compared with a 99% response rate with the licensed vaccine. The corresponding geometric mean titres were significantly higher for the novel vaccine compared to the standard vaccine: 15,468 and 2,745 mIU/ml at Months 7 and 12 vs. 6,274 and 1,883 mIU/ml, respectively. There was a higher prevalence of local symptoms with the adjuvant vaccine (90% of doses) than with the standard vaccine (48% of doses). However, these symptoms (pain, swelling and redness) were predominantly of mild-to-moderate intensity and resolved rapidly without treatment. A 2-dose regimen of the new HBsAg/AS04 adjuvant vaccine therefore compared favourably to the standard regimen in healthy young adults. It is anticipated that the simplified vaccination schedule may improve compliance and reduce costs.
PubMed ID
12238579 View in PubMed
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[3, 4, or more. An epidemic of multiple pregnancies]

https://arctichealth.org/en/permalink/ahliterature65051
Source
Lakartidningen. 1991 Jul 10;88(28-29):2435-7
Publication Type
Article
Date
Jul-10-1991
Author
B S Lindberg
Author Affiliation
Kvinnokliniken, Akademiska sjukhuset, Uppsala.
Source
Lakartidningen. 1991 Jul 10;88(28-29):2435-7
Date
Jul-10-1991
Language
Swedish
Publication Type
Article
Keywords
Comparative Study
Costs and Cost Analysis
Female
Great Britain
Humans
Pregnancy
Pregnancy, Multiple - physiology - psychology
Risk factors
Socioeconomic Factors
Sweden
PubMed ID
1857168 View in PubMed
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[3',5'-cAMP phosphodiesterase inhibitors in the combined treatment of patients with rheumatoid arthritis]

https://arctichealth.org/en/permalink/ahliterature14188
Source
Lik Sprava. 1998 Aug;(6):34-7
Publication Type
Article
Date
Aug-1998
Author
O I Bakaliuk
M I Shved
M V Hrebenyk
Source
Lik Sprava. 1998 Aug;(6):34-7
Date
Aug-1998
Language
Ukrainian
Publication Type
Article
Keywords
3',5'-Cyclic-Nucleotide Phosphodiesterase - antagonists & inhibitors
Antirheumatic Agents - therapeutic use
Arthritis, Rheumatoid - drug therapy - immunology - metabolism
Combined Modality Therapy
Comparative Study
Drug Evaluation
English Abstract
Glucosephosphate Dehydrogenase - blood - drug effects
Humans
Immunity, Cellular - drug effects
Immunity, Natural - drug effects
Lipid Peroxidation - drug effects
Papaverine - therapeutic use
Phosphodiesterase Inhibitors - therapeutic use
Prospidium - therapeutic use
Abstract
A study was made of clinical effectiveness and mechanism of action of the inhibitor of the specific 3',5'-cAMP phosphodiesterase papaverine in a therapeutic complex of measures designed to treat RA patients involving an immunodepressive preparation free from any cytopenic effect prospidin as a basic mediator. It has been shown that the papaverine antiarthritic action is associated with its positive effects on the unspecific component of the immune-complex inflammation, viz. processes of lipid peroxidation, activity of the antioxidant system of defence as well as on the vascular tone and microcirculation. All this improves tissue metabolism, and in this way enhances efficiency of RA basic therapy.
PubMed ID
9844866 View in PubMed
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3M diffractive multifocal intraocular lens: eight year follow-up.

