Skip header and navigation

4 records – page 1 of 1.

EBV-positive lymphoepithelial carcinoma of salivary gland in a woman of a non-endemic area--a case report.

https://arctichealth.org/en/permalink/ahliterature3921
Source
Pol J Pathol. 2002;53(4):235-8
Publication Type
Article
Date
2002
Author
Magdalena Bialas
Anna Sinczak
Agnieszka Choinska-Stefanska
Aneta Zygulska
Author Affiliation
Department of Pathomorphology, Collegium Medicum, Jagiellonian University, Kraków.
Source
Pol J Pathol. 2002;53(4):235-8
Date
2002
Language
English
Publication Type
Article
Keywords
Aged
Carcinoma, Squamous Cell - pathology - virology
Endemic Diseases
Epstein-Barr Virus Infections - epidemiology - pathology - virology
Female
Humans
In Situ Hybridization
Poland
RNA, Messenger - analysis
Salivary Gland Neoplasms - pathology - virology
Viral Matrix Proteins - metabolism
Abstract
Lymphoepithelial carcinoma of the salivary glands is a very rare malignancy comprising not more than 0.4% of all salivary gland neoplasms in the non-endemic areas. In contrast it is much more frequent among native Greenlanders, North American Inuit (Eskimo) and Southern Chinese people living in Hong Kong. We report a case of a 74-year-old woman of Polish origin diagnosed with a lymphoepithelial carcinoma of the right parotid gland. The neoplastic cells were negative for EBV latent membrane protein (LMP-1), but in situ hybridisation for EBV mRNA (EBER) demonstrated positivity in almost all epithelial cells. No signs of EBV infection were found in the reactive lymphocytic component. The patient was treated with radiotherapy.
PubMed ID
12597342 View in PubMed
Less detail

HPV genotypes in invasive cervical cancer in Danish women.

https://arctichealth.org/en/permalink/ahliterature113113
Source
Acta Obstet Gynecol Scand. 2013 Sep;92(9):1023-31
Publication Type
Article
Date
Sep-2013
Author
Benny Kirschner
Jette Junge
Katsiaryna Holl
Mats Rosenlund
Sabrina Collas de Souza
Wim Quint
Anco Molijn
David Jenkins
Doris Schledermann
Author Affiliation
Department of Gynecology and Obstetric, Hvidovre University Hospital, Hvidovre, Denmark. benny.kirschner@dadlnet.dk
Source
Acta Obstet Gynecol Scand. 2013 Sep;92(9):1023-31
Date
Sep-2013
Language
English
Publication Type
Article
Keywords
Adenocarcinoma - pathology - virology
Adult
Aged
Aged, 80 and over
Alphapapillomavirus - genetics
Carcinoma, Squamous Cell - pathology - virology
Cross-Sectional Studies
DNA, Viral - genetics
Denmark
Female
Genotype
Humans
Middle Aged
Uterine Cervical Neoplasms - pathology - virology
Abstract
Human papillomavirus (HPV) genotype distribution in invasive cervical cancers may differ by geographic region. The primary objective of this study was to estimate HPV-genotype distribution in Danish women with a diagnosis of invasive cervical cancer.
Observational, cross-sectional.
Danish data from a multi-center study undertaken in 12 European countries.
A total of 342 archived fixed tissue samples with diagnosis of invasive cervical cancer from the Departments of Pathology in the University Hospitals in Hvidovre and Odense, Denmark, were anonymized and shipped to a central laboratory for histopathology review and PCR testing for HPV DNA. A standardized HPV-test methodology was used to enable comparison of HPV-type distribution.
Occurrence of HPV genotypes in Danish women with cervical cancer.
There were 261 samples evaluated as histologically adequate and 251 (96%) of these were HPV-positive (HPV+). The most frequent diagnosis was squamous cell carcinoma (78.9% of histological adequate and 79.3% of HPV+). Adenocarcinoma, adenosquamous carcinoma and other types were found in 14.9, 3.4 and 2.7% of the histologically adequate group and 14.7, 3.6 and 2.4% of the HPV+ group, respectively. In 92.8% of HPV+ women only a single HPV type was diagnosed. HPV-type distribution in the latter population was as follows: HPV-16: 62.2%; HPV-18: 14.6%; HPV-33: 6.9%; HPV-45: 6.4% and HPV-31: 3.4%. Of the HPV+ women, 6.4% were diagnosed with multiple HPV types and 0.8% had unknown HPV types.
HPV-16 and -18 are detected in 74.3% of Danish women with diagnosis of invasive cervical cancer, while HPV-16, -18, -31, -33, -45 and 58 are detected in 90.0% of women with invasive cervical disease.
PubMed ID
23763577 View in PubMed
Less detail

