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The -238 and -308 G-->A polymorphisms of the tumor necrosis factor alpha gene promoter are not associated with features of the insulin resistance syndrome or altered birth weight in Danish Caucasians.

https://arctichealth.org/en/permalink/ahliterature47878
Source
J Clin Endocrinol Metab. 2000 Apr;85(4):1731-4
Publication Type
Article
Date
Apr-2000
Author
S K Rasmussen
S A Urhammer
J N Jensen
T. Hansen
K. Borch-Johnsen
O. Pedersen
Author Affiliation
Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Denmark.
Source
J Clin Endocrinol Metab. 2000 Apr;85(4):1731-4
Date
Apr-2000
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Birth Weight - genetics
Body constitution
Body mass index
Denmark
Diabetes Mellitus, Type 2 - genetics
Female
Genotype
Humans
Insulin - blood
Insulin Resistance - genetics
Lipids - blood
Male
Obesity - genetics
Polymorphism, Restriction Fragment Length
Promoter Regions (Genetics)
Research Support, Non-U.S. Gov't
Tumor Necrosis Factor-alpha - genetics
Abstract
Recently, two G-->A polymorphisms at positions -308 and -238, in the promoter of the tumor necrosis factor alpha (TNF-alpha) gene, have been identified. These variants have, in different ethnic groups, been linked to estimates of insulin resistance and obesity. The objective of the present study was to investigate whether these genetic variants of TNF-alpha were associated with features of the insulin resistance syndrome or alterations in birth weight in two Danish study populations comprising 380 unrelated young healthy subjects and 249 glucose-tolerant relatives of type 2 diabetic patients, respectively. All study participants underwent an iv glucose tolerance test with the addition of tolbutamide after 20 min. In addition, a number of biochemical and anthropometric measures were performed on each subject. The subjects were genotyped for the polymorphisms by applying PCR restriction fragment length polymorphism. Neither of the variants was related to altered insulin sensitivity index or other features of the insulin resistance syndrome (body mass index, waist to hip ratio, fat mass, fasting serum lipids or fasting serum insulin or C-peptide). Birth weight and the ponderal index were also not associated with the polymorphisms. In conclusion, although the study was carried out on sufficiently large study samples, the study does not support a major role of the -308 or -238 substitutions of the TNF-alpha gene in the pathogenesis of insulin resistance or altered birth weight among Danish Caucasian subjects.
PubMed ID
10770222 View in PubMed
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An association between high birth weight and schizophrenia in a Finnish schizophrenia family study sample.

https://arctichealth.org/en/permalink/ahliterature133792
Source
Psychiatry Res. 2011 Dec 30;190(2-3):181-6
Publication Type
Article
Date
Dec-30-2011
Author
Asko Wegelius
Annamari Tuulio-Henriksson
Maiju Pankakoski
Jari Haukka
Ulriika Lehto
Tiina Paunio
Jouko Lönnqvist
Jaana Suvisaari
Author Affiliation
National Institute for Health and Welfare, Department of Mental Health and Substance Abuse Services, Helsinki, Finland. asko.wegelius@hus.fi
Source
Psychiatry Res. 2011 Dec 30;190(2-3):181-6
Date
Dec-30-2011
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Aged
Birth Weight - genetics
Family Health
Female
Finland - epidemiology
Humans
Longitudinal Studies
Male
Middle Aged
Proportional Hazards Models
Psychiatric Status Rating Scales
Risk factors
Schizophrenia - epidemiology - genetics - mortality
Survival Analysis
Abstract
Longitudinal cohort studies have implicated an association between both low and high birth weight and schizophrenia. It has been suggested that schizophrenia associated genes could augment an individual's susceptibility to adverse prenatal and perinatal environmental events. We investigated the association between birth weight and schizophrenia in a large Finnish schizophrenia family study sample. We utilized the birth weight data of 1051 offspring from 315 Finnish families with at least one offspring with a diagnosis of schizophrenia. We used a multivariate COX frailty model to analyze the effect of birth weight on the risk of developing schizophrenia within the families. Using information from the Medication Reimbursement Register and patient interviews, we further investigated the association of maternal type 2 diabetes and schizophrenia risk among offspring. High birth weight (>4000g) was associated with a 1.68-fold increase in schizophrenia susceptibility. Maternal diabetes at the time of data collection, a proxy for gestational diabetes, was associated with a 1.66-fold increase in the risk of developing schizophrenia among offspring. Our results corroborate recent findings showing an association between high birth weight and schizophrenia. Our results also point to a potential birth-weight independent association between maternal type 2 diabetes and schizophrenia among offspring.
PubMed ID
21664700 View in PubMed
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An interaction between NDE1 and high birth weight increases schizophrenia susceptibility.

