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Acute-phase proteins and incidence of diabetes: a population-based cohort study.

https://arctichealth.org/en/permalink/ahliterature279590
Source
Acta Diabetol. 2016 Dec;53(6):981-989
Publication Type
Article
Date
Dec-2016
Author
Iram Faqir Muhammad
Yan Borné
Bo Hedblad
Peter M Nilsson
Margaretha Persson
Gunnar Engström
Source
Acta Diabetol. 2016 Dec;53(6):981-989
Date
Dec-2016
Language
English
Publication Type
Article
Keywords
Acute-Phase Proteins - analysis
Aged
C-Reactive Protein - analysis
Ceruloplasmin - analysis
Diabetes Mellitus - blood - epidemiology
Female
Follow-Up Studies
Haptoglobins - analysis
Humans
Incidence
Male
Middle Aged
Orosomucoid - analysis
Proportional Hazards Models
Risk factors
Sweden - epidemiology
alpha 1-Antitrypsin - analysis
Abstract
To examine the relationship between plasma levels of the acute-phase proteins ceruloplasmin, alpha-1-antitrypsin, orosomucoid, haptoglobin and C-reactive protein (CRP), and incidence of diabetes in the population-based Malmö Diet and Cancer Study-Cardiovascular Cohort (MDCS-CC).
The study population consists of 4246 participants (aged 46-67 years, 60.8 % women) with no previous history of diabetes. Participants were followed, and incidence of diabetes was assessed by linkage with national registers and a clinical re-examination of the cohort. Cox proportional hazard regression analysis was used to compare incidence of diabetes in relation to sex-specific quartiles of the acute-phase proteins.
During a mean follow-up period of 15.6 ± 3.4 years, a total of 390 participants were diagnosed with diabetes. Orosomucoid, haptoglobin, and CRP showed a significant increased risk of diabetes after adjustment for potential confounders. However, further adjustments for fasting glucose at baseline resulted in significant association only for CRP. The multivariable-adjusted hazard ratios (HR: 4th vs. 1st quartile) were 1.18 (95 % CI: 0.83-1.67; p = 0.51), 1.19 (CI: 0.85-1.62; p = 0.10), and 1.40 (CI: 1.01-1.95; p = 0.046) for orosomucoid, haptoglobin, and CRP respectively.
The study demonstrated that there are associations between orosomucoid, haptoglobin and CRP and the risk of incidence of diabetes. However, after additional adjustment for fasting glucose levels at baseline, the association stayed significant only for CRP.
PubMed ID
27581604 View in PubMed
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[Ceruloplasmin, transferrin and insulin blood levels in those with diabetes mellitus type II and in nondiabetics who participated in the clean-up after the Chernobyl accident]

https://arctichealth.org/en/permalink/ahliterature47673
Source
Lik Sprava. 2001 May-Jun;(3):14-6
Publication Type
Article
Author
N A Zueva
L N Iukhimuk
T I Gerasimenko
A N Kovalenko
A S Efimov
Source
Lik Sprava. 2001 May-Jun;(3):14-6
Language
Russian
Publication Type
Article
Keywords
Accidents, Radiation
Adult
Ceruloplasmin - analysis
Cohort Studies
Comparative Study
Diabetes Mellitus, Type 2 - blood - epidemiology
Dose-Response Relationship, Radiation
English Abstract
Female
Follow-Up Studies
Humans
Insulin - blood
Male
Middle Aged
Power Plants
Transferrin - analysis
Ukraine - epidemiology
Abstract
In those persons who had taken part in the elimination of the effects of the Chernobyl accident (AEEP), an oxidative stress with disturbed functioning of the antioxidant defence extracellular factors ceruloplasmin and transferrin is recordable over a long time range together with direct and indirect manifestations of insulin resistance. Submitted in the paper is an analysis of indices for ceruloplasmin, transferrin, free iron (FI), and insulin in the blood plasma of AEEP in different age groups and in those AEEP suffering from type II diabetes mellitus (DM) as well. The group of comparison was participants in the military operations (MOP) in Afghanistan. In the older age group AEEP (beyond 40 years of age) and in those AEEP presenting with type II DM similar alterations have been shown to be the case, such as decrease in the content of transferrin and augmentation of ceruloplasmin against the background of hyperinsulinemia. The above alterations can be regarded as a risk factor for origination of type II DM in Chernobyl AEEP.
PubMed ID
11560002 View in PubMed
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[Changes in the activity of some enzyme systems in septic forms of pneumonia in infants]

https://arctichealth.org/en/permalink/ahliterature61076
Source
Pediatr Akus Ginekol. 1972;6:6-8
Publication Type
Article
Date
1972

