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Nasopharyngeal carcinoma in Alaskan Eskimos Indians, and Aleuts: a review of cases and study of Epstein-Barr virus, HLA, and environmental risk factors.

https://arctichealth.org/en/permalink/ahliterature3613
Source
Cancer. 1980 Nov 1;46(9):2100-6
Publication Type
Article
Date
Nov-1-1980
Author
A. Lanier
T. Bender
M. Talbot
S. Wilmeth
C. Tschopp
W. Henle
G. Henle
D. Ritter
P. Terasaki
Source
Cancer. 1980 Nov 1;46(9):2100-6
Date
Nov-1-1980
Language
English
Geographic Location
U.S.
Publication Type
Article
Physical Holding
Alaska Medical Library
Keywords
Adult
Aged
Alaska
Antigens, Viral - analysis
Blood groups, general
Carcinoma - epidemiology - immunology
Diet
EBV
Ethnic Groups
Female
HLA Antigens - analysis
Head and Neck Neoplasms - epidemiology
Herpesvirus 4, Human - immunology
HLA-typing
Humans
Indians, North American
Inuits
Male
Middle Aged
Nasopharyngeal Neoplasms - epidemiology - immunology
NPC
Risk
Smoking
Abstract
The records of thirty-one patients with nasopharyngeal carcinoma (NPC) diagnosed from 1966 through 1976 among the Alaskan native population (Eskimo, Aleut, Indian) were reviewed. There were 25 males and six females, which results in relatively high incidence rates per 100,000 of 13.5 for males and 3.7 for females. Clinical and pathologic features were similar to those found among southern Chinese NPC patients. Five-year survival rate was 48%. Antibodies to Epstein-Barr virus were higher in NPC patients than in patients with other tumors or matched controls. On histocompatibility testing Sin-2 was not detected, nor was there significantly increased frequency of A2. Instead, BW40 and a second locus blank occurred more often among NPC patients than among other groups. In response to a questionnaire, NPC patients more often reported use of salt fish in the childhood diet, smoking of cigarettes, and exposure to noxious inhalants than did controls, but the differences were not statistically significant.
Notes
From: Fortuine, Robert et al. 1993. The Health of the Inuit of North America: A Bibliography from the Earliest Times through 1990. University of Alaska Anchorage.
PubMed ID
6253051 View in PubMed
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