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Interrelations between brachial endothelial function and carotid intima-media thickness in young adults: the cardiovascular risk in young Finns study.

https://arctichealth.org/en/permalink/ahliterature177754
Source
Circulation. 2004 Nov 2;110(18):2918-23
Publication Type
Article
Date
Nov-2-2004
Author
Markus Juonala
Jorma S A Viikari
Tomi Laitinen
Jukka Marniemi
Hans Helenius
Tapani Rönnemaa
Olli T Raitakari
Author Affiliation
Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Source
Circulation. 2004 Nov 2;110(18):2918-23
Date
Nov-2-2004
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Arteriosclerosis - epidemiology
Blood Glucose - analysis
Body mass index
Brachial Artery - physiology - ultrasonography
C-Reactive Protein - analysis
Cardiovascular Diseases - epidemiology - physiopathology
Carotid Artery, Common - ultrasonography
Child
Child, Preschool
Cholesterol - blood
Cohort Studies
Coronary Disease - genetics
Cross-Sectional Studies
Endothelium, Vascular - physiology - physiopathology - ultrasonography
Female
Finland - epidemiology
Follow-Up Studies
Hemorheology
Homocysteine - blood
Humans
Male
Middle Aged
Prospective Studies
Risk factors
Sampling Studies
Sex Factors
Smoking - epidemiology
Tunica Intima - ultrasonography
Tunica Media - ultrasonography
Vasodilation
Waist-Hip Ratio
Abstract
Endothelial vasodilator dysfunction and carotid intima-media thickening (IMT) are 2 indicators of subclinical cardiovascular disease. We examined their correlation and interaction with risk factors in a large, community-based cohort of young adults.
As part of the longitudinal Cardiovascular Risk in Young Finns Study, we measured endothelium-dependent brachial artery flow-mediated dilatation (FMD) and carotid artery IMT by ultrasound in 2109 healthy adults aged 24 to 39 years. FMD was inversely associated with IMT (P0.2).
Brachial FMD is inversely associated with carotid IMT. The number of risk factors in young adults is correlated with increased IMT in subjects with evidence of endothelial dysfunction, but not in subjects with preserved endothelial function. These observations suggest that endothelial dysfunction is an early event in atherosclerosis and that the status of systemic endothelial function may modify the association between risk factors and atherosclerosis.
Notes
Comment In: Circulation. 2004 Nov 2;110(18):2774-715520334
PubMed ID
15505080 View in PubMed
Less detail

Physical Inactivity from Youth to Adulthood and Risk of Impaired Glucose Metabolism.

