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[Acetylcholine-cholinesterase-choline acetylase system in the brain tissue of cats]

https://arctichealth.org/en/permalink/ahliterature13358
Source
Ukr Biokhim Zh. 1974 Jan-Feb;46(1):54-6
Publication Type
Article

Age-related reductions in brain cholinergic and dopaminergic indices in two rat strains differing in longevity.

https://arctichealth.org/en/permalink/ahliterature12595
Source
Brain Res. 1987 Apr 7;408(1-2):247-50
Publication Type
Article
Date
Apr-7-1987
Author
G M Gilad
V H Gilad
Source
Brain Res. 1987 Apr 7;408(1-2):247-50
Date
Apr-7-1987
Language
English
Publication Type
Article
Keywords
Acetylcholine - metabolism
Aging - metabolism
Animals
Brain - metabolism
Choline - metabolism
Choline O-Acetyltransferase - metabolism
Comparative Study
Dopamine - metabolism
Longevity
Male
Rats
Rats, Inbred BN
Rats, Inbred WKY
Species Specificity
Synaptosomes - metabolism
Abstract
We have recently reported that inbred Wistar-Kyoto rats which are highly reactive to stressful stimuli, have a much shorter mean life-span (21.5) compared to the less reactive Brown-Norway rats (31.0 +/- 4.5 months). In the present study we found a reduction in forebrain cholinergic neurotransmission indices in 24-month-old Wistar-Kyotos but not in Brown-Norways as compared to their respective young (3-month-old) counterparts. Also only in Wistar-Kyotos dopamine uptake was reduced in the aged striatum, but in the septum it remained unchanged in both strains. In Brown-Norways, age-related changes were observed only in choline acetyltransferase activity and only in brain regions known to contain mainly cholinergic nerve cell bodies. We conclude that at 24 months of age, reductions in brain cholinergic and dopaminergic neurotransmission are more prominent in the highly stress-reactive and shorter-lived Wistar-Kyoto strain, and may be genetically determined.
PubMed ID
3594213 View in PubMed
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Aging and stress-induced changes in choline and glutamate uptake in hippocampus and septum of two rat strains differing in longevity and reactivity to stressors.

https://arctichealth.org/en/permalink/ahliterature12259
Source
Int J Dev Neurosci. 1990;8(6):709-13
Publication Type
Article
Date
1990
Author
G M Gilad
V H Gilad
Y. Tizabi
Author Affiliation
Neuropsychiatry Branch, NIMH Neuroscience Center, Saint Elizabeths Hospital, Washington, DC 20032.
Source
Int J Dev Neurosci. 1990;8(6):709-13
Date
1990
Language
English
Publication Type
Article
Keywords
Aging - metabolism
Animals
Brain - metabolism
Choline - metabolism
Glutamates - metabolism
Glutamic Acid
Hippocampus - metabolism
Longevity
Male
Rats
Rats, Inbred Strains - metabolism - physiology
Septum Pellucidum - metabolism
Stress - metabolism
Abstract
Stress induced changes in neurochemical indices of neurotransmission are more pronounced in the septohippocampal cholinergic system of Wistar Kyoto rats, which are behaviorally more reactive to stressors and have a shorter life span, than in Brown Norway rats. Moreover, pronounced degeneration of septohippocampal cholinergic neurons occurs earlier in life in Wistar Kyoto rats. In the present study the high affinity synaptosomal uptakes of choline and glutamate were used as indices for cholinergic and glutamatergic systems respectively. Following 2 hr of mild restrain stress increases in both uptake systems were observed in all regions examined (hippocampus, septum and frontal cortex). The stress-induced increases were generally similar in young (3 months) and aged (20 months) rats of both strains. The noted exception was that choline uptake levels, which were reduced in the hippocampus of unhandled aged WKY rats, remained unchanged after stress. The results confirm the involvement of the septohippocampal cholinergic system in the response to acute stress and extend the findings to include the hippocamposeptal glutamatergic system activation as well. It is suggested that in spite of neuronal degeneration during aging, these responses to stress can be maintained by compensatory efforts of neurons that remain intact.
PubMed ID
1981122 View in PubMed
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[Availability of Mg2+, Na+, and K+-ATPase in the nuclei of the skeletal muscles of rabbits normally and during experimental muscular dystrophy]

