To assess the role of four biomarkers of neuroendocrine activation and endothelial dysfunction in the longitudinal prediction of fragility fractures.
We analysed a population-based prospective cohort of 5415 community-dwelling individuals (mean age, 68.9±6.2 years) enrolled in the Malmö Preventive Project followed during 8.1±2.9 years, and investigated the longitudinal association between C-terminal pro-arginine vasopressin (CT-proAVP), C-terminal endothelin-1 precursor fragment (CT-proET-1), the mid-regional fragments of pro-adrenomedullin (MR-proADM) and pro-atrial natriuretic peptide (MR-proANP), and incident vertebral, pelvic and extremity fractures.
Overall, 1030 (19.0%) individuals suffered vertebral, pelvic or extremity fracture. They were older (70.7±5.8 vs 68.4±6.3 years), more likely women (46.9% vs 26.3%), had lower body mass index and diastolic blood pressure, were more often on antihypertensive treatment (44.1% vs 38.4%) and had more frequently history of fracture (16.3% vs 8.1%). Higher levels of MR-proADM (adjusted HR (aHR) per 1 SD: 1.51, 95% CI 1.01 to 2.28, p
High incidence of cobalt deficiency (89%) was found in 7-8-year-old girls residents of the Republic of Tatarstan. Significant correlations were revealed between parameters of physical development and cardiovascular system and hair cobalt content. These data suggest that positive balance of cobalt is essential for normal growth and development of child's body and function of the cardiovascular system.
The primary aim was to determine whether incidental physical activity (IPA), expressed either as duration or intensity, was associated with cardiorespiratory fitness (CRF).
Participants were inactive abdominally obese men (n = 43, waist circumference = 102 cm) and women (n = 92, waist circumference = 88 cm) recruited from Kingston, Canada. IPA (>100 counts per minute) was determined by accelerometry during 7 d and categorized into duration (min·d(-1)) and intensity (counts per minute). In secondary analyses, IPA was further categorized as light physical activity (LPA, 100-1951 counts per minute) and sporadic moderate physical activity (MPA, = 1952 counts per minute accumulated in bouts 0.05). Sporadic MPA was associated with CRF (r2 = 0.20, P
Erratum In: Med Sci Sports Exerc. 2012 Mar;44(3):562
[Methodological approaches to the hygienic evaluation of total artificial lighting of classrooms with different light sources on the basis of the response of the cardiovascular system of schoolchildren].
Hygienic evaluation of innovative equipment in educational institutions requires the use of appropriate methods permitting to establish valuable criterias for the effectiveness of the application of new technologies. The study of the response of the cardiovascular system of schoolchildren under using different light sources allowed to establish the increase in adaptive capacities and the improvement of the functional state of the organism in LED in comparison with fluorescent lighting.
In order to study structurally functional changes of cardiovascular system and metabolic indicators at going in for sports in Yakutia, 146 men of the Yakut nationality (18-29 years) living in Yakutsk city have been surveyed. The basic group - sportsmen of high level of skill (free-style wresling, boxing) (n = 108, middle age 20.2 +/- 0.2 years). Control group - the healthy men who are not going in for sports (n = 38, middle age 24.5 +/- 0.4 years). METHODS: anthropometry, echocardiography, rheography, arterial pressure (AP), biochemical analysis of blood serum. The basic group has been divided into 2 subgroups depending on level AP (1a-AP sist from 110 to 130, group 1b-AP sist more than 130 mm Hg). Results of research have shown, that playing sports leads to specialized changes of functioning of cardiovascular system, conserned with point of view on "adaptation to function" and "sports heart". Condition of the North can promote occurrence of changes at separate sportsmen (risk group - 10%) who are shown by disorder of hemodynamic parameters at at preservation of normal values of indicators of blood lipid profile.
We studied the influence of structural and functional disorders in cardiovascular and renal system and metabolic disturbances on perinatal outcomes in pregnant women with chronic arterial hypertension. The study included 100 women with these pathologies and 30 patients with physiological pregnancy. Comprehensive evaluation of the cardiovascular system, metabolic status, and perinatal outcomes was undertaken. The results indicate that atherogenic dyslipidemia is significantly associated with the reduction of body mass while glomerular filtration rate, concentric and eccentric left ventricular hypertrophy with the decrease of both weight and height of the newborns.