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9 records – page 1 of 1.

[Characteristics of bioelectrical activity, vascular-autonomic tone and biogenic amine metabolism in psychogenic depression]

https://arctichealth.org/en/permalink/ahliterature46824
Source
Fiziol Zh. 1976 Jan-Feb;22(1):47-55
Publication Type
Article

[Characteristics of the changes in brain bioelectrical activity, vascular and autonomic tonus and in biogenic amine metabolism in somatogenic depression]

https://arctichealth.org/en/permalink/ahliterature46819
Source
Fiziol Zh. 1976 Jul-Aug;22(4):457-64
Publication Type
Article

Evaluation of oxidative status and depression-like responses in Brown Norway rats with acute myeloid leukemia.

https://arctichealth.org/en/permalink/ahliterature89746
Source
Prog Neuropsychopharmacol Biol Psychiatry. 2009 Jun 15;33(4):596-604
Publication Type
Article
Date
Jun-15-2009
Author
Papiez Monika A
Dybala Malgorzata
Sowa-Kucma Magdalena
Krzysciak Wirginia
Taha Hevidar
Jozkowicz Alicja
Nowak Gabriel
Author Affiliation
Department of Cytobiology & Histochemistry, Faculty of Pharmacy, Jagiellonian University, Krakow, Poland. mfpapiez@cyf-kr.edu.pl
Source
Prog Neuropsychopharmacol Biol Psychiatry. 2009 Jun 15;33(4):596-604
Date
Jun-15-2009
Language
English
Publication Type
Article
Keywords
Analysis of Variance
Animals
Behavior, Animal
Biliverdine - genetics - metabolism
Body Weight
Cerebral Cortex - metabolism
Depression - etiology
Disease Models, Animal
Ferritins - genetics - metabolism
Glutathione - metabolism
Heme Oxygenase (Decyclizing) - genetics - metabolism
Hippocampus - metabolism
Leukemia, Myeloid, Acute - complications - pathology
Lipid Peroxidation - physiology
Male
Motor Activity - physiology
Oxidative Stress - physiology
Protein Binding - physiology
Radioligand Assay - methods
Rats
Rats, Inbred BN
Receptors, Biogenic Amine - metabolism
Spectrophotometry
Spleen - metabolism
Swimming
Abstract
It has been proved that oxidative stress increases when leukemia is accompanied by depression. This fact may indicate the role of oxidative stress in the development of depression in cancer patients. The aim of this study was to determine whether the acute myeloid leukemia of Brown Norway rats, which is accompanied by oxidative stress, evoked behavioral and receptor changes resembling alterations characteristic of rat models of depression. The rats were divided into two groups: leukemic rats and healthy control. Leukemia was induced through intraperitoneal injection of 10(7) promyelocytic leukemia cells to the Brown Norway rats. Depression-like behavior was evaluated in the forced swim test at 30 or 34 days after leukemic cells injection. The rats were killed after the evaluation and the spleen, brain cortex and hippocampus were excised. The red-ox state was assessed in homogenates of tissues by measuring total glutathione (GSH) content, the ferric ion reducing ability of plasma (FRAP) level, expression of heme oxygenase-1 (HO-1), biliverdin reductase (BvR) and ferritin mRNA, superoxide dismutase (SOD) activity, as well as malondialdehyde (MDA) concentration. Radioligand binding assay was used to assess of the effect of leukemia on cortical receptors. Leukemic cells were identified using RM-124 antibody by FACS Calibur flow cytometry. Leukemia influenced locomotory activity as well as forced swim test behavior in a 34-day series of experiments. Signs of oxidative stress in leukemic rats were observed in each examined stage of leukemia development. The FRAP values and glutathione contents, were significantly lowered whereas HO-1 mRNA expression, and malonodialdehyde concentrations were significantly increased in the spleen and brain structures of leukemic rats in comparison with the healthy controls. A significant increase in the potency of glycine to displace [(3)H]L-689,560 from the strychnine-insensitive glycine site of the N-methyl-D-aspartic (NMDA) receptors receptor complex in cortical homogenates of the leukemic rats in 30- and 34-day experimental series was observed in comparison with the control. Upregulation of 5-HT(2A) receptors was observed in rat cortex after 30 days of leukemia development but not in 34-days series compared with the control. It is concluded that disturbances in antioxidant system in brain cortex were accompanied by an activation of glycine sites of the NMDA receptor complex, regardless of stage of leukemia development, which are characteristic of model of depression. Findings of our study demonstrate the link between glutamatergic activity, oxidative stress and leukemia.
PubMed ID
19268504 View in PubMed
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[Modern views on the correlation of brain metabolites in pathogenesis of epilepsy in children]