https://arctichealth.org/en/permalink/ahliterature13296
Source
Ukr Biokhim Zh. 1975 Jan-Feb;47(1):31-5
Publication Type
Article
Author
A I Sylakova
O L Konoplyts'ka
T N Huseva
Source
Ukr Biokhim Zh. 1975 Jan-Feb;47(1):31-5
Language
Ukrainian
Publication Type
Article
Keywords
Adenosine Triphosphate - metabolism
Adenosinetriphosphatase - metabolism
Animals
Cesium - metabolism
Chlorides - metabolism
Choline - metabolism
English Abstract
Lithium - metabolism
Magnesium - metabolism
Muscles - drug effects - metabolism
Muscular Dystrophy, Animal - metabolism
Ouabain - pharmacology
Potassium - metabolism
Rabbits
Sodium - metabolism
Abstract
A comparative study was carried out in the properties of ATPase system of the skeletal muscle nuclei in the rabbits in norm and with experimental muscular dystrophy conditioned by E-avitaminosis. It is shown that in the system, containing 1.5 mM of MgCl2, ATPase system of the nuclei is activated by sodium and potassium ions. In norm maximum activation is observed with their presence in the medium, the concentration being 80 and 70 mM, respectively. With experimental muscular dystrophy maximum activating concentrations decrease and are equal for both cations - 30 mM. Activation of the enzymatic system by these ions is specific because the introduction of equimolar quantities of cholin-chloride or lithium, cesium ions instead of sodium ions into the incubation medium evokes no activation of the ATPase system of the rabbit skeletal muscles both in norm and with experimental muscular dystrophy. A simultaneous presence of sodium and potassium ions in optimum concentrations in the incubation medium makes for an increase of ATPase activity to the same extent as the presence of one of these cations. Oubain, a specific inhibitor of Mg2+, Na+, K+- ATPase, taken in the concentrations of 10(-4) and 10(-3) M did not decrease the intensity of ATP hydrolysis and its activation conditioned by the presence of sodium or potassium. A conclusion is made that Mg2+, Na+, K+-ATPase taking part in the work of "sodium pump" is absent in the nuclei of skeletal muscles.
PubMed ID
128169 View in PubMed
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Effect of low-choline diet and ethanol on electroconductivity of tissues in CBA mice.

https://arctichealth.org/en/permalink/ahliterature81943
Source
Bull Exp Biol Med. 2005 Nov;140(5):506-9
Publication Type
Article
Date
Nov-2005
Author
Tornuev Yu V
Nepomnyashchikh L M
Koldysheva E V
Author Affiliation
Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
Source
Bull Exp Biol Med. 2005 Nov;140(5):506-9
Date
Nov-2005
Language
English
Publication Type
Article
Keywords
Adrenal Cortex - metabolism
Adrenal Glands - metabolism
Animal Feed
Animals
Central Nervous System Depressants - pharmacology
Choline - metabolism - pharmacology
Cytoplasm - metabolism
Diet
Electrophysiology - methods
Ethanol - pharmacology
Male
Mice
Mice, Inbred CBA
Spleen - metabolism
Time Factors
Abstract
We studied electrophysiological parameters and morphological changes in the adrenal glands and spleen of CBA mice feeding a low-choline diet and/or ethanol-containing diet. The polarization coefficient underwent similar changes in the adrenal glands and spleen, which was associated with different contribution of impedance frequency components. Morphological changes in the adrenal glands were more pronounced than in the spleen and consisted in delipidation of the adrenocortical cell cytoplasm in the zona fasciculata and increase in cell heterogeneity in the zona reticularis of animals of different groups. The observed morphological and electrophysiological changes can serve as a criterion of the severity of stress. The method for a quantitative study of tissue electroconductivity is informative for evaluation of the effects of internal and external factors on organs and tissues.
PubMed ID
16758610 View in PubMed
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[Effect of nicotinic acid and prozerin on choline metabolism]

