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102 records – page 1 of 11.

15 years after Chernobyl: new evidence of thyroid cancer.

https://arctichealth.org/en/permalink/ahliterature19395
Source
Lancet. 2001 Dec 8;358(9297):1965-6
Publication Type
Article
Date
Dec-8-2001
Author
Y. Shibata
S. Yamashita
V B Masyakin
G D Panasyuk
S. Nagataki
Source
Lancet. 2001 Dec 8;358(9297):1965-6
Date
Dec-8-2001
Language
English
Publication Type
Article
Keywords
Accidents, Radiation
Adolescent
Byelarus - epidemiology
Child
Female
Humans
Male
Mass Screening
Neoplasms, Radiation-Induced - epidemiology
Nuclear Reactors
Population Surveillance
Radioactive fallout
Research Support, Non-U.S. Gov't
Thyroid Neoplasms - epidemiology - etiology
Ukraine - epidemiology
Abstract
The Chernobyl nuclear power plant accident happened on April 26, 1986. We investigated the cause of the striking increase in frequency of thyroid cancer in children who lived within a 150 km radius of Chernobyl and who were born before and after the accident. No thyroid cancer was seen in 9472 children born in 1987-89, whereas one and 31 thyroid cancers were recorded in 2409 children born April 27, 1986, to Dec 31, 1986, and 9720 born Jan 1, 1983, to April 26, 1986, respectively. Short-lived radioactive fallout caused by the Chernobyl accident probably induced thyroid cancer in children living near Chernobyl.
PubMed ID
11747925 View in PubMed
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[15 years after the accident at the Chernobyl Nuclear Power Plant]

https://arctichealth.org/en/permalink/ahliterature19138
Source
Radiats Biol Radioecol. 2002 Mar-Apr;42(2):228-33
Publication Type
Article
Author
L A Buldakov
A K Gus'kova
Author Affiliation
State Research Centre-Institute of Biophysics, Russian Ministry of Health, Moscow, 123182 Russia.
Source
Radiats Biol Radioecol. 2002 Mar-Apr;42(2):228-33
Language
Russian
Publication Type
Article
Keywords
Accidents, Radiation
Adolescent
Adult
Age Factors
Byelarus - epidemiology
Child
Child, Preschool
Comparative Study
English Abstract
Female
Follow-Up Studies
Humans
Infant
Infant, Newborn
Male
Neoplasms, Radiation-Induced - epidemiology - etiology
Power Plants
Pregnancy
Prognosis
Radiation Dosage
Radiation Injuries - epidemiology
Risk factors
Russia - epidemiology
Thyroid Neoplasms - epidemiology - etiology
Time Factors
Ukraine - epidemiology
Abstract
Health effects as a result of the accident at the Chernobyl nuclear power plant occurred in 1986 are considered in the paper. Wrong prognosis of the health effects with respect to mortality and morbidity among the population exposed to low radiation doses is shown. Proven increase in thyroid cancer cases among people who were children aged from 0 to 18 at the time of the accident is shown. Linear relationship between thyroid cancer cases and dose to thyroid ranged from 0.2 to 4.0 Gy is considered. An additional absolute risk of thyroid cancer in children varies in the range 1.9-2.6 cases per 10(4) person-year Gy. During the fifteen years following the accident no cases of acute and chronic radiation sickness have been revealed because the population living in contaminated areas received low radiation doses. Also, exposures to low radiation doses did not result in excess of malignant tumors among population. In some cases the outcomes of acute radiation sickness were as follows: radiation damages to the skin, cancer cataracts, development of oncopathology.
PubMed ID
12004624 View in PubMed
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Absence of G(s)alpha gene mutations in childhood thyroid tumors after Chernobyl in contrast to sporadic adult thyroid neoplasia.

https://arctichealth.org/en/permalink/ahliterature22036
Source
Cancer Res. 1997 Jun 15;57(12):2358-61
Publication Type
Article
Date
Jun-15-1997
Author
V. Waldmann
H M Rabes
Author Affiliation
Institute of Pathology, Ludwig Maximilians University of Munich, München, Germany.
Source
Cancer Res. 1997 Jun 15;57(12):2358-61
Date
Jun-15-1997
Language
English
Publication Type
Article
Keywords
Accidents, Radiation
Byelarus - epidemiology
Carcinoma, Papillary - epidemiology - genetics - pathology
Child
GTP-Binding Protein alpha Subunits, Gs - genetics
Humans
Mutation
Polymerase Chain Reaction
Research Support, Non-U.S. Gov't
Thyroid Neoplasms - epidemiology - genetics - pathology
Ukraine
Abstract
Heterotrimeric G proteins participate in the signal transduction cascade. Adult thyroid tumors have been shown to harbor specific point mutations in codons 201 and 227 of the G(s)alpha subunit of the adenylate cyclase stimulator. This protein affects the GDP/GTP turnover and finally results in an enhanced activation of G(s) and thus adenylate cyclase. We attempted to find out if G(s)alpha gene mutations were present in thyroid tumors of children from Belarus after the Chernobyl nuclear accident. Paraffin sections of 20 thyroid tumors were used for PCR amplification by oligonucleotide intron primers flanking exons 8 and 9, encompassing codon 201 and 227, respectively. By direct sequencing of the 274-bp amplification product, we did not detect any mutations of the G(s)alpha gene in codon 201 or 227. In contrast to thyroid neoplasia of adults, G(s)alpha gene mutations do not play a role in the development of childhood thyroid tumors after the Chernobyl reactor accident.
PubMed ID
9192808 View in PubMed
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[Activities of the Byelorussian scientific association of phthisiatrists and the phthisiatric organization of the Republic in the circumstances of complicated critical state of tuberculosis in connection with the Chernobyl AES accident]

https://arctichealth.org/en/permalink/ahliterature36884
Source
Probl Tuberk. 1992;(1-2):59-61
Publication Type
Article
Date
1992

