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25-Hydroxyvitamin D Concentration and Leukocyte Telomere Length in Young Adults: Findings From the Northern Finland Birth Cohort 1966.

https://arctichealth.org/en/permalink/ahliterature273332
Source
Am J Epidemiol. 2016 Feb 1;183(3):191-8
Publication Type
Article
Date
Feb-1-2016
Author
Dylan M Williams
Saranya Palaniswamy
Sylvain Sebert
Jessica L Buxton
Alexandra I F Blakemore
Elina Hyppönen
Marjo-Riitta Jarvelin
Source
Am J Epidemiol. 2016 Feb 1;183(3):191-8
Date
Feb-1-2016
Language
English
Publication Type
Article
Keywords
Adiposity
Adult
Body mass index
C-Reactive Protein - metabolism
Cross-Sectional Studies
Female
Finland
Humans
Leukocytes
Male
Prospective Studies
Telomere Homeostasis
Vitamin D - analogs & derivatives - blood
Abstract
Higher vitamin D status, lower adiposity, and longer telomere length are each reportedly associated with lower risk of several chronic diseases and all-cause mortality. However, direct relationships between vitamin D status (measured by circulating 25-hydroxyvitamin D (25(OH)D) concentration), adiposity, and telomere length are not well established. We conducted a cross-sectional analysis of associations of 25(OH)D and body mass index (BMI; weight (kg)/height (m)(2)) with mean relative leukocyte telomere length (LTL) using data gathered on 5,096 participants from Northern Finland Birth Cohort 1966 at age 31 years (1997). 25(OH)D was not associated with LTL in either basic or confounder/mediator-adjusted models. BMI was inversely associated with LTL after adjustment for potential confounding by age, sex, socioeconomic position, physical activity, diet, smoking, alcohol intake, and use of oral contraceptives (per 1-unit increase in BMI, mean difference in LTL = -0.4%, 95% confidence interval: -0.6, -0.2). The BMI-LTL association was also independent of 25(OH)D and was attenuated slightly, but remained, after adjustment for C-reactive protein, a marker of low-grade inflammation (mean difference in LTL = -0.3%, 95% confidence interval -0.6, -0.1). These findings suggest that vitamin D status is unlikely to be an important determinant of LTL, at least by young adulthood. Inflammation may partly mediate associations of adiposity with LTL.
Notes
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PubMed ID
26797572 View in PubMed
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Acute and chronic effects of biliopancreatic diversion with duodenal switch surgery on plasma visfatin and apelin levels in patients with severe obesity.

https://arctichealth.org/en/permalink/ahliterature114747
Source
Obes Surg. 2013 Nov;23(11):1806-14
Publication Type
Article
Date
Nov-2013
Author
Sarah-Maude Caron-Cantin
Julie Martin
Marjorie Bastien
Mercedes Nancy Munkonda
Huiling Lu
Katherine Cianflone
Fady Moustarah
Laurent Biertho
Simon Marceau
Frédéric-Simon Hould
Jean Bussières
Paul Poirier
Author Affiliation
Institut universitaire de cardiologie et de pneumologie de Québec, 2725 Chemin Sainte-Foy, Quebec City, QC, Canada, G1V 4G5.
Source
Obes Surg. 2013 Nov;23(11):1806-14
Date
Nov-2013
Language
English
Publication Type
Article
Keywords
Adipose Tissue - metabolism - surgery
Adult
Apolipoproteins B - metabolism
Biliopancreatic Diversion
Body mass index
C-Reactive Protein - metabolism
Cholesterol, LDL - metabolism
Cytokines - blood
Duodenum - surgery
Female
Hemoglobin A, Glycosylated - metabolism
Humans
Inflammation - epidemiology - metabolism
Insulin Resistance
Intercellular Signaling Peptides and Proteins - blood
Male
Nicotinamide Phosphoribosyltransferase - blood
Obesity, Morbid - blood - epidemiology - surgery
Quebec - epidemiology
Treatment Outcome
Weight Loss
Abstract
Visfatin is an adipokine linked to obesity and inflammation, and it has insulin-mimetic properties. Apelin is an adipokine with positive cardiac inotropic effects, and it may be related to inflammatory molecules. Variations in plasma visfatin and apelin levels following bariatric surgery remain controversial.
In this study, patients who underwent a biliopancreatic diversion with duodenal switch (BPD-DS) were compared to a severely obese group (control group). Anthropometric measures and blood samples were taken before surgery, on days 1 and 5, as well as at 6 and 12 months after surgery in the BDP-DS group. For the control group, the tests were performed at baseline and at 6 and 12 months.