https://arctichealth.org/en/permalink/ahliterature273909
Source
Psychiatry Res. 2015 Dec 15;230(2):194-9
Publication Type
Article
Date
Dec-15-2015
Author
Asko Wegelius
Maiju Pankakoski
Liisa Tomppo
Ulriika Lehto
Jouko Lönnqvist
Jaana Suvisaari
Tiina Paunio
William Hennah
Source
Psychiatry Res. 2015 Dec 15;230(2):194-9
Date
Dec-15-2015
Language
English
Publication Type
Article
Keywords
Adult
Aged
Birth Weight - genetics
Cohort Studies
Disease Susceptibility
Female
Finland - epidemiology
Haplotypes - genetics
Humans
Male
Microtubule-Associated Proteins - genetics
Middle Aged
Nerve Tissue Proteins - genetics
Polymorphism, Single Nucleotide - genetics
Retrospective Studies
Schizophrenia - diagnosis - epidemiology - genetics
Abstract
Pre- and perinatal environmental factors have been shown to increase schizophrenia risk particularly when combined with genetic liability. The investigation of specific gene environment interactions in the etiology of psychiatric disorders has gained momentum. We used multivariate GEE regression modeling to investigate the interaction between genes of the DISC1 pathway and birth weight, in relation to schizophrenia susceptibility in a Finnish schizophrenia family cohort. The study sample consisted of 457 subjects with both genotype and birth weight information. Gender and place of birth were adjusted for in the models. We found a significant interaction between birth weight and two NDE1 markers in relation to increased schizophrenia risk: a four SNP haplotype spanning NDE1 (b=1.26, SE=0.5, p=0.012) and one of its constituent SNPs rs4781678 (b=1.33, SE=0.51, p=0.010). Specifically, high birth weight (>4000g) was associated with increased schizophrenia risk among subjects homozygous for the previously identified risk alleles. The study was based on a family study sample with high genetic loading for schizophrenia and thus our findings cannot directly be generalized as representing the general population. Our results suggest that the functions mediated by NDE1 during the early stages of neurodevelopment are susceptible to the additional disruptive effects of pre- and perinatal environmental factors associated with high birth weight, augmenting schizophrenia susceptibility.
PubMed ID
26350705 View in PubMed
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Biometrical modelling in genetics: are complex traits too complex?

https://arctichealth.org/en/permalink/ahliterature94033
Source
Stat Methods Med Res. 2008 Feb;17(1):75-96
Publication Type
Article
Date
Feb-2008
Author
Gjessing Håkon K
Lie Rolv Terje
Author Affiliation
Divison of Epidemiology, Norwegian Institute of Public Health, Norway. hakon.gjessing@fhi.no
Source
Stat Methods Med Res. 2008 Feb;17(1):75-96
Date
Feb-2008
Language
English
Publication Type
Article
Keywords
Biometry
Birth Weight - genetics
Humans
Infant, Newborn
Models, Genetic
Models, Statistical
Norway
Pedigree
Registries
Abstract
The field of traditional biometrical genetics uses mixed-effects models to quantify the influence of genetic and environmental factors on a biological trait, based essentially on estimating within-family trait correlations. Such analyses provide a useful preview of what may be discovered with the emerging full-scale genotyping strategies. However, biometrical analyses require unrealistically large sample sizes to obtain a reasonable precision, particularly for dichotomous traits. In addition, it may be very difficult to separate genetic and environmental effects because environmental correlations are poorly understood. We illustrate these and other difficulties using population-based cousins and nuclear family data for birth weight, collected from the Medical Birth Registry of Norway.
PubMed ID
17855744 View in PubMed
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Birth characteristics and risk of prostate cancer: the contribution of genetic factors.

