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1389 records – page 1 of 139.

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) poisoning in Victor Yushchenko: identification and measurement of TCDD metabolites.

https://arctichealth.org/en/permalink/ahliterature95137
Source
Lancet. 2009 Oct 3;374(9696):1179-85
Publication Type
Article
Date
Oct-3-2009
Author
Sorg O.
Zennegg M.
Schmid P.
Fedosyuk R.
Valikhnovskyi R.
Gaide O.
Kniazevych V.
Saurat J-H
Author Affiliation
Dermato-Toxicology, Swiss Centre for Applied Human Toxicology, and Department of Dermatology, University Hospital, Geneva, Switzerland.
Source
Lancet. 2009 Oct 3;374(9696):1179-85
Date
Oct-3-2009
Language
English
Publication Type
Article
Keywords
Adipose Tissue - chemistry
Biopsy
Drug Residues - analysis - metabolism
Fatal Outcome
Feces - chemistry
Forensic Medicine - methods
Half-Life
Homicide
Humans
Male
Middle Aged
Politics
Substance Abuse Detection - methods
Sweat - chemistry
Tetrachlorodibenzodioxin - analysis - chemistry - metabolism - poisoning
Time Factors
Ukraine
Abstract
BACKGROUND: 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has a long half-life of 5-10 years in human beings as a result of its high lipophilicity, and little or no metabolism. We monitored TCDD, its form, distribution, and elimination in Victor Yushchenko after he presented with severe poisoning. METHODS: In late December, 2004, a patient presented with TCDD poisoning; the levels in his blood serum (108000 pg/g lipid weight) were more than 50 000-fold greater than those in the general population. We identified TCDD and its metabolites, and monitored their levels for 3 years using gas chromatography and high-resolution mass spectrometry in samples of blood serum, adipose tissue, faeces, skin, urine, and sweat, after they were extracted and cleaned with different organic solvents. FINDINGS: The amount of unmodified TCDD in the samples that were analysed accounted for about 60% of TCDD eliminated from the body during the same period. Two TCDD metabolites-2,3,7-trichloro-8-hydroxydibenzo-p-dioxin and 1,3,7,8-tetrachloro-2-hydroxydibenzo-p-dioxin-were identified in the faeces, blood serum, and urine. The faeces contained the highest concentration of TCDD metabolites, and were the main route of elimination. Altogether, the different routes of elimination of TCDD and its metabolites accounted for 98% of the loss of the toxin from the body. The half-life of TCDD in our patient was 15.4 months. INTERPRETATION: This case of poisoning with TCDD suggests that the design of methods for routine assessment of TCDD metabolites in human beings should be a main aim of TCDD research in the metabolomic era. FUNDING: University of Geneva Dermatology Fund, and Swiss Centre for Applied Human Toxicology.
Notes
Comment In: Lancet. 2009 Oct 3;374(9696):1131-219660808
PubMed ID
19660807 View in PubMed
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5-year review of a unique multidisciplinary nonmelanoma skin cancer clinic.

https://arctichealth.org/en/permalink/ahliterature132764
Source
J Cutan Med Surg. 2011 Jul-Aug;15(4):220-6
Publication Type
Article
Author
Shaelyn Culleton
Dale Breen
Dalal Assaad
Liying Zhang
Judith Balogh
May Tsao
Juhu Kamra
Greg Czarnota
Oleh Antonyshyn
Jeffery Fialkov
Elizabeth Barnes
Author Affiliation
Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.
Source
J Cutan Med Surg. 2011 Jul-Aug;15(4):220-6
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Biopsy
Carcinoma, Basal Cell - pathology - therapy
Carcinoma, Squamous Cell - pathology - therapy
Chi-Square Distribution
Child
Delivery of Health Care, Integrated - organization & administration
Female
Humans
Male
Middle Aged
Ontario
Outcome and Process Assessment (Health Care)
Skin Neoplasms - pathology - therapy
Abstract
A multidisciplinary nonmelanoma skin cancer (NMSC) clinic is held weekly at our center, where all new patients are jointly assessed by dermatology/dermatopathology, radiation oncology, and plastic surgery. A new patient database was established in 2004. The purpose of this study was to provide a preliminary report on the patients seen in the NMSC clinic and the treatment recommendations rendered.
The new patient database was reviewed from January 2004 to December 2008, and patient demographics, tumor characteristics, and treatment recommendations were extracted. Cochran-Mantel-Harnszel (CMH) testing and chi-square analysis were used to detect any associations or relationships between variables within the database. A p value of less than .05 was considered significant.
During the 5-year study period, 2,146 new patients were seen in the NMSC clinic. The majority of patients presented with basal cell carcinoma (64%) or squamous cell carcinoma (22%), with a median tumor size of 1 to 2 cm (range 0 to > 9 cm). Tumors were located in the head and neck region (80%), extremities (14%), and torso (6%). Previous treatment included biopsy only (62%), surgery (20%), electrodesiccation and curettage (11%), topical imiquimod (3%), and radiotherapy (1%). Treatment recommendations included surgery (55%) (with either simple excision [31%] or excision with margin control under frozen-section guidance [24%]), radiotherapy (19%), topical imiquimod (10%), observation (7%), and electrodesiccation and curettage (4%).
The NMSC clinic at our center sees a high volume of patients who benefit from the multidisciplinary assessment provided. Treatment recommendations were based on patient and disease characteristics as well as patient preference.
PubMed ID
21781628 View in PubMed
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[4199 biopsies from the endoscopic normal lower duodenum].

