Skip header and navigation

Refine By

5 records – page 1 of 1.

Genetic susceptibility to non-insulin dependent diabetes mellitus and glucose intolerance are located in HLA region.

https://arctichealth.org/en/permalink/ahliterature220654
Source
BMJ. 1993 Jul 17;307(6897):155-9
Publication Type
Article
Date
Jul-17-1993
Author
E. Tuomilehto-Wolf
J. Tuomilehto
G A Hitman
A. Nissinen
J. Stengård
J. Pekkanen
P. Kivinen
E. Kaarsalo
M J Karvonen
Author Affiliation
Department of Epidemiology, National Public Health Institute, Helsinki, Finland.
Source
BMJ. 1993 Jul 17;307(6897):155-9
Date
Jul-17-1993
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Blood Glucose - analysis - genetics
Cohort Studies
Diabetes Mellitus, Type 2 - blood - epidemiology - genetics
Disease Susceptibility - blood - epidemiology
Finland - epidemiology
Genetic Predisposition to Disease
HLA Antigens - genetics
Haplotypes - genetics
Humans
Male
Prospective Studies
Random Allocation
Abstract
To test the hypothesis that the genetic susceptibility to non-insulin dependent diabetes mellitus is the same as that to insulin dependent disease and to see whether glucose intolerance is associated with specific HLA haplotypes.
Population based study of men in 1989 first tested for glucose tolerance in 1984. HLA haplotypes, including HLA-A, C, B, DR, and DQ, were defined serologically. HLA haplotype data from a population based Finnish study of childhood diabetes were used for predicting non-insulin dependent diabetes and impaired glucose tolerance.
Two communities in Finland.
Representative cohort of Finnish men aged 70-89, comprising 98 men with non-insulin dependent diabetes mellitus and a randomly selected group of 74 men, who served as controls, who were tested for glucose tolerance twice within five years.
Non-insulin dependent diabetes, impaired glucose tolerance, blood glucose concentration.
Diabetes associated HLA haplotypes were present in 94% (85/90) of diabetic subjects, 79% (27/34) of subjects with impaired glucose tolerance, and only 13% (3/23) of non-diabetic subjects. In this group of elderly men sensitivity of the diabetes associated HLA haplotypes for non-insulin dependent diabetes and impaired glucose tolerance was 90%, specificity 87%, and predictive power 97%. Mean fasting blood glucose concentration was only just significantly higher in men with diabetes associated haplotypes than in men with no such haplotypes, but there was a substantial difference in blood glucose values two hours after glucose loading (10.4 and 6.4 mmol/l in men with diabetes associated HLA haplotypes and men with no such haplotypes, respectively (p
Notes
Cites: Diabetes. 1973 Jun;22(6):429-324541338
Cites: Diabetologia. 1992 Mar;35(3):254-601348711
Cites: Lancet. 1974 Oct 12;2(7885):864-64137711
Cites: Br Med J. 1975 Jul 19;3(5976):133-51139259
Cites: Clin Endocrinol Metab. 1977 Jul;6(2):285-303330036
Cites: Diabetes. 1980 Jan;29(1):68-717380108
Cites: N Engl J Med. 1980 Oct 30;303(18):10657421907
Cites: Diabetologia. 1981 Feb;20(2):87-937193616
Cites: Med J Aust. 1981 May 2;1(9):462-46942207
Cites: S Afr Med J. 1981 Jul 18;60(3):93-67020102
Cites: Diabetologia. 1981 Nov;21(5):460-37297796
Cites: Chin Med J (Engl). 1982 Aug;95(8):609-126814864
Cites: Diabetologia. 1983 Jul;25(1):13-76350082
Cites: Acta Endocrinol (Copenh). 1983 Dec;104(4):475-86581663
Cites: Diabetologia. 1984 Sep;27(3):370-26594299
Cites: Age Ageing. 1986 Jul;15(4):203-113751746
Cites: Diabetologia. 1986 Sep;29(9):611-53792694
Cites: Diabetes. 1988 Jun;37(6):796-93384181
Cites: World Health Stat Q. 1988;41(3-4):179-892466379
Cites: Diabetologia. 1989 Jan;32(1):2-62707516
Cites: Lancet. 1989 Aug 5;2(8658):299-3022569104
Cites: Diabetologia. 1992 Jan;35(1):70-61541383
Comment In: BMJ. 1994 Feb 19;308(6927):5348136682
PubMed ID
8343743 View in PubMed
Less detail