Seventy subjects in the BPD-DS group and 28 in the control group were included. The expected reduction in body weight at 1 year after a BPD-DS was observed (85.9?±?18.5 vs. 136.6?±?27.7 kg at baseline; p?
PubMed ID
23585024 View in PubMed
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Adherence to the ERAS protocol is Associated with 5-Year Survival After Colorectal Cancer Surgery: A Retrospective Cohort Study.

https://arctichealth.org/en/permalink/ahliterature280275
Source
World J Surg. 2016 07;40(7):1741-7
Publication Type
Article
Date
07-2016
Author
Ulf O Gustafsson
Henrik Oppelstrup
Anders Thorell
Jonas Nygren
Olle Ljungqvist
Source
World J Surg. 2016 07;40(7):1741-7
Date
07-2016
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
C-Reactive Protein - metabolism
Clinical Protocols
Cohort Studies
Colorectal Neoplasms - mortality - surgery
Digestive System Surgical Procedures - methods
Early Ambulation
Enteral Nutrition
Female
Fluid Therapy
Guideline Adherence - statistics & numerical data
Humans
Length of Stay
Male
Middle Aged
Perioperative Care - methods
Postoperative Period
Prognosis
Proportional Hazards Models
Retrospective Studies
Sweden
Abstract
Surgical stress can influence oncological outcome and survival. The enhanced recovery after surgery (ERAS) protocol is designed to reduce perioperative stress and has been shown to reduce postoperative morbidity. We studied if adherence to ERAS is associated with increased long-term survival.
Between the years 2002 and 2007, 911 consecutive patients, operated with major colorectal cancer surgery at Ersta Hospital, Stockholm, Sweden were analyzed. The histopathological reports of the resected specimen, date, and cause of death of the patients as well as postoperative CRP levels were obtained. The relation between the rate of adherence to the ERAS protocol at the time of surgery, and the short-term outcomes in relation to 5-year overall and colorectal cancer-specific survival was determined in this retrospective cohort study.
In patients with =70 % adherence to ERAS interventions (N = 273,), the risk of 5-year cancer-specific death was lowered by 42 %, HR 0.58 (0.39-0.88, cox regression) compared to all other patients (
PubMed ID
26913728 View in PubMed
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Adipocytokines, C-reactive protein, and cardiovascular disease: a population-based prospective study.

https://arctichealth.org/en/permalink/ahliterature272267
Source
PLoS One. 2015;10(6):e0128987
Publication Type
Article
Date
2015
Author
Ekim Seven
Lise L N Husemoen
Thomas S G Sehested
Hans Ibsen
Kristian Wachtell
Allan Linneberg
Jørgen L Jeppesen
Source
PLoS One. 2015;10(6):e0128987
Date
2015
Language
English
Publication Type
Article
Keywords
Adipokines - metabolism
Adult
Aged
Blood pressure
C-Reactive Protein - metabolism
Cardiovascular Diseases - epidemiology - etiology - metabolism
Denmark - epidemiology
Early Medical Intervention
Female
Humans
Incidence
Insulin Resistance
Leptin - metabolism
Longitudinal Studies
Male
Middle Aged
Obesity - complications
Prognosis
Prospective Studies
Risk factors
Abstract
Being overweight or obese is associated with a greater risk of coronary heart disease and stroke compared with normal weight. The role of the specific adipose tissue-derived substances, called adipocytokines, in overweight- and obesity-related cardiovascular disease (CVD) is still unclear.
To investigate the associations of three adipose tissue-derived substances: adiponectin, leptin, and interleukin-6 with incident CVD in a longitudinal population-based study, including extensive adjustments for traditional and metabolic risk factors closely associated with overweight and obesity. C-reactive protein (CRP) was used as a proxy for interleukin-6.
Prospective population-based study of 6.502 participants, 51.9% women, aged 30-60 years, free of CVD at baseline, with a mean follow-up time of 11.4 years, equivalent to 74,123 person-years of follow-up. As outcome, we defined a composite outcome comprising of the first event of fatal and nonfatal coronary heart disease and fatal and nonfatal stroke.