https://arctichealth.org/en/permalink/ahliterature13250
Source
Ukr Biokhim Zh. 1975 Nov-Dec;47(6):739-42
Publication Type
Article
Author
O M Vasylyev
M E Kucherenko
Source
Ukr Biokhim Zh. 1975 Nov-Dec;47(6):739-42
Language
Ukrainian
Publication Type
Article
Keywords
Animals
Brain - drug effects - metabolism
Choline - metabolism
English Abstract
Liver - drug effects - metabolism
Muscles - drug effects - metabolism
Neostigmine - pharmacology
Nicotinic Acids - pharmacology
Organ Specificity
Phosphorylcholine - metabolism
Rats
Abstract
The content and specific activity of labelled methyl groups of choline and phosphorylcholine in the brain, liver and skeletal muscles of rats was studied as affected by nicotinic acid and prozerin, injected subcutaneously 4h before decapitation. It was found that under the effect of prozerin the specific activity of choline lowers only in the muscles and nicotinic acid evokes its decrease in the liver and muscles. The specific activity of phosphorylcholine lowers in the brain and liver with introduction of prozerin and nicotinic acid. The intensity of phosphorylcholine phosphate renewal increases in the liver and skeletal muscles after introduction of both prozerin and nicotinic acid. The activity of choline dehydrogenase in the liver homogenates lowers only with injection of nicotinic acid.
PubMed ID
1202708 View in PubMed
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[Metabolism of ATP in rat tissues under different experimental states]

https://arctichealth.org/en/permalink/ahliterature13271
Source
Ukr Biokhim Zh. 1975 May-Jun;47(3):374-8
Publication Type
Article
Author
Z M Miroshnychenko
M Ie Kucherenko
B O Tsudzevych
Source
Ukr Biokhim Zh. 1975 May-Jun;47(3):374-8
Language
Ukrainian
Publication Type
Article
Keywords
Adenosine Triphosphate - metabolism
Animals
Brain - metabolism
Choline - metabolism
English Abstract
Liver - metabolism
Methionine - metabolism
Muscles - metabolism
Neostigmine - pharmacology
Nicotinic Acids - pharmacology
Organ Specificity
Rats
Vagotomy
Abstract
The content and incorporation intensity of tritium from methionine CH33-groups as well as ATP phosphorus renewal of the skeletal muscles, liver and brain were studied in albino rats as effected by proserin, nicotinic acid and the vagus cutting. It is established that the organs and tissues with a high metabolic activity of ATP are characterized by a higher level of its renewal of ATP. Proserin and the vagus cutting are most likely to affect the renewal of ATP through choline metabolism. Nicotinic acid may affect the renewal of ATP through pyridine nucleotides in the process of oxidative phosphorylation.
PubMed ID
1216353 View in PubMed
Less detail

Myo-inositol changes precede amyloid pathology and relate to APOE genotype in Alzheimer disease.

