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714 records – page 1 of 72.

[20-year experience with modified dose fractionation of radiotherapy in primary Hodgkin's disease].

https://arctichealth.org/en/permalink/ahliterature154608
Source
Vopr Onkol. 2008;54(4):529-31
Publication Type
Article
Date
2008
Author
N V Il'in
E N Nikolaeva
E V Smirnova
Iu N Vinogradova
E I Ivanova
B M Izotov
I A Shenderova
Source
Vopr Onkol. 2008;54(4):529-31
Date
2008
Language
Russian
Publication Type
Article
Keywords
Adult
Aged
Biomedical research
Disease-Free Survival
Dose Fractionation
Female
Hodgkin Disease - radiotherapy
Humans
Incidence
Kaplan-Meier Estimate
Leukopenia - epidemiology - etiology
Male
Middle Aged
Pericarditis - epidemiology - etiology
Pneumonia - epidemiology - etiology
Radiotherapy - adverse effects
Recurrence
Retrospective Studies
Russia - epidemiology
Severity of Illness Index
Thrombocytopenia - epidemiology - etiology
Treatment Outcome
Abstract
Significantly lower frequency of relapse, incidence of pulmonitis and pericarditis, leukopenia and thrombocytopenia stage IV and longer recurrence-free survival were reported after acceleration of multifractionation of STD of 1.35Gy was used for treatment of patients with primary Hodgkin's disease, as compared with standard fractionation. When STD was reduced to 1.2Gy (modified multifractionation), subtotal exposure of lymph nodes was followed by a significant drop in frequency and severity of leukopenia and thrombocytopenia stage III-IV. The latter complications, rates decreased further, with perspective response to therapy, as irradiation was limited to that of areas exposed during modified multifractionation.
PubMed ID
18942416 View in PubMed
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35 years of marine natural product research in Sweden: Cool molecules and models from cold waters.

https://arctichealth.org/en/permalink/ahliterature283493
Source
Prog Mol Subcell Biol. 2017;55:1-34
Publication Type
Article
Date
2017
Author
Lars Bohlin
Paco Cárdenas
Anders Backlund
Ulf Göransson
Source
Prog Mol Subcell Biol. 2017;55:1-34
Date
2017
Language
English
Publication Type
Article
Keywords
Animals
Aquatic Organisms - chemistry - genetics
Biological Products - chemistry - therapeutic use
Biomedical Research - trends
Cold Temperature
Marine Biology - trends
Oceans and Seas
Porifera - chemistry - genetics
Sweden
Technology, Pharmaceutical - trends
Abstract
Currents efforts in marine biodiscovery have essentially focused on temperate to tropical shallow water organisms. With more than 6000 species of marine plants and animals, the Kosterfjord area has the richest marine biodiversity in Swedish waters, but it remains understudied. The overall objective of our marine pharmacognosy research is to explore and reveal the pharmacological potential of organisms from this poorly explored region. More generally, we wish to understand aspects of structure-activity relationships of chemical interactions in cold-water marine environment (shallow and deep). Our strategy is based on ecologically guided search for compounds through studies of physiology and organism interactions coupled to identification of bioactive molecules guided by especially in vivo assays. The research programme originated in the beginning of the 1980s with a broad screening of Swedish marine organisms using both in vitro and in vivo assays, resulting in isolation and identification of several different bioactive molecules. Two congenerous cyclopeptides, i.e. barettin and 8,9-dihydrobarettin, were isolated from the deep-sea sponge Geodia barretti, and structurally elucidated, guided by their antifouling activity and their affinity to a selection of human serotonin receptors. To optimize the activity a number of analogues of barettin were synthezised and tested for antifouling activity. Within the EU project BlueGenics, two larger homologous peptides, barrettides A and B, were isolated from G. baretti. Also, metabolic fingerprinting combined with sponge systematics was used to further study deep-sea natural product diversity in the genus Geodia. Finally, the chemical property space model 'ChemGPS-NP' has been developed and used in our research group, enabling a more efficient use of obtained compounds and exploration of possible biological activities and targets. Another approach is the broad application of phylogenetic frameworks, which can be used in prediction of where-in which organisms-to search for novel molecules or better sources of known molecules in marine organisms. In a further perspective, the deeper understanding of evolution and development of life on Earth can also provide answers to why marine organisms produce specific molecules.
PubMed ID
28238034 View in PubMed
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[50 years anniversary of Research Institute for Occupational Medicine and Human Ecology with Siberian Division of RAMSc].

https://arctichealth.org/en/permalink/ahliterature137599
Source
Med Tr Prom Ekol. 2010;(10):1-5
Publication Type
Article
Date
2010
Author
V S Rukavishnikov
S F Shaiakhmetov
T M Gus'kova
Source
Med Tr Prom Ekol. 2010;(10):1-5
Date
2010
Language
Russian
Publication Type
Article
Keywords
Academies and Institutes - history
Anniversaries and Special Events
Biomedical Research - history
Ecology - history
History, 20th Century
History, 21st Century
Humans
Occupational Medicine - history
Siberia
Abstract
The article covers main steps of establishment and development of Research Institute for Occupational medicine and Human ecology with Siberian Division of RAMSc over 50 years of activities, major results of research, contribution of the Institute personnel into development of hygienic science and practical medicine in Siberia.
PubMed ID
21265049 View in PubMed
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110 million dollars vaccine research centre to be built in Saskatoon.