During the follow-up period, 453 composite CV outcomes occurred among participants with complete datasets. In models, including gender, age, smoking status, systolic blood pressure, treatment for hypertension, diabetes, body mass index (BMI), total cholesterol, high-density-lipoprotein cholesterol, homeostasis model assessment of insulin resistance, estimated glomerular filtration rate, adiponectin, leptin, and CRP, neither adiponectin (hazard ratio [HR] with 95% confidence interval [CI]: 0.97 [0.87-1.08] per SD increase, P = 0.60) nor leptin (0.97 [0.85-1.12] per SD increase, P = 0.70) predicted the composite outcome, whereas CRP was significantly associated with the composite outcome (1.19 [1.07-1.35] per SD increase, P = 0.002). Furthermore, in mediation analysis, adjusted for age and sex, CRP decreased the BMI-associated CV risk by 43% (95%CI 29-72).
In this study, neither adiponectin nor leptin were independently associated with CVD, raising questions over their role in CVD. The finding that CRP was significantly associated with an increased risk of CVD and decreased the BMI-associated CVD risk substantially, could imply that interleukin-6-related pathways may play a role in mediating overweight- and obesity-related CVD.
Notes
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PubMed ID
26035431 View in PubMed
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Adipokines and incident type 2 diabetes in an Aboriginal Canadian [corrected] population: the Sandy Lake Health and Diabetes Project.

https://arctichealth.org/en/permalink/ahliterature93453
Source
Diabetes Care. 2008 Jul;31(7):1410-5
Publication Type
Article
Date
Jul-2008
Author
Ley Sylvia H
Harris Stewart B
Connelly Philip W
Mamakeesick Mary
Gittelsohn Joel
Hegele Robert A
Retnakaran Ravi
Zinman Bernard
Hanley Anthony J G
Author Affiliation
Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada.
Source
Diabetes Care. 2008 Jul;31(7):1410-5
Date
Jul-2008
Language
English
Publication Type
Article
Keywords
Adipokines - blood
Adult
C-Reactive Protein - metabolism
Canada - epidemiology
Diabetes Mellitus, Type 2 - epidemiology
Female
Follow-Up Studies
Humans
Incidence
Insulin Resistance
Inuits - statistics & numerical data
Leptin - blood
Male
Obesity - complications
Abstract
OBJECTIVE: The aim of this study was to investigate associations of adiponectin, leptin, C-reactive protein (CRP), interleukin (IL)-6, and serum amyloid A (SAA), individually or in combinations, with risk of incident type 2 diabetes in a Aboriginal Canadian [corrected] population. RESEARCH DESIGN AND METHODS: Of the 606 Sandy Lake Health and Diabetes Project cohort subjects who were free of diabetes at baseline, 540 (89.1%) participated in 10-year follow-up assessments. Concentrations of fasting adiponectin, leptin, CRP, IL-6, SAA, and covariates were measured at baseline. Fasting glucose and a 75-g oral glucose tolerance test were obtained at baseline and follow-up to determine incident type 2 diabetes, defined as clinically diagnosed type 2 diabetes or as fasting plasma glucose > or =7.0 mmol/l or 2-h postload plasma glucose > or =11.1 mmol/l at follow-up. RESULTS: Low adiponectin, high leptin, and low adiponectin-to-leptin ratio at baseline were associated with increased risk of incident type 2 diabetes after adjustment for age, sex, triglycerides, HDL cholesterol, hypertension, and impaired glucose tolerance (odds ratio 0.63 [95% CI 0.48-0.83], 1.50 [1.02-2.21], and 0.54 [0.37-0.77], respectively). When the models were additionally adjusted for waist circumference or BMI, however, only low adiponectin remained significantly associated with increased incident diabetes (0.68 [0.51-0.90]). Combinations of leptin, CRP, IL-6, and/or SAA with adiponectin, assessed using either the ratio or joint effects, did not improve diabetes prediction. CONCLUSIONS: Low baseline adiponectin is associated with increased risk of incident type 2 diabetes independent of leptin, CRP, IL-6, SAA, and metabolic syndrome variables including obesity.
Notes
Erratum In: Diabetes Care. 2008 Aug;31(8):1713
PubMed ID
18339973 View in PubMed
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ADMA concentration changes across the menstrual cycle and during oral contraceptive use: the Cardiovascular Risk in Young Finns Study.

https://arctichealth.org/en/permalink/ahliterature147193
Source
Eur J Endocrinol. 2010 Feb;162(2):259-65
Publication Type
Article
Date
Feb-2010
Author
Pirjo Valtonen
Kari Punnonen
Heli Saarelainen
Nonna Heiskanen
Olli T Raitakari
Markus Juonala
Jorma S A Viikari
Georg Alfthan
Mika Kähönen
Reijo Laaksonen
Tiina Lyyra-Laitinen
Tomi Laitinen
Seppo Heinonen
Author Affiliation
Departments of Clinical Chemistry Obstetrics and Gynaecology, Kuopio University Hospital and University of Kuopio, FIN-70210 Kuopio, Finland.