https://arctichealth.org/en/permalink/ahliterature282328
Source
Neurology. 2016 May 10;86(19):1754-61
Publication Type
Article
Date
May-10-2016
Author
Olga Voevodskaya
Pia C Sundgren
Olof Strandberg
Henrik Zetterberg
Lennart Minthon
Kaj Blennow
Lars-Olof Wahlund
Eric Westman
Oskar Hansson
Source
Neurology. 2016 May 10;86(19):1754-61
Date
May-10-2016
Language
English
Publication Type
Article
Keywords
Aged
Alzheimer Disease - diagnostic imaging - epidemiology - genetics - metabolism
Amyloidogenic Proteins - metabolism
Apolipoprotein E4 - genetics
Aspartic Acid - analogs & derivatives - metabolism
Brain - diagnostic imaging - metabolism
Brain Mapping
Choline - metabolism
Cognition Disorders - diagnostic imaging - epidemiology - genetics - metabolism
Cross-Sectional Studies
Female
Humans
Inositol - metabolism
Longitudinal Studies
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Male
Positron-Emission Tomography
Prodromal Symptoms
Prospective Studies
Sweden - epidemiology
tau Proteins - cerebrospinal fluid
Abstract
We aimed to test whether in vivo levels of magnetic resonance spectroscopy (MRS) metabolites myo-inositol (mI), N-acetylaspartate (NAA), and choline are abnormal already during preclinical Alzheimer disease (AD), relating these changes to amyloid or tau pathology, and functional connectivity.
In this cross-sectional multicenter study (a subset of the prospective Swedish BioFINDER study), we included 4 groups, representing the different stages of predementia AD: (1) cognitively healthy elderly with normal CSF ß-amyloid 42 (Aß42), (2) cognitively healthy elderly with abnormal CSF Aß42, (3) patients with subjective cognitive decline and abnormal CSF Aß42, (4) patients with mild cognitive decline and abnormal CSF Aß42 (Ntotal = 352). Spectroscopic markers measured in the posterior cingulate/precuneus were considered alongside known disease biomarkers: CSF Aß42, phosphorylated tau, total tau, [(18)F]-flutemetamol PET, f-MRI, and the genetic risk factor APOE.
Amyloid-positive cognitively healthy participants showed a significant increase in mI/creatine and mI/NAA levels compared to amyloid-negative healthy elderly (p
Notes
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PubMed ID
27164711 View in PubMed
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[On choline and adrenalinergic activity in uterine mucosa in climacteric disorders of women]

https://arctichealth.org/en/permalink/ahliterature13619
Source
Pediatr Akus Ginekol. 1966 May-Jun;3:63-4
Publication Type
Article

Quantification of metabolites from single-voxel in vivo 1H NMR data of normal human brain by means of time-domain data analysis.

https://arctichealth.org/en/permalink/ahliterature11357
Source
MAGMA. 1995 Sep-Dec;3(3-4):129-36
Publication Type
Article
Author
M. Ala-Korpela
J P Usenius
J. Keisala
A. van den Boogaart
P. Vainio
J. Jokisaari
S. Soimakallio
R. Kauppinen
Author Affiliation
Department of Physical Sciences, University of Oulu, Finland.
Source
MAGMA. 1995 Sep-Dec;3(3-4):129-36
Language
English
Publication Type
Article
Keywords
Aspartic Acid - analogs & derivatives - metabolism
Brain - anatomy & histology - metabolism
Choline - metabolism
Comparative Study
Creatine - metabolism
Humans
Magnetic Resonance Spectroscopy - methods
Protons
Research Support, Non-U.S. Gov't
Signal Processing, Computer-Assisted
Abstract
We present here a combination of time-domain signal analysis procedures for quantification of human brain in vivo 1H NMR spectroscopy (MRS) data. The method is based on a separate removal of a residual water resonance followed by a frequency-selective time-domain line-shape fitting analysis of metabolite signals. Calculation of absolute metabolite concentrations was based on the internal water concentration as a reference. The estimated average metabolite concentrations acquired from six regions of normal human brain with a single-voxel spin-echo technique for the N-acetylaspartate, creatine, and choline-containing compounds were 11.4 +/- 1.0, 6.5 +/- 0.5, and 1.7 +/- 0.2 mumol kg-1 wet weight, respectively. The time-domain analyses of in vivo 1H MRS data from different brain regions with their specific characteristics demonstrate a case in which the use of frequency-domain methods pose serious difficulties.
PubMed ID
8749730 View in PubMed
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13 records – page 1 of 2.