https://arctichealth.org/en/permalink/ahliterature30269
Source
Lik Sprava. 2004 Mar;(2):15-9
Publication Type
Article
Date
Mar-2004
Author
A Iu Rudenko
V O Svystil'nyk
Source
Lik Sprava. 2004 Mar;(2):15-9
Date
Mar-2004
Language
Ukrainian
Publication Type
Article
Keywords
Biogenic Amines - metabolism
Brain - metabolism
Child
English Abstract
Epilepsy - etiology - metabolism
Glutamic Acid - metabolism
Humans
gamma-Aminobutyric Acid - metabolism
Abstract
The article presents current view on formation and expansion of epileptiform activity. Still the role of the correlation of cerebral metabolites in pathogenesis of epilepsy among children hasn't been illustrated sufficiently. It was shown in the article that topical diagnostics of an epileptogenous zone as well as an analysis of the interaction among elements of the epileptogenic system help organize and realize successful therapeutic actions.
PubMed ID
15208866 View in PubMed
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Role of arylalkylamine N-acetyltransferase in regulation of biogenic amines levels by gonadotropins in Drosophila.

https://arctichealth.org/en/permalink/ahliterature86053
Source
J Comp Physiol [B]. 2008 Mar;178(3):315-20
Publication Type
Article
Date
Mar-2008
Author
Rauschenbach I Yu
Adonyeva N V
Alekseev A A
Chentsova N A
Gruntenko N E
Author Affiliation
Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Lavrentjev ave., 10, Novosibirsk, 630090, Russia. iraushen@bionet.nsc.ru
Source
J Comp Physiol [B]. 2008 Mar;178(3):315-20
Date
Mar-2008
Language
English
Publication Type
Article
Keywords
Animals
Arylalkylamine N-Acetyltransferase - metabolism
Biogenic Amines - metabolism
Dopamine - metabolism
Drosophila Proteins - metabolism
Drosophila melanogaster - metabolism
Ecdysterone - metabolism - pharmacology
Female
Gonadotropins - pharmacology
Juvenile Hormones - metabolism - pharmacology
Octopamine - metabolism
Abstract
The effect of 20-hydroxyecdysone (20E) and the juvenile hormone (JH) on the activity of the arylalkylamine N-acetyltransferase (AANAT) was studied in young females of wild-type D. virilis and D. melanogaster. 20E feeding of the flies led to a decrease in AANAT activity in both species when dopamine (DA) was used as substrate, but did not affect the enzyme activity when octopamine (OA) was used as substrate. JH application increased AANAT activity with DA as substrate in both species, but did not change it with OA as substrate. AANAT activity was also measured in young females of a JH-deficient strain of D. melanogaster, apterous ( 56f ). A decrease in the enzyme activity was observed in the mutant females as compared to wild-type. Mechanisms of regulation of DA level by gonadotropins in Drosophila are discussed.
PubMed ID
18038140 View in PubMed
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Role of ecdysone 20-monooxygenase in regulation of 20-hydroxyecdysone levels by juvenile hormone and biogenic amines in Drosophila.