https://arctichealth.org/en/permalink/ahliterature149056
Source
Cancer Epidemiol Biomarkers Prev. 2009 Sep;18(9):2422-6
Publication Type
Article
Date
Sep-2009
Author
Sven Cnattingius
Frida Lundberg
Sven Sandin
Henrik Grönberg
Anastasia Iliadou
Author Affiliation
Department of Medicine, Karolinska Institutet at Karolinska University Hospital Solna, Stockholm, Sweden. sven.cnattingius@ki.se
Source
Cancer Epidemiol Biomarkers Prev. 2009 Sep;18(9):2422-6
Date
Sep-2009
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Birth Weight - genetics
Cohort Studies
Genetic Predisposition to Disease
Humans
Incidence
Male
Middle Aged
Proportional Hazards Models
Prospective Studies
Prostatic Neoplasms - epidemiology - genetics
Risk factors
Socioeconomic Factors
Sweden - epidemiology
Twins, Dizygotic
Twins, Monozygotic
Abstract
Prostate cancer has a strong hereditary component, but it has been proposed that hormonal influences in utero may contribute to offspring risk. We investigated the associations between birth characteristics and the risk of prostate cancer in twins, and whether possible associations could be confounded by familial factors, such as shared environment and common genes.
All like-sexed male twins in the Swedish Twin Registry, born from 1926 to 1958 and alive in 1973, were eligible. Data were obtained from birth records, and 11,420 male twins with reliable birth weight data were included in the final study population. Hazard ratios with 95% confidence intervals (CI) from Cox regression models were used to estimate associations between birth characteristics and risk of prostate cancer. Paired analysis was done to account for potential confounding by familial factors.
Compared with twins with a birth weight of 2,500 to 2,999 g, the hazard ratio (95% CI) for twins with a higher birth weight (>or=3,000 g) corresponded to 1.22 (0.94-1.57). In analyses within twin pairs, in which both twins had a birth weight of >or=2,500 g, a 500 g increase in birth weight was associated with an increased risk of prostate cancer within dizygotic twin pairs (odds ratio, 1.41; 95% CI, 1.02-1.57), but not within monozygotic twin pairs (odds ratio, 1.06; 95% CI, 0.61-1.84).
High birth weight is associated with an increased risk of prostate cancer. The difference in risk within dizygotic and monozygotic twin pairs may be due to genetic factors playing an important role in this association.
PubMed ID
19690187 View in PubMed
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Birth characteristics of offspring and parental diabetes: evidence for the fetal insulin hypothesis.

https://arctichealth.org/en/permalink/ahliterature47302
Source
J Epidemiol Community Health. 2004 Feb;58(2):126-8
Publication Type
Article
Date
Feb-2004

Birth weight and length as predictors for adult height.

https://arctichealth.org/en/permalink/ahliterature58893
Source
Am J Epidemiol. 1999 Apr 15;149(8):726-9
Publication Type
Article
Date
Apr-15-1999
Author
H T Sørensen
S. Sabroe
K J Rothman
M. Gillman
F H Steffensen
P. Fischer
T I Sørensen
Author Affiliation
Danish Epidemiology Science Centre at the Department of Epidemiology and Social Medicine, University of Aarhus.
Source
Am J Epidemiol. 1999 Apr 15;149(8):726-9
Date
Apr-15-1999
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Birth Weight - genetics
Body Height - genetics
Denmark
Embryonic and Fetal Development - genetics
Gestational Age
Humans
Infant, Newborn
Male
Phenotype
Registries - statistics & numerical data
Research Support, Non-U.S. Gov't
Abstract
Adult height has been found to be inversely associated with mortality. Recently, it has been suggested that growth in utero is linked with adult risk of several chronic diseases. The authors examined possible associations between birth weight, birth length, and adult height in young Danish men. They conducted the study in the fifth conscription district of Denmark including all the men born after January 1, 1973 who were residents in the study area during the period August 1, 1993 to July 31, 1994. The Danish Medical Birth Register contains information on all births in Denmark since January 1, 1973. Data on height from the Conscription Register were linked to the Danish Medical Birth Register in 4,300 conscripts examined. Nearly all Danish men have to register with the draft board around age 18 years of age where they undergo a physical examination. There was a strong positive association between birth weight and adult height; for subjects with birth weight or = 4,501 g, mean height was 184.1 cm. A positive association was also found between birth length and adult height. For subjects with birth length 56 cm. The associations between birth length and adult height persisted after adjustment for birth weight, gestational age, and other confounders, while the associations between birth weight and adult height almost disappeared when adjusting for birth length and the same confounders. Genetic and/or environmental factors operating both during the pre- and postnatal period may be responsible for the association between birth length and adult height.
PubMed ID
10206622 View in PubMed
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Birthweight discordant female twins and their offspring: is the intergenerational influence on birthweight due to genes or environment?