https://arctichealth.org/en/permalink/ahliterature186945
Source
Z Gastroenterol. 2003 Jan;41(1):69-74
Publication Type
Article
Date
Jan-2003
Author
S. Walker
U. Rühl
Author Affiliation
Innere Medizin I, Krankenhaus Bietigheim, Bietighein-Bissingen. walker.innere1@kh-bietigheim.de
Source
Z Gastroenterol. 2003 Jan;41(1):69-74
Date
Jan-2003
Language
German
Publication Type
Article
Keywords
Adult
Biopsy
Celiac Disease - diagnosis - pathology
Diagnosis, Differential
Duodenal Diseases - diagnosis - pathology
Duodenoscopy
Duodenum - pathology
Female
Giardiasis - diagnosis - pathology
Humans
Inflammation - pathology
Lymphangiectasis - diagnosis - pathology
Male
Sensitivity and specificity
Abstract
Lower duodenal biopsies (LDB) are not taken at every oesophago-gastro-duodenoscopy (EGD). In the present study, biopsies from the endoscopic normal lower duodenum were checked as a measure of quality assurance. From 1996 to 2000, 9,955 EGD were performed and 4,199 LDB were taken (42.2 %). Of these, 667 showed pathological histology (15.9 %). A non-specific inflammation was seen in 537 cases and lymphangiectasia in 30 cases. Signs of indigenous sprue were described histologically in 6 LDB. In 4 of the 6 first diagnoses, the LDB was taken owing to clinical suspicion of malabsorption syndrome. Giardia lamblia could be detected in 22 patients. Only 6 of the 22 patients had diarrhoea. A total of 18 clinically relevant first diagnoses were made by LDB in asymptomatic patients with normal endoscopic findings in the duodenum. In order to make a relevant first diagnosis, 233 LDB had to be taken. LDB can be dispensed within EGD when there is neither diarrhoea nor loss of weight, and no anemia, iron deficiency, vitamin deficiency, macrocytosis, hypoproteinaemia, meteorism, joint symptoms or fever.
PubMed ID
12541178 View in PubMed
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Ablation therapy guided by contrast-enhanced sonography with Sonazoid for hepatocellular carcinoma lesions not detected by conventional sonography.

