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The Norwegian dietary guidelines and colorectal cancer survival (CRC-NORDIET) study: a food-based multicentre randomized controlled trial.
BMC Cancer. 2017 Jan 30;17(1):83
Publication Type
HB Henriksen
H. Ræder
SK Bøhn
I. Paur
AS Kværner
SÅ Billington
MT Eriksen
G. Wiedsvang
I. Erlund
A. Færden
MB Veierød
M. Zucknick
S. Smeland
R. Blomhoff
BMC Cancer. 2017 Jan 30;17(1):83
Publication Type
Aged, 80 and over
Colorectal Neoplasms - diet therapy - mortality - pathology
Disease-Free Survival
Middle Aged
Multicenter Studies as Topic
Neoplasm Recurrence, Local - mortality - prevention & control
Oxidative Stress
Randomized Controlled Trials as Topic
Research Design
Treatment Outcome
Colorectal cancer survivors are not only at risk for recurrent disease but also at increased risk of comorbidities such as other cancers, cardiovascular disease, diabetes, hypertension and functional decline. In this trial, we aim at investigating whether a diet in accordance with the Norwegian food-based dietary guidelines and focusing at dampening inflammation and oxidative stress will improve long-term disease outcomes and survival in colorectal cancer patients.
This paper presents the study protocol of the Norwegian Dietary Guidelines and Colorectal Cancer Survival study. Men and women aged 50-80 years diagnosed with primary invasive colorectal cancer (Stage I-III) are invited to this randomized controlled, parallel two-arm trial 2-9 months after curative surgery. The intervention group (n?=?250) receives an intensive dietary intervention lasting for 12 months and a subsequent maintenance intervention for 14 years. The control group (n?=?250) receives no dietary intervention other than standard clinical care. Both groups are offered equal general advice of physical activity. Patients are followed-up at 6 months and 1, 3, 5, 7, 10 and 15 years after baseline. The study center is located at the Department of Nutrition, University of Oslo, and patients are recruited from two hospitals within the South-Eastern Norway Regional Health Authority. Primary outcomes are disease-free survival and overall survival. Secondary outcomes are time to recurrence, cardiovascular disease-free survival, compliance to the dietary recommendations and the effects of the intervention on new comorbidities, intermediate biomarkers, nutrition status, physical activity, physical function and quality of life.
The current study is designed to gain a better understanding of the role of a healthy diet aimed at dampening inflammation and oxidative stress on long-term disease outcomes and survival in colorectal cancer patients. Since previous research on the role of diet for colorectal cancer survivors is limited, the study may be of great importance for this cancer population. Identifier: NCT01570010 .
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PubMed ID
28137255 View in PubMed
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Whole grain intake and survival among Scandinavian colorectal cancer patients.
Nutr Cancer. 2014;66(1):6-13
Publication Type
Guri Skeie
Tonje Braaten
Anja Olsen
Cecilie Kyrø
Anne Tjønneland
Lena Maria Nilsson
Rikard Landberg
Eiliv Lund
Author Affiliation
a Department of Community Medicine , University of Tromsø , Tromsø , Norway.
Nutr Cancer. 2014;66(1):6-13
Publication Type
Colorectal Neoplasms - diet therapy
Dietary Fiber - administration & dosage
Food Habits
Life Style
Middle Aged
Proportional Hazards Models
Prospective Studies
Risk factors
To our knowledge, no studies of associations between intake of whole grain (WHG) and survival of colorectal cancer have been published, despite evidence that dietary fiber, and to some extent WHG, are associated with lower risk of colorectal cancer. Scandinavia is an area where the WHG consumption traditionally is high. We performed a case-only (N = 1119) study in the Scandinavian HELGA cohort of pre-diagnosis WHG intake (total WHG, WHG wheat, WHG rye, and WHG oats) and survival of colorectal cancer. Cox regression analyses were used to study the associations, both in categorical and continuous models, stratified by location (proximal, distal, rectum) and country. No evidence of an association was found, neither for total WHG intake (hazard ratio = 1.32, 95% confidence interval: 0.88-1.97 lowest vs. highest tertile, adjusted for age at diagnosis, metastasis status, smoking, folate, margarine, and energy), nor for specific grains. Prediagnosis consumption of WHG does not seem to improve survival of colorectal cancer in subjects diagnosed within this prospective population-based Scandinavian cohort.
PubMed ID
24274588 View in PubMed
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