https://arctichealth.org/en/permalink/ahliterature119612
Source
Hum Reprod. 2013 Feb;28(2):480-7
Publication Type
Article
Date
Feb-2013
Author
L. Högberg
C. Lundholm
S. Cnattingius
S. Oberg
A N Iliadou
Author Affiliation
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, Stockholm SE-171 77, Sweden. lovisa.hogberg@ki.se
Source
Hum Reprod. 2013 Feb;28(2):480-7
Date
Feb-2013
Language
English
Publication Type
Article
Keywords
Adult
Aged
Birth Weight - genetics
Cohort Studies
Environment
Female
Fetal Development
Humans
Infant, Low Birth Weight
Infant, Newborn
Middle Aged
Risk factors
Sweden - epidemiology
Twins
Abstract
Does the intergenerational influence on birthweight and birth length remain within female dizygotic and monozygotic twin pairs?
The intergenerational influence on birthweight and birth length remained within dizygotic but not within monozygotic twin pairs.
Low birthweight is associated with increased morbidity and mortality in both the short and long term; therefore it is important to understand determinants of fetal growth. There is a known intergenerational association between parents' and offspring's size at birth.
This is a register-based cohort study with a nested within-twin-pair comparison. The study is retrospective, but based on prospectively collected information. The study population included 8685 monozygotic and like-sexed dizygotic female twins born in Sweden from 1926 to 1985, who had given birth to their first infant between 1973 and 2009.
This study is set in Sweden and used data from the Swedish Twin Register and the Swedish Medical Birth Register. We used generalized estimating equations to obtain regression coefficients with 95% confidence intervals (CI) for the outcomes: offspring birthweight and birth length. To control for genetic and shared environmental factors, we performed within-twin-pair analyses in 1479 dizygotic and 1526 monozygotic twin pairs.
In the cohort of both dizygotic and monozygotic twins, there was an association between mother's and offspring's size at birth. Within-dizygotic twin pairs, a 500-g increase from the twin pair's mean birthweight was associated with increased offspring birthweight [70 g (95% CI: 35-106)] and birth length [0.22 cm (95% CI: 0.07-0.38)]. The corresponding increase in birth length of 1 cm was estimated to increase offspring's birthweight by 26 g (95% CI: 12-40) and birth length by 0.11 cm (95% CI: 0.04-0.17). Within-monozygotic twin pairs there were no such associations.
This study is limited to twins who themselves or whose co-twin voluntarily responded to questionnaires.
The intergenerational influence on size at birth is suggested to be due to direct or indirect genetic factors.
PubMed ID
23087023 View in PubMed
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Birth weight in newborn infants with different diabetes-associated HLA genotypes in three neighbouring countries: Finland, Estonia and Russian Karelia.

