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350 records – page 1 of 35.

Absent post-ischemic increase of blood flowmotion in the cutaneous microcirculation of healthy chronic cigarette smokers.

https://arctichealth.org/en/permalink/ahliterature78655
Source
Clin Hemorheol Microcirc. 2007;36(2):163-71
Publication Type
Article
Date
2007
Author
Rossi M.
Carpi A.
Di Maria C.
Galetta F.
Santoro G.
Author Affiliation
Department of Internal Medicine, University of Pisa, Italy. mrossi@int.med.unipi.it
Source
Clin Hemorheol Microcirc. 2007;36(2):163-71
Date
2007
Language
English
Publication Type
Article
Keywords
Adult
Blood Flow Velocity - drug effects - physiology
Female
Forearm - blood supply
Hemorheology - drug effects
Humans
Ischemia - physiopathology
Laser-Doppler Flowmetry
Male
Matched-Pair Analysis
Microcirculation - drug effects
Middle Aged
Regional Blood Flow
Skin - blood supply
Smoking - adverse effects
Abstract
The aim of the study was to investigate whether chronic cigarette smoke habit is associated with changes of laser Doppler (LD) skin blood flowmotion (SBF). We performed spectral analysis of skin forearm LD signal detected by a LD flowmetry (Periflux PF4, Perimed, Sweden) before and during forearm post-ischemic hyperaemia, in 14 healthy chronic smoker subjects and 14 age and sex matched nonsmoker subjects. Forearm skin ischemia was obtained by a pneumatic cuff, positioned at the right arm and inflated for 3 minutes to 30 mmHg above systolic blood pressure. Power spectral density (PSD) of the SBF total spectrum (0.009-1.6 Hz), as well as 0.009-0.02 Hz , 0.02-0.06 Hz, 0.06-0.2 Hz, 0.2-0.6 Hz and 0.6-1.6 Hz frequency intervals (FI), referred to endothelial, sympathetic, myogenic, respiratory and heart activity, respectively, were measured in LD conventional perfusion units (PU)/Hz. Smokers showed a basal SBF total spectrum PSD mean values not significantly different from nonsmokers (2.14+/-1.58 PU/Hz and 1.93+/-1.35 PU/Hz, respectively). Following ischemia, PSD mean value of SBF total spectrum, as well of five FI considered, significantly increased in nonsmokers (p
PubMed ID
17325440 View in PubMed
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Abstracts from the 14th Congress of the Scandinavian Society of Anaesthesiologists. Uppsala, Sweden, June 28-July 2, 1977.

https://arctichealth.org/en/permalink/ahliterature250477
Source
Ups J Med Sci Suppl. 1977;25:1-170
Publication Type
Conference/Meeting Material
Date
1977

Acute administration of a single dose of valsartan improves left ventricular functions: a pilot study to assess the role of tissue velocity echocardiography in patients with systemic arterial hypertension in the TVE-valsartan study I.