Levels of some biological risk indicators among elderly men in Finland.

https://arctichealth.org/en/permalink/ahliterature236810
Source
Age Ageing. 1986 Jul;15(4):203-11
Publication Type
Article
Date
Jul-1986
Author
A. Nissinen
S L Kivela
J. Pekkanen
J. Tuomilehto
E. Kostiainen
H. Piippo
U K Lammi
E. Kaarsalo
M. Romo
S. Punsar
Source
Age Ageing. 1986 Jul;15(4):203-11
Date
Jul-1986
Language
English
Publication Type
Article
Keywords
Aged
Blood Glucose - analysis
Blood pressure
Body Weight
Calcium - blood
Cholesterol, HDL - blood
Coronary Disease - epidemiology - etiology
Finland
Follow-Up Studies
Heart rate
Humans
Male
Risk
Abstract
A 25-year follow-up survey of the Finnish men examined in the Seven Countries Study and now 65-84 years old was carried out in the East and the South-West of Finland in 1984. The follow-up examinations were carried out as in the previous surveys. Systolic and diastolic blood pressures were now significantly lower in the East than in the South-West of Finland. Serum total cholesterol and HDL-cholesterol were on the same level in both areas. The East/South-West difference in serum cholesterol, observed in previous studies, had levelled off and that in the blood pressure level had even reversed among the study cohorts. The mean fasting serum glucose was higher in the East than in the South-West of Finland. The mean serum calcium level was the same in both areas.
PubMed ID
3751746 View in PubMed
Less detail

Mapping genes for NIDDM. Design of the Finland-United States Investigation of NIDDM Genetics (FUSION) Study.

https://arctichealth.org/en/permalink/ahliterature205492
Source
Diabetes Care. 1998 Jun;21(6):949-58
Publication Type
Article
Date
Jun-1998
Author
T. Valle
J. Tuomilehto
R N Bergman
S. Ghosh
E R Hauser
J. Eriksson
S J Nylund
K. Kohtamäki
L. Toivanen
G. Vidgren
E. Tuomilehto-Wolf
C. Ehnholm
J. Blaschak
C D Langefeld
R M Watanabe
V. Magnuson
D S Ally
W A Hagopian
E. Ross
T A Buchanan
F. Collins
M. Boehnke
Author Affiliation
Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland. timo.valle@ktl.fi
Source
Diabetes Care. 1998 Jun;21(6):949-58
Date
Jun-1998
Language
English
Publication Type
Article
Keywords
Age of Onset
Aged
Blood Glucose - analysis
Diabetes Mellitus, Type 2 - blood - genetics - physiopathology
Female
Finland
Genetic Predisposition to Disease
Genotype
Humans
Insulin - blood
International Cooperation
Male
Middle Aged
Nuclear Family
Phenotype
Quantitative Trait, Heritable
Sex Characteristics
United States
Abstract
To map and identify susceptibility genes for NIDDM and for the intermediate quantitative traits associated with NIDDM.
We describe the methodology and sample of the Finland-United States Investigation of NIDDM Genetics (FUSION) study. The whole genome search approach is being applied in studies of several different ethnic groups to locate susceptibility genes for NIDDM. Detailed description of the study materials and designs of such studies are important, particularly when comparing the findings in these studies and when combining different data sets.
Using a careful selection strategy, we have ascertained 495 families with confirmed NIDDM in at least two siblings and no history of IDDM among the first-degree relatives. These families were chosen from more than 22,000 NIDDM patients, representative of patients with NIDDM in the Finnish population. In a subset of families, a spouse and offspring were sampled, and they participated in a frequently sampled intravenous glucose tolerance test (FSIGT) analyzed with the Minimal Model. An FSIGT was completed successfully for at least two nondiabetic offspring in 156 families with a confirmed nondiabetic spouse and no history of IDDM in first-degree relatives.
Our work demonstrates the feasibility of collecting a large number of affected sib-pair families with NIDDM to provide data that will enable a whole genome search approach, including linkage analysis.
PubMed ID
9614613 View in PubMed
Less detail

Prevalence of diabetes mellitus in elderly men aged 65 to 84 years in eastern and western Finland.

