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Role of glutathione-S-transferase M1 (GSTM1) and T1 (GSTT1) genes in the development and progress of chronic myeloid leukemia and in the formation of response to imatinib therapy.

https://arctichealth.org/en/permalink/ahliterature265786
Source
Bull Exp Biol Med. 2014 Dec;158(2):242-5
Publication Type
Article
Date
Dec-2014
Author
V A Ovsepyan
A S Luchinin
T P Zagoskina
Source
Bull Exp Biol Med. 2014 Dec;158(2):242-5
Date
Dec-2014
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Benzamides - metabolism - therapeutic use
Cytogenetic Analysis
Gene Deletion
Genetic Predisposition to Disease - genetics
Genotype
Glutathione Transferase - genetics - metabolism
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy - epidemiology - metabolism - physiopathology
Middle Aged
Odds Ratio
Piperazines - metabolism - therapeutic use
Pyrimidines - metabolism - therapeutic use
Risk factors
Russia - epidemiology
Abstract
The effects of GSTM1 and GSTT1 gene deletion ("zero") polymorphisms on the risk of chronic myeloid leukemia development and progress and on response to imatinib monotherapy were studied in the representatives of the Russian nationality in the Vyatka region of Russia. Homozygotic carriership of GSTT1 "zero" allele was associated with a 3.66 times higher risk of chronic myeloid leukemia development in residents of the Vyatka region (OR=3.66, 95% CI=2.12-6.30; p
PubMed ID
25432281 View in PubMed
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