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Asthma, lung function and allergy in 12-year-old children with very low birth weight: a prospective study.

https://arctichealth.org/en/permalink/ahliterature15260
Source
Pediatr Allergy Immunol. 2003 Jun;14(3):184-92
Publication Type
Article
Date
Jun-2003
Author
Xiao-Mei Mai
Per-Olof Gäddlin
Lennart Nilsson
Orvar Finnström
Bengt Björkstén
Maria C Jenmalm
Ingemar Leijon
Author Affiliation
Department of Molecular and Clinical Medicine, Division of Paediatrics, Linköping University, Linköping, Sweden. xiama@imk.liu.se
Source
Pediatr Allergy Immunol. 2003 Jun;14(3):184-92
Date
Jun-2003
Language
English
Publication Type
Article
Keywords
Asthma - etiology - physiopathology
Bronchopulmonary Dysplasia - complications - physiopathology
Child
Dermatitis, Atopic - etiology - physiopathology
Humans
Infant, Newborn
Infant, Very Low Birth Weight
Oxygen Inhalation Therapy
Prevalence
Prospective Studies
Questionnaires
Research Support, Non-U.S. Gov't
Risk factors
Skin Tests
Spirometry
Sweden
Abstract
We assessed the relationship between very low birth weight (VLBW) (or= 9 days was the only remaining significant risk factor for a history of asthma (adjusted OR 6.7, 95%CI 1.0-44). The VLBW children who required mechanical ventilation during the neonatal period were more likely to have bronchial hyperresponsiveness than those not requiring mechanical ventilation (60% vs. 28%, p = 0.050). The spirometric values were similar among the VLBW and the term children at 12 years. Very low birth weight was not significantly related to allergic rhinoconjunctivitis, eczema or positive skin prick tests. Furthermore, the levels of IL-4, IL-5 and IFN-gamma in stimulated cell cultures were similar in the VLBW and the term children. A history of asthma by 12 years of age was twice as common among the VLBW as the term children, and neonatal oxygen supplementation seemed to be associated with the increased risk. Furthermore, mechanical ventilation during the neonatal period was associated with bronchial hyperresponsiveness at age 12. Very low birth weight per se was not, however, related to atopy.
PubMed ID
12787297 View in PubMed
Less detail

A 1-year follow-up of low birth weight infants with and without bronchopulmonary dysplasia: health, growth, clinical lung disease, cardiovascular and neurological sequelae.

https://arctichealth.org/en/permalink/ahliterature59584
Source
Early Hum Dev. 1992 Sep;30(2):109-20
Publication Type
Article
Date
Sep-1992