Source
Eur J Endocrinol. 2010 Feb;162(2):259-65
Date
Feb-2010
Language
English
Publication Type
Article
Keywords
Adult
Arginine - analogs & derivatives - blood
Atherosclerosis - epidemiology - metabolism
Brachial Artery - physiology
C-Reactive Protein - metabolism
Contraceptives, Oral - therapeutic use
Creatinine - blood
Estrogens - therapeutic use
Female
Finland - epidemiology
Humans
Menstrual Cycle - metabolism
Progesterone Congeners - therapeutic use
Prospective Studies
Risk factors
Vasodilation - physiology
Young Adult
Abstract
The aim of this study was to evaluate changes in the nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA) levels during different menstrual cycle phases in young adult women with or without oral contraceptive (OC) use.
The subjects (n=1079) originated from a large population-based, prospective cohort study conducted in Finland. Plasma ADMA, symmetric dimethylarginine (SDMA), L-arginine, C-reactive protein, creatinine, and brachial artery flow-mediated dilatation (FMD) were measured. The use of OCs and menstrual cycle phase were determined from a questionnaire.
In non-OC users, ADMA (P=0.017), L-arginine (P=0.002), and ADMA/SDMA ratio (P
PubMed ID
19934267 View in PubMed
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Age and duration of follow-up as modulators of the risk for ischemic heart disease associated with high plasma C-reactive protein levels in men.

https://arctichealth.org/en/permalink/ahliterature192391
Source
Arch Intern Med. 2001 Nov 12;161(20):2474-80
Publication Type
Article
Date
Nov-12-2001
Author
M. Pirro
J. Bergeron
G R Dagenais
P M Bernard
B. Cantin
J P Després
B. Lamarche
Author Affiliation
Lipid Research Center, R-9600, CHUL Research Center, 2705 Laurier Blvd, Ste-Foy, Québec, Canada G1V 4G2.
Source
Arch Intern Med. 2001 Nov 12;161(20):2474-80
Date
Nov-12-2001
Language
English
Publication Type
Article
Keywords
Adult
Age Distribution
Age Factors
Aged
Biological Markers - blood
C-Reactive Protein - metabolism
Confounding Factors (Epidemiology)
Coronary Disease - blood - diagnosis - epidemiology - etiology
Follow-Up Studies
Humans
Inflammation
Male
Middle Aged
Multivariate Analysis
Population Surveillance
Predictive value of tests
Proportional Hazards Models
Quebec - epidemiology
Risk factors
Survival Analysis
Time Factors
Abstract
Plasma C-reactive protein (CRP) levels recently have been identified as an emerging risk factor for ischemic heart disease (IHD). However, whether plasma CRP levels predict an increased risk for future IHD beyond traditional risk factors has yet to be evaluated in a large prospective, population-based study.
The association between elevated plasma CRP levels and the risk for future IHD was investigated in the prospective, population-based cohort of 2037 IHD-free middle-aged men from the Quebec Cardiovascular Study. During a 5-year follow-up, 105 first IHD events were recorded. Baseline plasma CRP levels were measured using a highly sensitive assay.
High plasma CRP concentrations (equal to or above vs below the median level of 1.77 mg/L) were associated with a significant 1.8-fold increase in IHD risk (95% confidence interval [CI], 1.2-2.7). This association remained significant after adjustment for lipid risk factors but not when the simultaneous contribution of nonlipid traditional risk factors was taken into account. Multivariate analyses indicated that CRP level predicted short-term risk for IHD (events that occurred 2 years). Moreover, high plasma CRP levels predicted an increased risk for IHD, independent of any other confounder, in younger (55 years) individuals.
Plasma CRP levels may provide independent information on IHD risk only in younger middle-aged men and in the case of IHD events that may occur relatively soon after the baseline evaluation.
PubMed ID
11700160 View in PubMed
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Aggregation of lipoprotein and inflammatory parameters in families with a history of premature myocardial infarction: the Tallinn myocardial infarction study.