https://arctichealth.org/en/permalink/ahliterature50890
Source
J Cataract Refract Surg. 2000 Mar;26(3):402-7
Publication Type
Article
Date
Mar-2000
Author
J E Slagsvold
Author Affiliation
Eye Department, ASA, Arendal, Norway.
Source
J Cataract Refract Surg. 2000 Mar;26(3):402-7
Date
Mar-2000
Language
English
Publication Type
Article
Keywords
Aged
Aphakia, Postcataract - surgery
Capsulorhexis
Comparative Study
Follow-Up Studies
Humans
Lens Implantation, Intraocular
Lenses, Intraocular
Phacoemulsification
Polymethyl Methacrylate
Postoperative Complications
Prosthesis Design
Refraction, Ocular
Reoperation
Retrospective Studies
Treatment Outcome
Visual acuity
Abstract
PURPOSE: To study the long-term results of implantation of the 3M diffractive multifocal intraocular lens (IOL). SETTING: Eye Department, ASA, Arendal, Norway. METHODS: The study comprised 97 eyes in 72 patients. Follow-up was 8 years. Distance and near visual acuities, refractive results, contrast sensitivity, IOL centration, and neodymium:YAG (Nd:YAG) capsulotomies to treat posterior capsule opacification were evaluated. RESULTS: All patients without ocular pathology achieved a best corrected visual acuity (BCVA) of 0.5 or better (i.e., 98.7% had a BCVA of 1.0 or better). Without correction, 73.8% of eyes had a Jaeger acuity of J3 or better and with distance correction, 92.1%. Emmetropia or within +/-0.25 diopter (D) of it was achieved in 58.8% of eyes. An astigmatic shift of 0.827 D cylinder correction was induced. This shift was mainly against the rule (0.717 D). Contrast sensitivity was reduced with spatial frequencies of 6 to 18 cycles per degree. No need for spectacles was reported by 54.2% of patients and by 68.0% of those with bilateral implantation. For near tasks, 63.9% of patients never used spectacles. The IOLs were well centered or minimally decentered in 99.0% of eyes. Posterior capsule opacification was treated by Nd:YAG laser capsulotomy in 55.7% of eyes, with a mean time between surgery and treatment of 34.0 months +/- 23.2 (SD). CONCLUSION: This long-term study proved the 3M diffractive IOL to be safe and effective despite some reduction in contrast sensitivity at higher spatial frequencies. More than half the patients never wore spectacles; 2 of 3 patients with IOLs in both eyes never wore spectacles. Proper patient selection is crucial.
PubMed ID
10713237 View in PubMed
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The 3 mm skin prick test (SPT) threshold criterion is not reliable for Tyrophagus putrescentiae: the re-evaluation of SPT criterion to dust mites.

https://arctichealth.org/en/permalink/ahliterature71486
Source
Allergy. 2002 Dec;57(12):1187-90
Publication Type
Article
Date
Dec-2002
Author
B. Kanceljak-Macan
J. Macan
D. Plavec
T. Klepac
S. Milkovic-Kraus
Author Affiliation
Institute for Medical Research and Occupational Health, Zagreb, Croatia.
Source
Allergy. 2002 Dec;57(12):1187-90
Date
Dec-2002
Language
English
Publication Type
Article
Keywords
Adult
Antibody Specificity - immunology
Comparative Study
Croatia
Cross Reactions - immunology
Dermatophagoides farinae - immunology
Dermatophagoides pteronyssinus - immunology
Female
Humans
Immunoglobulin E - blood - immunology
Male
Middle Aged
Proteins - immunology
Pyroglyphidae - immunology
Regression Analysis
Reproducibility of Results
Sensitivity and specificity
Skin Tests - standards
Urban health
Abstract
BACKGROUND: The mean wheal diameter >/= 3 mm is the usual criterion for positive skin prick test (SPT) reaction to dust mites. The study assessed the accuracy of this SPT criterion with respect to specific IgE values of above 0.35 kUA/l (+ sIgE). METHODS: Specific IgE (ImmunoCAP, Pharmacia AB Diagnostics, Uppsala, Sweden) and standard SPT to Dermatophagoides pteronyssinus (DP) and farinae (DF), Lepidoglyphus destructor (LD) and Tyrophagus putrescentiae (TP) (ALK, Hørsholm, Denmark) were performed in a random sample of 457 subjects, of whom 273 men (mean age 35.3 +/- 11.0 years) and 184 women (mean age 37.9 +/- 9.5 years). Statistical analysis was performed using the chi-square test, regression analysis and discriminant analysis. RESULTS: When the mean wheal diameter of >/= 3 mm was considered positive (+ SPT), the correlation between + SPT and + sIgE was 0.47 for DP (P
PubMed ID
12464048 View in PubMed
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A 3-year follow-up of a multidisciplinary rehabilitation programme for back and neck pain.

