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Multimodal event-related potentials in occupational chronic solvent encephalopathy.

https://arctichealth.org/en/permalink/ahliterature126689
Source
Neurotoxicology. 2012 Aug;33(4):703-9
Publication Type
Article
Date
Aug-2012
Author
Petra Keski-Säntti
Kirsi Palmu
Miia Pitkonen
Sara Liljander
Juhani V Partanen
Ritva Akila
Markku Sainio
Anu Holm
Author Affiliation
Finnish Institute of Occupational Health, Department of Occupational Medicine, Brain and Work Research Centre, Topeliuksenkatu 41 a A, FI-00250, Helsinki, Finland. petra.keski-santti@hus.fi
Source
Neurotoxicology. 2012 Aug;33(4):703-9
Date
Aug-2012
Language
English
Publication Type
Article
Keywords
Acoustic Stimulation
Aged
Air Pollutants, Occupational - adverse effects
Analysis of Variance
Attention - drug effects
Auditory Perception - drug effects
Brain - drug effects - physiopathology
Case-Control Studies
Chronic Disease
Cognition - drug effects
Electroencephalography
Event-Related Potentials, P300 - drug effects
Female
Finland
Humans
Male
Middle Aged
Neuropsychological Tests
Neurotoxicity Syndromes - diagnosis - etiology - physiopathology - psychology
Occupational Diseases - chemically induced - diagnosis - physiopathology - psychology
Occupational Exposure - adverse effects
Occupational Health
Photic Stimulation
Predictive value of tests
Reaction Time - drug effects
Recognition (Psychology) - drug effects
Solvents - adverse effects
Time Factors
Visual Perception - drug effects
Abstract
The aim of this study was to test a multimodal event-related potential (ERP) paradigm in chronic solvent encephalopathy (CSE) to develop a sensitive method for the clinical diagnostics to CSE. The study comprised 11 CSE patients and 13 healthy controls. We used three tasks: an auditory odd-ball (AUD), a visual detection (VIS), and a recognition memory (MEM) task. The auditory and visual stimuli were presented in single- and dual-task conditions. The auditory P300 amplitude in single-task condition was smaller in the patient group than in the control group at the parietal (Pz) but not at the frontal midline electrode location. The auditory P300 response in the dual task condition AUD+VIS was unrecognizable in 8 of 11 patients and in 1 of 13 controls and in the AUD+MEM condition in 10 of 11 patients and in 4 of 13 controls. In the AUD+MEM condition, the auditory P300 amplitude at Pz was smaller in the patient group than in the control group. Reaction time for auditory stimuli in both dual conditions as well as for visual stimuli in AUD+VIS condition were in the patient group prolonged. The ERP results indicate that CSE patients present with slowed performance speed and difficulties in allocation of attention. Based on ERP results, the disturbance in brain activity in CSE seems to affect posterior aspects of the frontoparietal continuity. The multimodal paradigm seems promising as a tool for the clinical diagnostics of CSE.
PubMed ID
22366255 View in PubMed
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