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Alcohol consumption during adolescence is associated with reduced grey matter volumes.
Addiction. 2017 Apr; 112(4):604-613
Publication Type
Journal Article
Noora Heikkinen
Eini Niskanen
Mervi Könönen
Tommi Tolmunen
Virve Kekkonen
Petri Kivimäki
Heikki Tanila
Eila Laukkanen
Ritva Vanninen
Author Affiliation
Department of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland.
Addiction. 2017 Apr; 112(4):604-613
Publication Type
Journal Article
Adolescent Development
Brain - diagnostic imaging - growth & development
Case-Control Studies
Cerebral Cortex - diagnostic imaging - growth & development
Gray Matter - diagnostic imaging - growth & development
Gyrus Cinguli - diagnostic imaging - growth & development
Longitudinal Studies
Magnetic Resonance Imaging
Organ Size
Prefrontal Cortex - diagnostic imaging - growth & development
Temporal Lobe - diagnostic imaging - growth & development
Underage Drinking - statistics & numerical data
Young Adult
Cognitive impairment has been associated with excessive alcohol use, but its neural basis is poorly understood. Chronic excessive alcohol use in adolescence may lead to neuronal loss and volumetric changes in the brain. Our objective was to compare the grey matter volumes of heavy- and light-drinking adolescents.
This was a longitudinal study: heavy-drinking adolescents without an alcohol use disorder and their light-drinking controls were followed-up for 10 years using questionnaires at three time-points. Magnetic resonance imaging was conducted at the last time-point.
The area near Kuopio University Hospital, Finland.
The 62 participants were aged 22-28 years and included 35 alcohol users and 27 controls who had been followed-up for approximately 10 years.
Alcohol use was measured by the Alcohol Use Disorders Identification Test (AUDIT)-C at three time-points during 10 years. Participants were selected based on their AUDIT-C score. Magnetic resonance imaging was conducted at the last time-point. Grey matter volume was determined and compared between heavy- and light-drinking groups using voxel-based morphometry on three-dimensional T1-weighted magnetic resonance images using predefined regions of interest and a threshold of P 
PubMed ID
27865039 View in PubMed
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