https://arctichealth.org/en/permalink/ahliterature86820
Source
J Ultrasound Med. 2008 Mar;27(3):395-406
Publication Type
Article
Date
Mar-2008
Author
Numata Kazushi
Morimoto Manabu
Ogura Takashi
Sugimori Kazuya
Takebayashi Shigeo
Okada Masahiro
Tanaka Katsuaki
Author Affiliation
Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Kanagawa 232-0024, Japan. kz-numa@zero.ad.jp
Source
J Ultrasound Med. 2008 Mar;27(3):395-406
Date
Mar-2008
Language
English
Publication Type
Article
Keywords
Aged
Analysis of Variance
Biopsy
Carcinoma, Hepatocellular - radiography - surgery - ultrasonography
Catheter Ablation
Chi-Square Distribution
Contrast Media
Female
Ferric Compounds - diagnostic use
Humans
Iron - diagnostic use
Liver Neoplasms - radiography - surgery - ultrasonography
Male
Middle Aged
Oxides - diagnostic use
Tomography, X-Ray Computed
Treatment Outcome
Ultrasonography, Interventional
Abstract
OBJECTIVE: We evaluated the usefulness of contrast-enhanced harmonic gray scale sonography with a newly developed sonographic contrast medium as a means of guidance for percutaneous ablation therapy of hepatocellular carcinoma lesions not detected by conventional sonography. METHODS: We examined 85 patients with 108 hepatocellular carcinoma lesions that were identified as hypervascular by multidetector-row computed tomography by using contrast-enhanced harmonic gray scale sonography after injection of Sonazoid (GE Healthcare, Oslo, Norway), a lipid-stabilized suspension of a perfluorobutane gas microbubble contrast agent. We scanned the whole liver by this modality at a low mechanical index in the late phase to detect lesions not detected by conventional sonography and then scanned the lesions again by this modality at a high mechanical index to visualize tumor vessels and enhancement. We also performed percutaneous ablation therapy guided by this modality to treat viable hepatocellular carcinoma lesions that could not be detected by conventional sonography. RESULTS: Conventional sonography identified 90 (83%) of 108 hepatocellular carcinoma lesions; 15 (14%) additional viable lesions not detected by conventional sonography were detected in the late phase of contrast-enhanced harmonic gray scale sonography at a low mechanical index, and tumor vessels and enhancement were observed in the late phase at a high mechanical index. Contrast-enhanced harmonic gray scale sonography diagnosed 105 (97%) of the 108 viable hepatocellular carcinoma lesions, and 14 (93%) of the 15 lesions not detected by conventional sonography were successfully treated by percutaneous ablation therapy guided by this modality. CONCLUSIONS: Contrast-enhanced harmonic gray scale sonography is useful for guidance of percutaneous ablation therapy of hepatocellular carcinoma lesions not detected by conventional sonography.
PubMed ID
18314518 View in PubMed
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Absence of p53 mutations in benign and pre-malignant male genital lesions with over-expressed p53 protein.

https://arctichealth.org/en/permalink/ahliterature21534
Source
Int J Cancer. 1998 Aug 31;77(5):674-8
Publication Type
Article
Date
Aug-31-1998
Author
K. Castrén
K. Vähäkangas
E. Heikkinen
A. Ranki
Author Affiliation
Department of Pharmacology and Toxicology, University of Oulu, Finland.
Source
Int J Cancer. 1998 Aug 31;77(5):674-8
Date
Aug-31-1998
Language
English
Publication Type
Article
Keywords
Biopsy
Bowen's Disease - genetics - pathology
Carcinoma in Situ - genetics - pathology
Carcinoma, Squamous Cell - genetics - pathology
Condylomata Acuminata - genetics - pathology
Exons
Female
Genes, p53
Genital Diseases, Male - genetics - pathology - surgery
Genital Neoplasms, Male - genetics - pathology - surgery
Humans
Male
Mutation
Papillomavirus, Human - isolation & purification
Precancerous Conditions - genetics - pathology - surgery
Research Support, Non-U.S. Gov't
Skin Neoplasms - genetics - pathology
Tumor Suppressor Protein p53 - biosynthesis
Uterine Cervical Neoplasms - genetics
Vulvar Neoplasms - pathology
Abstract
Mutations of the tumor-suppressor gene p53 are common in epithelial tumors. Clonal mutations of p53 have been found in cervical and vulvar carcinomas negative for human papillomavirus (HPV), though at least in cervical cancer HPV infection and p53 mutations are not mutually exclusive. We have previously shown that about 40% of male genital warts and bowenoid papulosis lesions exhibit immunohistochemically detectable aberrant p53 protein, irrespective of the presence of HPV DNA. We studied p53 mutations in exons 4-8 with SSCP and sequencing in 13 male patients with 1 to 3 therapy-resistant genital warts or intra-epithelial neoplasias each and in 4 patients with penile squamous cell carcinoma. Thus, 13 genital warts, 6 bowenoid papulosis, 1 Queyrat's erythroplasia and 1 carcinoma in situ were studied. p53 protein was detected immunohistochemically, and HPV status was analyzed with DNA in situ hybridization and amplification of HPV-specific DNA. There was no correlation between p53 protein expression and HPV status. No mutations in exons 5-8 of the p53 gene were found in any of the lesions, and furthermore, no exon 4 mutations were found in lesions positive in p53 immunohistochemistry. In conclusion, overexpression of p53 does not indicate a p53 mutation in male genital warts, pre-malignant lesions or malignant squamous cell carcinomas. Our study thus suggests that p53 mutations are not important, or at least not early, events in male genital carcinogenesis.
PubMed ID
9688297 View in PubMed
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Acanthamoeba keratitis in the south of Sweden.