https://arctichealth.org/en/permalink/ahliterature154200
Source
Clin Chem Lab Med. 2008;46(11):1602-8
Publication Type
Article
Date
2008
Author
Katrin Aasvee
Elvira Kurvinen
Jouko Sundvall
Matti Jauhiainen
Inna Tur
Author Affiliation
Department of Chronic Disease Prevention, National Institute for Health Development, Tallinn, Estonia. katrin.aasvee@tai.ee
Source
Clin Chem Lab Med. 2008;46(11):1602-8
Date
2008
Language
English
Publication Type
Article
Keywords
Acute-Phase Proteins - metabolism
Adolescent
Adult
Age Factors
Apolipoprotein A-I - blood
Apolipoproteins B - blood
Apolipoproteins E - genetics
C-Reactive Protein - metabolism
Child
Cholesterol - blood
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Family Health
Female
Finland
Humans
Lipoprotein(a) - blood
Lipoproteins - blood
Male
Middle Aged
Myocardial Infarction - blood - genetics
Polymorphism, Genetic
Risk factors
Sex Factors
Triglycerides - blood
Abstract
The offspring of individuals with a history of premature myocardial infarction are at increased risk of premature coronary attacks. The aim of this study was to determine parent/offspring associations of coronary risk factors in families affected by premature myocardial infarction and to compare these to corresponding control families.
The cohort of cases consisted of 71 male survivors of myocardial infarction and their 128 descendants (aged 7-18 years). As control families, 85 randomly selected healthy males with their 66 descendants were investigated. Besides traditional risk factors, serum high sensitive C-reactive protein (hsCRP), apolipoprotein (apo) E phenotypes and lipoprotein(a) were analyzed.
In the offspring of the patients, fibrinogen and atherogenic lipoprotein parameters were higher than in the corresponding controls, but hsCRP, lipoprotein(a) and anthropometric data did not differ between the groups. The adult-offspring positive correlations were detected in fibrinogen and in almost all measured lipoprotein fractions in the affected families; amongst the controls, the association was observed only for triglyceride levels. Multiple logistic regression analysis demonstrated independent association of offspring apoB, apoA-I and fibrinogen levels with a family history of premature myocardial infarction.
The most informative predictors of future coronary attacks during childhood are apoB-100 and apoB/apoA-I ratio; serum hsCRP and lipoprotein(a) do not have predictive value in childhood.
PubMed ID
19012525 View in PubMed
Less detail
Source
Psychother Psychosom. 2011;80(6):359-64
Publication Type
Article
Date
2011
Author
Kirsi Honkalampi
Soili M Lehto
Heli Koivumaa-Honkanen
Jukka Hintikka
Leo Niskanen
Minna Valkonen-Korhonen
Heimo Viinamäki
Author Affiliation
Kuopio Psychiatric Center, Kuopio, Finland. kirsi.honkalampi @ kuh.fi
Source
Psychother Psychosom. 2011;80(6):359-64
Date
2011
Language
English
Publication Type
Article
Keywords
Affective Symptoms - diagnosis - immunology - pathology
Biological Markers - blood
C-Reactive Protein - metabolism
Cluster analysis
Depression - immunology - pathology
Female
Finland
Health Surveys
Humans
Inflammation - diagnosis - immunology - pathology
Interleukin-6 - blood
Logistic Models
Male
Middle Aged
Psychiatric Status Rating Scales
Registries
Abstract
Altered immune responses are seen in depression, and recent data suggest that similar changes could also be observable in alexithymia. We examined whether the inflammatory markers high-sensitivity C-reactive protein (hs-CRP) and interleukin (IL)-6 are independently related to alexithymia or its factors in a population-based sample.
This study formed a clinical part of the Kuopio Depression (KUDEP) general population study focusing on the mental health of a general population of adults aged 25-64 years (n = 308). Alexithymia was measured using the Toronto Alexithymia Scale (TAS-20), and depressive symptoms were assessed using the Beck Depression Inventory (BDI-21).
The levels of IL-6 (in picograms per milliliter) and hs-CRP (in milligrams per liter) were significantly higher in alexithymic than in nonalexithymic subjects (IL-6 effect size, ES: 0.50; hs-CRP ES: 0.27). The BDI scores, hs-CRP and IL-6 explained 33.5% of the variation in TAS scores in the whole study population. According to logistic regression analysis, hs-CRP but not IL-6 increased the likelihood of belonging to the alexithymic group. This observation remained unaltered after additional adjustments for chronic inflammation-related disorders, the use of inflammation-modulating medications and depressive symptoms.
Our findings suggest that the association between hs-CRP and alexithymia resembles that observed in depressed patients. It is, however, independent of depressive symptoms. These findings widen our view on the stress-alexithymia concept.
PubMed ID
21829048 View in PubMed
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