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1,3-Butadiene and leukemia among synthetic rubber industry workers: exposure-response relationships.

https://arctichealth.org/en/permalink/ahliterature166384
Source
Chem Biol Interact. 2007 Mar 20;166(1-3):15-24
Publication Type
Article
Date
Mar-20-2007
Author
Hong Cheng
Nalini Sathiakumar
John Graff
Robert Matthews
Elizabeth Delzell
Author Affiliation
University of Alabama at Birmingham, Ryals School of Public Health, Department of Epidemiology, Birmingham, AL, USA. hcheng@ms.soph.uab.edu
Source
Chem Biol Interact. 2007 Mar 20;166(1-3):15-24
Date
Mar-20-2007
Language
English
Publication Type
Article
Keywords
Butadienes - adverse effects
Canada - epidemiology
Carcinogens - chemical synthesis - chemistry - toxicity
Chemical Industry - manpower - statistics & numerical data
Confidence Intervals
Dimethyldithiocarbamate - adverse effects
Humans
Leukemia, Lymphoid - chemically induced - epidemiology
Leukemia, Myeloid - chemically induced - epidemiology
Likelihood Functions
Male
Middle Aged
Occupational Exposure - statistics & numerical data
Proportional Hazards Models
Rubber - adverse effects - chemical synthesis - chemistry
United States - epidemiology
Abstract
Previous research updated the mortality experience of North American synthetic rubber industry workers during the period 1944-1998, determined if leukemia and other cancers were associated with several employment factors and carried out Poisson regression analysis to examine exposure-response associations between estimated exposure to 1,3-butadiene (BD) or other chemicals and cancer. The present study used Cox regression procedures to examine further the exposure-response relationship between several unlagged and lagged, continuous, time-dependent BD exposure indices (BD parts per million (ppm)-years, the total number of exposures to BD concentrations >100 ppm ("peaks") and average intensity of BD) and leukemia, lymphoid neoplasms and myeloid neoplasms. All three BD exposure indices were associated positively with leukemia. Using continuous, untransformed BD ppm-years the regression coefficient (beta) from an analysis that controlled only for age was 2.9 x 10(-4) (p
PubMed ID
17123495 View in PubMed
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1,3-Butadiene: exposure estimation, hazard characterization, and exposure-response analysis.

https://arctichealth.org/en/permalink/ahliterature186649
Source
J Toxicol Environ Health B Crit Rev. 2003 Jan-Feb;6(1):55-83
Publication Type
Article
Author
K. Hughes
M E Meek
M. Walker
R. Beauchamp
Author Affiliation
Existing Substances Division, Environmental Health Directorate, Health Canada, Environmental Health Centre, Tunney's Pasture PL0802B1, Ottawa, Ontario, Canada K1A 0L2.
Source
J Toxicol Environ Health B Crit Rev. 2003 Jan-Feb;6(1):55-83
Language
English
Publication Type
Article
Keywords
Animals
Butadienes - metabolism - toxicity
Canada - epidemiology
Carcinogens, Environmental - toxicity
Environmental Exposure
Hazardous Substances - toxicity
Humans
Mutagens - toxicity
Neoplasms - chemically induced - epidemiology
Occupational Diseases - chemically induced - epidemiology
Risk assessment
Abstract
1,3-Butadiene has been assessed as a Priority Substance under the Canadian Environmental Protection Act. The general population in Canada is exposed to 1,3-butadiene primarily through ambient air. Inhaled 1,3-butadiene is carcinogenic in both mice and rats, inducing tumors at multiple sites at all concentrations tested in all identified studies. In addition, 1,3-butadiene is genotoxic in both somatic and germ cells of rodents. It also induces adverse effects in the reproductive organs of female mice at relatively low concentrations. The greater sensitivity in mice than in rats to induction of these effects by 1,3-butadiene is likely related to species differences in metabolism to active epoxide metabolites. Exposure to 1,3-butadiene in the occupational environment has been associated with the induction of leukemia; there is also some limited evidence that 1,3-butadiene is genotoxic in exposed workers. Therefore, in view of the weight of evidence of available epidemiological and toxicological data, 1,3-butadiene is considered highly likely to be carcinogenic, and likely to be genotoxic, in humans. Estimates of the potency of butadiene to induce cancer have been derived on the basis of both epidemiological investigation and bioassays in mice and rats. Potencies to induce ovarian effects have been estimated on the basis of studies in mice. Uncertainties have been delineated, and, while there are clear species differences in metabolism, estimates of potency to induce effects are considered justifiably conservative in view of the likely variability in metabolism across the population related to genetic polymorphism for enzymes for the critical metabolic pathway.
PubMed ID
12587254 View in PubMed
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5-year outcome after transcatheter aortic valve implantation.