https://arctichealth.org/en/permalink/ahliterature51052
Source
Acta Ophthalmol Scand. 1996 Dec;74(6):593-7
Publication Type
Article
Date
Dec-1996
Author
A. Skarin
I. Florén
K. Kiss
H. Miörner
U. Stenevi
Author Affiliation
Department of Ophthalmology, University Hospital of Lund, Sweden.
Source
Acta Ophthalmol Scand. 1996 Dec;74(6):593-7
Date
Dec-1996
Language
English
Publication Type
Article
Keywords
Acanthamoeba - isolation & purification
Acanthamoeba Keratitis - drug therapy - epidemiology - etiology - pathology
Adult
Aged
Amebicides - therapeutic use
Animals
Anti-Bacterial Agents
Antifungal Agents - therapeutic use
Biopsy
Cornea - drug effects - parasitology - pathology
Drug Therapy, Combination - therapeutic use
Female
Humans
Incidence
Male
Middle Aged
Retrospective Studies
Sweden - epidemiology
Abstract
Eight patients with Acanthamoeba keratitis were diagnosed and treated at our clinic between February 1991 and February 1993. Five of these were contact lens wearers, two had suffered recent corneal trauma and one had recently undergone penetrating keratoplasty. The diagnoses were based on both culture and histological examination of biopsy material in three cases, on culture alone in two cases and on histological examination alone in three cases. In all but one primary treatment was Propamidine isethionate and Neomycin/Polymyxin B topically and Ketoconazole orally. Because of poor healing three patients additionally received Paromomycin and Miconazole or Clotrimazol topically; two of these were further treated with Polyhexamethylene biguanide topically. The interval from initial symptoms to accurate diagnoses varied from one to eleven months. In one patient the eye could not be saved; in the remaining patients visual acuity after healing ranged from hand movements to 1.0.
PubMed ID
9017049 View in PubMed
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Accuracy in celiac disease diagnostics by controlling the small-bowel biopsy process.

https://arctichealth.org/en/permalink/ahliterature135188
Source
J Pediatr Gastroenterol Nutr. 2011 May;52(5):549-53
Publication Type
Article
Date
May-2011
Author
Charlotta Webb
Britta Halvarsson
Fredrik Norström
Anna Myléus
Annelie Carlsson
Lars Danielsson
Lotta Högberg
Anneli Ivarsson
Eva Karlsson
Lars Stenhammar
Olof Sandström
Author Affiliation
Department of Pediatrics, Lund University, Lund, Sweden.
Source
J Pediatr Gastroenterol Nutr. 2011 May;52(5):549-53
Date
May-2011
Language
English
Publication Type
Article
Keywords
Biological Markers - blood
Biopsy - methods
Celiac Disease - epidemiology - pathology - surgery
Child
Diagnostic Errors - prevention & control
Endoscopy - methods
Humans
Intestinal Mucosa - pathology - surgery
Intestine, Small - pathology - surgery
Mass Screening - methods
Prevalence
Retrospective Studies
Suction
Sweden - epidemiology
Abstract
In a Swedish celiac disease screening study (Exploring the Iceberg of Celiacs in Sweden), we systematically reviewed the clinical diagnostic procedures with the aim to evaluate the diagnostic accuracy and to take advantage of lessons learned for improving diagnostic routines.
A school-based celiac disease screening study involving 5 Swedish centers, with 10,041 invited 12-year-olds with 7567 consenting participation. All 192 children with elevated serological markers were recommended to undergo small-bowel biopsy, performed and evaluated according to local clinical routines. All of the mucosal specimens were reevaluated by 1 and, when needed, 2 expert pathologists to reach diagnostic consensus.
Small-bowel biopsies were performed in 184 children: 130 by endoscopy and 54 by suction capsule. Endoscopic biopsies were inconclusive in 0.6%, compared with 7.4% of biopsies by suction capsule. A patchy enteropathy was found in 9.1%. Reevaluation by the expert pathologist resulted in 6 additional cases with celiac disease and 1 cleared. Sixteen children with normal or inconclusive biopsies, 4 after endoscopy, and 12 after suction capsule were endoscopically rebiopsied, resulting in another 8 cases. The celiac disease prevalence of 30 of 1000 (95% confidence interval 26-34) was not statistically different from that previously reported.
The present review revealed the importance of controlling each step of the diagnostic procedure. Several cases would have been missed by relying only on local routines. To improve the quality of childhood celiac disease diagnostics, we recommend multiple endoscopic biopsies from both proximal and distal duodenum and standardized evaluation by a pathologist with good knowledge of celiac disease.
PubMed ID
21502825 View in PubMed
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Accuracy of adrenal biopsy guided by ultrasound and CT.

