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An analysis of the clinical development of drugs in Norway for the year 2000: the completion of research and publication of results.

https://arctichealth.org/en/permalink/ahliterature153525
Source
Eur J Clin Pharmacol. 2009 Mar;65(3):315-8
Publication Type
Article
Date
Mar-2009
Author
Ola P Hole
Sigurd Nitter-Hauge
Henrik R Cederkvist
Finn O Winther
Author Affiliation
Faculty Division Rikshospitalet, University of Oslo, 0027 Oslo, Norway.
Source
Eur J Clin Pharmacol. 2009 Mar;65(3):315-8
Date
Mar-2009
Language
English
Publication Type
Article
Keywords
Academies and Institutes - economics - statistics & numerical data
Biomedical Research - economics - ethics - statistics & numerical data
Clinical Trials as Topic - economics - ethics - statistics & numerical data
Drug Industry - economics - ethics - statistics & numerical data
Ethics Committees, Research - ethics - standards
Hospitals, Private - economics - statistics & numerical data
Hospitals, Public - economics - statistics & numerical data
Humans
Information Dissemination - ethics
Norway
Publishing - ethics - standards - statistics & numerical data
Questionnaires
Research Design - standards - statistics & numerical data
Research Support as Topic - ethics - statistics & numerical data
Time Factors
Abstract
In Norway, very little data are available on the relation between the total number of research projects on the clinical development of drugs that have been started, the number of these projects in which the research phase has been completed and the number of projects for which results have been published. The aim of this study was to determine the number of projects in which the research phase had been completed and the results published.
Information on research projects carried out on the clinical development of drugs during the year 2000 was obtained from the archives of the Norwegian Research Ethical Committee (REC) and subsequently analysed.
The final analysis revealed that 245 research projects on the clinical development of drugs had been started in 2000. Of these, 178 (73%) completed the research phase as planned. The results of 131 (54%) of these projects were published in a scientific journal, and another 34 (14%) were reported as a congress abstract or as report to a sponsor; 80 (33%) were not published at all. Industrial sponsors seemed to promote both the completion of the research process and the publication of results in scientific journals.
PubMed ID
19104790 View in PubMed
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An analysis of the clinical development of drugs in Norway for the years 2000 and 2004: the influence of the pharmaceutical industry.

https://arctichealth.org/en/permalink/ahliterature162102
Source
Eur J Clin Pharmacol. 2007 Oct;63(10):909-12
Publication Type
Article
Date
Oct-2007
Author
Finn O Winther
Ola P Hole
Sigurd Nitter-Hauge
Author Affiliation
Faculty Division Rikshospitalet, University of Oslo, 0027, Oslo, Norway. finnow@ulrik.uio.no
Source
Eur J Clin Pharmacol. 2007 Oct;63(10):909-12
Date
Oct-2007
Language
English
Publication Type
Article
Keywords
Academies and Institutes - economics - statistics & numerical data
Bias (epidemiology)
Biomedical Research - economics - ethics - statistics & numerical data
Clinical Trials as Topic - economics - ethics - statistics & numerical data
Conflict of Interest
Drug Industry - economics - ethics - statistics & numerical data
Hospitals, Private - economics - statistics & numerical data
Hospitals, Public - economics - statistics & numerical data
Humans
Norway - epidemiology
Research Support as Topic - ethics - statistics & numerical data
Time Factors
Abstract
Little has been published either concerning the total number of research projects in connection with clinical development of drugs or the number of projects financially supported by the industry.
From the archives of the five regional Norwegian Research Ethical Committees (REC), all research projects in connection with clinical development of drugs for the years 2000 and 2004 were analysed with the intention of finding the number of projects financially supported by the industry, the type of research institution, the industrial company, the topic of the research as classified in the international Anatomic Therapeutic Classification system (ATC), the research phase and the approval status of the drug by the Norwegian Medicines Agency (NMA).
The total number of research projects for the clinical development of drugs for the years 2000 and 2004 was 489, and 75.7% were financially supported by the industry. More than two-thirds of the projects were done in academic institutions and about one-third were equally divided between public health hospitals and private health service/hospitals. Eight of the 88 drug companies involved were among the world's largest and supported 38% of the projects. Fifty-nine percent of all the projects were within four therapeutic groups: antineoplastic/immunomodulating agents, nervous system, cardiovascular system and alimentary tract/metabolism. The distribution of research phases was as follows: phase I 1.2%, phase II 16.4%, phase III 26.6% and phase IV 55.8%. In the phase IV drug trials, drugs had been approved for sale by the NMA.
The share of research projects related to the development of drugs supported by the industry is high. Research independent of the industry is of importance to avoid bias and selective publications and to prevent research as a means of marketing. Independent research should be encouraged and financially supported by sources with no connection to the drug industry.
PubMed ID
17673994 View in PubMed
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Assessing payback from research investment.

https://arctichealth.org/en/permalink/ahliterature144336
Source
Can J Ophthalmol. 2010 Apr;45(2):113-4
Publication Type
Article
Date
Apr-2010
Author
Yvonne M Buys
Source
Can J Ophthalmol. 2010 Apr;45(2):113-4
Date
Apr-2010
Language
English
French
Publication Type
Article
Keywords
Biomedical Research - economics
Canada
Cost-Benefit Analysis
Financing, Government - statistics & numerical data
Health Services Research - economics
Humans
Program Evaluation
Research Support as Topic
Notes
Comment On: Can J Ophthalmol. 2010 Apr;45(2):132-420379296
PubMed ID
20379291 View in PubMed
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[A survey of research funding at Danish regional hospitals].