Lymphoepithelioma-like salivary gland carcinoma in Taiwan: a clinicopathological study of nine cases demonstrating a strong association with Epstein-Barr virus.

https://arctichealth.org/en/permalink/ahliterature4019
Source
Histopathology. 1997 Jul;31(1):75-82
Publication Type
Article
Date
Jul-1997
Author
T. Kuo
C. Hsueh
Author Affiliation
Department of Pathology, Chang Gung College of Medicine and Technology, Taiwan.
Source
Histopathology. 1997 Jul;31(1):75-82
Date
Jul-1997
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Carcinoma, Squamous Cell - pathology - virology
Diagnosis, Differential
Female
Herpesvirus 4, Human - isolation & purification
Humans
Immunohistochemistry
In Situ Hybridization
Male
Middle Aged
Parotid Neoplasms - pathology - virology
RNA, Viral - analysis
Research Support, Non-U.S. Gov't
Submandibular Gland Neoplasms - pathology - virology
Abstract
AIMS: Lymphoepithelioma-like carcinoma (LELC) of the salivary glands is a rather rare tumour. Previous studies have shown its strong association with Epstein-Barr virus (EBV) among Chinese and Eskimos. We tested this observation with nine Chinese patients with salivary gland LELC in Taiwan including one with coexisting nasopharyngeal carcinoma (NPC) and studied the prognostic significance of their histopathological features. METHODS AND RESULTS: This series showed a predilection for female patients and parotid glands with a median age of 50 years. Three patients died 18.5-26 months after the diagnosis including the case with NPC. Six patients were alive without recurrence for 14-45 months with a median follow-up of 34.5 months. Histopathologically, the tumours showed either lobular or diffuse growth pattern. Granulomas and/or germinal centres were observed in most cases and both B- and T-cells were found in the lymphoid infiltrates, indicating that the salivary gland LELC was capable of inducing a strong host immune reaction. Microscopic growth pattern, lymph node metastasis, and presence or absence of granulomas and/or germinal centres seemed to be important prognostic factors. Both salivary gland LELC and NPC shared similar histopathological appearance and positive immunostaining for epithelial membrane antigen and cytokeratin AE1 but not AE3. Granulomas and amyloid might occur in both tumours. A nasopharyngeal examination is indicated in patients with salivary gland LELC to exclude the possibility of coexisting or metastatic NPC. All nine cases showed positive nuclear signals for EBV-encoded RNA by in situ hybridization including the case with NPC. CONCLUSIONS: Our study and the previously published studies show that the association of salivary gland LELC and EBV is strongly related to racial and geographical factors.
PubMed ID
9253628 View in PubMed
Less detail

Malignant lymphoepithelial lesion of the parotid gland: a case report and review of the literature.

https://arctichealth.org/en/permalink/ahliterature3940
Source
Ear Nose Throat J. 2001 Nov;80(11):803-6
Publication Type
Article
Date
Nov-2001
Author
D L Wu
L. Shemen
T. Brady
D. Saw
Author Affiliation
Department of Medicine, New York Hospital Medical Center of Queens, Flushing, N.Y., USA.
Source
Ear Nose Throat J. 2001 Nov;80(11):803-6
Date
Nov-2001
Language
English
Publication Type
Article
Keywords
Carcinoma, Squamous Cell - pathology - virology
Cell Transformation, Neoplastic
Epstein-Barr Virus Infections - pathology - virology
Female
Humans
Magnetic Resonance Imaging
Middle Aged
Parotid Neoplasms - pathology - virology
Abstract
Malignant lymphoepithelial lesions are rare tumors of the major salivary glands. They most often occur in Asians and Greenland Eskimos and are strongly associated with Epstein-Barr virus infection. We report a case of a malignant lymphoepithelial lesion of the parotid gland that developed in an Italian-American woman whose serology was positive for Epstein-Barr virus antibody. The patient underwent a left total parotidectomy and upper neck dissection, followed by radiation therapy. At the 2-year follow-up, she remained free of disease.
PubMed ID
11816892 View in PubMed
Less detail