[Characteristics of the clinical course of ischemic heart diseases in patients with hypertensive dyscirculatory encephalopathy]

https://arctichealth.org/en/permalink/ahliterature53895
Source
Lik Sprava. 2000 Sep;(6):57-61
Publication Type
Article
Date
Sep-2000
Author
O M Toronchenko
Source
Lik Sprava. 2000 Sep;(6):57-61
Date
Sep-2000
Language
Ukrainian
Publication Type
Article
Keywords
Adult
Aged
Angina Pectoris - diagnosis - metabolism - pathology
Catalase - blood
Cerebrovascular Disorders - diagnosis - metabolism - pathology
Ceruloplasmin - analysis
English Abstract
Humans
Hypertension - diagnosis - metabolism - pathology
Lipid Peroxidation
Malondialdehyde - blood
Middle Aged
Myocardial Ischemia - diagnosis - metabolism - pathology
Stress, Psychological - complications
Superoxide Dismutase - blood
Syndrome
Weather
Abstract
Association of ischemic heart disease (IHD) with vascular affections of the brain is the cardiocerebrovascular syndrome having common pathogenetic mechanisms of formation in the structure of cardiovascular pathology. Some specificities were studied of the clinical course of IHD concomitant with hypertensive dyscirculatory encephalopathy (HDE) in 35 patients (main group), with 25 IHD controls free from manifestations of neurological symptomatology. In IHD HDE patients the anginous syndrome is characterized by a lesser dependency on time in each period of 24 hours and physical load and greater dependency on arterial pressure, meteofactors, it is often accompanied by cephalgia appearing with the intake of antianginal drugs, dizziness, memory, sleep disturbances. The main group patients demonstrated elevated levels of LPO products, those of lipid metabolism, and the AO system tension.
PubMed ID
11452923 View in PubMed
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[Comparative evaluation of biochemical study methods in the diagnosis of biliary tract lesions in viral hepatitis in children]

https://arctichealth.org/en/permalink/ahliterature41828
Source
Pediatr Akus Ginekol. 1977 Dec;(6):22-3
Publication Type
Article
Date
Dec-1977

[Comparison of diagnostic value of some laboratory indices in rheumatism in children]

https://arctichealth.org/en/permalink/ahliterature14872
Source
Pediatr Akus Ginekol. 1969 May-Jun;3:17-8
Publication Type
Article

[Copper and ceruloplasmin in the body in benign ovarian tumors before and after treatment]

https://arctichealth.org/en/permalink/ahliterature27643
Source
Pediatr Akus Ginekol. 1977 Dec;(6):54-5
Publication Type
Article
Date
Dec-1977

Diagnostic and prognostic value of laboratory tests assessed in a follow-up study of 200 patients with liver disease.

https://arctichealth.org/en/permalink/ahliterature56994
Source
Clin Chem. 1982 May;28(5):1177-81
Publication Type
Article
Date
May-1982
Author
S. Skrede
H E Solberg
S. Ritland
J P Blomhoff
E. Schrumpf
K. Elgjo
E. Gjone
Source
Clin Chem. 1982 May;28(5):1177-81
Date
May-1982
Language
English
Publication Type
Article
Keywords
Biopsy
Blood Coagulation Factors - analysis
Ceruloplasmin - analysis
Comparative Study
Diagnosis, Differential
Diagnostic Errors
Hepatitis - diagnosis
Humans
Immunoglobulin G - analysis
Immunoglobulin M - analysis
Liver Cirrhosis, Alcoholic - diagnosis
Liver Cirrhosis, Biliary - diagnosis
Liver Diseases - blood - diagnosis - pathology
Norway
Probability
Prognosis
Retrospective Studies
Abstract
Two hundred patients with liver disease were re-studied after six to eight years. The initial routine diagnosis (mainly based on morphological criteria) was confirmed in almost 80% of cases of chronic liver disease. In chronic active hepatitis, agreement was found in 86%. An alternative classification based on cluster analysis of clinical chemical results from the first admission was also to a great extent confirmed by the follow-up study. Discriminant analysis of clinical chemical data correctly allocated 94% of patients with alcoholic cirrhosis (who had low haptoglobin and albumin) into groups with different prognosis. Clinical chemical results differed between verified and non-verified cases of primary biliary cirrhosis. By retrospective examination , we found that 15 of 16 patients with this disease or chronic active hepatitis who were initially misclassified by biopsy findings could be correctly diagnosed by discriminant analysis of clinical chemical results.
PubMed ID
7074900 View in PubMed
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28 records – page 1 of 3.