https://arctichealth.org/en/permalink/ahliterature80206
Source
Clin Physiol Funct Imaging. 2006 Nov;26(6):351-6
Publication Type
Article
Date
Nov-2006
Author
Govind Satish C
Brodin Lars-Ake
Nowak Jacek
Ramesh S S
Saha Samir K
Author Affiliation
BMJ Heart Center, Department of Non-invasive Cardiology, Bangalore, India.
Source
Clin Physiol Funct Imaging. 2006 Nov;26(6):351-6
Date
Nov-2006
Language
English
Publication Type
Article
Keywords
Adult
Aged
Antihypertensive Agents - administration & dosage
Blood Flow Velocity - drug effects
Blood Pressure - drug effects
Dose-Response Relationship, Drug
Echocardiography, Doppler, Color
Female
Heart Rate - drug effects
Humans
Hypertension - drug therapy - physiopathology - ultrasonography
Image Processing, Computer-Assisted
Male
Middle Aged
Myocardial Contraction - drug effects
Pilot Projects
Research Design
Stroke Volume - drug effects
Sweden
Tetrazoles - administration & dosage
Time Factors
Treatment Outcome
Valine - administration & dosage - analogs & derivatives
Ventricular Function, Left - drug effects
Abstract
BACKGROUND: The advent of colour-coded tissue velocity echocardiography (TVE) has now made it possible to quantify left ventricular (LV) functions in patients with systemic arterial hypertension (HTN). Hypothesis In this project, we have studied the cardiac effects of a single dose of orally administered valsartan in patients with known HTN. METHODS: Fifty-five patients with HTN with a mean age of 56 +/- 10 years were given an early morning dose of 80 mg valsartan withholding regular antihypertensive medications on the day of investigation. TVE images, acquired on VIVID systems were digitized for postprocessing of longitudinal and radial peak systolic velocities, strain rate, and systolic and diastolic time intervals before (pre) and 5 h after (post) administration of the drug. RESULTS: Blood pressure (mmHg) pre and post, respectively, were 147 +/- 15 versus 137 +/- 14 systolic and 90 +/- 7 versus 86 +/- 7 diastolic (all P
PubMed ID
17042901 View in PubMed
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Acute antioxidant supplementation and skeletal muscle vascular conductance in aged rats: role of exercise and fiber type.

https://arctichealth.org/en/permalink/ahliterature101895
Source
Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1536-44
Publication Type
Article
Date
Apr-2011
Author
Daniel M Hirai
Steven W Copp
Peter J Schwagerl
Mark D Haub
David C Poole
Timothy I Musch
Author Affiliation
Department of Anatomy and Physiology, Kansas State University, Manhattan, 66506-5802, USA.
Source
Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1536-44
Date
Apr-2011
Language
English
Publication Type
Article
Keywords
Animals
Antioxidants - pharmacology
Blood Pressure - drug effects - physiology
Cyclic N-Oxides - pharmacology
Dietary Supplements
Hindlimb - drug effects - physiology
Male
Muscle Fibers, Skeletal - drug effects - physiology
Muscle, Skeletal - blood supply - drug effects - physiology
Physical Conditioning, Animal - physiology
Rats
Rats, Inbred F344
Regional Blood Flow - drug effects - physiology
Rest - physiology
Spin Labels
Vascular Resistance - drug effects - physiology
Vasodilation - drug effects - physiology
Abstract
Age-related increases in oxidative stress contribute to impaired skeletal muscle vascular control. However, recent evidence indicates that antioxidant treatment with tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl) attenuates flow-mediated vasodilation in isolated arterioles from the highly oxidative soleus muscle of aged rats. Whether antioxidant treatment with tempol evokes similar responses in vivo at rest and during exercise in senescent individuals and whether this effect varies based on muscle fiber type composition are unknown. We tested the hypothesis that redox modulation via acute systemic tempol administration decreases vascular conductance (VC) primarily in oxidative hindlimb locomotor muscles at rest and during submaximal whole body exercise (treadmill running at 20 m/min, 5% grade) in aged rats. Eighteen old (25-26 mo) male Fischer 344 x Brown Norway rats were assigned to either rest (n = 8) or exercise (n = 10) groups. Regional VC was determined via radiolabeled microspheres before and after intra-arterial administration of tempol (302 µmol/kg). Tempol decreased mean arterial pressure significantly by 9% at rest and 16% during exercise. At rest, similar VC in 26 out of 28 individual hindlimb muscles or muscle parts following tempol administration compared with control resulted in unchanged total hindlimb muscle VC (control: 0.18 ± 0.02; tempol: 0.17 ± 0.05 ml·min(-1)·100 g(-1)·mmHg(-1); P > 0.05). During exercise, all individual hindlimb muscles or muscle parts irrespective of fiber type composition exhibited either an increase or no change in VC with tempol (i.e., ?11 and ?17 muscles or muscle parts), such that total hindlimb VC increased by 25% (control: 0.93 ± 0.04; tempol: 1.15 ± 0.09 ml·min(-1)·100 g(-1)·mmHg(-1); P = 0.05). These results demonstrate that acute systemic administration of the antioxidant tempol significantly impacts the control of regional vascular tone in vivo presumably via redox modulation and improves skeletal muscle vasodilation independently of fiber type composition during submaximal whole body exercise in aged rats.
PubMed ID
21239634 View in PubMed
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The acute dose-dependent effects of ethanol on canine myocardial perfusion.

