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Pre- and perinatal hypoxia associated with hippocampus/amygdala volume in bipolar disorder.

https://arctichealth.org/en/permalink/ahliterature261475
Source
Psychol Med. 2014 Apr;44(5):975-85
Publication Type
Article
Date
Apr-2014
Author
U K Haukvik
T. McNeil
E H Lange
I. Melle
A M Dale
O A Andreassen
I. Agartz
Source
Psychol Med. 2014 Apr;44(5):975-85
Date
Apr-2014
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Amygdala - pathology
Asphyxia Neonatorum - epidemiology - pathology
Bipolar Disorder - epidemiology - pathology
Comorbidity
Female
Fetal Hypoxia - epidemiology - pathology
Hippocampus - pathology
Humans
Magnetic Resonance Imaging
Male
Norway - epidemiology
Registries - statistics & numerical data
Young Adult
Abstract
Pre- and perinatal adversities may increase the risk for schizophrenia and bipolar disorder. Hypoxia-related obstetric complications (OCs) are associated with brain anatomical abnormalities in schizophrenia, but their association with brain anatomy variation in bipolar disorder is unknown.
Magnetic resonance imaging brain scans, clinical examinations and data from the Medical Birth Registry of Norway were obtained for 219 adults, including 79 patients with a DSM-IV diagnosis of bipolar disorder (age 29.4 years, s.d. = 11.8 years, 39% male) and 140 healthy controls (age 30.8 years, s.d. = 12.0 years, 53% male). Severe hypoxia-related OCs throughout pregnancy/birth and perinatal asphyxia were each studied in relation to a priori selected brain volumes (hippocampus, lateral ventricles and amygdala, obtained with FreeSurfer), using linear regression models covarying for age, sex, medication use and intracranial volume. Multiple comparison adjustment was applied.
Perinatal asphyxia was associated with smaller left amygdala volume (t = -2.59, p = 0.012) in bipolar disorder patients, but not in healthy controls. Patients with psychotic bipolar disorder showed distinct associations between perinatal asphyxia and smaller left amygdala volume (t = -2.69, p = 0.010), whereas patients with non-psychotic bipolar disorder showed smaller right hippocampal volumes related to both perinatal asphyxia (t = -2.60, p = 0.015) and severe OCs (t = -3.25, p = 0.003). No associations between asphyxia or severe OCs and the lateral ventricles were found.
Pre- and perinatal hypoxia-related OCs are related to brain morphometry in bipolar disorder in adulthood, with specific patterns in patients with psychotic versus non-psychotic illness.
Notes
Cites: Schizophr Res. 2010 Mar;117(1):1-1220071149
Cites: Behav Brain Res. 2010 Apr 2;208(2):609-1820085787
Cites: Int Rev Psychiatry. 2009;21(4):314-2220374146
Cites: Schizophr Bull. 2010 Jul;36(4):830-519176474
Cites: Biol Psychiatry. 2010 Jul 1;68(1):41-5020609836
Cites: Psychiatry Res. 2010 Jun 30;178(1):84-9120471103
Cites: Arch Gen Psychiatry. 2010 Sep;67(9):923-3020819986
Cites: Prog Neuropsychopharmacol Biol Psychiatry. 2010 Oct 1;34(7):1259-6520638435
Cites: Schizophr Bull. 2011 Jan;37(1):73-8319443616
Cites: Biol Psychiatry. 2011 Feb 15;69(4):326-3521030008
Cites: Eur J Neurosci. 2011 Mar;33(6):1170-421395861
Cites: Arch Gen Psychiatry. 2011 Apr;68(4):340-5021135314
Cites: Psychiatry Res. 2011 Dec 30;194(3):400-222041535
Cites: Eur Neuropsychopharmacol. 2012 Jan;22(1):1-1621723712
Cites: Neuroimage. 2012 Feb 15;59(4):3845-5121982932
Cites: Schizophr Bull. 2012 Mar;38(2):209-1421857009
Cites: Dev Med Child Neurol. 2012 Apr;54(4):313-2322283622
Cites: Neurosci Biobehav Rev. 2012 Apr;36(4):1342-5622244985
Cites: Neuroscientist. 2012 Apr;18(2):180-20021531988
Cites: Psychol Med. 2012 Jun;42(6):1329-3722029970
Cites: Bipolar Disord. 2012 Jun;14(4):326-3922631618
Cites: J Affect Disord. 2012 Aug;139(3):298-30122521854
Cites: Bipolar Disord. 2009 Feb;11(1):95-10119133972
Cites: Schizophr Bull. 2009 May;35(3):528-4819223657
Cites: Nature. 2009 Aug 6;460(7256):748-5219571811
Cites: Curr Pharm Des. 2009;15(22):2550-919689327
Cites: Br J Psychiatry. 2009 Sep;195(3):194-20119721106
Cites: J Affect Disord. 2010 Jan;120(1-3):200-619435640
Cites: Arch Gen Psychiatry. 2010 Feb;67(2):133-4320124113
Cites: Neuroimage. 2012 Aug 15;62(2):774-8122248573
Cites: Prog Neuropsychopharmacol Biol Psychiatry. 2012 Oct 1;39(1):1-822613185
Cites: J Psychiatry Neurosci. 2012 Sep;37(5):333-4322498078
Cites: Arch Gen Psychiatry. 2012 Jun;69(6):E1-822660967
Cites: Neuropharmacology. 2013 Jan;64:506-1422898496
Cites: Mol Psychiatry. 2012 Dec;17(12):1228-3822488257
Cites: Biol Psychiatry. 2013 Mar 15;73(6):565-7322980587
Cites: Schizophr Bull. 2014 Mar;40(2):410-923419977
Cites: Am J Psychiatry. 2000 Feb;157(2):203-1210671388
Cites: Am J Psychiatry. 2000 May;157(5):737-4410784466
Cites: Acta Obstet Gynecol Scand. 2000 Jun;79(6):435-910857866
Cites: JAMA. 2000 Oct 18;284(15):1939-4711035890
Cites: Arch Gen Psychiatry. 2002 Jan;59(1):35-4111779280
Cites: Neuron. 2002 Jan 31;33(3):341-5511832223
Cites: Am J Psychiatry. 2002 Sep;159(9):1514-2012202271
Cites: J Neuroimaging. 2003 Jan;13(1):68-7412593134
Cites: Biol Psychiatry. 2003 Apr 1;53(7):562-7012679233
Cites: J Pharmacol Exp Ther. 2003 May;305(2):434-912606697
Cites: Schizophr Res. 2004 Dec 1;71(2-3):405-1615474912
Cites: JAMA. 1994 Dec 14;272(22):1749-567966923
Cites: J Psychiatr Res. 1994 Nov-Dec;28(6):519-307699611
Cites: BMJ. 1999 Feb 13;318(7181):421-69974454
Cites: Arch Gen Psychiatry. 1999 Apr;56(4):356-6310197833
Cites: Biol Psychiatry. 2005 Mar 15;57(6):633-915780850
Cites: J Psychiatry Neurosci. 2007 May;32(3):203-1017476367
Cites: Cell Mol Neurobiol. 2007 May;27(3):351-817235693
Cites: Biol Psychiatry. 2007 Oct 15;62(8):884-9317698040
Cites: Int J Dev Neurosci. 2008 Feb;26(1):3-1117981423
Cites: Arch Gen Psychiatry. 2008 Sep;65(9):1017-3218762588
Cites: Schizophr Res. 2008 Sep;104(1-3):71-818656329
PubMed ID
23803260 View in PubMed
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