https://arctichealth.org/en/permalink/ahliterature236575
Source
Diabetologia. 1986 Sep;29(9):611-5
Publication Type
Article
Date
Sep-1986
Author
J. Tuomilehto
A. Nissinen
S L Kivelä
J. Pekkanen
E. Kaarsalo
E. Wolf
A. Aro
S. Punsar
M J Karvonen
Source
Diabetologia. 1986 Sep;29(9):611-5
Date
Sep-1986
Language
English
Publication Type
Article
Keywords
Aged
Blood Glucose - analysis
Diabetes Mellitus, Type 2 - epidemiology
Finland
Glucose Tolerance Test
Humans
Male
Abstract
We studied the prevalence of diabetes mellitus in men aged 65 to 84 years in Finland. The study sample consisted of 763 men, the survivors of the Finnish cohort of the "Seven Countries Study" first examined in 1959. The participation rate in the present survey was 94%. Blood glucose, fasting and 2 h after a 75-g oral glucose load, was determined from capillary blood. Current WHO criteria for diabetes mellitus were used. The mean fasting blood glucose level, adjusted for age and body mass index, was higher in east than west Finland. It rose with age in both areas. The prevalence of diabetes was 38% in the east and 36% in west Finland. About one-third of the men had impaired glucose tolerance. In the age group 75 to 79 years, the prevalence of diabetes was 65% in the east and 50% in the west. No systematic variation in the prevalence of impaired glucose tolerance with age was found. The mean levels of body mass index decreased with age in the same way in men with diabetes, impaired glucose tolerance and normal glucose tolerance. Body mass index was not higher in men with diabetes or impaired glucose tolerance than in men with normal glucose tolerance.
PubMed ID
3792694 View in PubMed
Less detail

Prevention of Type II diabetes in subjects with impaired glucose tolerance: the Diabetes Prevention Study (DPS) in Finland. Study design and 1-year interim report on the feasibility of the lifestyle intervention programme.

https://arctichealth.org/en/permalink/ahliterature201203
Source
Diabetologia. 1999 Jul;42(7):793-801
Publication Type
Article
Date
Jul-1999
Author
J. Eriksson
J. Lindström
T. Valle
S. Aunola
H. Hämäläinen
P. Ilanne-Parikka
S. Keinänen-Kiukaanniemi
M. Laakso
M. Lauhkonen
P. Lehto
A. Lehtonen
A. Louheranta
M. Mannelin
V. Martikkala
M. Rastas
J. Sundvall
A. Turpeinen
T. Viljanen
M. Uusitupa
J. Tuomilehto
Author Affiliation
National Public Health Institute, Department of Epidemiology and Health Promotion, Helsinki, Finland.
Source
Diabetologia. 1999 Jul;42(7):793-801
Date
Jul-1999
Language
English
Publication Type
Article
Keywords
Blood Glucose - analysis
Blood pressure
Body Weights and Measures
Diabetes Mellitus, Type 2 - prevention & control
Exercise
Finland
Glucose Intolerance - diet therapy - therapy
Humans
Obesity - diet therapy - therapy
Treatment Outcome
Triglycerides - blood
Abstract
AIMS/HYPOTHESIS; The aim of the Diabetes Prevention Study is to assess the efficacy of an intensive diet-exercise programme in preventing or delaying Type II (non-insulin-dependent) diabetes mellitus in subjects with impaired glucose tolerance, to evaluate the effects of the intervention programme on cardiovascular risk factors and to assess the determinants for the progression to diabetes in persons with impaired glucose tolerance.
A total of 523 overweight subjects with impaired glucose tolerance ascertained by two oral glucose tolerance tests were randomised to either a control or intervention group. The control subjects received general information at the start of the trial about the lifestyle changes necessary to prevent diabetes and about annual follow-up visits. The intervention subjects had seven sessions with a nutritionist during the first year and a visit every 3 months thereafter aimed at reducing weight, the intake of saturated fat and increasing the intake of dietary fibre. Intervention subjects were also guided individually to increase their physical activity.
During the first year, weight loss in the first 212 study subjects was 4.7 +/- 5.5 vs 0.9 +/- 4.1 kg in the intervention and control group, respectively (p
PubMed ID
10440120 View in PubMed
Less detail