https://arctichealth.org/en/permalink/ahliterature11527
Source
Alcohol. 1994 Sep-Oct;11(5):351-4
Publication Type
Article
Author
R V Kettunen
J. Timisjärvi
J. Heikkilä
P. Saukko
Author Affiliation
Department of Physiology, University of Oulu, Finland.
Source
Alcohol. 1994 Sep-Oct;11(5):351-4
Language
English
Publication Type
Article
Keywords
Animals
Blood Flow Velocity
Coronary Circulation - drug effects
Dogs
Dose-Response Relationship, Drug
Ethanol - administration & dosage - pharmacology
Hemodynamic Processes - drug effects
Microspheres
Research Support, Non-U.S. Gov't
Vascular Resistance - drug effects
Ventricular Function, Left - drug effects
Abstract
The acute effects of ethanol (1.0 g/kg and 1.5 g/kg, n = 4 and n = 5, yielding blood concentrations of 1.3 +/- 0.2 mg/ml and 2.4 +/- 0.3 mg/ml) on myocardial perfusion were studied in anesthetized, thoracotomized, artificially ventilated dogs by using a radioactive microsphere technique. The control group (n = 5) received saline. The smaller dose of ethanol decreased perfusion in the left ventricular myocardium from 0.737 +/- 0.122 to 0.555 +/- 0.122 ml/g/min (NS), whereas the greater dose nonsignificantly increased it, from 0.744 +/- 0.115 to 0.819 +/- 0.119 ml/g/min (p
PubMed ID
7818790 View in PubMed
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Adaptations of Native populations to cold

https://arctichealth.org/en/permalink/ahliterature1235
Source
Papers presented at the Symposium on Circumpolar Health Related Problems, Fairbanks, Alaska, July 23-28, 1967. Archives of Environmental Health. 17(4):592-594
Publication Type
Article
Date
Oct-1968
  1 document  
Author
Irving, L
Author Affiliation
University of Alaska Fairbanks
Source
Papers presented at the Symposium on Circumpolar Health Related Problems, Fairbanks, Alaska, July 23-28, 1967. Archives of Environmental Health. 17(4):592-594
Date
Oct-1968
Language
English
Geographic Location
U.S.
Publication Type
Article
Digital File Format
Text - PDF
Physical Holding
Alaska Medical Library
Keywords
Blood flow
Clothing
Thermoregulation
Notes
From: Fortuine, Robert et al. 1993. The Health of the Inuit of North America: A Bibliography from the Earliest Times through 1990. University of Alaska Anchorage. Citation number 1028.
Documents

67-25-Adaptions of Native Populations to Cold.pdf

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Adiponectin is related with carotid artery intima-media thickness and brachial flow-mediated dilatation in young adults--the Cardiovascular Risk in Young Finns Study.