https://arctichealth.org/en/permalink/ahliterature24747
Source
Acta Radiol. 1991 Sep;32(5):371-4
Publication Type
Article
Date
Sep-1991
Author
T. Tikkakoski
M. Taavitsainen
M. Päivänsalo
S. Lähde
M. Apaja-Sarkkinen
Author Affiliation
Department of Radiology, University Central Hospitals, Oulu, Finland.
Source
Acta Radiol. 1991 Sep;32(5):371-4
Date
Sep-1991
Language
English
Publication Type
Article
Keywords
Adrenal Gland Neoplasms - diagnosis - pathology - radiography - ultrasonography
Adult
Aged
Aged, 80 and over
Biopsy, Needle - methods
Female
Humans
Male
Middle Aged
Tomography, X-Ray Computed
Abstract
We reviewed the results of fine needle biopsy of the adrenal glands guided by ultrasonography or CT in 56 patients. The final diagnoses, obtained at operation, autopsy or follow-up were: metastasis (n = 22), adenoma (n = 21), adrenal cyst (n = 6), hematoma (n = 3), lymphoma (n = 1), pheochromocytoma (n = 1), lymph node (n = 1), and amyloid mass (n = 1). Sufficient cytologic material was obtained in 96.4% (54/56). The overall accuracy to differentiate benign from malignant disease was 85.7% (48/56), 2 were false-negative, one was false-positive. The biopsy was inconclusive ("possibly malignant") in 3 patients, 2 of whom had an additional cutting needle biopsy yielding a correct positive finding. No complications occurred. We conclude that in disseminated malignant disease with suspected adrenal metastases diagnostic results can be obtained with guided fine needle biopsy. Biopsy in primary adrenal lesions is helpful, especially if the aspirate of the lesion turns out to be composed of something other than adrenal cells.
PubMed ID
1910990 View in PubMed
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Accuracy of fine needle aspiration in the pre-operative diagnosis of thyroid neoplasia.

https://arctichealth.org/en/permalink/ahliterature217279
Source
J Otolaryngol. 1994 Oct;23(5):360-5
Publication Type
Article
Date
Oct-1994
Author
S M Vojvodich
R H Ballagh
H. Cramer
H B Lampe
Author Affiliation
Department of Otolaryngology, University of Western Ontario, London.
Source
J Otolaryngol. 1994 Oct;23(5):360-5
Date
Oct-1994
Language
English
Publication Type
Article
Keywords
Adenoma - pathology - surgery
Biopsy, Needle - statistics & numerical data
Carcinoma, Papillary - pathology - surgery
Cysts - pathology - surgery
Forecasting
Frozen Sections - statistics & numerical data
Goiter - pathology - surgery
Humans
Intraoperative Care
Ontario - epidemiology
Preoperative Care
Sensitivity and specificity
Thyroid Diseases - pathology - surgery
Thyroid Neoplasms - pathology - surgery
Thyroid Nodule - pathology - surgery
Thyroiditis, Autoimmune - pathology - surgery
Abstract
The aim of this study was to determine the accuracy and clinical utility of fine needle aspiration (FNA) for the preoperative diagnosis of patients presenting with solitary thyroid nodules. Between 1987 and 1991, 317 patients with a thyroid nodule underwent FNA. Surgery was performed on 98 of the patients, and the cytologic findings were correlated with the final histologic diagnoses for these cases. Of the 98 patients operated on, satisfactory aspirates were obtained in 85 patients and classified as either malignant, suspicious for malignancy, or benign. The FNA was correct in predicting malignancy in 29 of 35 nodules (82.9%). With the benign nodules, FNA was correct in 44 of 50 nodules (88%). The overall accuracy of FNA was 85.9%. The accuracy for the combination of FNA and frozen section (FS) was 92.6%. We conclude that both FNA and FS are accurate tests that play a useful role in the pre- and intraoperative diagnostic evaluation of patients presenting with solitary thyroid nodules.
PubMed ID
7807641 View in PubMed
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1389 records – page 1 of 139.