Skip header and navigation

1 records – page 1 of 1.

Antenatal corticosteroids for preterm birth: dose-dependent reduction in birthweight, length and head circumference.

https://arctichealth.org/en/permalink/ahliterature139521
Source
Acta Paediatr. 2011 Mar;100(3):364-9
Publication Type
Article
Date
Mar-2011
Author
Hanna Norberg
Jannica Stålnacke
Rochellys Diaz Heijtz
Ann-Charlotte Smedler
Margareta Nyman
Hans Forssberg
Mikael Norman
Author Affiliation
Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden. hanna.norberg@karolinska.se
Source
Acta Paediatr. 2011 Mar;100(3):364-9
Date
Mar-2011
Language
English
Publication Type
Article
Keywords
Birth Weight - drug effects
Body Height - drug effects
Cohort Studies
Dose-Response Relationship, Drug
Female
Gestational Age
Glucocorticoids - adverse effects - therapeutic use
Head - growth & development
Humans
Infant, Newborn
Infant, Premature
Male
Pregnancy
Premature Birth - drug therapy
Prenatal Exposure Delayed Effects
Sweden
Treatment Outcome
Abstract
This study was undertaken to evaluate the effects of repeated courses of antenatal corticosteroids (ACS) on foetal growth.
We studied 94 infants exposed to 2-9 courses of ACS. Mean gestational age (GA) at first exposure was 29 and at birth 34 weeks. Exposure data were retrieved from case record files. Information on potential confounders was collected from the Swedish Medical Birth Registry. Standard deviation scores (SDS) for birthweight (BW), birthlength (BL) and head circumference (HC) were calculated and considered as outcomes.
GA at start of ACS did not affect outcome. BW-SDS, BL-SDS and HC-SDS were -0.21, -0.19 and +0.25 in infants exposed to two courses, compared to -1.01, -1.04 and -0.23 in infants exposed to = 4 courses of ACS (p = 0.04-0.07). In multiple regression analyses, = 4 courses were associated with lower BW-SDS, BL-SDS and HC-SDS (p = 0.007-0.04) compared to SDS after 2-3 courses. The effects from = 4 courses on BW and BL were comparable to reduction in birth size seen in twins and on HC to that observed after maternal smoking.
Multiple courses of ACS are associated with a dose-dependent decline in foetal growth, which may affect later development and health.
PubMed ID
21054513 View in PubMed
Less detail