https://arctichealth.org/en/permalink/ahliterature140840
Source
Ann Med. 2010 Dec;42(8):603-11
Publication Type
Article
Date
Dec-2010
Author
Liisa A Saarikoski
Risto K Huupponen
Jorma S A Viikari
Jukka Marniemi
Markus Juonala
Mika Kähönen
Olli T Raitakari
Author Affiliation
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Source
Ann Med. 2010 Dec;42(8):603-11
Date
Dec-2010
Language
English
Publication Type
Article
Keywords
Adiponectin - blood
Adult
Atherosclerosis - epidemiology - pathology - physiopathology
Biological Markers - blood
Brachial Artery - physiopathology - ultrasonography
Carotid Arteries - pathology - physiopathology - ultrasonography
Elasticity Imaging Techniques
Female
Finland - epidemiology
Follow-Up Studies
Humans
Male
Regional Blood Flow
Regression Analysis
Risk factors
Tunica Intima - pathology - ultrasonography
Young Adult
Abstract
Adiponectin may be involved in the pathogenesis of atherosclerosis. We investigated the relation of adiponectin on early functional and structural markers of subclinical atherosclerosis in a large population-based cohort of young men and women.
We measured serum adiponectin using radioimmunoassay in 2,147 young adults (ages 24-39 years) participating in the Cardiovascular Risk in Young Finns Study. The subjects had ultrasound data on carotid intima-media thickness (IMT), carotid artery elasticity (n = 2,139) and brachial flow-mediated dilatation (FMD) (n = 1,996). In univariate analysis, adiponectin was inversely associated with IMT (r = -0.16, P
PubMed ID
20839916 View in PubMed
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Altered regional blood flow responses to submaximal exercise in older rats.

https://arctichealth.org/en/permalink/ahliterature49729
Source
J Appl Physiol. 2004 Jan;96(1):81-8
Publication Type
Article
Date
Jan-2004
Author
Timothy I Musch
Kevin E Eklund
K Sue Hageman
David C Poole
Author Affiliation
Department of Kinesiology, Kansas State University, Manhattan, KS 66506-5602, USA. musch@vet.ksu.edu
Source
J Appl Physiol. 2004 Jan;96(1):81-8
Date
Jan-2004
Language
English
Publication Type
Article
Keywords
Aging - physiology
Animals
Blood pressure
Exertion - physiology
Heart rate
Hindlimb
Microspheres
Muscle, Skeletal - blood supply - physiology
Rats
Rats, Inbred BN
Rats, Inbred F344
Regional Blood Flow - physiology
Renal Circulation - physiology
Research Support, U.S. Gov't, P.H.S.
Rest - physiology
Abstract
Maximal aerobic capacity and the ability to sustain submaximal exercise (Ex) declines with advancing age. Whether altered muscle blood flow (BF) plays a mechanistic role in these effects remains to be resolved. The present investigation determined the effects of aging on the hemodynamic and regional BF response to submaximal Ex in rats. Heart rate (HR), mean arterial pressure (MAP), and BF to different organs (kidneys, splanchnic organs, and 28 hindlimb muscles) were determined at rest and during submaximal treadmill Ex (20 m/min, 5% grade) with radiolabeled microspheres in young (Y; 6-8 mo old, 339 +/- 8 g, n = 9) and old (O; 27-29 mo old, 504 +/- 18 g, n = 7) Fischer 344 x Brown Norway rats. Results demonstrated that HR, MAP, and BF to the pancreas, small and large intestine, and total hindlimb musculature were similar between Y and O rats at rest. BF to the kidneys, spleen, and stomach were 33, 60, and 43% lower, respectively, in O compared with Y rats. BF to the total hindlimb musculature increased (P
PubMed ID
12959955 View in PubMed
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Angiosome-targeted infrapopliteal endovascular revascularization for treatment of diabetic foot ulcers.