https://arctichealth.org/en/permalink/ahliterature61395
Source
Pain. 2005 Jun;115(3):273-83
Publication Type
Article
Date
Jun-2005
Author
Jensen IB
Bergström G
Ljungquist T
Bodin L
Author Affiliation
Section for Personal Injury Prevention, Karolinska Institutet, Box 127 18, 112 94 Stockholm, Sweden. irene.jensen@cns.ki.se
Source
Pain. 2005 Jun;115(3):273-83
Date
Jun-2005
Language
English
Publication Type
Article
Keywords
Adult
Back Pain - economics - rehabilitation
Cognitive Therapy
Comparative Study
Cost-Benefit Analysis
Delivery of Health Care - utilization
Employment
Female
Follow-Up Studies
Health Care Costs
Humans
Male
Middle Aged
Neck Pain - economics - rehabilitation
Pensions
Physical Therapy (Specialty) - economics - organization & administration
Program Evaluation
Quality of Life
Rehabilitation - economics - organization & administration
Research Support, Non-U.S. Gov't
Sick Leave
Abstract
The aim of the present study was to evaluate the long-term outcome of a behavioural medicine rehabilitation programme and the outcome of its two main components, compared to a 'treatment-as-usual' control group. The study employed a 4 x 5 repeated-measures design with four groups and five assessment periods during a 3-year follow-up. The group studied consisted of blue-collar and service/care workers on sick leave, identified in a nationwide health insurance scheme in Sweden. After inclusion, the subjects were randomised to one of the four conditions: behaviour-oriented physiotherapy (PT), cognitive behavioural therapy (CBT), behavioural medicine rehabilitation consisting of PT+CBT (BM) and a 'treatment-as-usual' control group (CG). Outcome variables were sick leave, early retirement and health-related quality of life. A cost-effectiveness analysis, comparing the programmes, was made. The results showed, consistently, the full-time behavioural medicine programme being superior to the three other conditions. The strongest effect was found on females. Regarding sick leave, the mean difference in the per-protocol analysis between the BM programme and the control group was 201 days, thus reducing sick leave by about two-thirds of a working year. Rehabilitating women has a substantial impact on costs for production losses, whereas rehabilitating men seem to be effortless with no significant effect on either health or costs. In conclusion, a full-time behavioural medicine programme is a cost-effective method for improving health and increasing return to work in women working in blue-collar or service/care occupations and suffering from back/neck pain.
PubMed ID
15911154 View in PubMed
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6-bit and 8-bit digital radiography for detecting simulated periodontal lesions.

https://arctichealth.org/en/permalink/ahliterature51165
Source
Oral Surg Oral Med Oral Pathol. 1994 Apr;77(4):406-11
Publication Type
Article
Date
Apr-1994
Author
B. Pass
A J Furkart
S B Dove
W D McDavid
P H Gregson
Author Affiliation
Division of Oral and Maxillofacial Radiology, Faculty of Dentistry, Dalhousie University, Halifax, Nova Scotia, Canada.
Source
Oral Surg Oral Med Oral Pathol. 1994 Apr;77(4):406-11
Date
Apr-1994
Language
English
Publication Type
Article
Keywords
Analysis of Variance
Comparative Study
Contrast Sensitivity
Dental Caries - radiography
Humans
Mandible - radiography
Periodontal Diseases - radiography
ROC Curve
Radiographic Image Enhancement - methods
Reproducibility of Results
Abstract
The purpose of this study was to compare the diagnostic performance of a digital radiography system that uses 6- and 8-bit displays with conventional D-speed film for the detection of simulated periodontal bone lesions. Eleven human hemimandibles were used as specimens. Simulated lesions were created at the buccal cortical plate in the marginal bone area with the use of a round bur 1.4 mm in diameter. Lesions were created in a defined sequence to preclude visual cues as to the depth of the lesions. Lesion size progressed in 0.5 mm increments. At each stage the mandibles were imaged with a Sens-A-Ray system (REGAM Medical Systems AB, Sundsvall, Sweden) and D-speed film. Exposure parameters for each specimen/receptor combination were standardized by either the mean optical density or mean gray value at the approximal crestal bone area. Film images and digital images displayed with 64 and 256 gray levels were presented to six observers for evaluation. Observers were ask to rate their confidence as to the presence or absence of a lesion using a 5-point confidence scale. A total of 96 lesion sites and 96 control sites were presented to the observers. Receiver operating characteristic curves were generated for each system. The area under the curve was used as the index of diagnostic accuracy. The mean receiver operating characteristic areas for 6-bit and 8-bit displays and D-speed film were 0.746 +/- 0.043, 0.717 +/- 0.056 and 0.742 +/- 0.059, respectively. Analysis of variance was used to compare the means. No statistical difference was found between any of the three image displays (p > 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
PubMed ID
8015807 View in PubMed
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10148 records – page 1 of 1015.