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Role of the intestinal microbiota in resistance to colonization by Clostridium difficile.

https://arctichealth.org/en/permalink/ahliterature105040
Source
Gastroenterology. 2014 May;146(6):1547-53
Publication Type
Article
Date
May-2014
Author
Robert A Britton
Vincent B Young
Author Affiliation
Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan.
Source
Gastroenterology. 2014 May;146(6):1547-53
Date
May-2014
Language
English
Publication Type
Article
Keywords
Animals
Anti-Bacterial Agents - adverse effects
Bile Acids and Salts - metabolism
Biological Therapy - methods
Clostridium difficile - growth & development - metabolism - pathogenicity
Disease Models, Animal
Dysbiosis
Enterocolitis, Pseudomembranous - metabolism - microbiology - prevention & control
Feces - microbiology
Host-Pathogen Interactions
Humans
Intestines - drug effects - metabolism - microbiology
Microbiota - drug effects
Probiotics - therapeutic use
Abstract
Antibiotic-associated infection with the bacterial pathogen Clostridium difficile is a major cause of morbidity and increased health care costs. C difficile infection follows disruption of the indigenous gut microbiota by antibiotics. Antibiotics create an environment within the intestine that promotes C difficile spore germination, vegetative growth, and toxin production, leading to epithelial damage and colitis. Studies of patients with C difficile infection and animal models have shown that the indigenous microbiota can inhibit expansion and persistence of C difficile. Although the specific mechanisms of these processes are not known, they are likely to interfere with key aspects of the pathogen's physiology, including spore germination and competitive growth. Increasing our understanding of how the intestinal microbiota manage C difficile could lead to better means of controlling this important nosocomial pathogen.
PubMed ID
24503131 View in PubMed
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