https://arctichealth.org/en/permalink/ahliterature118329
Source
J Vasc Surg. 2013 Feb;57(2):427-35
Publication Type
Article
Date
Feb-2013
Author
Maria Söderström
Anders Albäck
Fausto Biancari
Kimmo Lappalainen
Mauri Lepäntalo
Maarit Venermo
Author Affiliation
Department of Vascular Surgery, Helsinki University Central Hospital, Helsinki, Finland. maria.soderstrom@hus.fi
Source
J Vasc Surg. 2013 Feb;57(2):427-35
Date
Feb-2013
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Amputation
Angioplasty, Balloon - adverse effects - mortality
Anti-Infective Agents - therapeutic use
Chi-Square Distribution
Debridement
Diabetic Foot - mortality - physiopathology - radiography - therapy
Female
Finland
Humans
Kaplan-Meier Estimate
Limb Salvage
Logistic Models
Male
Middle Aged
Multivariate Analysis
Negative-Pressure Wound Therapy
Peripheral Arterial Disease - mortality - physiopathology - radiography - therapy
Popliteal Artery - physiopathology - radiography
Propensity Score
Proportional Hazards Models
Regional Blood Flow
Registries
Retrospective Studies
Severity of Illness Index
Skin Transplantation
Surgical Flaps
Time Factors
Treatment Outcome
Wound Healing
Abstract
Because of the prolonged healing time of diabetic foot ulcers, methods for identifying ways to expedite the ulcer healing process are needed. The angiosome concept delineates the body into three-dimensional blocks of tissue fed by specific source arteries. The aim of this study was to evaluate the benefit of infrapopliteal endovascular revascularization guided by an angiosome model of perfusion in the healing process of diabetic foot ulcers.
A total of 250 consecutive legs with diabetic foot ulcers in 226 patients who had undergone infrapopliteal endovascular revascularization in a single center were evaluated. Patient records and periprocedural leg angiograms were reviewed. The legs were divided into two groups depending on whether direct arterial flow to the site of the foot ulcer based on the angiosome concept was achieved (direct group) or not achieved (indirect group). Ulcer healing time was compared between the two groups. A propensity score was used for adjustment of differences in pretreatment covariables in multivariate analysis and for 1:1 matching.
Direct flow to the angiosome feeding the ulcer area was achieved in 121 legs (48%) compared with indirect revascularization in 129 legs. Foot ulcers treated with angiosome-targeted infrapopliteal percutaneous transluminal angioplasty healed better. The ulcer healing rate was mean (standard deviation) 72% (5%) at 12 months for the direct group compared with 45% (6%) for the indirect group (P
PubMed ID
23219512 View in PubMed
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[Angiotensin converting enzyme, NO-synthase, and endothelin-1 genes and left ventricular hypertrophy in natives of Yakutia with hypertensive disease].

https://arctichealth.org/en/permalink/ahliterature176274
Source
Kardiologiia. 2005;45(1):41-4
Publication Type
Article
Date
2005
Author
L O Minushkina
I R Petrova
T A Romanova
V V Antipina
E R Makarova
D A Zateishikov
V V Nosikov
B A Sidorenko
Source
Kardiologiia. 2005;45(1):41-4
Date
2005
Language
Russian
Publication Type
Article
Keywords
Adult
Alanine
Asparagine
Blood Flow Velocity
Endothelin-1 - genetics
Female
Gene Frequency
Genotype
Glycine
Humans
Hypertension - complications - enzymology - genetics - pathology - physiopathology
Hypertrophy, Left Ventricular - complications - enzymology - genetics - pathology - physiopathology
Lysine
Male
Middle Aged
Mitral Valve
Nitric Oxide Synthase - genetics
Peptidyl-Dipeptidase A - genetics
Polymerase Chain Reaction
Polymorphism, Genetic
Russia
Severity of Illness Index
Abstract
Association of polymorphic markers G7831A of ACE gene, Lys198Asn of endothelin-1 (EDN1) gene, and 4a/4b of NOS3 gene with characteristics of structure and function of the left ventricle was studied in 70 (31 men and 39 women) natives of Yakutia with hypertension. Mean age of patients was 48.3+/-0.74 years, duration of hypertension -- 12.4+/-0.99 years; 60 (85.7%), 7 (10%) and 3 (4.3%) patients had III, II and I degree of hypertension, respectively. Polymerase chain reaction was used for identification of alleles of polymorphic markers G7831A of ACE gene, Lys198Asn of EDN1 gene, and 4a/4b of NOS3 gene. Polymorphic marker G7831A of ACE gene was not associated with severity of hypertrophy of left ventricular myocardium as well as with state of systolic and diastolic left ventricular function. Patients with allele Asn of EDN1 gene in the genotype had significantly lower value of peak A integral of trans-mitral blood flow. Patients with allele 4a of NOS3 gene had thicker left ventricular walls, greater left ventricular myocardial mass and mass index.
PubMed ID
15699938 View in PubMed
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350 records – page 1 of 35.