https://arctichealth.org/en/permalink/ahliterature117830
Source
J Am Coll Cardiol. 2013 Jan 29;61(4):413-9
Publication Type
Article
Date
Jan-29-2013
Author
Stefan Toggweiler
Karin H Humphries
May Lee
Ronald K Binder
Robert R Moss
Melanie Freeman
Jian Ye
Anson Cheung
David A Wood
John G Webb
Author Affiliation
St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Source
J Am Coll Cardiol. 2013 Jan 29;61(4):413-9
Date
Jan-29-2013
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Aortic Valve - physiopathology - surgery - ultrasonography
Aortic Valve Stenosis - diagnosis - epidemiology - physiopathology - surgery
Canada - epidemiology
Equipment Failure Analysis - statistics & numerical data
Female
Heart Valve Prosthesis Implantation - adverse effects - methods - mortality - statistics & numerical data
Humans
Male
Outcome and Process Assessment (Health Care)
Postoperative Period
Prognosis
Prosthesis Design
Prosthesis Failure - etiology
Risk factors
Severity of Illness Index
Survival Rate
Survivors - statistics & numerical data
Time Factors
Treatment Outcome
Abstract
The purpose of this study was to investigate the 5-year outcome following transcatheter aortic valve implantation (TAVI).
Little is known about long-term outcomes following TAVI.
The 5-year outcomes following successful TAVI with a balloon-expandable valve were evaluated in 88 patients. Patients who died within 30 days after TAVI were excluded.
Mean aortic valve gradient decreased from 46 ± 18 mm Hg to 10 ± 4.5 mm Hg after TAVI and 11.8 ± 5.7 mm Hg at 5 years (p for post-TAVI trend = 0.06). Mean aortic valve area increased from 0.62 ± 0.17 cm(2) to 1.67 ± 0.41 cm(2) after TAVI and 1.40 ± 0.25 cm(2) at 5 years (p for post-TAVI trend
PubMed ID
23265333 View in PubMed
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7-year stability of blood pressure in the Canadian population.

https://arctichealth.org/en/permalink/ahliterature197147
Source
Prev Med. 2000 Oct;31(4):403-9
Publication Type
Article
Date
Oct-2000
Author
P T Katzmarzyk
T. Rankinen
L. Pérusse
R M Malina
C. Bouchard
Author Affiliation
Department of Kinesiology and Health Science, York University, North York, Ontario, Canada M3J IP3. katzmarz@yorku.ca
Source
Prev Med. 2000 Oct;31(4):403-9
Date
Oct-2000
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age Distribution
Aged
Aging - physiology
Blood Pressure - physiology
Body mass index
Canada - epidemiology
Child
Female
Follow-Up Studies
Humans
Hypertension - epidemiology
Incidence
Male
Middle Aged
Prevalence
Retrospective Studies
Risk factors
Sex Distribution
Abstract
The purpose of the study was to examine the 7-year stability of systolic (SBP) and diastolic (DBP) blood pressures in the Canadian population.
The sample included 1,503 participants 7-69 years of age from the 1981 Canada Fitness Survey who were remeasured in Campbell's Survey of 1988. Both SBP and DBP were adjusted for the effects of body mass index (BMI) using regression procedures.
Interage correlations from baseline to follow-up ranged from -0.17 to 0.61 for SBP and from -0.22 to 0. 51 for DBP. With few exceptions, correlations were positive and significant, and were highest and most consistent in adulthood. Further, between 27 and 39% of participants in the upper or lower quintiles in 1981 remained there in 1988. There were few differences in adiposity between those who remained in the upper or lower quintiles and those who did not. One exception was that males who remained in the upper quintile of SBP had greater values for BMI, sum of skinfolds, and waist circumference at baseline. Among adults, the best predictor of future blood pressure was baseline blood pressure, which accounted for between 12 and 34% of the variance in follow-up blood pressure, followed by age, follow-up BMI, and, in females, baseline physical activity levels.
Blood pressure demonstrated low to moderate stability over 7 years in Canada, and baseline level of adiposity was related to the stability of SBP in males.
PubMed ID
11006066 View in PubMed
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10 times as many prostate cancers in 2021?

https://arctichealth.org/en/permalink/ahliterature133774
Source
Manag Care. 2011 May;20(5):51
Publication Type
Article
Date
May-2011
Source
Manag Care. 2011 May;20(5):51
Date
May-2011
Language
English
Publication Type
Article
Keywords
Canada - epidemiology
Forecasting
Humans
Male
Prostatic Neoplasms - epidemiology
PubMed ID
21667630 View in PubMed
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A 10-year review of p-phenylenediamine allergy and related para-amino compounds at the Ottawa Patch Test Clinic.