An epidemiological overview of Chernobyl-related research.

https://arctichealth.org/en/permalink/ahliterature22297
Source
Stem Cells. 1997;15 Suppl 2:205-6
Publication Type
Article
Date
1997

[A preliminary analysis of oral morbidity in the children of Byelarus after the accident at the Chernobyl Atomic Electric Power Station]

https://arctichealth.org/en/permalink/ahliterature36318
Source
Stomatologiia (Mosk). 1993 Apr-Jun;72(2):67-8
Publication Type
Article
Author
E M Mel'nichenko
L I Leus
K A Gorbacheva
L P Belik
E M Gul'ko
T K Ostromentskaia
O V Pyleva
L V Shuglia
Source
Stomatologiia (Mosk). 1993 Apr-Jun;72(2):67-8
Language
Russian
Publication Type
Article
Keywords
Accidents, Occupational
Air Pollution, Radioactive - adverse effects
Byelarus - epidemiology
Child
Child, Preschool
Comparative Study
Ecology
English Abstract
Humans
Incidence
Mouth Diseases - epidemiology - etiology
Nuclear Reactors
Power Plants
Radiation Injuries - complications - epidemiology
Ukraine
Abstract
Presents the data of analysis of medical files of therapeutic institutions, of questionnaires distributed among dentists, and the results of examinations of 883 children aged 3 to 6, living in 19 towns of Byelorussia. The incidence and clinical picture of a number of dental diseases were found changed in the children living in the regions contaminated with radionuclides, as well as the general well-being of these children.
PubMed ID
8048139 View in PubMed
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Breast cancer trends in two oblasts of Belarus and the Chernobyl accident.

https://arctichealth.org/en/permalink/ahliterature79412
Source
Int J Occup Environ Health. 2006 Oct-Dec;12(4):415-22
Publication Type
Article
Author
Dardynskaia Irina
Imrey Peter B
Okeanov Alexei
Hryhorczuk Daniel
Author Affiliation
Great Lakes Centers for Occupational and Environmental Safety and Health, School of Public Health (M/C 922), University of Illinois at Chicago, 2121 W. Taylor Street, Chicago, IL 60612, USA. dardynsk@uic.edu
Source
Int J Occup Environ Health. 2006 Oct-Dec;12(4):415-22
Language
English
Publication Type
Article
Keywords
Accidents, Radiation
Adult
Breast Neoplasms - epidemiology
Byelarus - epidemiology
Female
Humans
Incidence
Middle Aged
Power Plants
Ukraine
Abstract
The 1986 Chernobyl accident contaminated 23% of Belarus with radioactive iodine and long half-life radionuclides. Radiation causes breast cancer. Population-based breast cancer incidence data from the Belarus National Cancer Registry were used to study secular trends and urban-rural differences, and determine whether an effect of Chernobyl radiation exposure was discernable. Trends in age-standardized incidences in Gomel and Vitebsk oblasts maximally and minimally exposed to Chernobyl radiation, respectively, were compared for 1978-2003 among all women, and women aged 30-49, separately for urban and rural areas. Incidences were higher and increasing more rapidly in urban than rural areas of both oblasts, annually increasing 0.150 +/- 0.008 vs. 0.098 +/- 0.007 new cases per 10,000 persons, p
PubMed ID
17168231 View in PubMed
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Changes in registered congenital anomalies in the Republic of Belarus after the Chernobyl accident.

https://arctichealth.org/en/permalink/ahliterature34444
Source
Stem Cells. 1997;15 Suppl 2:255-60
Publication Type
Article
Date
1997
Author
G I Lazjuk
D L Nikolaev
I V Novikova
Author Affiliation
Belarus Institute for Hereditary Diseases, Minsk.
Source
Stem Cells. 1997;15 Suppl 2:255-60
Date
1997
Language
English
Publication Type
Article
Keywords
Abnormalities - classification - embryology - epidemiology
Abnormalities, Radiation-Induced - classification - embryology - epidemiology
Abortion, Legal - statistics & numerical data
Accidents, Radiation
Byelarus - epidemiology
Cesium radioisotopes
Comparative Study
Female
Humans
Incidence
Infant, Newborn
Power Plants
Pregnancy
Prenatal Exposure Delayed Effects
Radioactive fallout
Registries
Ukraine
Abstract
A descriptive analysis of birth defects and malformations was performed to assess whether the rates of these defects correlate with the geographic areas of Belarus that received different levels of 137Cs contamination resulting from the Chernobyl catastrophe. Since this accident in 1986, the frequency of both congenital and fetal abnormalities in the Republic of Belarus has apparently increased. This increase is most prominent in areas with at least 555 9Bq/m2 radioactive contamination, although it has not been possible to correlate the individual dose received by a pregnant woman with the incidence of congenital malformations. The types of anomalies that were most increased in frequency were multiple congenital malformations, polydactyly, and reduction limb defects. These malformations are commonly associated with dominant new mutations. Chromosomal disorders such as occur in Down syndrome were not increased in frequency, nor could teratogenic effects be attributed to exposure to ionizing radiation. Preventive measures have apparently reduced the number of births with congenital abnormalities but have had no apparent effect on the frequency of fetal defects. Results of our analysis are consistent with the hypothesis that ionizing radiation released during the Chernobyl accident may have placed fetuses and neonates at risk for congenital malformations. Epidemiological studies are now required to determine whether a mother's radiation dose correlates with congenital malformations in her children.
PubMed ID
9368311 View in PubMed
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102 records – page 1 of 11.