https://arctichealth.org/en/permalink/ahliterature125325
Source
Diabetes Metab Res Rev. 2012 Jul;28(5):455-61
Publication Type
Article
Date
Jul-2012
Author
Aleksandr Peet
Pille Kool
Jorma Ilonen
Mikael Knip
Vallo Tillmann
Author Affiliation
Department of Pediatrics, University of Tartu, Tartu, Estonia. aleksandr.peet@kliinikum.ee
Source
Diabetes Metab Res Rev. 2012 Jul;28(5):455-61
Date
Jul-2012
Language
English
Publication Type
Article
Keywords
Adult
Birth Weight - genetics
Diabetes Mellitus, Type 1 - epidemiology - genetics
Estonia - epidemiology
Female
Finland - epidemiology
Genetic Predisposition to Disease
Genotype
HLA Antigens - genetics
Haplotypes - genetics
Humans
Infant
Infant, Newborn
Male
Russia - epidemiology
Young Adult
Abstract
Human leukocyte antigen (HLA) genotypes associated with increased risk for type 1 diabetes mellitus (T1D) have been reported to be associated with increased birth weight. We set out to investigate the association between HLA haplotypes conferring risk for T1D and birth weight and search for possible differences in the strength of these associations among populations with contrasting incidence of T1D.
As a part of the EU-funded DIABIMMUNE study, genotyping for the HLA haplotypes associated with T1D was performed in 8369 newborn infants from Estonia, Finland and Russian Karelia. Infants born before 35 gestational weeks, from mothers with diabetes, and multiple pregnancies were excluded. Relative birth weight, expressed in standard deviation scores, was estimated for each gestational week, sex and country. The standard deviation scores were calculated internally using the actual population studied. According to their HLA haplotypes, participants were divided into risk groups, and the distribution of birth weight between quartiles was analysed.
We did not find any direct association between various HLA risk-associated genotypes (HLA DR3-DQ2/DR4-DQ8, DR3-DQ2/X or DR4-DQ8/X) and birth weight. We observed a significant relationship between increased relative birth weight and the protective HLA-DR2-DQ6 and DR13-DQ6 haplotypes. This association was significant only when these haplotypes were found together with the DR4-DQ8 haplotype.
The previously reported association between HLA-risk haplotypes for T1D and an increased birth weight was not confirmed. This suggests that the mechanisms behind the association between high birth weight and risk for T1D may be not directly HLA related.
PubMed ID
22492720 View in PubMed
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Comparison of Texel- and Suffolk-sired crossbred lambs for survival, growth, and compositional traits.

https://arctichealth.org/en/permalink/ahliterature62131
Source
J Anim Sci. 1993 Apr;71(4):859-69
Publication Type
Article
Date
Apr-1993
Author
K A Leymaster
T G Jenkins
Author Affiliation
Roman L. Hruska U.S. Meat Animal Research Center, ARS, USDA, Clay Center, NE 68933-0166.
Source
J Anim Sci. 1993 Apr;71(4):859-69
Date
Apr-1993
Language
English
Publication Type
Article
Keywords
Adipose Tissue - growth & development
Animals
Birth Weight - genetics
Body Composition - genetics
Breeding
Comparative Study
Crosses, Genetic
Female
Least-Squares Analysis
Male
Meat - standards
Muscle Development
Protein Biosynthesis
Regression Analysis
Sheep - genetics - growth & development
Weaning
Weight Gain - genetics
Wool - growth & development
Abstract
Texel sheep were imported from Finland and Denmark for evaluation as a terminal sire population relative to the Suffolk breed. The objective was to estimate effects of sire breed on fitness, growth, and compositional traits of crossbred progeny that were serially slaughtered at 63, 105, 147, and 189 d of age. A total of 325 lambs, sired by 19 Texel and 20 Suffolk rams, were born to mature, half-Finnsheep ewes during a 2-yr period. Carcass traits were recorded on 183 lambs. Texel-sired lambs had greater survival to weaning (P = .06) and similar birth and weaning weights compared with Suffolk progeny. Lambs by Texel sires grew 11% less rapidly from 63 to 189 d of age. Estimated accretion rates of carcass fat at 189 d of age were 96.1 and 78.5 g/d for Suffolk and Texel progeny, respectively. Corresponding values for carcass protein were 17.4 and 16.0 g/d. At fixed ages, area of the longissimus muscle did not differ between sire breeds. Texel progeny weighed less at 189 d of age, producing lighter, leaner carcasses of shorter length (P
PubMed ID
8478288 View in PubMed
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36 records – page 1 of 4.