https://arctichealth.org/en/permalink/ahliterature123867
Source
Dermatitis. 2011 Nov-Dec;22(6):332-4
Publication Type
Article
Author
Lauren LaBerge
Melanie Pratt
Bensun Fong
Genevieve Gavigan
Author Affiliation
Department of Dermatology, University of Ottawa, 1053 Carling Ave., Ottawa, Ontario, Canada. lfratesi@hotmail.com
Source
Dermatitis. 2011 Nov-Dec;22(6):332-4
Language
English
Publication Type
Article
Keywords
4-Aminobenzoic Acid - adverse effects
Allergens - adverse effects
Amines - adverse effects
Azo Compounds - adverse effects
Canada - epidemiology
Coloring Agents - adverse effects
Cross Reactions
Dermatitis, Allergic Contact - epidemiology - etiology
Female
Hair Dyes - adverse effects
Humans
Male
Occupational Exposure - adverse effects
Ontario - epidemiology
Patch Tests
Phenylenediamines - adverse effects
Sulfonamides - adverse effects
Textiles
Time Factors
Abstract
p-Phenylenediamine (PPD) is an important allergen; 5.0% of patients tested positive to PPD when patch-tested, according to the North American Contact Dermatitis Group. Hair dyes are the main source of exposure.
To assess the significance of PPD allergy at the Ottawa Patch Test Clinic.
We assessed the epidemiology of PPD allergies and determined the cross-reactivity with other para-amino compounds. Charts of patients visiting the Ottawa Patch Test Clinic between May 1997 and July 2009 were reviewed.
One hundred thirty-four patients were found to have a contact allergy to PPD; 75.4% were female, 24.6% were male, 13.4% were hairdressers, 18.7% had a history of atopy, 90.3% were sensitized by hair dye, 2.2% were sensitized by henna tattoos, and 7.5% were sensitized by other sources. Positive patch-test reactions to textile dyes were seen in 24.6%, 7.5% reacted to benzocaine, 6.0% reacted to sulfa drugs, 1.5% reacted to isopropyl-para-phenylenediamine, and 1.5% reacted to para-aminobenzoic acid.
PPD is an important source of allergic contact allergy. Our results show a significant relationship of PPD with other related para-amino compounds.
PubMed ID
22653006 View in PubMed
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12-month prevalence of depression among single and married mothers in the 1994 National Population Health Survey.

https://arctichealth.org/en/permalink/ahliterature200239
Source
Can J Public Health. 1999 Sep-Oct;90(5):320-4
Publication Type
Article
Author
J. Cairney
C. Thorpe
J. Rietschlin
W R Avison
Author Affiliation
Department of Health Studies, Brock University, St. Catharines, ON.
Source
Can J Public Health. 1999 Sep-Oct;90(5):320-4
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Canada - epidemiology
Depressive Disorder - epidemiology
Female
Humans
Marital status
Middle Aged
Mothers - psychology
Multivariate Analysis
Odds Ratio
Prevalence
Single Parent - psychology
Abstract
While a number of studies have documented higher period prevalence rates of depression among single as compared to married mothers, all of the data have been based upon community surveys of mental illness. In Canada, all of the published work comes from Ontario. As a result, we do not know whether these results hold true for other regions of the country. Using a nationally representative sample, we find, consistent with previous work, that single mothers have almost double the 12-month prevalence rates of married mothers (15.4% versus 6.8%). As well, there are no significant differences in rates of depression between single and married mothers by region/province of the country. Our findings are compared with other epidemiologic data on the mental health of single mothers from Ontario.
PubMed ID
10570576 View in PubMed
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A 12-year cohort study on adverse pregnancy outcomes in Eastern Townships of Canada: impact of endometriosis.

https://arctichealth.org/en/permalink/ahliterature256963
Source
Gynecol Endocrinol. 2014 Jan;30(1):34-7
Publication Type
Article
Date
Jan-2014
Author
Aziz Aris
Author Affiliation
Department of Obstetrics-Gynecology, Clinical Research Centre of Sherbrooke University Hospital Centre , Sherbrooke, Quebec , Canada.
Source
Gynecol Endocrinol. 2014 Jan;30(1):34-7
Date
Jan-2014
Language
English
Publication Type
Article
Keywords
Adult
Canada - epidemiology
Cohort Studies
Endometriosis - complications - epidemiology
Female
Humans
Incidence
Infant, Low Birth Weight
Infant, Newborn
Peritoneal Diseases - complications - epidemiology
Pregnancy
Pregnancy Complications - epidemiology
Pregnancy Outcome - epidemiology
Quebec - epidemiology
Young Adult
Abstract
The aim of this study was to provide a temporal-spatial reference of adverse pregnancy outcomes (APO) and examine whether endometriosis promotes APO in the same population. Among the 31?068 women who had a pregnancy between 1997 and 2008 in Eastern Townships of Canada, 6749 (21.7%) had APO. These APO increased significantly with maternal age and over time (r(2?)=?0.522, p?=?0.008); and were dominated by preterm birth (9.3%), pregnancy-induced hypertension (8.3%) including gestational hypertension (6.5%), low birth weight (6.3%), gestational diabetes (3.4%), pregnancy loss (2.2%) including spontaneous abortion (1.5%) and stillbirth (0.6%), intrauterine growth restriction (2.1%) and preeclampsia (1.8%). Among the 31?068 pregnancies, 784 (2.5%) had endometriosis and 183 (23.3%) had both endometriosis and APO. Endometriosis has been shown to increase the incidence of fetal loss (OR?=?2.03; 95% CI?=?1.42-2.90, p?
PubMed ID
24134807 View in PubMed
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8391 records – page 1 of 840.