https://arctichealth.org/en/permalink/ahliterature299033
Source
Med Sci Sports Exerc. 2018 06; 50(6):1192-1198
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Date
06-2018
Author
Petri Kallio
Katja Pahkala
Olli J Heinonen
Tuija Tammelin
Mirja Hirvensalo
Risto Telama
Markus Juonala
Costan G Magnussen
Suvi Rovio
Harri Helajärvi
Nina Hutri-Kähönen
Jorma Viikari
Olli T Raitakari
Author Affiliation
Paavo Nurmi Centre and Department of Health and Physical Activity, University of Turku, Turku, FINLAND.
Source
Med Sci Sports Exerc. 2018 06; 50(6):1192-1198
Date
06-2018
Language
English
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Keywords
Adolescent
Adult
Blood Glucose - analysis
Child
Child, Preschool
Cross-Sectional Studies
Diabetes Mellitus, Type 2 - epidemiology
Exercise
Female
Finland
Glucose - metabolism
Humans
Life Style
Longitudinal Studies
Male
Middle Aged
Risk factors
Sedentary Behavior
Surveys and Questionnaires
Abstract
Physical activity (PA) is important in the prevention and treatment of impaired glucose metabolism. However, association of physical inactivity during the transition between childhood and adulthood with glucose metabolism is unknown. Therefore, we studied the association of persistent physical inactivity since childhood with glucose metabolism in adulthood.
Data were drawn from the ongoing, Cardiovascular Risk in Young Finns Study with repeated follow-ups between 1980 and 2011 (baseline age, 3-18 yr; n = 3596). Impaired glucose metabolism was defined as having impaired fasting glucose (6.1-6.9 mmol·L) or type 2 diabetes in adulthood. Leisure-time PA habits were repeatedly collected with a standardized questionnaire and expressed as a PA Index. Using PA Index, four groups were formed (n = 2000): 1) persistently low PA, 2) decreasingly active, 3) increasingly active, and 4) persistently active subjects. Poisson regression model was used to examine the association between PA groups and impaired glucose metabolism.
The proportion of the sample with impaired glucose metabolism was 16.1% in individuals with persistently low PA, 14.5% in decreasingly active, 6.8% in increasingly active, and 11.1% in persistently active. Compared with individuals with persistently low PA, age and sex-adjusted risk for impaired glucose metabolism were lower in those who increased PA (relative risk [RR], 0.47; 95% confidence interval [CI], 0.29-0.76) and in those who were persistently active (RR, 0.70; 95% CI, 0.51-0.97), but similar in those who decreased PA (RR, 0.93; 95% CI, 0.66-1.36).
Persistently physically inactive lifestyle from youth to adulthood is associated with increased risk of impaired glucose metabolism in adulthood. Importantly, a moderate increase in PA lowered the risk. The results highlight the importance of avoiding physically inactive lifestyle at all stages of life.
PubMed ID
29337718 View in PubMed
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Subtle changes in ADMA and l-arginine concentrations in normal pregnancies are unlikely to account for pregnancy-related increased flow-mediated dilatation.

https://arctichealth.org/en/permalink/ahliterature159725
Source
Clin Physiol Funct Imaging. 2008 Mar;28(2):120-4
Publication Type
Article
Date
Mar-2008
Author
Heli Saarelainen
Pirjo Valtonen
Kari Punnonen
Tomi Laitinen
Olli T Raitakari
Markus Juonala
Nonna Heiskanen
Tiina Lyyra-Laitinen
Jorma S A Viikari
Esko Vanninen
Seppo Heinonen
Author Affiliation
Department of Ob/Gyn, Kuopio University Hospital, University of Kuopio, Kuopio, Finland. heli.saarelainen@kuh.fi
Source
Clin Physiol Funct Imaging. 2008 Mar;28(2):120-4
Date
Mar-2008
Language
English
Publication Type
Article
Keywords
Adult
Arginine - analogs & derivatives - blood
Blood Flow Velocity - physiology
Blood Glucose - analysis
Brachial Artery - physiology - ultrasonography
Case-Control Studies
Cross-Sectional Studies
Endothelium, Vascular - physiology
Female
Finland
Humans
Lipids - blood
Pregnancy
Pregnancy Complications, Cardiovascular - blood - physiopathology
Prospective Studies
Statistics, nonparametric
Vasodilation - physiology
Abstract
Our objective was to investigate whether serum concentrations of asymmetric dimethylarginine (ADMA) or l-arginine correlate to hyperlipidemia or endothelial function in normal pregnancy compared with the non-pregnant subjects.
As a part of population-based, prospective cohort Cardiovascular Risk in Young Finns study conducted in Finland we examined 57 pregnant Finnish women throughout gestation and 62 control women matched for age and smoking. Serum glucose, triglycerides (TG), total cholesterol (TC), low-density cholesterol (LDL-C), high-density cholesterol (HDL-C) and ADMA, symmetric dimethylarginine (SDMA) and l-arginine were determined concomitantly with endothelium-dependent brachial artery flow-mediated dilation (FMD), measured by ultrasound. All serum lipid concentrations were significantly higher in pregnant women than in non-pregnant women (P
PubMed ID
18093231 View in PubMed
Less detail

Variation of the transcription factor 7-like 2 (TCF7L2) gene predicts impaired fasting glucose in healthy young adults: the Cardiovascular Risk in Young Finns Study.

https://arctichealth.org/en/permalink/ahliterature163249
Source
Diabetes Care. 2007 Sep;30(9):2299-301
Publication Type
Article
Date
Sep-2007