https://arctichealth.org/en/permalink/ahliterature94069
Source
J Comp Physiol B. 2008 Jan;178(1):27-32
Publication Type
Article
Date
Jan-2008
Author
Rauschenbach Inga Yu
Gruntenko N E
Chentsova N A
Adonyeva N V
Alekseev A A
Author Affiliation
Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Lavrentjev ave., 10, Novosibirsk , 630090, Russia. iraushen@bionet.nsc.ru
Source
J Comp Physiol B. 2008 Jan;178(1):27-32
Date
Jan-2008
Language
English
Publication Type
Article
Keywords
Age Factors
Animals
Aryl Hydrocarbon Hydroxylases - metabolism
Biogenic Amines - metabolism
Dopamine - metabolism
Drosophila Proteins - metabolism
Drosophila melanogaster - enzymology
Ecdysterone - metabolism
Female
Juvenile Hormones - metabolism
Kinetics
Levodopa - metabolism
Octopamine - metabolism
Steroid Hydroxylases - metabolism
Abstract
The effects of increased levels of dopamine (feeding flies with dopamine precursor, L: -dihydroxyphenylalanine) and octopamine (feeding flies with octopamine) on ecdysone 20-monooxygenase activity in young (2 days old) wild type females (the strain wt) of Drosophila virilis have been studied. L: -dihydroxyphenylalanine and octopamine feeding increases ecdysone 20-monooxygenase activity by a factor of 1.6 and 1.7, respectively. Ecdysone 20-monooxygenase activity in the young (1 day old) octopamineless females of the strain Tbetah ( nM18 ), in females of the strain P845 (precursor of Tbetah ( nM18 ) strain) and in wild type females (Canton S) of Drosophila melanogaster have been measured. The absence of octopamine leads to a considerable decrease in the enzyme activity. We have also studied the effects of juvenile hormone application on ecdysone 20-monooxygenase activity in 2-day-old wt females of D. virilis and demonstrated that an increase in juvenile hormone titre leads to an increase in the enzyme activity. We discuss the supposition that ecdysone 20-monooxygenase occupies a key position in the regulation of 20-hydroxyecdysone titre under the conditions that lead to changes in juvenile hormone titre and biogenic amine levels.
PubMed ID
17703313 View in PubMed
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[The effect of medikhronal on the biogenic amine level in the brain structures and blood of animals with alcohol dependence]

https://arctichealth.org/en/permalink/ahliterature10622
Source
Fiziol Zh. 1999;45(4):111-9
Publication Type
Article
Date
1999
Author
N K Kharchenko
Author Affiliation
Ukrainian Scientific-Research Institute of Social and Forensic Psychiatry, Ministry of Public Health of Ukraine, Kiev.
Source
Fiziol Zh. 1999;45(4):111-9
Date
1999
Language
Ukrainian
Publication Type
Article
Keywords
Alcohol Deterrents - therapeutic use
Alcoholic Intoxication - drug therapy - metabolism
Alcoholism - drug therapy - metabolism
Animals
Biogenic Amines - metabolism
Brain - drug effects - metabolism
Brain Chemistry - drug effects
Comparative Study
Drug Combinations
Drug Evaluation, Preclinical
English Abstract
Formates - therapeutic use
Glucose - therapeutic use
Glycine - therapeutic use
Male
Rats
Time Factors
Abstract
Peculiarities of changes in the content of biogenic amines in the brain structures (hypothalamus, midbrain and new cortex) and blood of rats under alcohol intoxication and formation of alcohol dependence were investigated, and the effect of medichronal and its components on the mentioned processes was found out. It has been established that accumulation of acetaldehide plays a considerable role in the mechanism of formation of alcohol dependence. Changes in the level of ethanol (E) and AcA in blood after the arrival of exogenic E to the organism evokes phase dynamics of content of biogenic amines in the blood and brain sections. Medichronal components, binding and inactivating AcA, as well as taking the mutually supplementing effect on synthesis of biogenic amines, promote normalization of the mentioned processes and elimination of alcohol dependence.
PubMed ID
10474811 View in PubMed
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9 records – page 1 of 1.