https://arctichealth.org/en/permalink/ahliterature146742
Source
Ugeskr Laeger. 2009 Dec 7;171(50):3698-701
Publication Type
Article
Date
Dec-7-2009
Author
Gunnar Lauge Nielsen
Lars Jelstrup Petersen
Nete Hornung
Claus Rasmussen
Lars Frost
Jens Fedder
Ole Lederballe
Finn Lauszus
Author Affiliation
Medicinsk afdeling, Sygehus Himmerland, DK-9640 Farsø, Denmark. guln@rn.dk
Source
Ugeskr Laeger. 2009 Dec 7;171(50):3698-701
Date
Dec-7-2009
Language
Danish
Publication Type
Article
Keywords
Biomedical Research - economics - legislation & jurisprudence
Budgets
Denmark
Hospitals, District
Humans
Questionnaires
Research Personnel - economics
Research Support as Topic
Resource Allocation
Abstract
According to recently passed Danish legislation, all Danish hospitals are obliged to take part in scientific research. As data on financial support for research activities are lacking, we assessed the resources allocated to research from the budget of the central hospital management as a percentage of the total budget at Danish regional hospitals in 2007.
A postal survey was conducted at 13 hospitals in the Western part of Denmark. The questionnaire comprised items in the following major categories: 1) budget allocated specifically for research and travel grants; 2) employment of scientific and technical support staff; 3) facilities and equipment for research; and 4) research dissemination.
Questionnaires were returned from 11 hospitals. Six hospitals reported to have dedicated fixed amounts on the budget for research, exact figures were reported in four cases only equivalent to 0.1%, 0.3%, 0.3% and 0.6% of the total budget. Most hospitals had associate professors, but only five had full professors. Seven hospitals supplied laboratories and technical facilities, eight hospitals held staff-meetings on a regular basis and four published an annual report on research activities.
In the majority of regional hospitals in Western Denmark, less than 0.3% of the total budget administered by the central hospital management was allocated specifically for research. These figures, however, may not be accurate as individual departments may allocate additional resources from local budgets. We recommend that regional hospitals define research strategies and allocate the necessary funding in their budgets.
PubMed ID
20003866 View in PubMed
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Canada supports agency criticised as an "AIDS denier".

https://arctichealth.org/en/permalink/ahliterature182544
Source
BMJ. 2003 Dec 6;327(7427):1306
Publication Type
Article
Date
Dec-6-2003

Clinical research lags behind biomedical, population-based health, and health services research at multiple levels.

https://arctichealth.org/en/permalink/ahliterature161754
Source
Clin Invest Med. 2007;30(4):E152-8
Publication Type
Article
Date
2007
Author
Malathi Raghavan
J Dean Sandham
Author Affiliation
Office of the Dean, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada. raghavan@cc.umanitoba.ca
Source
Clin Invest Med. 2007;30(4):E152-8
Date
2007
Language
English
Publication Type
Article
Keywords
Biomedical Research - economics - statistics & numerical data - trends
Canada
Health Services Research - economics - statistics & numerical data - trends
Humans
Research Personnel - statistics & numerical data
Research Support as Topic - statistics & numerical data
Retrospective Studies
Abstract
Concerns regarding a decline in clinical research have been raised internationally. In this study, research initiatives and competitiveness of investigators seeking funding for clinical research were compared with those for three other health research themes in Canada, namely, biomedical, population-based, and health services research.
A retrospective, multi-level descriptive study was conducted using administrative data from the Canadian Institutes for Health Research (CIHR) research grants program. Annual growth rates in numbers of proposals submitted since year 2000 (level I of comparison), success rates of submissions (level II), and growth rates in funding received since fiscal-year 1999-00 (level III) were compared across themes.
Proposal submission (Level I): The average annual rate of growth in proposal submissions for biomedical, clinical, population-based and health services research was 11.8%, 6.3%, 105.0% and 43.2%, respectively. Success rate (Level II) was lower in clinical research (24%; P-value
PubMed ID
17716593 View in PubMed
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[Clinical research pays off. Big net profits are to be gained by improved health according to an American study].

https://arctichealth.org/en/permalink/ahliterature167277
Source
Lakartidningen. 2006 Sep 6-12;103(36):2542
Publication Type
Article
Author
Bengt Jönsson
Author Affiliation
Handelshögskolan, Stockholm. bengt.jonsson@hhs.se
Source
Lakartidningen. 2006 Sep 6-12;103(36):2542
Language
Swedish
Publication Type
Article
Keywords
Biomedical Research - economics
Clinical Trials as Topic - economics
Cost-Benefit Analysis
Humans
Quality-Adjusted Life Years
Research Support as Topic - economics
Sweden
United States
PubMed ID
17007197 View in PubMed
Less detail

CMA, health advocacy groups laud tobacco control, dementia investments in budget.

https://arctichealth.org/en/permalink/ahliterature104952
Source
CMAJ. 2014 Mar 18;186(5):E173-4
Publication Type
Article
Date
Mar-18-2014

[Corrupt research may damage public health].

https://arctichealth.org/en/permalink/ahliterature172479
Source
Tidsskr Nor Laegeforen. 2005 Oct 6;125(19):2672-3
Publication Type
Article
Date
Oct-6-2005

49 records – page 1 of 5.