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Comparative neurohormonal responses in patients with preserved and impaired left ventricular ejection fraction: results of the Studies of Left Ventricular Dysfunction (SOLVD) Registry. The SOLVD Investigators.

https://arctichealth.org/en/permalink/ahliterature220148
Source
J Am Coll Cardiol. 1993 Oct;22(4 Suppl A):146A-153A
Publication Type
Article
Date
Oct-1993
Author
C R Benedict
D H Weiner
D E Johnstone
M G Bourassa
J K Ghali
J. Nicklas
P. Kirlin
B. Greenberg
M A Quinones
S. Yusuf
Author Affiliation
Division of Cardiology, University of Texas Medical School, Houston 77030.
Source
J Am Coll Cardiol. 1993 Oct;22(4 Suppl A):146A-153A
Date
Oct-1993
Language
English
Publication Type
Article
Keywords
Adult
Aged
Analysis of Variance
Belgium
Canada - epidemiology
Chi-Square Distribution
Female
Heart Failure - blood - epidemiology - physiopathology
Hormones - blood
Humans
Male
Middle Aged
Reproducibility of Results
Sensitivity and specificity
Stroke Volume
United States - epidemiology
Ventricular Function, Left
Abstract
The aim of this study was to determine the differences in neurohumoral responses between patients with pulmonary congestion with and without impaired left ventricular ejection fraction.
Previous studies have established the presence of neurohumoral activation in patients with congestive heart failure. It is not known whether the activation of these neurohumoral mechanisms is related to the impairment in systolic contractility.
The 898 patients recruited into the Studies of Left Ventricular Dysfunction (SOLVD) Registry substudy were examined to identify those patients with pulmonary congestion on chest X-ray film who had either impaired ( 45%, group II) left ventricular ejection fraction. Plasma norepinephrine, plasma renin activity, arginine vasopressin and atrial natriuretic peptide levels were measured in these two groups of patients and compared with values in matched control subjects.
Distribution of the New York Heart Association symptom classification was the same in the two groups of patients. Compared with control subjects, patients in group II with pulmonary congestion and preserved ejection fraction had no activation of the neurohumoral mechanisms, except for a small but statistically significant increase in arginine vasopressin and plasma renin activity. Compared with patients in group II, those in group I with pulmonary congestion and impaired ejection fraction had significant increases in plasma norepinephrine (p
PubMed ID
8376686 View in PubMed
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Natural history and patterns of current practice in heart failure. The Studies of Left Ventricular Dysfunction (SOLVD) Investigators.

https://arctichealth.org/en/permalink/ahliterature220149
Source
J Am Coll Cardiol. 1993 Oct;22(4 Suppl A):14A-19A
Publication Type
Article
Date
Oct-1993
Author
M G Bourassa
O. Gurné
S I Bangdiwala
J K Ghali
J B Young
M. Rousseau
D E Johnstone
S. Yusuf
Author Affiliation
Montreal Heart Institute, Montreal, Quebec, Canada.
Source
J Am Coll Cardiol. 1993 Oct;22(4 Suppl A):14A-19A
Date
Oct-1993
Language
English
Publication Type
Article
Keywords
Age Factors
Aged
Belgium - epidemiology
Canada - epidemiology
Chi-Square Distribution
Continental Population Groups
Female
Follow-Up Studies
Heart Failure - diagnosis - drug therapy - mortality
Humans
Male
Middle Aged
Odds Ratio
Physician's Practice Patterns - statistics & numerical data
Registries - statistics & numerical data
Risk factors
Sex Factors
United States - epidemiology
Ventricular Function, Left
Abstract
A total of 6,273 consecutive relatively unselected patients with heart failure or left ventricular dysfunction, or both (mean age 62 +/- 12 years, mean ejection fraction 31 +/- 9%), were enrolled in the Studies of Left Ventricular Dysfunction (SOLVD) Registry over a period of 14 months. All patients were followed up for vital status and hospital admissions at 1 year. Ischemic heart disease was the underlying cause of failure or dysfunction in approximately 70% of patients, whereas hypertensive heart disease was considered to be primarily involved in only 7%. There were striking differences in the etiology of heart failure among blacks and whites: 73% of whites had an ischemic etiology of failure versus only 36% of blacks; 32% of blacks had a hypertensive condition versus only 4% of whites. The total 1-year mortality rate was 18%; 19% of patients had hospital admissions for heart failure and 27% either died or had a hospital admission for congestive heart failure during the 1st year of follow-up. Factors related to 1-year mortality or hospital admission for congestive heart failure included age, ejection fraction, diabetes mellitus, atrial fibrillation and female gender. There was no difference in mortality associated with congestive heart failure among blacks and whites, but hospital admissions for heart failure were more frequent in blacks. Digitalis and diuretic agents were the drugs most often used in these patients, who were often taking many medications in relation to severity of congestive heart failure symptoms and ejection fraction.(ABSTRACT TRUNCATED AT 250 WORDS)
PubMed ID
8376685 View in PubMed
Less detail