https://arctichealth.org/en/permalink/ahliterature164710
Source
CMAJ. 2007 Mar 13;176(6):751
Publication Type
Article
Date
Mar-13-2007
Source
Nature. 2005 Oct 6;437(7060):794-5
Publication Type
Article
Date
Oct-6-2005
Source
Nature. 2005 Oct 6;437(7060):794-5
Date
Oct-6-2005
Language
English
Publication Type
Article
Keywords
Alaska
Biomedical Research - ethics - legislation & jurisprudence
Bioterrorism - prevention & control
Evolution, Molecular
Female
History, 20th Century
Humans
Influenza, Human - epidemiology - history - prevention & control - virology
Orthomyxoviridae - genetics - pathogenicity
Publishing
Time Factors
Virulence - genetics
Virulence Factors
Notes
Comment In: Nature. 2006 Jan 19;439(7074):26616421546
Comment On: Nature. 2005 Oct 6;437(7060):889-9316208372
Erratum In: Nature. 2005 Oct 13;437(7061):940
PubMed ID
16208326 View in PubMed
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[Academician of the RAS, MD, PhD, DSc, Professor G G Onishchenko (the 65th anniversary)].

https://arctichealth.org/en/permalink/ahliterature270120
Source
Gig Sanit. 2015;94(8):83
Publication Type
Article
Date
2015

Access and benefits sharing of genetic resources and associated traditional knowledge in northern Canada: understanding the legal environment and creating effective research agreements

https://arctichealth.org/en/permalink/ahliterature284320
Source
Pages 912-920 in N. Murphy and A. Parkinson, eds. Circumpolar Health 2012: Circumpolar Health Comes Full Circle. Proceedings of the 15th International Congress on Circumpolar Health, Fairbanks, Alaska, USA, August 5-10, 2012. International Journal of Circumpolar Health 2013;72 (Suppl 1):912-920
Publication Type
Article
Date
2013
  1 document  
Author
Geary J1, Jardine CG, Guebert J, Bubela T.
Author Affiliation
School of Public Health, University of Alberta, Edmonton, Canada
Source
Pages 912-920 in N. Murphy and A. Parkinson, eds. Circumpolar Health 2012: Circumpolar Health Comes Full Circle. Proceedings of the 15th International Congress on Circumpolar Health, Fairbanks, Alaska, USA, August 5-10, 2012. International Journal of Circumpolar Health 2013;72 (Suppl 1):912-920
Date
2013
Publication Type
Article
Digital File Format
Text - PDF
Physical Holding
University of Alaska Anchorage
Keywords
Access to Information/legislation & jurisprudence
Biomedical Research/legislation & jurisprudence
Biomedical Research/organization & administration
Canada
Community-Institutional Relations/legislation & jurisprudence
Culture
Financing, Government
Genetics, Medical/legislation & jurisprudence
Genetics, Medical/organization & administration
Health Policy
Humans
Indians, North American/ethnology
Indians, North American/genetics
Indians, North American/legislation & jurisprudence
Documents
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Access Governance for Biobanks: The Case of the BioSHaRE-EU Cohorts.

https://arctichealth.org/en/permalink/ahliterature279361
Source
Biopreserv Biobank. 2016 Jun;14(3):201-6
Publication Type
Article
Date
Jun-2016
Author
Jane Kaye
Linda Briceño Moraia
Colin Mitchell
Jessica Bell
Jasper Adriaan Bovenberg
Anne-Marie Tassé
Bartha Maria Knoppers
Source
Biopreserv Biobank. 2016 Jun;14(3):201-6
Date
Jun-2016
Language
English
Publication Type
Article
Keywords
Biological Specimen Banks - legislation & jurisprudence - organization & administration
Biomedical Research - legislation & jurisprudence
Cooperative Behavior
Databases, Factual
European Union
Finland
Germany
Humans
Information Dissemination - legislation & jurisprudence
Interprofessional Relations
Netherlands
Norway
United Kingdom
Abstract
Currently, researchers have to apply separately to individual biobanks if they want to carry out studies that use samples and data from multiple biobanks. This article analyzes the access governance arrangements of the original five biobank members of the Biobank Standardisation and Harmonisation for Research Excellence in the European Union (BioSHaRE-EU) project in Finland, Germany, the Netherlands, Norway, and the United Kingdom to identify similarities and differences in policies and procedures, and consider the potential for internal policy "harmonization." Our analysis found differences in the range of researchers and organizations eligible to access biobanks; application processes; requirements for Research Ethics Committee approval; and terms of Material Transfer Agreements relating to ownership and commercialization. However, the main elements of access are the same across biobanks; access will be granted to bona fide researchers conducting research in the public interest, and all biobanks will consider the scientific merit of the proposed use and it's compatibility with the biobank's objectives. These findings suggest potential areas for harmonization across biobanks. This could be achieved through a single centralized application to a number of biobanks or a system of mutual recognition that places a presumption in favor of access to one biobank if already approved by another member of the same consortium. Biobanking and Biomolecular Resources Research Infrastructure-European Research Infrastructure Consortia (BBMRI-ERIC), a European consortium of biobanks and bioresources with its own ethical, legal, and social implications (ELSI) common service, could provide a platform by developing guidelines for harmonized internal processes.
PubMed ID
27183185 View in PubMed
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714 records – page 1 of 72.